GREMLIN Database
YQHA - UPF0114 protein YqhA
UniProt: P67244 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13011
Length: 164 (158)
Sequences: 469 (241)
Seq/√Len: 19.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
137_M141_I6.4461.00
37_E40_H4.3031.00
22_G34_F3.4381.00
110_A150_A2.4710.97
124_V136_L2.3910.96
33_K36_Q2.3690.96
61_V103_T2.3140.95
39_I43_P2.3020.95
70_L140_V2.2950.95
123_R127_D2.2110.94
67_G126_M2.1470.93
117_S143_H2.0720.91
143_H149_S1.9030.87
138_W141_I1.8730.87
148_L152_V1.8170.85
27_L101_D1.7470.82
73_V120_H1.7420.82
44_N47_S1.7230.81
117_S149_S1.7160.81
83_S117_S1.6890.80
10_Y94_L1.6680.79
41_V56_V1.6450.78
6_E86_D1.6130.77
39_I44_N1.6110.77
155_Y158_R1.6080.77
110_A118_S1.6050.77
12_S24_S1.5930.76
73_V101_D1.5500.74
110_A153_M1.5440.74
97_L150_A1.5310.73
61_V119_I1.5290.73
132_P135_K1.5280.73
136_L142_I1.5270.73
55_L101_D1.5200.72
32_L46_F1.5190.72
76_S99_K1.4910.71
49_A52_D1.4640.69
94_L109_V1.4580.69
5_L9_M1.4390.68
8_A11_A1.4290.68
54_I126_M1.4230.67
73_V111_A1.4170.67
83_S143_H1.4000.66
97_L110_A1.3980.66
89_E144_L1.3940.66
57_L70_L1.3930.66
105_L146_F1.3890.65
15_L28_V1.3430.63
73_V153_M1.3400.62
55_L73_V1.3390.62
66_V118_S1.3210.61
20_Y77_G1.2870.59
40_H50_E1.2860.59
32_L36_Q1.2840.59
80_N112_S1.2810.59
8_A21_F1.2790.59
30_L75_F1.2700.58
83_S149_S1.2680.58
75_F97_L1.2570.57
27_L73_V1.2390.56
150_A156_L1.2270.55
83_S92_E1.2180.55
65_L76_S1.2110.54
37_E123_R1.1800.53
110_A156_L1.1620.51
68_G109_V1.1580.51
45_I53_L1.1570.51
111_A153_M1.1570.51
10_Y68_G1.1480.50
124_V139_Y1.1180.49
105_L157_D1.1170.49
29_A53_L1.1140.48
38_I153_M1.1060.48
21_F90_N1.0930.47
120_H153_M1.0930.47
84_Q97_L1.0800.46
9_M28_V1.0730.46
48_M53_L1.0630.45
109_V141_I1.0350.43
101_D104_S1.0300.43
70_L100_M1.0220.43
136_L140_V1.0170.42
25_L28_V1.0170.42
19_V31_A1.0090.42
136_L148_L0.9960.41
61_V120_H0.9890.40
127_D152_V0.9760.40
52_D127_D0.9750.40
32_L42_L0.9700.39
76_S139_Y0.9600.39
86_D103_T0.9400.38
20_Y68_G0.9310.37
32_L113_I0.9220.36
110_A145_T0.9140.36
72_M150_A0.9070.36
99_K104_S0.9020.35
72_M102_A0.8970.35
9_M146_F0.8900.35
38_I54_I0.8820.34
80_N115_A0.8820.34
21_F53_L0.8820.34
144_L147_V0.8800.34
93_K150_A0.8720.34
113_I118_S0.8520.32
27_L65_L0.8510.32
68_G111_A0.8500.32
29_A43_P0.8490.32
102_A110_A0.8450.32
39_I42_L0.8440.32
113_I136_L0.8290.31
33_K53_L0.8270.31
19_V64_T0.8190.31
107_N159_L0.8190.31
70_L74_M0.8060.30
16_L73_V0.8050.30
26_A57_L0.8030.30
43_P46_F0.8020.30
21_F130_N0.7900.29
36_Q73_V0.7890.29
11_A160_T0.7880.29
136_L159_L0.7820.29
65_L109_V0.7810.29
40_H157_D0.7790.29
131_V135_K0.7760.28
5_L25_L0.7760.28
121_L142_I0.7730.28
61_V71_V0.7670.28
29_A42_L0.7600.28
22_G156_L0.7550.27
19_V126_M0.7500.27
15_L160_T0.7450.27
118_S145_T0.7450.27
26_A82_V0.7420.27
20_Y120_H0.7410.27
78_Y117_S0.7400.27
52_D141_I0.7340.26
4_F144_L0.7290.26
134_N141_I0.7150.25
41_V70_L0.7130.25
43_P107_N0.7120.25
6_E103_T0.6990.25
74_M154_G0.6880.24
45_I95_N0.6850.24
66_V80_N0.6810.24
113_I140_V0.6810.24
93_K145_T0.6790.24
127_D130_N0.6770.24
16_L98_G0.6760.23
10_Y18_P0.6740.23
17_A28_V0.6740.23
65_L107_N0.6720.23
93_K110_A0.6690.23
5_L21_F0.6670.23
91_K127_D0.6660.23
19_V85_L0.6660.23
76_S115_A0.6650.23
91_K100_M0.6650.23
20_Y101_D0.6650.23
24_S35_F0.6630.23
19_V37_E0.6630.23
113_I147_V0.6610.23
16_L115_A0.6610.23
155_Y159_L0.6550.23
24_S68_G0.6510.22
14_W79_E0.6500.22
55_L72_M0.6500.22
49_A137_M0.6450.22
26_A65_L0.6440.22
132_P160_T0.6390.22
96_W138_W0.6370.22
26_A105_L0.6330.22
26_A45_I0.6310.22
19_V160_T0.6280.21
85_L103_T0.6180.21
43_P145_T0.6140.21
32_L43_P0.6130.21
151_F155_Y0.6110.21
82_V134_N0.6090.21
71_V74_M0.6080.21
5_L130_N0.6080.21
34_F105_L0.6020.20
85_L88_S0.6020.20
39_I84_Q0.6010.20
27_L139_Y0.6000.20
68_G85_L0.5990.20
110_A115_A0.5930.20
112_S119_I0.5900.20
59_S63_M0.5900.20
5_L48_M0.5890.20
94_L154_G0.5870.20
24_S151_F0.5830.20
41_V107_N0.5790.19
76_S113_I0.5770.19
14_W18_P0.5750.19
40_H119_I0.5740.19
10_Y154_G0.5710.19
14_W69_L0.5710.19
66_V110_A0.5670.19
30_L76_S0.5640.19
87_I159_L0.5580.19
48_M127_D0.5530.18
114_V117_S0.5530.18
63_M132_P0.5520.18
103_T156_L0.5500.18
21_F45_I0.5490.18
98_G145_T0.5480.18
8_A29_A0.5480.18
84_Q87_I0.5450.18
137_M159_L0.5430.18
59_S74_M0.5390.18
64_T91_K0.5380.18
102_A150_A0.5350.18
41_V72_M0.5340.18
29_A154_G0.5340.18
127_D133_D0.5340.18
10_Y83_S0.5330.18
19_V113_I0.5310.18
104_S109_V0.5310.18
32_L44_N0.5300.17
27_L144_L0.5290.17
43_P47_S0.5290.17
73_V104_S0.5260.17
45_I56_V0.5250.17
102_A118_S0.5250.17
68_G154_G0.5250.17
5_L86_D0.5220.17
63_M68_G0.5200.17
85_L139_Y0.5170.17
133_D137_M0.5140.17
4_F39_I0.5140.17
84_Q92_E0.5140.17
111_A115_A0.5140.17
127_D135_K0.5080.17
132_P158_R0.5060.17
16_L30_L0.5050.17
11_A91_K0.5050.17
9_M161_R0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ar4A 1 0.4634 2.4 0.971 Contact Map
3ixzA 1 0.5122 2.2 0.972 Contact Map
4u2pA 4 0.2439 1.9 0.973 Contact Map
2mofA 1 0.1951 1.6 0.974 Contact Map
1ifpA 7 0.122 1.4 0.975 Contact Map
4us3A 1 0.9207 1.4 0.975 Contact Map
2x5qA 2 0.3537 1.3 0.975 Contact Map
2zxeA 1 0.5061 1.3 0.975 Contact Map
4w6vA 1 0.4695 1.3 0.975 Contact Map
1obbA 2 0.3293 1.2 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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