GREMLIN Database
YQFA - UPF0073 inner membrane protein YqfA
UniProt: P67153 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13077
Length: 219 (200)
Sequences: 3659 (2522)
Seq/√Len: 178.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_F205_S4.1291.00
177_V207_C3.4221.00
177_V203_G3.0211.00
102_F211_A2.9511.00
26_G202_L2.8131.00
60_S97_G2.7341.00
150_W179_S2.7051.00
27_L66_L2.6421.00
34_L58_G2.6401.00
177_V204_G2.6221.00
27_L62_I2.6041.00
117_I121_S2.5031.00
199_G203_G2.4281.00
48_A52_T2.3451.00
146_L179_S2.3401.00
20_S73_A2.3341.00
169_T173_V2.2401.00
165_A169_T2.1541.00
55_S59_G2.1041.00
82_W86_F2.0961.00
100_T120_W2.0071.00
130_K141_S1.9641.00
170_L207_C1.9121.00
114_G118_V1.8811.00
113_R117_I1.8731.00
146_L182_V1.8431.00
60_S93_L1.8281.00
35_V39_V1.8021.00
187_C190_I1.7991.00
61_M205_S1.7811.00
170_L210_L1.7741.00
113_R116_M1.7501.00
190_I193_N1.7321.00
18_A195_A1.7151.00
51_I55_S1.6981.00
16_E19_N1.6891.00
67_A86_F1.6651.00
93_L127_I1.6531.00
206_V210_L1.6101.00
111_L114_G1.5741.00
185_Y188_K1.5411.00
182_V197_W1.5391.00
111_L154_V1.5281.00
96_A123_A1.5161.00
24_G69_T1.5111.00
96_A120_W1.4851.00
167_S215_Y1.4671.00
22_S195_A1.4631.00
173_V177_V1.4461.00
40_Q213_Y1.3951.00
61_M94_L1.3871.00
209_F213_Y1.3771.00
17_I21_V1.3761.00
22_S199_G1.3631.00
176_V180_L1.3591.00
66_L70_L1.3441.00
172_A176_V1.3201.00
157_Y161_V1.3031.00
50_A105_V1.3021.00
173_V207_C1.2991.00
71_Y84_K1.2961.00
114_G117_I1.2891.00
33_G209_F1.2721.00
30_G61_M1.2701.00
149_G175_G1.2691.00
52_T55_S1.2611.00
110_P114_G1.2571.00
203_G207_C1.2481.00
53_S104_L1.2421.00
103_L115_L1.2321.00
106_G163_L1.2111.00
36_L40_Q1.2101.00
34_L62_I1.2031.00
33_G37_L1.1981.00
155_V158_E1.1961.00
115_L155_V1.1901.00
19_N22_S1.1861.00
111_L158_E1.1731.00
168_V172_A1.1711.00
49_T108_D1.1561.00
122_L148_M1.1501.00
171_L211_A1.1471.00
108_D112_A1.1301.00
210_L214_L1.1241.00
89_C127_I1.1231.00
183_I187_C1.1171.00
38_L55_S1.1041.00
67_A90_A1.0941.00
60_S94_L1.0851.00
72_H194_H1.0701.00
62_I66_L1.0691.00
139_I143_V1.0671.00
109_S112_A1.0651.00
64_L94_L1.0361.00
128_L132_T1.0341.00
88_H185_Y1.0341.00
102_F212_I1.0270.99
89_C131_L1.0220.99
166_G169_T1.0200.99
189_R193_N1.0030.99
119_I148_M1.0010.99
166_G215_Y0.9860.99
47_S50_A0.9860.99
118_V151_L0.9770.99
74_I79_A0.9690.99
84_K134_A0.9670.99
49_T104_L0.9650.99
56_L100_T0.9610.99
138_K188_K0.9600.99
177_V200_F0.9600.99
57_Y61_M0.9560.99
98_T174_G0.9470.99
21_V25_I0.9450.99
28_V32_V0.9450.99
18_A22_S0.9400.99
36_L213_Y0.9370.99
160_A168_V0.9220.99
79_A82_W0.9200.99
178_Y205_S0.9190.99
41_A54_Y0.9160.99
122_L144_T0.9030.99
124_L128_L0.9000.99
92_Y126_G0.8930.99
184_F187_C0.8840.98
95_I178_Y0.8790.98
53_S105_V0.8710.98
90_A93_L0.8670.98
42_V51_I0.8630.98
178_Y204_G0.8570.98
190_I195_A0.8560.98
99_Y119_I0.8550.98
134_A137_F0.8520.98
104_L112_A0.8480.98
152_S155_V0.8450.98
38_L42_V0.8400.98
146_L150_W0.8380.98
74_I83_L0.8360.98
133_I137_F0.8310.98
81_M135_H0.8310.98
142_L182_V0.8290.98
115_L151_L0.8280.98
94_L98_T0.8130.97
15_E195_A0.8110.97
160_A165_A0.8090.97
142_L197_W0.8070.97
126_G144_T0.8060.97
123_A148_M0.8050.97
115_L158_E0.8050.97
19_N194_H0.7970.97
54_Y212_I0.7960.97
96_A100_T0.7910.97
153_L156_I0.7820.97
16_E194_H0.7710.96
190_I196_I0.7700.96
20_S24_G0.7670.96
77_Q81_M0.7660.96
143_V147_A0.7640.96
150_W175_G0.7560.96
98_T178_Y0.7520.96
98_T208_H0.7510.96
103_L112_A0.7500.96
189_R192_Y0.7490.96
194_H198_H0.7480.96
52_T56_L0.7440.95
111_L155_V0.7420.95
74_I77_Q0.7410.95
49_T53_S0.7400.95
57_Y65_F0.7400.95
103_L107_L0.7360.95
20_S69_T0.7350.95
182_V186_V0.7340.95
122_L151_L0.7330.95
205_S208_H0.7140.94
141_S145_Y0.7120.94
196_I200_F0.7110.94
200_F203_G0.7110.94
63_L67_A0.7080.94
34_L55_S0.7070.94
40_Q44_L0.7050.94
76_H79_A0.7040.94
170_L211_A0.7020.94
175_G179_S0.7000.94
82_W85_K0.6990.94
19_N72_H0.6970.94
82_W131_L0.6950.94
27_L69_T0.6940.93
187_C193_N0.6930.93
95_I99_Y0.6900.93
197_W208_H0.6890.93
109_S114_G0.6890.93
21_V24_G0.6870.93
103_L152_S0.6810.93
31_I35_V0.6810.93
157_Y160_A0.6690.92
180_L200_F0.6630.92
121_S125_L0.6590.92
167_S211_A0.6580.92
22_S202_L0.6570.92
63_L90_A0.6570.92
15_E19_N0.6520.91
48_A51_I0.6460.91
100_T116_M0.6460.91
170_L214_L0.6450.91
146_L149_G0.6420.91
138_K186_V0.6410.90
46_A50_A0.6370.90
106_G162_K0.6350.90
57_Y178_Y0.6340.90
85_K89_C0.6340.90
68_S72_H0.6310.90
119_I151_L0.6280.90
94_L205_S0.6240.89
152_S159_M0.6230.89
179_S183_I0.6220.89
16_E72_H0.6220.89
78_R82_W0.6220.89
70_L83_L0.6210.89
61_M178_Y0.6210.89
52_T124_L0.6210.89
133_I136_R0.6190.89
191_P195_A0.6170.89
50_A53_S0.6140.89
38_L58_G0.6130.88
27_L31_I0.6130.88
87_D198_H0.6090.88
29_F206_V0.6060.88
180_L189_R0.6040.88
188_K193_N0.6030.88
42_V48_A0.6020.88
84_K88_H0.6000.87
70_L73_A0.5980.87
129_F140_L0.5980.87
78_R180_L0.5940.87
104_L116_M0.5930.87
132_T155_V0.5920.87
210_L213_Y0.5900.87
103_L119_I0.5880.86
116_M148_M0.5870.86
132_T135_H0.5860.86
27_L202_L0.5860.86
57_Y205_S0.5850.86
197_W201_V0.5840.86
101_P212_I0.5800.86
57_Y94_L0.5790.85
32_V36_L0.5780.85
160_A172_A0.5750.85
18_A27_L0.5750.85
32_V35_V0.5740.85
89_C93_L0.5740.85
184_F197_W0.5710.85
208_H211_A0.5690.85
152_S172_A0.5680.84
103_L116_M0.5650.84
81_M85_K0.5630.84
84_K138_K0.5630.84
153_L160_A0.5620.84
69_T73_A0.5610.84
26_G148_M0.5600.84
50_A54_Y0.5570.83
16_E22_S0.5550.83
180_L183_I0.5540.83
163_L167_S0.5540.83
184_F192_Y0.5540.83
21_V98_T0.5520.83
109_S158_E0.5500.82
201_V204_G0.5460.82
130_K192_Y0.5450.82
163_L168_V0.5420.82
49_T113_R0.5410.81
18_A199_G0.5360.81
38_L51_I0.5340.81
202_L206_V0.5330.80
99_Y148_M0.5320.80
152_S156_I0.5320.80
39_V180_L0.5310.80
104_L108_D0.5280.80
47_S108_D0.5280.80
17_I24_G0.5270.80
142_L186_V0.5260.80
138_K142_L0.5240.79
169_T172_A0.5240.79
87_D91_I0.5230.79
96_A99_Y0.5220.79
140_L143_V0.5220.79
36_L209_F0.5200.79
74_I80_K0.5200.79
85_K131_L0.5200.79
39_V44_L0.5180.79
192_Y195_A0.5160.78
25_I29_F0.5150.78
107_L158_E0.5140.78
119_I123_A0.5140.78
173_V176_V0.5120.78
22_S194_H0.5110.78
29_F32_V0.5100.78
61_M65_F0.5080.77
65_F204_G0.5080.77
30_G62_I0.5060.77
57_Y212_I0.5020.76
39_V42_V0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wxwA 1 0.9817 100 0.177 Contact Map
2jmfB 1 0.0365 2.9 0.965 Contact Map
4fbzA 3 0.274 2.4 0.966 Contact Map
3am6A 3 0.2648 2.1 0.967 Contact Map
2lx0A 1 0.1279 1.8 0.968 Contact Map
3ddlA 2 0.2831 1.5 0.97 Contact Map
3pjzA 2 0.4018 1.3 0.971 Contact Map
2ls2A 1 0.1142 1.3 0.971 Contact Map
2latA 1 0.1689 1.2 0.972 Contact Map
3c75L 1 0.2603 1.2 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0075 seconds.