GREMLIN Database
YHGN - UPF0056 inner membrane protein YhgN
UniProt: P67143 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12941
Length: 197 (191)
Sequences: 2479 (1654)
Seq/√Len: 119.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
188_L194_W4.1301.00
32_E35_R3.4031.00
48_L146_W3.3251.00
74_I188_L3.1851.00
51_M120_I3.1331.00
82_L85_I2.8941.00
71_T185_Q2.8701.00
150_F154_L2.6901.00
41_V150_F2.5871.00
8_A144_L2.4871.00
70_E193_M2.4831.00
46_I107_I2.4731.00
48_L143_L2.4591.00
185_Q189_D2.3691.00
50_V112_I2.2671.00
164_G167_G2.0981.00
59_E63_A2.0981.00
81_F187_F2.0751.00
45_L49_L2.0511.00
44_L146_W2.0221.00
4_I141_A2.0181.00
7_A141_A1.9451.00
24_F28_L1.9311.00
56_F139_V1.8881.00
4_I140_I1.8771.00
84_A180_V1.8401.00
52_L139_V1.8081.00
8_A148_G1.8071.00
47_A146_W1.7941.00
37_R154_L1.7601.00
48_L52_L1.7441.00
158_L161_R1.7301.00
86_K91_S1.7201.00
46_I111_A1.6961.00
70_E73_S1.6811.00
78_I81_F1.6671.00
16_D19_G1.6551.00
15_M145_A1.6511.00
192_R195_M1.6281.00
24_F40_M1.5271.00
51_M116_A1.5181.00
78_I187_F1.5021.00
74_I194_W1.4801.00
7_A127_L1.4771.00
73_S189_D1.4751.00
11_L124_L1.4741.00
50_V116_A1.4721.00
115_V149_T1.4061.00
51_M124_L1.3981.00
147_G151_V1.3931.00
52_L143_L1.3831.00
81_F183_A1.3591.00
155_Q158_L1.3301.00
24_F110_L1.3181.00
4_I144_L1.2951.00
55_L124_L1.2921.00
41_V154_L1.2901.00
44_L149_T1.2861.00
36_R157_S1.2600.99
71_T188_L1.2570.99
106_F111_A1.2460.99
124_L142_L1.2410.99
128_S138_L1.2360.99
55_L139_V1.2280.99
74_I191_I1.2260.99
31_T35_R1.2230.99
19_G22_P1.2140.99
44_L150_F1.2070.99
77_G187_F1.1880.99
55_L128_S1.1840.99
87_M176_G1.1780.99
33_P37_R1.1700.99
15_M146_W1.1690.99
28_L36_R1.1650.99
43_E47_A1.1640.99
188_L191_I1.1630.99
31_T39_I1.1600.99
87_M175_M1.1580.99
11_L142_L1.1510.99
4_I8_A1.1460.99
20_N153_L1.1400.99
73_S193_M1.1380.99
42_R104_E1.1340.99
163_L167_G1.1280.99
49_L53_V1.1220.99
38_A42_R1.1210.99
33_P36_R1.1160.99
120_I124_L1.1050.99
158_L162_L1.1030.99
57_A61_I1.1020.99
77_G190_G1.0980.99
50_V111_A1.0980.99
179_L183_A1.0880.98
13_L16_D1.0850.98
87_M172_E1.0800.98
68_R185_Q1.0760.98
41_V45_L1.0630.98
78_I85_I1.0570.98
79_I83_I1.0430.98
74_I187_F1.0330.98
180_V183_A1.0310.98
22_P25_M1.0300.98
81_F180_V1.0070.97
13_L65_L0.9880.97
79_I180_V0.9850.97
151_V155_Q0.9680.97
37_R41_V0.9670.97
24_F36_R0.9650.97
62_L181_M0.9600.97
12_I148_G0.9580.97
15_M120_I0.9560.97
16_D80_L0.9530.96
14_I119_T0.9470.96
33_P157_S0.9460.96
81_F85_I0.9360.96
46_I106_F0.9350.96
14_I123_T0.9330.96
99_L102_G0.8900.95
74_I190_G0.8760.94
19_G23_I0.8750.94
53_V57_A0.8710.94
25_M160_L0.8690.94
80_L126_L0.8640.94
92_A95_N0.8580.94
147_G158_L0.8460.93
51_M121_L0.8360.93
19_G149_T0.8330.93
47_A111_A0.8290.93
60_K63_A0.8250.92
121_L125_M0.8190.92
43_E105_P0.8180.92
75_S184_T0.8170.92
133_N136_G0.8090.92
141_A145_A0.8030.91
44_L47_A0.8020.91
74_I184_T0.7940.91
49_L100_P0.7910.91
79_I168_V0.7910.91
12_I152_I0.7870.90
72_V122_A0.7840.90
116_A142_L0.7840.90
42_R46_I0.7700.89
61_I121_L0.7680.89
24_F156_S0.7660.89
68_R71_T0.7590.89
17_P145_A0.7560.89
24_F118_P0.7530.88
10_L123_T0.7460.88
62_L125_M0.7450.88
51_M142_L0.7380.87
16_D22_P0.7320.87
173_R184_T0.7310.87
86_K89_F0.7250.86
21_L25_M0.7210.86
90_P176_G0.7190.86
21_L153_L0.7160.86
116_A176_G0.7160.86
16_D175_M0.7130.86
145_A148_G0.7130.86
57_A60_K0.7110.85
21_L152_I0.7060.85
90_P173_R0.7010.85
111_A116_A0.6970.84
35_R39_I0.6960.84
20_N115_V0.6930.84
132_P136_G0.6910.84
54_F125_M0.6910.84
107_I166_K0.6880.84
49_L136_G0.6870.83
20_N114_L0.6840.83
88_I176_G0.6840.83
112_I177_L0.6810.83
70_E188_L0.6790.83
166_K170_A0.6760.82
71_T75_S0.6720.82
12_I145_A0.6720.82
17_P118_P0.6720.82
16_D54_F0.6680.82
16_D120_I0.6680.82
76_G122_A0.6660.81
8_A12_I0.6610.81
13_L177_L0.6610.81
79_I124_L0.6570.81
84_A88_I0.6550.80
144_L162_L0.6510.80
72_V195_M0.6510.80
65_L126_L0.6510.80
79_I114_L0.6500.80
72_V123_T0.6400.79
136_G140_I0.6380.79
100_P103_E0.6370.79
72_V146_W0.6350.78
14_I182_M0.6340.78
10_L177_L0.6330.78
20_N79_I0.6320.78
119_T173_R0.6270.77
84_A169_N0.6270.77
42_R106_F0.6240.77
11_L51_M0.6210.77
132_P135_M0.6190.77
55_L174_L0.6160.76
13_L180_V0.6140.76
175_M186_M0.6130.76
35_R38_A0.6120.76
37_R150_F0.6090.75
28_L31_T0.6050.75
93_S96_S0.6040.75
24_F68_R0.6020.75
10_L14_I0.6010.74
99_L103_E0.6000.74
114_L117_G0.5990.74
97_S101_A0.5970.74
86_K95_N0.5930.73
82_L89_F0.5920.73
105_P110_L0.5860.73
39_I43_E0.5840.72
64_F182_M0.5830.72
91_S94_G0.5790.72
72_V177_L0.5780.72
140_I144_L0.5770.71
13_L70_E0.5760.71
165_E169_N0.5730.71
122_A125_M0.5730.71
128_S137_H0.5700.71
62_L76_G0.5700.71
38_A191_I0.5690.70
127_L138_L0.5670.70
12_I86_K0.5660.70
58_G117_G0.5650.70
76_G87_M0.5650.70
47_A115_V0.5630.70
25_M171_L0.5620.69
119_T179_L0.5600.69
191_I195_M0.5600.69
108_V179_L0.5590.69
134_Q137_H0.5570.69
50_V155_Q0.5560.69
93_S97_S0.5560.69
8_A141_A0.5540.68
62_L72_V0.5540.68
113_P117_G0.5510.68
90_P169_N0.5460.67
18_L171_L0.5420.67
16_D75_S0.5420.67
29_K165_E0.5410.67
34_K37_R0.5400.66
36_R182_M0.5390.66
104_E191_I0.5380.66
11_L163_L0.5360.66
14_I50_V0.5360.66
67_L93_S0.5350.66
63_A143_L0.5350.66
84_A183_A0.5340.66
55_L142_L0.5330.65
100_P195_M0.5330.65
60_K174_L0.5320.65
90_P175_M0.5310.65
34_K162_L0.5300.65
43_E111_A0.5270.65
20_N110_L0.5260.64
101_A134_Q0.5260.64
22_P114_L0.5260.64
117_G173_R0.5250.64
126_L183_A0.5230.64
99_L151_V0.5220.64
65_L183_A0.5210.64
8_A50_V0.5200.64
27_V105_P0.5200.64
174_L178_I0.5190.63
69_A84_A0.5190.63
81_F184_T0.5170.63
170_A174_L0.5170.63
62_L68_R0.5170.63
6_S168_V0.5160.63
80_L182_M0.5150.63
56_F124_L0.5120.62
22_P115_V0.5120.62
13_L172_E0.5110.62
54_F115_V0.5080.62
168_V177_L0.5060.61
10_L66_S0.5060.61
120_I142_L0.5040.61
69_A138_L0.5030.61
6_S9_V0.5020.61
62_L109_P0.5000.61
46_I54_F0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cfqA 1 0.533 20.9 0.943 Contact Map
4lz6A 1 0.7665 13.2 0.948 Contact Map
4humA 1 0.8173 10.6 0.95 Contact Map
4wgvA 2 0.4162 6.5 0.954 Contact Map
3w4tA 1 0.7665 6 0.955 Contact Map
3mktA 1 0.8071 5.9 0.955 Contact Map
4hw9A 3 0.3198 5.7 0.956 Contact Map
1pw4A 1 0.5279 5.6 0.956 Contact Map
4k0jA 3 0.8376 4.9 0.957 Contact Map
3qe7A 2 0.6751 4.5 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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