GREMLIN Database
YFCE - Phosphodiesterase YfcE
UniProt: P67095 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14108
Length: 184 (154)
Sequences: 4208 (3313)
Seq/√Len: 266.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_L124_V4.0851.00
33_V103_L3.8291.00
142_F159_G3.7881.00
23_L158_Y2.8611.00
31_W68_I2.8461.00
5_M24_F2.7921.00
133_A140_F2.7041.00
101_L122_V2.5371.00
5_M29_A2.5041.00
35_L103_L2.3231.00
18_E59_R2.3221.00
125_Y132_V2.2911.00
10_I34_I2.2541.00
6_F124_V2.2451.00
102_F120_N2.2131.00
99_Q121_D2.1691.00
6_F161_L2.0581.00
10_I147_V1.9671.00
3_K162_D1.9491.00
100_R121_D1.8061.00
125_Y141_H1.7671.00
131_P157_S1.7381.00
68_I92_Q1.7221.00
21_L59_R1.7001.00
29_A160_M1.6461.00
38_V69_A1.5961.00
6_F142_F1.5831.00
7_A20_V1.5811.00
44_R55_K1.5111.00
5_M20_V1.5061.00
8_S35_L1.4731.00
14_L55_K1.4341.00
34_I69_A1.4251.00
10_I17_T1.4191.00
34_I38_V1.4161.00
8_S126_G1.3941.00
152_G157_S1.3811.00
18_E22_E1.3771.00
128_T143_N1.3771.00
32_L67_V1.3741.00
3_K160_M1.3701.00
13_S16_A1.3671.00
7_A17_T1.3451.00
14_L59_R1.3441.00
24_F32_L1.3351.00
20_V147_V1.3321.00
16_A156_A1.3311.00
150_P156_A1.2981.00
54_A58_E1.2921.00
135_Q140_F1.2921.00
144_P159_G1.2871.00
19_R23_L1.2841.00
13_S148_S1.2561.00
5_M158_Y1.2541.00
59_R62_E1.2261.00
5_M32_L1.2251.00
113_N117_L1.2221.00
104_T109_F1.2161.00
135_Q138_E1.1991.00
14_L18_E1.1591.00
152_G172_N1.1371.00
147_V158_Y1.1331.00
103_L124_V1.1261.00
133_A142_F1.1031.00
15_P18_E1.0921.00
4_L31_W1.0881.00
114_L118_N1.0631.00
99_Q166_L1.0461.00
25_A65_H1.0421.00
39_L74_C1.0211.00
76_S111_P1.0201.00
7_A34_I1.0191.00
104_T108_L1.0131.00
122_V140_F1.0091.00
86_P89_A0.9921.00
23_L171_L0.9841.00
95_L100_R0.9821.00
124_V142_F0.9811.00
146_S150_P0.9741.00
15_P44_R0.9661.00
33_V94_V0.9571.00
112_E116_A0.9561.00
24_F158_Y0.9491.00
24_F29_A0.9451.00
20_V24_F0.9361.00
123_L139_I0.9171.00
122_V161_L0.9111.00
5_M160_M0.9071.00
38_V56_V0.9071.00
20_V158_Y0.9051.00
25_A63_V0.8981.00
164_D167_S0.8941.00
106_G128_T0.8921.00
99_Q163_N0.8901.00
25_A28_G0.8871.00
85_F89_A0.8851.00
97_E163_N0.8711.00
7_A10_I0.8621.00
89_A92_Q0.8611.00
57_A61_N0.8611.00
71_R76_S0.8551.00
7_A32_L0.8521.00
63_V66_K0.8481.00
4_L161_L0.8441.00
146_S151_K0.8400.99
73_N127_H0.8390.99
6_F33_V0.8290.99
19_R22_E0.8270.99
53_P57_A0.8270.99
31_W96_L0.8240.99
124_V161_L0.8240.99
2_M162_D0.8200.99
115_P139_I0.8100.99
120_N123_L0.8100.99
16_A19_R0.8080.99
136_R139_I0.8050.99
125_Y128_T0.7950.99
99_Q122_V0.7930.99
24_F28_G0.7930.99
2_M96_L0.7820.99
22_E25_A0.7790.99
87_I90_P0.7720.99
131_P154_N0.7660.99
111_P125_Y0.7620.99
2_M30_Q0.7610.99
54_A57_A0.7600.99
89_A95_L0.7580.99
74_C149_I0.7570.99
21_L63_V0.7560.99
159_G170_A0.7470.99
115_P123_L0.7460.99
123_L141_H0.7440.99
104_T123_L0.7430.99
162_D169_I0.7420.99
90_P107_H0.7350.99
58_E61_N0.7290.99
74_C151_K0.7230.98
107_H110_G0.7220.98
107_H158_Y0.7160.98
82_L86_P0.7150.98
82_L85_F0.7130.98
29_A32_L0.7080.98
18_E55_K0.7060.98
163_N166_L0.6990.98
133_A170_A0.6970.98
157_S172_N0.6810.98
117_L120_N0.6810.98
35_L70_V0.6800.98
116_A137_G0.6800.98
124_V144_P0.6700.98
101_L124_V0.6570.97
83_L86_P0.6560.97
95_L98_K0.6530.97
9_D129_H0.6510.97
16_A148_S0.6490.97
17_T60_L0.6490.97
31_W66_K0.6450.97
15_P19_R0.6400.97
11_H129_H0.6390.97
44_R56_V0.6340.97
106_G110_G0.6330.97
112_E136_R0.6310.96
34_I75_D0.6270.96
55_K58_E0.6270.96
5_M28_G0.6270.96
126_G144_P0.6260.96
21_L25_A0.6240.96
101_L163_N0.6220.96
92_Q103_L0.6160.96
60_L67_V0.6120.96
81_M86_P0.6070.96
91_W94_V0.6060.96
7_A24_F0.6040.95
96_L99_Q0.6000.95
119_Q167_S0.5990.95
97_E166_L0.5980.95
17_T20_V0.5920.95
76_S80_Q0.5920.95
17_T56_V0.5910.95
154_N172_N0.5900.95
128_T145_G0.5880.95
131_P152_G0.5870.95
17_T147_V0.5770.94
102_F118_N0.5770.94
59_R63_V0.5760.94
54_A61_N0.5760.94
12_G53_P0.5720.94
5_M23_L0.5720.94
120_N139_I0.5690.94
7_A147_V0.5630.93
38_V71_R0.5590.93
9_D73_N0.5590.93
12_G56_V0.5570.93
136_R140_F0.5530.93
8_S106_G0.5530.93
154_N157_S0.5530.93
104_T107_H0.5520.93
16_A20_V0.5510.93
2_M97_E0.5500.93
116_A136_R0.5500.93
38_V76_S0.5480.93
17_T21_L0.5480.93
149_I154_N0.5470.92
53_P56_V0.5450.92
87_I91_W0.5450.92
100_R119_Q0.5440.92
20_V23_L0.5400.92
2_M164_D0.5380.92
93_Q120_N0.5370.92
58_E62_E0.5360.92
114_L136_R0.5360.92
102_F114_L0.5330.91
115_P118_N0.5310.91
19_R156_A0.5300.91
135_Q168_V0.5300.91
10_I38_V0.5280.91
3_K30_Q0.5210.91
4_L124_V0.5160.90
69_A92_Q0.5140.90
91_W114_L0.5130.90
106_G150_P0.5130.90
159_G168_V0.5110.90
33_V101_L0.5100.90
22_E138_E0.5090.90
2_M163_N0.5080.89
14_L44_R0.5080.89
98_K121_D0.5070.89
55_K59_R0.5070.89
88_T95_L0.5050.89
85_F95_L0.5000.89
112_E139_I0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nnwA 2 0.9511 100 0.353 Contact Map
3qfmA 2 0.9457 100 0.377 Contact Map
1su1A 3 0.9837 100 0.385 Contact Map
3rqzA 1 0.9402 100 0.389 Contact Map
1s3lA 1 0.8533 100 0.445 Contact Map
3ck2A 1 0.8587 100 0.461 Contact Map
2a22A 1 0.9293 100 0.468 Contact Map
1uf3A 6 0.8641 100 0.48 Contact Map
1z2wA 2 0.8804 100 0.48 Contact Map
1g5bA 4 0.8261 100 0.488 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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