GREMLIN Database
RSMI - Ribosomal RNA small subunit methyltransferase I
UniProt: P67087 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12777
Length: 286 (269)
Sequences: 3931 (2677)
Seq/√Len: 163.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_T90_V4.5261.00
25_A33_E3.9831.00
80_K85_Q3.5371.00
191_Y233_E3.2111.00
82_Q112_A3.0971.00
33_E37_A2.7871.00
29_Q32_L2.7841.00
18_P119_L2.7371.00
188_E211_G2.6461.00
152_R181_D2.6321.00
192_V213_L2.5421.00
192_V210_V2.4571.00
110_R207_G2.4521.00
131_A205_I2.2581.00
27_I32_L2.1851.00
50_G54_Q2.1851.00
182_I210_V2.1721.00
32_L56_F2.0391.00
39_D86_N1.9591.00
108_T111_E1.9331.00
145_L156_L1.9211.00
82_Q114_I1.8891.00
196_R204_T1.8631.00
145_L155_A1.8591.00
146_P155_A1.8581.00
124_A169_Y1.8371.00
17_V31_A1.8271.00
140_C164_R1.7861.00
13_Q117_V1.7671.00
18_P95_T1.7451.00
13_Q115_R1.7451.00
40_L87_I1.6671.00
17_V88_A1.6441.00
109_C114_I1.6421.00
118_P205_I1.6361.00
195_A205_I1.6351.00
74_A108_T1.6251.00
66_H69_N1.6141.00
73_K76_T1.6141.00
38_V88_A1.5891.00
208_A212_E1.5771.00
38_V86_N1.5761.00
42_A77_L1.5561.00
248_R270_H1.5481.00
178_S230_L1.5381.00
180_E218_K1.5371.00
193_V205_I1.5331.00
182_I232_V1.5251.00
248_R269_I1.5241.00
142_E155_A1.5201.00
125_A169_Y1.5201.00
258_P261_K1.5081.00
79_A83_E1.4991.00
40_L80_K1.4951.00
16_I106_V1.4751.00
142_E164_R1.4721.00
95_T130_S1.4671.00
252_L269_I1.4601.00
208_A213_L1.4511.00
108_T112_A1.4491.00
168_F232_V1.4461.00
118_P131_A1.4311.00
81_L114_I1.4311.00
42_A87_I1.4311.00
138_R142_E1.4251.00
153_R181_D1.4241.00
43_A62_L1.4171.00
272_V277_L1.4051.00
39_D85_Q1.4041.00
250_L254_Q1.4041.00
118_P130_S1.4031.00
263_A267_A1.4021.00
17_V34_V1.3991.00
99_N141_Y1.3951.00
257_L265_L1.3941.00
14_L81_L1.3921.00
78_L82_Q1.3861.00
140_C162_E1.3791.00
170_E174_R1.3681.00
153_R157_K1.3621.00
123_C126_I1.3571.00
259_L263_A1.3531.00
63_F73_K1.3511.00
206_H213_L1.3121.00
70_E104_H1.2981.00
65_L74_A1.2971.00
42_A63_F1.2951.00
27_I56_F1.2931.00
117_V203_E1.2921.00
259_L281_A1.2901.00
150_K154_D1.2871.00
157_K160_E1.2841.00
190_R234_G1.2681.00
155_A158_A1.2671.00
64_A73_K1.2561.00
32_L36_Q1.2541.00
80_K83_E1.2491.00
95_T118_P1.2371.00
265_L269_I1.2361.00
149_S181_D1.2341.00
156_L182_I1.2271.00
209_P212_E1.2201.00
153_R184_A1.2121.00
193_V231_I1.2081.00
27_I31_A1.2021.00
175_L228_M1.1981.00
183_V214_L1.1871.00
182_I186_L1.1821.00
61_R80_K1.1801.00
206_H216_W1.1791.00
215_A218_K1.1711.00
79_A82_Q1.1561.00
183_V211_G1.1531.00
103_Y135_P1.1521.00
252_L265_L1.1391.00
13_Q81_L1.1311.00
75_E108_T1.1301.00
183_V188_E1.1261.00
125_A167_I1.1241.00
194_L217_V1.1221.00
158_A163_P1.1191.00
187_G210_V1.1111.00
107_R191_Y1.1071.00
263_A281_A1.1021.00
183_V210_V1.0961.00
18_P127_T1.0901.00
65_L70_E1.0901.00
216_W222_N1.0841.00
215_A219_E1.0831.00
217_V224_R1.0740.99
253_L259_L1.0630.99
264_A274_K1.0520.99
33_E36_Q1.0510.99
15_Y34_V1.0360.99
193_V207_G1.0330.99
103_Y107_R1.0310.99
24_L55_H1.0310.99
214_L218_K1.0260.99
180_E214_L1.0250.99
40_L63_F1.0240.99
41_I53_L1.0210.99
194_L228_M1.0180.99
196_R228_M1.0140.99
15_Y38_V1.0100.99
123_C169_Y1.0070.99
13_Q86_N1.0030.99
29_Q36_Q0.9930.99
127_T131_A0.9880.99
28_T122_P0.9830.99
107_R111_E0.9820.99
159_I162_E0.9800.99
48_H51_L0.9560.99
51_L54_Q0.9470.99
266_A277_L0.9450.99
175_L217_V0.9450.99
29_Q56_F0.9440.99
118_P127_T0.9440.99
34_V88_A0.9440.99
140_C166_L0.9400.99
78_L109_C0.9370.99
26_D120_P0.9360.99
176_L214_L0.9320.99
166_L186_L0.9320.99
117_V131_A0.9290.98
249_T253_L0.9280.98
64_A69_N0.9220.98
260_K264_A0.9180.98
191_Y209_P0.9150.98
176_L180_E0.9110.98
262_A266_A0.9110.98
76_T80_K0.9100.98
153_R185_V0.9070.98
206_H217_V0.9010.98
149_S153_R0.9010.98
70_E74_A0.9000.98
34_V119_L0.8980.98
162_E166_L0.8930.98
194_L213_L0.8930.98
270_H277_L0.8790.98
40_L85_Q0.8790.98
41_I60_A0.8740.98
28_T119_L0.8700.98
134_L231_I0.8700.98
65_L73_K0.8680.98
176_L218_K0.8620.98
167_I231_I0.8620.98
63_F77_L0.8600.97
165_T231_I0.8580.97
178_S182_I0.8580.97
168_F178_S0.8580.97
263_A282_L0.8570.97
249_T281_A0.8510.97
182_I185_V0.8490.97
233_E236_K0.8470.97
250_L253_L0.8450.97
147_A174_R0.8430.97
252_L256_E0.8430.97
250_L281_A0.8380.97
16_I130_S0.8330.97
179_L217_V0.8330.97
142_E159_I0.8320.97
29_Q33_E0.8320.97
119_L127_T0.8290.97
97_L103_Y0.8240.97
50_G62_L0.8230.97
14_L89_L0.8200.97
128_A231_I0.8200.97
136_S165_T0.8200.97
249_T266_A0.8190.97
67_D70_E0.8130.96
222_N225_K0.8130.96
25_A29_Q0.8100.96
224_R228_M0.8070.96
212_E215_A0.8060.96
252_L257_L0.8060.96
77_L87_I0.8020.96
51_L55_H0.8010.96
175_L230_L0.8000.96
248_R252_L0.7990.96
97_L106_V0.7990.96
74_A78_L0.7970.96
103_Y137_D0.7910.96
129_L165_T0.7900.96
50_G59_N0.7900.96
179_L214_L0.7830.96
152_R178_S0.7750.95
156_L185_V0.7730.95
259_L282_L0.7710.95
279_K282_L0.7690.95
127_T198_L0.7690.95
91_S97_L0.7660.95
48_H92_D0.7590.95
95_T126_I0.7570.95
40_L61_R0.7570.95
74_A104_H0.7560.95
159_I186_L0.7520.95
69_N75_E0.7510.95
175_L224_R0.7470.94
14_L109_C0.7470.94
246_A280_Y0.7450.94
54_Q59_N0.7450.94
216_W224_R0.7410.94
127_T199_T0.7380.94
75_E79_A0.7360.94
272_V276_A0.7340.94
131_A193_V0.7320.94
166_L232_V0.7310.94
266_A269_I0.7310.94
154_D157_K0.7290.94
260_K275_N0.7240.93
273_K276_A0.7230.93
260_K274_K0.7210.93
251_A254_Q0.7190.93
173_H225_K0.7160.93
49_T62_L0.7140.93
210_V214_L0.7130.93
78_L112_A0.7110.93
135_P165_T0.7080.93
18_P131_A0.7070.93
36_Q57_G0.7060.93
159_I166_L0.7040.92
261_K265_L0.7040.92
53_L60_A0.7040.92
65_L105_L0.7020.92
67_D103_Y0.7020.92
175_L194_L0.6960.92
25_A37_A0.6960.92
263_A273_K0.6950.92
120_P127_T0.6920.92
18_P122_P0.6920.92
11_Q115_R0.6920.92
78_L114_I0.6910.92
241_D245_D0.6890.92
190_R232_V0.6880.92
97_L130_S0.6860.91
76_T79_A0.6830.91
248_R251_A0.6830.91
81_L87_I0.6830.91
181_D184_A0.6820.91
15_Y86_N0.6760.91
161_A235_H0.6730.91
194_L216_W0.6710.90
204_T222_N0.6690.90
160_E185_V0.6690.90
89_L105_L0.6680.90
106_V110_R0.6630.90
25_A56_F0.6620.90
242_L245_D0.6620.90
217_V228_M0.6620.90
178_S181_D0.6610.90
15_Y117_V0.6590.90
275_N279_K0.6580.90
168_F186_L0.6550.89
119_L199_T0.6540.89
179_L210_V0.6520.89
204_T224_R0.6470.89
157_K185_V0.6470.89
37_A86_N0.6460.89
18_P123_C0.6450.89
276_A280_Y0.6450.89
67_D104_H0.6420.88
131_A195_A0.6400.88
266_A270_H0.6390.88
128_A195_A0.6370.88
195_A231_I0.6340.88
136_S167_I0.6330.88
268_E275_N0.6320.88
160_E186_L0.6320.88
63_F80_K0.6310.88
56_F60_A0.6290.87
177_D181_D0.6290.87
251_A255_A0.6290.87
276_A279_K0.6250.87
255_A265_L0.6230.87
142_E166_L0.6220.87
263_A277_L0.6210.87
43_A49_T0.6200.87
134_L165_T0.6200.87
176_L224_R0.6190.87
175_L216_W0.6180.87
126_I130_S0.6170.86
34_V37_A0.6160.86
17_V41_I0.6150.86
129_L136_S0.6120.86
147_A151_G0.6070.86
138_R165_T0.5990.85
148_K151_G0.5990.85
249_T252_L0.5960.85
71_Q104_H0.5940.84
146_P151_G0.5930.84
134_L193_V0.5900.84
95_T123_C0.5860.84
256_E261_K0.5860.84
244_A247_L0.5850.83
206_H223_R0.5850.83
198_L205_I0.5840.83
247_L280_Y0.5840.83
67_D97_L0.5800.83
242_L246_A0.5800.83
39_D60_A0.5770.83
217_V223_R0.5770.83
259_L275_N0.5770.83
110_R133_G0.5760.82
175_L196_R0.5760.82
97_L136_S0.5730.82
195_A198_L0.5610.81
173_H228_M0.5600.81
156_L186_L0.5600.81
50_G53_L0.5600.81
18_P199_T0.5520.80
188_E209_P0.5500.80
128_A229_V0.5470.79
107_R110_R0.5460.79
243_P246_A0.5450.79
236_K241_D0.5440.79
138_R164_R0.5440.79
142_E162_E0.5430.79
15_Y88_A0.5410.78
194_L230_L0.5400.78
103_Y136_S0.5400.78
249_T269_I0.5380.78
95_T127_T0.5380.78
190_R233_E0.5380.78
125_A139_F0.5370.78
141_Y169_Y0.5370.78
104_H108_T0.5360.78
12_G81_L0.5360.78
194_L206_H0.5350.78
243_P247_L0.5330.77
210_V232_V0.5330.77
162_E234_G0.5320.77
119_L131_A0.5320.77
163_P237_A0.5310.77
151_G154_D0.5300.77
69_N73_K0.5290.77
17_V119_L0.5280.77
219_E222_N0.5260.76
46_T64_A0.5250.76
181_D185_V0.5250.76
180_E184_A0.5240.76
126_I169_Y0.5230.76
240_E244_A0.5230.76
159_I168_F0.5230.76
257_L262_A0.5200.76
210_V213_L0.5190.76
260_K268_E0.5180.75
48_H90_V0.5180.75
77_L81_L0.5170.75
263_A266_A0.5160.75
118_P193_V0.5150.75
249_T262_A0.5140.75
211_G215_A0.5140.75
225_K228_M0.5090.74
216_W219_E0.5050.74
175_L179_L0.5040.73
258_P263_A0.5040.73
255_A261_K0.5030.73
187_G190_R0.5030.73
26_D95_T0.5020.73
264_A275_N0.5020.73
89_L97_L0.5020.73
72_Q75_E0.5010.73
186_L210_V0.5010.73
246_A250_L0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kwpA 2 0.7972 100 0.334 Contact Map
1wyzA 2 0.7517 100 0.594 Contact Map
1cbfA 2 0.8042 100 0.612 Contact Map
4e16A 2 0.7762 100 0.619 Contact Map
3ndcA 2 0.8112 100 0.63 Contact Map
1s4dA 4 0.8776 100 0.631 Contact Map
2yboA 2 0.8357 100 0.632 Contact Map
1pjqA 2 0.8392 100 0.638 Contact Map
1va0A 2 0.7692 100 0.642 Contact Map
1ve2A 2 0.7692 100 0.644 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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