GREMLIN Database
BEPA - Beta-barrel assembly-enhancing protease
UniProt: P66948 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14199
Length: 487 (425)
Sequences: 1184 (917)
Seq/√Len: 44.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
358_K361_E4.5991.00
129_Q224_T4.2221.00
324_K327_E4.0781.00
116_L134_M3.7411.00
125_D228_K3.4691.00
391_Q394_E3.4511.00
382_L386_Y3.4141.00
80_G96_F3.1841.00
434_A441_G2.9931.00
432_A435_E2.8891.00
434_A446_A2.8831.00
333_Q349_A2.8641.00
446_A453_A2.8591.00
194_I197_T2.8381.00
274_F278_K2.7961.00
367_K394_E2.7581.00
441_G446_A2.6531.00
435_E453_A2.6001.00
353_D361_E2.5321.00
363_I382_L2.5151.00
132_S221_A2.4991.00
425_N428_Q2.4801.00
280_R284_M2.4541.00
449_L452_S2.4261.00
293_T297_L2.4111.00
319_A327_E2.3571.00
434_A453_A2.3411.00
386_Y394_E2.3071.00
354_L385_A2.2981.00
449_L453_A2.2721.00
432_A446_A2.2131.00
33_L36_M2.2021.00
34_P37_G2.1891.00
129_Q228_K2.1781.00
430_L449_L2.1501.00
429_E436_G2.1231.00
436_G449_L2.1071.00
430_L436_G2.0880.99
443_L446_A2.0270.99
434_A438_A2.0120.99
433_R436_G2.0080.99
436_G453_A2.0010.99
124_S130_L1.9590.99
432_A436_G1.9410.99
430_L453_A1.9160.99
274_F277_A1.8840.99
435_E438_A1.8840.99
297_L300_W1.8800.99
441_G453_A1.8550.99
223_P256_A1.8480.99
297_L301_A1.8340.99
429_E433_R1.8180.99
367_K382_L1.8130.99
432_A438_A1.8110.98
49_E144_R1.7940.98
309_R345_Y1.7640.98
436_G446_A1.7510.98
312_Q331_T1.7380.98
278_K281_T1.7190.98
430_L434_A1.7140.98
101_N117_H1.6840.98
103_E117_H1.6840.98
446_A449_L1.6730.97
438_A446_A1.6580.97
191_Q195_S1.6550.97
432_A441_G1.6520.97
84_V114_V1.6290.97
339_E342_N1.6270.97
430_L437_Y1.6150.97
366_L381_N1.6150.97
353_D365_R1.6110.97
430_L446_A1.6090.97
277_A281_T1.6010.97
438_A441_G1.5820.96
83_L138_I1.5820.96
239_P244_L1.5800.96
276_L280_R1.5740.96
86_H215_S1.5660.96
313_Y317_L1.5610.96
294_S297_L1.5520.96
349_A365_R1.5480.96
281_T284_M1.5360.96
121_F130_L1.5330.96
202_Q251_S1.5170.95
427_D436_G1.5120.95
436_G441_G1.5110.95
120_L133_V1.5080.95
438_A453_A1.5080.95
435_E446_A1.5000.95
435_E441_G1.4940.95
396_A420_E1.4910.95
427_D434_A1.4860.95
227_E257_R1.4850.95
441_G449_L1.4820.95
79_L217_F1.4810.95
434_A449_L1.4810.95
296_L300_W1.4760.95
443_L453_A1.4630.94
396_A416_L1.4570.94
220_Q261_N1.4570.94
56_Y109_F1.4540.94
241_E251_S1.4540.94
312_Q338_A1.4520.94
399_L416_L1.4460.94
280_R283_G1.4320.94
363_I385_A1.4290.94
413_W432_A1.4240.94
329_R349_A1.4240.94
316_A332_L1.4220.94
433_R441_G1.4130.93
274_F281_T1.3990.93
409_D413_W1.3970.93
131_A217_F1.3950.93
432_A443_L1.3880.93
277_A280_R1.3790.92
208_G215_S1.3770.92
290_N293_T1.3740.92
80_G134_M1.3660.92
432_A453_A1.3660.92
163_G185_T1.3590.92
339_E345_Y1.3550.92
124_S274_F1.3490.92
429_E438_A1.3430.91
278_K282_L1.3410.91
319_A324_K1.3330.91
436_G443_L1.3320.91
80_G94_F1.3310.91
278_K284_M1.3260.91
329_R333_Q1.3180.91
431_A435_E1.3130.90
426_R432_A1.3040.90
435_E447_I1.3010.90
370_R378_L1.2890.90
274_F279_A1.2860.90
353_D358_K1.2840.89
363_I389_G1.2710.89
72_L277_A1.2570.88
434_A437_Y1.2570.88
427_D435_E1.2530.88
427_D432_A1.2490.88
197_T202_Q1.2480.88
438_A443_L1.2470.88
33_L37_G1.2450.88
442_R445_Q1.2350.88
181_A184_G1.2350.88
50_M54_D1.2330.87
351_D355_G1.2310.87
434_A443_L1.2300.87
199_Q202_Q1.2290.87
432_A449_L1.2280.87
451_S455_S1.2270.87
186_L190_R1.2230.87
290_N297_L1.2170.87
284_M288_G1.2120.87
293_T296_L1.2110.86
437_Y453_A1.2100.86
310_A314_G1.2090.86
128_S270_S1.2080.86
436_G440_A1.1990.86
108_A112_G1.1990.86
208_G216_G1.1970.86
430_L452_S1.1960.86
226_L253_L1.1940.86
446_A450_L1.1920.86
336_L346_L1.1900.86
329_R353_D1.1870.85
94_F142_T1.1750.85
396_A419_A1.1710.85
429_E437_Y1.1710.85
444_D448_S1.1590.84
451_S454_S1.1590.84
125_D129_Q1.1580.84
312_Q334_P1.1520.84
209_I256_A1.1470.83
329_R356_Q1.1420.83
75_Y127_E1.1390.83
429_E449_L1.1380.83
429_E435_E1.1300.82
447_I450_L1.1300.82
349_A353_D1.1280.82
351_D381_N1.1270.82
385_A389_G1.1260.82
433_R453_A1.1200.82
279_A282_L1.1160.82
33_L38_T1.1150.82
384_N388_Q1.1140.81
274_F284_M1.1120.81
437_Y446_A1.1100.81
80_G138_I1.1050.81
448_S453_A1.1040.81
293_T301_A1.1020.81
444_D453_A1.1020.81
429_E432_A1.0980.81
437_Y449_L1.0870.80
126_N129_Q1.0810.79
434_A450_L1.0720.79
104_I229_L1.0720.79
173_A176_Q1.0690.79
165_L168_I1.0660.79
429_E453_A1.0630.78
75_Y79_L1.0630.78
449_L454_S1.0580.78
179_M183_T1.0560.78
443_L447_I1.0560.78
149_A196_F1.0490.77
447_I453_A1.0380.77
142_T211_V1.0380.77
118_S281_T1.0360.77
443_L449_L1.0330.76
107_F115_V1.0320.76
167_S182_L1.0250.76
290_N296_L1.0240.76
235_Y240_P1.0230.76
437_Y441_G1.0220.76
448_S452_S1.0220.76
435_E443_L1.0190.75
438_A449_L1.0130.75
279_A284_M1.0100.75
429_E447_I1.0070.74
429_E452_S1.0040.74
132_S222_M0.9970.74
277_A283_G0.9890.73
435_E449_L0.9870.73
277_A284_M0.9840.73
166_G171_A0.9820.73
167_S170_L0.9820.73
429_E443_L0.9780.72
427_D453_A0.9750.72
360_N391_Q0.9730.72
143_Q203_E0.9650.71
72_L98_L0.9560.70
208_G222_M0.9540.70
97_F113_N0.9540.70
368_N371_D0.9510.70
393_Q423_L0.9490.70
331_T334_P0.9490.70
206_R255_D0.9470.70
191_Q194_I0.9470.70
333_Q337_A0.9420.69
222_M260_A0.9420.69
164_A167_S0.9360.69
276_L279_A0.9340.69
76_I96_F0.9310.68
326_D356_Q0.9310.68
96_F138_I0.9310.68
292_L296_L0.9310.68
331_T335_L0.9300.68
49_E53_G0.9270.68
274_F280_R0.9260.68
433_R437_Y0.9240.68
367_K371_D0.9200.68
69_D119_A0.9190.67
79_L131_A0.9150.67
248_L253_L0.9150.67
359_A363_I0.9150.67
235_Y239_P0.9140.67
394_E397_N0.9110.67
427_D430_L0.9090.67
428_Q436_G0.9090.67
382_L398_I0.9070.66
272_E276_L0.9070.66
280_R288_G0.9040.66
427_D441_G0.9030.66
444_D452_S0.9030.66
380_L399_L0.8930.65
452_S455_S0.8920.65
258_N262_Q0.8890.65
387_L419_A0.8840.64
310_A313_Y0.8840.64
443_L450_L0.8830.64
57_V113_N0.8830.64
190_R193_M0.8730.63
443_L448_S0.8730.63
415_L418_Q0.8720.63
427_D446_A0.8720.63
212_L222_M0.8700.63
430_L433_R0.8700.63
278_K285_Y0.8700.63
432_A437_Y0.8690.63
108_A115_V0.8690.63
104_I225_F0.8660.63
298_D301_A0.8620.62
426_R436_G0.8620.62
421_A453_A0.8620.62
435_E439_L0.8600.62
167_S178_G0.8590.62
124_S196_F0.8540.62
360_N389_G0.8530.62
444_D449_L0.8520.62
315_R319_A0.8510.61
296_L299_E0.8510.61
386_Y398_I0.8500.61
396_A423_L0.8490.61
427_D449_L0.8480.61
334_P337_A0.8480.61
430_L438_A0.8460.61
223_P255_D0.8430.61
406_N409_D0.8410.61
437_Y452_S0.8360.60
368_N372_L0.8360.60
403_T413_W0.8350.60
293_T300_W0.8350.60
430_L441_G0.8340.60
431_A434_A0.8330.60
295_D299_E0.8280.59
320_M348_L0.8260.59
121_F281_T0.8250.59
143_Q148_R0.8230.59
430_L443_L0.8220.59
387_L392_P0.8210.59
439_L447_I0.8200.59
143_Q207_I0.8180.58
197_T200_N0.8180.58
80_G127_E0.8170.58
450_L453_A0.8160.58
57_V61_R0.8140.58
447_I452_S0.8120.58
136_H246_H0.8090.58
278_K283_G0.8030.57
432_A447_I0.8030.57
429_E441_G0.8020.57
290_N294_S0.8000.57
369_A378_L0.7990.57
159_L163_G0.7970.56
440_A446_A0.7970.56
257_R261_N0.7950.56
359_A385_A0.7900.56
110_F203_E0.7880.56
430_L435_E0.7860.55
144_R203_E0.7860.55
439_L452_S0.7840.55
141_V146_L0.7840.55
186_L189_T0.7840.55
274_F283_G0.7820.55
139_S211_V0.7810.55
429_E439_L0.7800.55
445_Q448_S0.7780.55
426_R429_E0.7750.54
413_W416_L0.7720.54
113_N146_L0.7710.54
75_Y112_G0.7660.53
163_G171_A0.7640.53
225_F229_L0.7640.53
143_Q259_R0.7640.53
221_A226_L0.7630.53
336_L349_A0.7610.53
124_S164_A0.7610.53
379_Q398_I0.7610.53
131_A215_S0.7610.53
57_V97_F0.7600.53
442_R446_A0.7590.53
441_G447_I0.7570.53
185_T221_A0.7540.52
433_R446_A0.7540.52
149_A200_N0.7510.52
319_A331_T0.7500.52
80_G114_V0.7490.52
158_P166_G0.7470.52
139_S142_T0.7470.52
42_S45_S0.7460.51
354_L388_Q0.7460.51
399_L403_T0.7460.51
400_N420_E0.7420.51
109_F146_L0.7410.51
421_A433_R0.7400.51
431_A441_G0.7400.51
316_A424_N0.7400.51
326_D358_K0.7390.51
89_S94_F0.7330.50
210_Q214_R0.7330.50
187_A191_Q0.7320.50
428_Q432_A0.7280.50
63_S66_L0.7280.50
276_L281_T0.7270.50
441_G444_D0.7260.50
433_R440_A0.7250.49
303_G308_Q0.7250.49
433_R449_L0.7250.49
436_G447_I0.7220.49
309_R339_E0.7210.49
131_A208_G0.7200.49
71_L280_R0.7200.49
137_E201_E0.7140.48
444_D451_S0.7130.48
191_Q243_L0.7100.48
52_M55_Y0.7090.48
206_R259_R0.7080.48
111_G147_A0.7080.48
124_S225_F0.7080.48
120_L253_L0.7080.48
432_A440_A0.7070.48
413_W435_E0.7050.48
416_L419_A0.7050.48
435_E440_A0.7050.48
343_A347_D0.7040.47
307_Q311_A0.7040.47
400_N416_L0.7030.47
105_N247_P0.7020.47
49_E147_A0.7020.47
121_F277_A0.7000.47
238_R244_L0.6990.47
82_R268_V0.6990.47
180_A184_G0.6970.47
283_G287_S0.6890.46
296_L301_A0.6860.46
421_A426_R0.6850.46
303_G306_R0.6840.45
427_D438_A0.6830.45
317_L348_L0.6770.45
48_Q51_Q0.6760.45
350_T366_L0.6740.45
433_R443_L0.6730.44
181_A324_K0.6690.44
112_G217_F0.6690.44
447_I454_S0.6670.44
194_I242_I0.6660.44
430_L448_S0.6640.44
221_A242_I0.6610.43
439_L450_L0.6580.43
175_P178_G0.6580.43
435_E444_D0.6580.43
128_S221_A0.6570.43
80_G97_F0.6550.43
431_A438_A0.6550.43
74_Q78_S0.6540.43
134_M298_D0.6510.42
115_V244_L0.6500.42
418_Q422_A0.6470.42
84_V94_F0.6460.42
330_K334_P0.6450.42
255_D259_R0.6430.42
275_Y278_K0.6430.42
140_H201_E0.6430.42
137_E140_H0.6430.42
431_A436_G0.6430.42
109_F147_A0.6420.42
136_H252_R0.6410.41
246_H252_R0.6410.41
130_L150_M0.6410.41
308_Q312_Q0.6390.41
443_L451_S0.6390.41
132_S223_P0.6380.41
332_L348_L0.6370.41
315_R331_T0.6360.41
201_E246_H0.6350.41
136_H201_E0.6350.41
137_E246_H0.6350.41
139_S174_S0.6320.41
225_F249_P0.6300.40
167_S171_A0.6300.40
420_E425_N0.6300.40
308_Q311_A0.6280.40
60_L141_V0.6280.40
440_A444_D0.6260.40
280_R285_Y0.6250.40
392_P422_A0.6240.40
291_Q298_D0.6220.40
221_A248_L0.6210.40
432_A439_L0.6210.40
427_D437_Y0.6200.39
313_Y316_A0.6170.39
440_A445_Q0.6170.39
196_F245_T0.6160.39
137_E204_A0.6140.39
201_E204_A0.6140.39
335_L345_Y0.6130.39
426_R435_E0.6120.39
444_D447_I0.6080.38
209_I258_N0.6080.38
213_Q263_M0.6070.38
343_A369_A0.6060.38
347_D351_D0.6020.38
421_A437_Y0.6020.38
164_A186_L0.6010.38
420_E428_Q0.6010.38
38_T41_G0.6000.38
383_A399_L0.5990.38
358_K393_Q0.5990.38
440_A448_S0.5980.37
72_L281_T0.5970.37
187_A243_L0.5970.37
96_F114_V0.5970.37
382_L394_E0.5960.37
415_L419_A0.5950.37
434_A440_A0.5940.37
194_I245_T0.5940.37
433_R454_S0.5920.37
361_E394_E0.5920.37
32_T39_S0.5920.37
281_T285_Y0.5920.37
403_T412_G0.5890.37
125_D278_K0.5890.37
84_V138_I0.5890.37
427_D433_R0.5890.37
49_E75_Y0.5860.36
215_S219_P0.5860.36
432_A445_Q0.5840.36
441_G452_S0.5830.36
430_L454_S0.5820.36
309_R338_A0.5790.36
138_I225_F0.5760.35
75_Y243_L0.5750.35
208_G213_Q0.5750.35
107_F242_I0.5750.35
160_T163_G0.5740.35
139_S223_P0.5740.35
427_D431_A0.5730.35
167_S186_L0.5730.35
358_K367_K0.5730.35
437_Y442_R0.5720.35
313_Y335_L0.5690.35
230_L249_P0.5680.35
433_R447_I0.5670.35
236_S240_P0.5670.35
236_S239_P0.5670.35
314_G318_Q0.5660.35
428_Q437_Y0.5660.35
276_L282_L0.5660.35
364_N392_P0.5640.34
421_A436_G0.5640.34
140_H246_H0.5640.34
136_H140_H0.5640.34
397_N401_R0.5630.34
198_Q251_S0.5620.34
228_K278_K0.5620.34
82_R217_F0.5620.34
54_D113_N0.5620.34
115_V226_L0.5610.34
366_L382_L0.5610.34
200_N203_E0.5610.34
448_S455_S0.5600.34
111_G208_G0.5590.34
393_Q397_N0.5590.34
67_I118_S0.5580.34
157_A160_T0.5570.34
116_L253_L0.5570.34
268_V271_S0.5570.34
440_A449_L0.5560.34
400_N404_F0.5550.34
437_Y440_A0.5540.34
438_A447_I0.5540.34
156_S159_L0.5530.33
448_S451_S0.5520.33
53_G61_R0.5520.33
82_R127_E0.5520.33
426_R430_L0.5510.33
428_Q433_R0.5510.33
357_N391_Q0.5500.33
45_S49_E0.5500.33
131_A212_L0.5490.33
140_H204_A0.5490.33
95_H113_N0.5490.33
445_Q449_L0.5480.33
244_L249_P0.5470.33
221_A260_A0.5470.33
199_Q321_E0.5470.33
80_G141_V0.5460.33
440_A452_S0.5460.33
379_Q389_G0.5440.33
127_E274_F0.5440.33
428_Q431_A0.5430.33
124_S212_L0.5420.33
414_D419_A0.5420.33
440_A447_I0.5410.32
148_R203_E0.5410.32
185_T189_T0.5410.32
149_A153_Q0.5400.32
52_M63_S0.5390.32
83_L211_V0.5390.32
114_V232_Q0.5380.32
447_I451_S0.5370.32
437_Y443_L0.5360.32
128_S268_V0.5360.32
180_A183_T0.5360.32
79_L130_L0.5350.32
51_Q59_Q0.5350.32
112_G127_E0.5340.32
240_P244_L0.5330.32
76_I98_L0.5320.32
413_W419_A0.5320.32
96_F191_Q0.5300.32
226_L256_A0.5290.31
204_A246_H0.5290.31
136_H204_A0.5290.31
96_F129_Q0.5280.31
201_E205_D0.5270.31
137_E205_D0.5270.31
79_L215_S0.5270.31
255_D258_N0.5270.31
320_M388_Q0.5270.31
205_D252_R0.5270.31
56_Y166_G0.5270.31
120_L197_T0.5260.31
431_A439_L0.5250.31
113_N226_L0.5250.31
238_R250_E0.5240.31
326_D371_D0.5240.31
154_Q177_A0.5230.31
43_T48_Q0.5230.31
344_W349_A0.5220.31
276_L283_G0.5220.31
130_L146_L0.5210.31
61_R218_D0.5210.31
104_I123_Y0.5210.31
429_E434_A0.5210.31
433_R452_S0.5190.31
349_A352_I0.5190.31
426_R443_L0.5190.31
348_L351_D0.5180.31
384_N387_L0.5180.31
41_G223_P0.5170.30
58_R61_R0.5170.30
437_Y445_Q0.5160.30
139_S207_I0.5140.30
360_N394_E0.5140.30
221_A244_L0.5130.30
111_G248_L0.5130.30
341_G371_D0.5120.30
426_R449_L0.5100.30
49_E187_A0.5090.30
388_Q415_L0.5090.30
75_Y130_L0.5080.30
109_F113_N0.5080.30
213_Q219_P0.5080.30
442_R454_S0.5080.30
426_R437_Y0.5070.30
197_T244_L0.5070.30
70_P164_A0.5070.30
418_Q421_A0.5070.30
416_L420_E0.5060.30
423_L449_L0.5050.29
189_T229_L0.5050.29
158_P163_G0.5030.29
70_P375_N0.5030.29
34_P61_R0.5020.29
344_W347_D0.5020.29
325_Y333_Q0.5010.29
58_R62_G0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c37A 1 0.4559 100 0.616 Contact Map
4aw6A 2 0.5051 100 0.746 Contact Map
4il3A 1 0.499 100 0.751 Contact Map
3dssA 1 0.4702 99.8 0.827 Contact Map
4l9pA 1 0.4908 99.8 0.828 Contact Map
3q7aA 1 0.4784 99.8 0.829 Contact Map
1dceA 1 0.4928 99.8 0.832 Contact Map
3draA 1 0.4969 99.8 0.835 Contact Map
4gywA 2 0.4333 99.8 0.835 Contact Map
2vsyA 1 0.3676 99.8 0.838 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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