GREMLIN Database
DPAL - Diaminopropionate ammonia-lyase
UniProt: P66899 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13054
Length: 398 (313)
Sequences: 14461 (7702)
Seq/√Len: 435.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_A138_A4.1831.00
61_K370_V3.7871.00
174_L177_Q3.3561.00
213_A372_L3.2931.00
49_A61_K3.1561.00
316_V349_A3.0431.00
141_Y178_H2.8981.00
226_H256_I2.8301.00
144_K165_D2.7541.00
254_H308_Q2.6901.00
177_Q181_Q2.6901.00
148_Q152_D2.6691.00
137_N160_E2.6361.00
261_D313_Q2.5541.00
139_V160_E2.5131.00
87_Q201_W2.5051.00
44_P216_Q2.4611.00
44_P215_E2.4131.00
89_L92_K2.3501.00
227_V244_L2.3231.00
267_Y271_V2.3161.00
248_Y253_L2.2251.00
241_L305_C2.1611.00
248_Y252_N2.1421.00
139_V162_I2.0921.00
47_L372_L2.0341.00
258_V346_V2.0061.00
366_N369_A2.0011.00
323_V331_D1.9821.00
264_D268_R1.9521.00
343_G373_V1.9421.00
225_T369_A1.9341.00
178_H182_H1.9311.00
224_P372_L1.9081.00
49_A63_L1.8941.00
289_L342_V1.8641.00
313_Q316_V1.8631.00
49_A54_A1.8561.00
114_T139_V1.8511.00
63_L370_V1.8411.00
210_A240_V1.8101.00
256_I308_Q1.7481.00
63_L217_M1.7401.00
56_L323_V1.7371.00
227_V240_V1.7301.00
323_V348_A1.6841.00
245_V307_T1.6821.00
225_T370_V1.6651.00
277_N293_E1.6491.00
151_V163_V1.6471.00
272_K276_V1.6261.00
176_M180_Q1.6191.00
268_R271_V1.6131.00
324_L336_S1.6091.00
228_L258_V1.6011.00
237_A306_A1.5881.00
226_H369_A1.5801.00
152_D155_L1.5171.00
89_L136_Q1.5151.00
226_H254_H1.5091.00
172_V176_M1.4991.00
56_L331_D1.4931.00
142_M154_I1.4861.00
267_Y311_S1.4331.00
210_A243_Y1.4291.00
210_A244_L1.4201.00
214_V247_V1.4131.00
73_L129_W1.4091.00
87_Q91_E1.4071.00
240_V374_I1.4041.00
228_L350_V1.4031.00
38_K83_Y1.3981.00
151_V155_L1.3841.00
51_D55_N1.3741.00
320_G345_G1.3671.00
336_S375_S1.3641.00
324_L344_L1.3611.00
207_A211_D1.3601.00
167_N170_D1.3581.00
124_G154_I1.3371.00
211_D243_Y1.3371.00
30_K33_R1.3281.00
270_G309_F1.3251.00
286_M317_A1.3241.00
241_L255_S1.3171.00
86_A134_L1.3161.00
191_A296_P1.3061.00
85_I115_F1.2991.00
262_K314_D1.2981.00
217_M224_P1.2951.00
248_Y251_Q1.2881.00
310_I346_V1.2831.00
37_Q40_A1.2781.00
268_R272_K1.2721.00
350_V353_H1.2701.00
226_H371_V1.2671.00
47_L217_M1.2611.00
231_A257_I1.2601.00
257_I309_F1.2591.00
228_L347_L1.2481.00
142_M163_V1.2381.00
264_D311_S1.2351.00
217_M372_L1.2341.00
285_I318_A1.2331.00
284_T290_A1.2311.00
256_I310_I1.2271.00
85_I134_L1.2151.00
52_D55_N1.2141.00
155_L160_E1.2091.00
62_I347_L1.2091.00
273_G303_R1.1921.00
325_G335_I1.1771.00
38_K41_G1.1681.00
57_F348_A1.1651.00
46_P69_K1.1651.00
173_R177_Q1.1631.00
47_L213_A1.1621.00
141_Y174_L1.1621.00
119_T124_G1.1611.00
52_D331_D1.1551.00
174_L178_H1.1511.00
48_C66_D1.1511.00
300_E304_N1.1501.00
320_G344_L1.1461.00
340_G376_T1.1281.00
114_T137_N1.1191.00
50_L64_V1.1191.00
117_T140_I1.1191.00
266_I294_P1.1171.00
139_V184_W1.1101.00
170_D173_R1.1051.00
45_T70_R1.1011.00
237_A257_I1.1001.00
321_M380_T1.0981.00
237_A302_L1.0931.00
82_A86_A1.0931.00
132_Q138_A1.0871.00
151_V161_C1.0871.00
209_L374_I1.0841.00
64_V375_S1.0751.00
213_A224_P1.0751.00
322_R326_N1.0691.00
127_V138_A1.0561.00
244_L253_L1.0561.00
206_Y246_D1.0481.00
315_S319_L1.0481.00
231_A309_F1.0301.00
191_A238_G1.0301.00
321_M341_A1.0291.00
229_L240_V1.0271.00
308_Q353_H1.0261.00
267_Y309_F1.0261.00
152_D156_N1.0191.00
154_I159_A1.0151.00
200_T297_L1.0141.00
266_I302_L1.0141.00
254_H369_A1.0101.00
312_C345_G1.0091.00
260_P289_L1.0071.00
37_Q41_G1.0051.00
319_L323_V0.9971.00
217_M370_V0.9961.00
209_L236_M0.9941.00
289_L339_S0.9921.00
177_Q180_Q0.9811.00
316_V319_L0.9811.00
129_W133_Q0.9811.00
347_L373_V0.9811.00
116_A184_W0.9811.00
58_G367_K0.9771.00
116_A175_T0.9731.00
214_V244_L0.9711.00
271_V308_Q0.9691.00
111_E136_Q0.9661.00
264_D267_Y0.9651.00
316_V345_G0.9631.00
231_A237_A0.9601.00
178_H181_Q0.9581.00
261_D311_S0.9541.00
297_L300_E0.9521.00
137_N184_W0.9511.00
31_L34_Q0.9511.00
209_L240_V0.9471.00
300_E303_R0.9461.00
113_M137_N0.9431.00
176_M179_A0.9381.00
231_A266_I0.9341.00
144_K166_M0.9321.00
228_L256_I0.9301.00
129_W157_L0.9261.00
203_M207_A0.9251.00
270_G302_L0.9201.00
318_A388_V0.9201.00
59_V62_I0.9191.00
90_C111_E0.9191.00
326_N331_D0.9191.00
219_E370_V0.9151.00
320_G348_A0.9121.00
254_H307_T0.9091.00
128_A159_A0.9091.00
88_L92_K0.8981.00
138_A159_A0.8971.00
175_T179_A0.8951.00
336_S341_A0.8931.00
36_H40_A0.8871.00
302_L306_A0.8861.00
321_M385_Y0.8841.00
228_L346_V0.8831.00
43_R72_G0.8811.00
266_I309_F0.8771.00
54_A61_K0.8741.00
160_E182_H0.8741.00
350_V354_P0.8721.00
35_F39_I0.8701.00
213_A240_V0.8671.00
383_K387_E0.8661.00
81_G126_G0.8661.00
90_C112_K0.8641.00
33_R37_Q0.8641.00
33_R36_H0.8611.00
118_T168_Y0.8611.00
173_R176_M0.8541.00
166_M170_D0.8501.00
340_G375_S0.8501.00
293_E296_P0.8491.00
203_M297_L0.8491.00
162_I174_L0.8481.00
47_L63_L0.8481.00
84_A202_I0.8471.00
211_D215_E0.8461.00
66_D375_S0.8421.00
139_V178_H0.8401.00
324_L375_S0.8391.00
349_A352_Y0.8381.00
139_V182_H0.8341.00
89_L111_E0.8291.00
203_M242_G0.8291.00
230_Q376_T0.8271.00
258_V310_I0.8261.00
61_K368_D0.8261.00
42_Y78_M0.8211.00
344_L373_V0.8201.00
68_S334_I0.8171.00
38_K86_A0.8161.00
132_Q157_L0.8161.00
209_L213_A0.8151.00
164_T174_L0.8131.00
78_M129_W0.8111.00
351_H354_P0.8101.00
345_G349_A0.8071.00
268_R276_V0.8061.00
346_V350_V0.8011.00
317_A342_V0.8011.00
127_V140_I0.7971.00
64_V324_L0.7961.00
318_A338_E0.7961.00
262_K282_M0.7951.00
113_M183_G0.7951.00
36_H215_E0.7941.00
262_K283_A0.7941.00
52_D332_P0.7921.00
188_Q191_A0.7911.00
84_A187_V0.7831.00
57_F323_V0.7831.00
114_T184_W0.7831.00
238_G298_G0.7821.00
243_Y247_V0.7801.00
30_K34_Q0.7791.00
89_L134_L0.7791.00
125_R154_I0.7751.00
218_R223_T0.7721.00
116_A178_H0.7721.00
53_L344_L0.7691.00
32_A35_F0.7691.00
144_K163_V0.7661.00
214_V243_Y0.7641.00
384_H387_E0.7621.00
203_M301_I0.7621.00
148_Q151_V0.7601.00
310_I349_A0.7581.00
269_S276_V0.7551.00
240_V255_S0.7551.00
169_D173_R0.7501.00
288_G339_S0.7471.00
168_Y171_T0.7471.00
213_A374_I0.7461.00
155_L163_V0.7441.00
168_Y172_V0.7411.00
88_L185_E0.7391.00
116_A179_A0.7361.00
237_A255_S0.7341.00
242_G246_D0.7311.00
81_G130_A0.7271.00
214_V248_Y0.7231.00
85_I130_A0.7211.00
113_M178_H0.7211.00
299_W303_R0.7191.00
84_A201_W0.7191.00
214_V218_R0.7161.00
325_G385_Y0.7151.00
50_L332_P0.7141.00
314_D317_A0.7141.00
42_Y70_R0.7141.00
322_R389_V0.7101.00
354_P369_A0.7101.00
86_A90_C0.7101.00
211_D247_V0.7091.00
66_D334_I0.7081.00
92_K185_E0.7071.00
111_E134_L0.7021.00
141_Y164_T0.7011.00
34_Q37_Q0.6971.00
227_V255_S0.6971.00
175_T186_V0.6941.00
60_K368_D0.6931.00
115_F136_Q0.6931.00
127_V187_V0.6921.00
265_C269_S0.6921.00
313_Q349_A0.6921.00
36_H211_D0.6921.00
275_I299_W0.6911.00
56_L348_A0.6911.00
200_T204_Q0.6911.00
57_F347_L0.6901.00
83_Y86_A0.6871.00
229_L237_A0.6861.00
269_S294_P0.6811.00
348_A352_Y0.6741.00
275_I296_P0.6731.00
224_P253_L0.6731.00
178_H184_W0.6701.00
146_S287_A0.6681.00
168_Y189_D0.6641.00
115_F131_A0.6631.00
36_H39_I0.6611.00
301_I305_C0.6561.00
33_R211_D0.6540.99
33_R247_V0.6520.99
172_V188_Q0.6490.99
92_K113_M0.6480.99
204_Q207_A0.6430.99
123_H206_Y0.6420.99
83_Y87_Q0.6410.99
202_I206_Y0.6350.99
42_Y82_A0.6340.99
148_Q155_L0.6330.99
150_R287_A0.6330.99
84_A87_Q0.6310.99
153_A156_N0.6310.99
54_A59_V0.6300.99
269_S272_K0.6300.99
336_S340_G0.6290.99
62_I373_V0.6280.99
223_T253_L0.6260.99
215_E247_V0.6250.99
259_E265_C0.6230.99
384_H388_V0.6210.99
120_D288_G0.6200.99
179_A186_V0.6190.99
310_I353_H0.6140.99
383_K386_R0.6110.99
50_L53_L0.6100.99
125_R153_A0.6080.99
240_V244_L0.6080.99
349_A353_H0.6070.99
179_A184_W0.6060.99
226_H350_V0.6040.99
298_G309_F0.6030.99
51_D54_A0.6020.99
117_T127_V0.6010.99
296_P300_E0.6010.99
256_I350_V0.6010.99
35_F40_A0.5990.99
245_V255_S0.5970.99
344_L375_S0.5960.99
230_Q343_G0.5950.99
204_Q242_G0.5940.99
162_I178_H0.5930.99
258_V342_V0.5930.99
34_Q38_K0.5920.99
347_L351_H0.5890.99
256_I346_V0.5880.99
276_V279_G0.5870.99
60_K369_A0.5870.99
83_Y204_Q0.5860.99
54_A62_I0.5860.99
66_D69_K0.5850.99
165_D170_D0.5850.99
227_V253_L0.5810.99
118_T186_V0.5800.99
316_V351_H0.5760.99
53_L56_L0.5750.99
85_I127_V0.5710.99
84_A188_Q0.5700.99
275_I278_V0.5700.99
213_A227_V0.5700.99
227_V372_L0.5700.99
141_Y162_I0.5690.99
115_F138_A0.5660.99
226_H354_P0.5650.99
142_M151_V0.5640.99
257_I306_A0.5640.99
112_K137_N0.5640.99
170_D174_L0.5640.99
274_D299_W0.5620.98
118_T175_T0.5610.98
263_A266_I0.5590.98
225_T368_D0.5580.98
153_A331_D0.5580.98
64_V336_S0.5580.98
118_T172_V0.5570.98
53_L57_F0.5560.98
53_L323_V0.5530.98
68_S375_S0.5520.98
245_V305_C0.5520.98
321_M338_E0.5510.98
137_N182_H0.5510.98
317_A341_A0.5470.98
126_G130_A0.5440.98
65_K212_E0.5430.98
67_E376_T0.5420.98
172_V175_T0.5420.98
312_C346_V0.5410.98
84_A92_K0.5400.98
73_L78_M0.5390.98
269_S273_G0.5380.98
116_A141_Y0.5380.98
111_E185_E0.5350.98
149_E382_V0.5350.98
335_I378_G0.5330.98
269_S299_W0.5310.98
55_N58_G0.5310.98
84_A185_E0.5310.98
60_K367_K0.5300.98
123_H187_V0.5290.98
275_I279_G0.5290.98
207_A243_Y0.5280.98
315_S318_A0.5280.98
64_V344_L0.5240.98
87_Q90_C0.5240.98
214_V217_M0.5230.98
245_V304_N0.5220.98
85_I187_V0.5220.98
146_S151_V0.5210.98
78_M133_Q0.5210.98
59_V371_V0.5200.97
319_L348_A0.5200.97
38_K87_Q0.5190.97
33_R40_A0.5190.97
39_I82_A0.5190.97
227_V374_I0.5180.97
171_T175_T0.5180.97
47_L216_Q0.5170.97
43_R70_R0.5150.97
124_G140_I0.5140.97
146_S163_V0.5120.97
160_E163_V0.5100.97
36_H41_G0.5100.97
54_A57_F0.5100.97
259_E267_Y0.5100.97
112_K183_G0.5090.97
258_V312_C0.5090.97
155_L161_C0.5070.97
386_R389_V0.5070.97
57_F351_H0.5060.97
286_M289_L0.5050.97
31_L204_Q0.5020.97
224_P248_Y0.5010.97
89_L185_E0.5010.97
243_Y246_D0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4d9iA 2 0.9623 100 0.242 Contact Map
1tdjA 2 0.8367 100 0.284 Contact Map
2gn0A 2 0.8241 100 0.287 Contact Map
1v71A 2 0.7965 100 0.29 Contact Map
3ss7X 1 0.9397 100 0.298 Contact Map
3l6bA 2 0.8065 100 0.303 Contact Map
1ve5A 3 0.7714 100 0.309 Contact Map
2rkbA 2 0.794 100 0.319 Contact Map
4h27A 1 0.7915 100 0.33 Contact Map
3iauA 1 0.8593 100 0.336 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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