GREMLIN Database
DIAA - DnaA initiator-associating protein DiaA
UniProt: P66817 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12780
Length: 196 (180)
Sequences: 2113 (1611)
Seq/√Len: 120.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_G137_M4.4501.00
47_C113_L4.0891.00
129_V150_L3.4891.00
141_A157_Q3.0281.00
37_S112_V2.8631.00
127_K130_E2.8451.00
129_V139_I2.7291.00
12_S16_Q2.6541.00
30_A140_V2.5491.00
37_S42_N2.5251.00
59_F179_V2.4041.00
133_V158_D2.2931.00
121_N149_E2.2791.00
42_N110_G2.0311.00
70_E93_R2.0121.00
115_A129_V1.9161.00
31_A185_L1.9071.00
46_C59_F1.9061.00
64_I85_V1.8411.00
45_L103_V1.8151.00
30_A159_V1.7901.00
73_S105_A1.7801.00
46_C114_L1.7631.00
163_I174_M1.7231.00
47_C125_I1.6871.00
27_I178_T1.6811.00
144_G171_I1.6721.00
131_A135_R1.6401.00
131_A134_T1.5871.00
117_S150_L1.5671.00
46_C179_V1.5671.00
85_V89_I1.5641.00
38_L44_I1.5221.00
113_L137_M1.5151.00
63_M186_I1.5111.00
142_L178_T1.5041.00
33_T138_T1.4671.00
96_D123_R1.4511.00
33_T159_V1.4271.00
97_E127_K1.4051.00
68_E167_R1.4031.00
90_A95_H1.4011.00
116_I142_L1.3981.00
73_S104_R1.3951.00
42_N108_H1.3941.00
65_N89_I1.3871.00
14_Q18_A1.3751.00
143_T162_R1.3591.00
146_D162_R1.3291.00
115_A125_I1.3261.00
130_E153_L1.3151.00
170_R173_E1.2841.00
8_C184_D1.2711.00
34_L44_I1.2681.00
34_L112_V1.2540.99
80_N102_Q1.2470.99
176_M179_V1.2410.99
121_N148_G1.2390.99
35_V189_T1.2230.99
143_T160_E1.2230.99
46_C60_A1.2210.99
151_A162_R1.2080.99
17_I21_E1.1960.99
28_S32_M1.1930.99
49_N124_D1.1900.99
47_C128_A1.1870.99
77_I106_L1.1780.99
118_T168_S1.1680.99
145_Y166_H1.1630.99
149_E152_G1.1510.99
14_Q17_I1.1510.99
44_I114_L1.1390.99
46_C56_A1.1180.99
123_R127_K1.1180.99
100_A131_A1.1120.99
148_G151_A1.1060.99
36_Q40_N1.1000.99
108_H135_R1.0950.99
43_K75_P1.0900.99
13_I17_I1.0790.98
58_H62_S1.0730.98
68_E169_A1.0720.98
65_N88_A1.0540.98
59_F63_M1.0510.98
47_C115_A1.0440.98
107_G113_L1.0400.98
101_K104_R1.0360.98
94_L97_E1.0190.98
12_S174_M1.0060.97
104_R131_A0.9970.97
46_C76_A0.9900.97
115_A139_I0.9840.97
142_L175_H0.9810.97
31_A182_L0.9770.97
62_S172_Q0.9710.97
86_L98_V0.9700.97
123_R149_E0.9700.97
141_A150_L0.9670.97
177_L181_C0.9660.97
145_Y162_R0.9660.97
38_L75_P0.9650.97
161_I178_T0.9620.97
80_N99_Y0.9530.96
81_T84_V0.9470.96
133_V139_I0.9450.96
19_A174_M0.9440.96
97_E104_R0.9440.96
64_I105_A0.9430.96
181_C185_L0.9410.96
45_L137_M0.9400.96
19_A23_L0.9240.96
10_T14_Q0.9150.96
45_L107_G0.9140.96
95_H98_V0.9130.96
74_L186_I0.9120.95
55_N62_S0.9090.95
57_Q80_N0.9080.95
25_D29_R0.9070.95
57_Q83_N0.8940.95
34_L182_L0.8830.95
18_A21_E0.8830.95
126_V149_E0.8820.95
184_D188_N0.8800.95
57_Q81_T0.8790.95
33_T37_S0.8750.94
130_E134_T0.8680.94
35_V186_I0.8660.94
34_L114_L0.8660.94
113_L128_A0.8620.94
34_L186_I0.8500.93
45_L77_I0.8490.93
13_I16_Q0.8410.93
109_A136_D0.8400.93
170_R177_L0.8340.93
118_T172_Q0.8290.93
34_L140_V0.8210.92
75_P108_H0.8200.92
103_V131_A0.8160.92
79_L102_Q0.8060.92
103_V128_A0.7970.91
143_T150_L0.7950.91
31_A186_I0.7920.91
163_I178_T0.7790.90
33_T112_V0.7790.90
165_S171_I0.7780.90
157_Q160_E0.7780.90
169_A183_C0.7730.90
91_N119_R0.7720.90
58_H180_N0.7720.90
60_A78_A0.7700.90
11_E14_Q0.7700.90
58_H91_N0.7680.89
26_A29_R0.7640.89
62_S168_S0.7600.89
37_S138_T0.7590.89
89_I97_E0.7580.89
100_A127_K0.7540.89
130_E149_E0.7540.89
36_Q138_T0.7530.89
55_N118_T0.7530.89
38_L74_L0.7440.88
83_N88_A0.7410.88
103_V113_L0.7400.88
85_V102_Q0.7390.88
65_N101_K0.7380.88
54_A84_V0.7320.87
119_R122_S0.7310.87
61_A65_N0.7220.86
60_A76_A0.7220.86
39_L189_T0.7190.86
51_T91_N0.7110.86
146_D166_H0.7010.85
55_N172_Q0.6990.85
32_M35_V0.6970.84
33_T36_Q0.6950.84
16_Q174_M0.6940.84
10_T17_I0.6930.84
138_T159_V0.6900.84
90_A98_V0.6900.84
91_N118_T0.6880.84
30_A182_L0.6880.84
66_R93_R0.6860.83
163_I175_H0.6830.83
29_R33_T0.6800.83
35_V190_L0.6790.83
141_A160_E0.6780.83
11_E167_R0.6760.83
38_L106_L0.6750.82
126_V130_E0.6730.82
62_S118_T0.6730.82
57_Q61_A0.6730.82
96_D127_K0.6660.82
90_A94_L0.6620.81
55_N176_M0.6590.81
97_E100_A0.6480.80
41_G108_H0.6460.80
119_R172_Q0.6460.80
32_M189_T0.6430.79
67_F169_A0.6390.79
99_Y102_Q0.6340.78
44_I76_A0.6240.77
61_A88_A0.6220.77
68_E184_D0.6140.76
49_N91_N0.6120.76
49_N92_D0.6080.75
151_A160_E0.6070.75
9_F181_C0.6060.75
53_A87_T0.6060.75
100_A104_R0.6010.75
103_V107_G0.5950.74
15_T19_A0.5930.74
63_M67_F0.5930.74
22_A164_P0.5860.73
61_A183_C0.5850.73
88_A94_L0.5840.72
51_T122_S0.5800.72
33_T140_V0.5790.72
89_I102_Q0.5780.72
45_L106_L0.5780.72
26_A159_V0.5770.72
59_F116_I0.5760.71
12_S15_T0.5740.71
75_P106_L0.5730.71
80_N84_V0.5720.71
52_S122_S0.5680.70
91_N122_S0.5670.70
123_R130_E0.5660.70
66_R70_E0.5640.70
80_N83_N0.5620.70
27_I182_L0.5590.69
15_T165_S0.5580.69
113_L129_V0.5540.69
117_S141_A0.5530.68
51_T118_T0.5500.68
55_N115_A0.5500.68
29_R159_V0.5440.67
49_N119_R0.5440.67
52_S119_R0.5430.67
60_A64_I0.5390.66
143_T151_A0.5390.66
132_A137_M0.5380.66
55_N168_S0.5380.66
59_F176_M0.5350.66
54_A57_Q0.5340.66
53_A102_Q0.5320.65
183_C187_D0.5320.65
43_K108_H0.5310.65
91_N124_D0.5300.65
122_S172_Q0.5300.65
72_P104_R0.5300.65
54_A61_A0.5290.65
141_A162_R0.5250.64
78_A81_T0.5240.64
23_L26_A0.5170.63
82_D102_Q0.5150.63
36_Q39_L0.5150.63
32_M36_Q0.5140.63
58_H92_D0.5130.63
51_T119_R0.5110.62
34_L46_C0.5090.62
43_K111_D0.5080.62
59_F114_L0.5070.62
112_V140_V0.5050.61
67_F187_D0.5050.61
145_Y148_G0.5050.61
91_N172_Q0.5030.61
49_N117_S0.5030.61
167_R184_D0.5010.61
63_M74_L0.5000.61
29_R32_M0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i2wA 4 0.9592 100 0.463 Contact Map
2yvaA 4 0.9694 100 0.464 Contact Map
3trjA 4 0.9643 100 0.479 Contact Map
1x92A 4 0.9847 100 0.479 Contact Map
1tk9A 4 0.949 100 0.495 Contact Map
2xblA 4 0.9643 100 0.497 Contact Map
3w0lB 1 0.9796 99.9 0.631 Contact Map
3cvjA 2 0.9541 99.9 0.635 Contact Map
4s12A 2 0.9643 99.9 0.647 Contact Map
1nriA 2 0.9643 99.9 0.651 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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