GREMLIN Database
QUED - 6-carboxy-5,6,7,8-tetrahydropterin synthase
UniProt: P65870 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13120
Length: 121 (114)
Sequences: 2476 (1530)
Seq/√Len: 143.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_E34_S3.2681.00
43_G52_I2.9281.00
107_M117_I2.5591.00
9_D36_M2.5411.00
105_A119_R2.4951.00
5_T42_T2.4281.00
90_K94_D2.4261.00
68_R95_Q2.4161.00
38_R107_M2.2731.00
9_D38_R2.2521.00
7_F40_E2.2331.00
17_R73_Y2.2191.00
42_T104_S2.1801.00
105_A117_I2.1681.00
69_L91_W2.0091.00
30_L73_Y1.9091.00
37_V108_V1.8821.00
39_L62_F1.7301.00
7_F115_G1.6781.00
38_R109_K1.6231.00
63_K67_E1.6081.00
29_R72_H1.6021.00
64_P99_V1.5821.00
93_W118_Y1.5731.00
21_V25_H1.5471.00
40_E105_A1.5411.00
5_T40_E1.5331.00
26_K56_A1.5091.00
69_L92_I1.5051.00
87_V90_K1.4981.00
5_T104_S1.4571.00
89_A106_V1.4451.00
41_I58_L1.3881.00
12_F37_V1.3871.00
41_I53_I1.3781.00
5_T117_I1.3111.00
7_F107_M1.3021.00
90_K118_Y1.2921.00
75_N83_P1.2801.00
91_W95_Q1.2681.00
10_F59_K1.2591.00
39_L96_V1.2561.00
10_F62_F1.2441.00
34_S112_C1.2051.00
15_A73_Y1.2031.00
19_P28_G1.1711.00
7_F38_R1.1671.00
78_P81_E1.0980.99
11_T113_T1.0890.99
95_Q98_P1.0730.99
35_F85_S1.0640.99
54_D57_E1.0540.99
40_E107_M1.0100.99
43_G46_D1.0080.99
7_F117_I0.9750.98
27_C110_E0.9690.98
4_T90_K0.9630.98
89_A116_C0.9610.98
10_F66_Y0.9530.98
14_A35_F0.9340.98
28_G84_T0.9330.98
10_F63_K0.9040.97
50_G87_V0.9000.97
107_M115_G0.8990.97
36_M109_K0.8950.97
56_A59_K0.8910.97
64_P67_E0.8900.97
40_E104_S0.8870.97
14_A74_L0.8860.97
8_K114_A0.8730.97
5_T105_A0.8670.96
11_T36_M0.8640.96
93_W106_V0.8520.96
11_T34_S0.8470.96
24_G28_G0.8430.96
68_R79_G0.8430.96
36_M112_C0.8330.96
51_W84_T0.8320.95
4_T45_V0.8280.95
62_F66_Y0.8260.95
17_R28_G0.8140.95
72_H76_D0.8020.94
65_T68_R0.7910.94
20_H49_T0.7790.94
85_S110_E0.7760.93
15_A30_L0.7740.93
5_T119_R0.7720.93
109_K115_G0.7720.93
72_H77_I0.7690.93
34_S109_K0.7670.93
12_F108_V0.7570.93
57_E60_A0.7550.93
69_L79_G0.7510.92
69_L88_L0.7360.92
6_L115_G0.7340.91
88_L92_I0.7260.91
97_K101_P0.7220.91
4_T46_D0.7150.90
8_K113_T0.7130.90
11_T112_C0.7090.90
61_A99_V0.7060.90
21_V24_G0.7040.90
108_V116_C0.7040.90
104_S119_R0.7030.90
17_R30_L0.7000.89
13_E112_C0.7000.89
55_F114_A0.6990.89
92_I96_V0.6970.89
94_D97_K0.6930.89
55_F59_K0.6920.89
56_A60_A0.6880.89
92_I106_V0.6840.88
46_D49_T0.6820.88
60_A64_P0.6800.88
6_L58_L0.6770.88
68_R72_H0.6760.88
59_K63_K0.6750.88
73_Y76_D0.6730.87
27_C71_H0.6700.87
21_V51_W0.6660.87
79_G91_W0.6590.86
93_W103_L0.6460.85
16_H86_E0.6420.85
46_D50_G0.6410.85
37_V62_F0.6390.85
85_S116_C0.6380.85
85_S112_C0.6240.83
39_L66_Y0.6140.82
93_W97_K0.6090.82
45_V90_K0.6060.81
92_I108_V0.5990.81
79_G82_N0.5960.80
25_H51_W0.5930.80
77_I80_L0.5930.80
65_T92_I0.5920.80
31_H110_E0.5910.80
12_F74_L0.5840.79
9_D112_C0.5820.79
53_I61_A0.5820.79
90_K93_W0.5800.79
8_K111_T0.5780.78
53_I57_E0.5720.78
85_S88_L0.5720.78
29_R76_D0.5710.77
63_K66_Y0.5710.77
34_S113_T0.5700.77
76_D79_G0.5680.77
111_T114_A0.5620.76
9_D113_T0.5610.76
99_V102_L0.5570.76
85_S114_A0.5520.75
17_R75_N0.5410.74
96_V103_L0.5390.73
89_A108_V0.5370.73
8_K62_F0.5350.73
6_L116_C0.5300.72
61_A64_P0.5280.72
35_F108_V0.5240.71
75_N81_E0.5240.71
35_F114_A0.5180.70
20_H48_H0.5170.70
68_R77_I0.5160.70
61_A100_V0.5150.70
98_P103_L0.5100.69
78_P82_N0.5100.69
69_L95_Q0.5090.69
27_C86_E0.5090.69
77_I81_E0.5080.69
15_A111_T0.5060.69
17_R84_T0.5030.68
98_P101_P0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ntkA 4 1 100 0.094 Contact Map
2obaA 4 1 100 0.108 Contact Map
3d7jA 4 0.9917 100 0.131 Contact Map
1b66A 4 1 100 0.151 Contact Map
2g64A 4 1 100 0.16 Contact Map
3jygA 4 0.9669 100 0.182 Contact Map
2dj6A 3 0.9256 100 0.205 Contact Map
1y13A 5 0.9504 100 0.215 Contact Map
3lx3A 4 0.9669 100 0.217 Contact Map
1dhnA 4 0.8595 36 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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