GREMLIN Database
EUTT - Ethanolamine utilization cobalamin adenosyltransferase
UniProt: P65643 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14189
Length: 267 (243)
Sequences: 105 (85)
Seq/√Len: 5.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_V198_A6.2391.00
110_L114_A2.8320.69
151_A242_Y2.4410.57
148_I158_L2.4310.57
96_H231_L2.4130.56
236_R239_S2.4070.56
175_S243_V2.3710.55
112_F154_L2.3670.55
153_A234_L2.3620.54
115_V209_E2.3310.53
5_I30_L2.3240.53
149_M154_L2.3050.53
176_H236_R2.2920.52
186_H242_Y2.2300.50
230_I245_M2.1890.49
194_G203_L2.1370.47
84_R94_L2.1230.46
132_E195_R2.0690.45
112_F210_T2.0610.44
183_D212_T2.0210.43
92_D217_V1.9940.42
119_T123_A1.9580.41
10_L43_L1.9370.40
137_W244_M1.9340.40
91_P94_L1.9140.40
10_L22_I1.8730.38
24_L200_L1.8690.38
38_L115_V1.8280.37
176_H239_S1.8240.37
78_A83_C1.8080.36
139_A190_E1.8060.36
5_I10_L1.8060.36
127_Q191_A1.8040.36
126_L205_T1.7620.35
165_G171_L1.7570.35
112_F121_A1.7550.35
120_I246_I1.7480.34
187_L242_Y1.7100.33
87_V120_I1.6910.33
142_R146_G1.6580.32
25_P198_A1.6130.30
24_L37_L1.6010.30
138_L172_H1.5780.29
173_R187_L1.5490.29
23_H226_L1.5450.28
31_T186_H1.5350.28
81_E242_Y1.5220.28
108_P247_L1.5200.28
65_P196_D1.5200.28
14_H37_L1.5120.28
231_L252_Q1.5070.27
66_V69_L1.5030.27
140_D240_T1.4820.27
96_H183_D1.4790.27
101_K224_E1.4640.26
19_G37_L1.4600.26
150_R154_L1.4550.26
112_F245_M1.4420.26
36_E81_E1.4320.25
116_L175_S1.4140.25
194_G246_I1.4090.25
150_R156_E1.4030.25
94_L102_M1.3690.24
44_R121_A1.3580.24
152_D242_Y1.3570.24
117_D236_R1.3530.23
45_I233_A1.3490.23
172_H217_V1.3490.23
54_L126_L1.3430.23
111_G216_Q1.3410.23
36_E190_E1.3390.23
13_N41_R1.3370.23
175_S194_G1.3310.23
10_L200_L1.3250.23
127_Q194_G1.3110.22
35_R192_S1.3090.22
97_L214_A1.2960.22
175_S239_S1.2900.22
17_S65_P1.2820.22
36_E83_C1.2740.22
80_C87_V1.2660.21
106_S231_L1.2650.21
153_A175_S1.2620.21
90_K105_K1.2600.21
137_W181_Y1.2370.21
105_K117_D1.2280.21
90_K102_M1.2160.20
36_E242_Y1.2040.20
149_M152_D1.1830.20
76_P252_Q1.1820.20
127_Q175_S1.1800.20
16_L37_L1.1770.19
117_D176_H1.1710.19
25_P28_S1.1510.19
31_T66_V1.1490.19
131_A228_P1.1340.19
153_A176_H1.1340.19
43_L92_D1.1300.18
85_Q164_V1.1270.18
116_L209_E1.1190.18
152_D186_H1.1170.18
187_L245_M1.1160.18
105_K211_E1.1130.18
103_V239_S1.1100.18
135_Q173_R1.1010.18
116_L122_L1.0950.18
105_K113_R1.0900.18
36_E161_Q1.0820.18
97_L234_L1.0820.18
96_H214_A1.0740.17
91_P165_G1.0570.17
110_L152_D1.0510.17
102_M239_S1.0440.17
75_H245_M1.0410.17
174_L182_L1.0380.17
31_T152_D1.0380.17
9_W212_T1.0380.17
43_L200_L1.0290.17
91_P236_R1.0240.16
42_H107_D1.0240.16
111_G171_L1.0240.16
38_L244_M1.0220.16
21_E149_M1.0210.16
8_A195_R1.0170.16
200_L246_I1.0130.16
105_K238_S1.0100.16
234_L245_M1.0000.16
47_F151_A0.9970.16
44_R118_S0.9960.16
90_K214_A0.9940.16
10_L51_Q0.9910.16
115_V159_G0.9870.16
138_L170_D0.9860.16
149_M171_L0.9790.16
118_S205_T0.9780.16
88_A224_E0.9770.16
27_D126_L0.9690.15
103_V127_Q0.9660.15
244_M248_S0.9570.15
5_I109_R0.9490.15
123_A145_L0.9480.15
16_L190_E0.9420.15
120_I146_G0.9420.15
35_R165_G0.9400.15
85_Q185_D0.9350.15
76_P231_L0.9320.15
17_S152_D0.9310.15
107_D110_L0.9310.15
90_K117_D0.9280.15
95_T211_E0.9220.15
107_D126_L0.9200.15
10_L203_L0.9130.14
95_T113_R0.9130.14
92_D102_M0.9040.14
69_L139_A0.9010.14
140_D223_F0.8870.14
40_S188_V0.8870.14
186_H197_A0.8780.14
117_D239_S0.8770.14
93_T231_L0.8740.14
91_P105_K0.8700.14
173_R249_V0.8690.14
133_P167_S0.8670.14
114_A152_D0.8630.14
117_D238_S0.8580.14
22_I45_I0.8550.14
98_S198_A0.8530.13
97_L127_Q0.8500.13
97_L166_L0.8480.13
90_K211_E0.8380.13
34_A208_R0.8380.13
32_P208_R0.8380.13
34_A204_R0.8380.13
32_P204_R0.8380.13
204_R208_R0.8380.13
87_V187_L0.8360.13
100_E247_L0.8350.13
180_R205_T0.8240.13
30_L41_R0.8240.13
90_K113_R0.8220.13
8_A31_T0.8190.13
196_D210_T0.8180.13
10_L37_L0.8170.13
215_A231_L0.8120.13
139_A143_S0.8080.13
36_E41_R0.8040.13
14_H19_G0.8020.13
141_I181_Y0.8010.13
153_A172_H0.7980.13
45_I168_D0.7960.13
102_M114_A0.7930.13
97_L153_A0.7900.13
38_L235_N0.7890.13
180_R239_S0.7840.12
5_I12_A0.7840.12
120_I205_T0.7800.12
93_T191_A0.7790.12
14_H134_W0.7790.12
105_K236_R0.7780.12
122_L202_L0.7770.12
124_V179_L0.7770.12
41_R150_R0.7770.12
138_L217_V0.7760.12
37_L123_A0.7730.12
102_M110_L0.7720.12
119_T210_T0.7700.12
33_S197_A0.7690.12
175_S236_R0.7680.12
10_L42_H0.7640.12
13_N232_Q0.7630.12
105_K114_A0.7630.12
54_L112_F0.7620.12
94_L218_F0.7620.12
58_D206_K0.7620.12
184_H246_I0.7600.12
186_H236_R0.7530.12
12_A31_T0.7520.12
96_H212_T0.7510.12
211_E229_D0.7490.12
24_L193_H0.7470.12
124_V197_A0.7440.12
120_I182_L0.7440.12
43_L115_V0.7430.12
90_K238_S0.7390.12
14_H89_K0.7390.12
27_D216_Q0.7390.12
145_L149_M0.7370.12
179_L185_D0.7370.12
139_A142_R0.7360.12
8_A207_V0.7350.12
31_T227_R0.7340.12
148_I151_A0.7320.12
87_V215_A0.7230.12
176_H234_L0.7190.12
138_L183_D0.7180.12
201_N245_M0.7180.12
99_A142_R0.7170.11
90_K218_F0.7140.11
120_I225_V0.7140.11
97_L107_D0.7140.11
105_K110_L0.7120.11
108_P245_M0.7090.11
102_M153_A0.7090.11
85_Q106_S0.7060.11
9_W139_A0.7050.11
12_A205_T0.7050.11
71_S157_P0.7030.11
43_L159_G0.7020.11
23_H203_L0.7010.11
112_F149_M0.7000.11
40_S183_D0.6990.11
112_F213_V0.6940.11
140_D252_Q0.6900.11
117_D211_E0.6890.11
56_V133_P0.6890.11
87_V123_A0.6890.11
155_G213_V0.6880.11
146_G172_H0.6880.11
9_W16_L0.6860.11
83_C242_Y0.6850.11
140_D145_L0.6830.11
35_R137_W0.6800.11
29_R115_V0.6800.11
130_L196_D0.6790.11
166_L246_I0.6790.11
106_S216_Q0.6780.11
37_L146_G0.6770.11
179_L198_A0.6760.11
11_R235_N0.6740.11
108_P227_R0.6710.11
147_N212_T0.6680.11
128_I189_P0.6680.11
38_L100_E0.6630.11
160_C247_L0.6610.11
125_W147_N0.6590.11
113_R117_D0.6570.11
106_S137_W0.6530.11
44_R183_D0.6510.11
33_S189_P0.6510.11
83_C104_A0.6490.11
13_N22_I0.6490.11
117_D201_N0.6490.11
146_G218_F0.6470.11
107_D114_A0.6440.11
64_Q226_L0.6410.10
36_E212_T0.6390.10
177_Q247_L0.6330.10
5_I18_E0.6320.10
87_V246_I0.6250.10
118_S250_T0.6180.10
35_R132_E0.6170.10
33_S232_Q0.6140.10
212_T240_T0.6130.10
40_S120_I0.6110.10
108_P189_P0.6100.10
83_C106_S0.6080.10
114_A211_E0.6060.10
17_S148_I0.6040.10
154_L213_V0.6010.10
75_H108_P0.6000.10
37_L182_L0.6000.10
52_G182_L0.5990.10
56_V230_I0.5970.10
91_P239_S0.5970.10
133_P205_T0.5950.10
30_L191_A0.5930.10
88_A139_A0.5840.10
48_I120_I0.5840.10
24_L29_R0.5820.10
75_H216_Q0.5790.10
22_I99_A0.5790.10
48_I150_R0.5780.10
77_Q86_P0.5750.10
16_L119_T0.5720.10
69_L234_L0.5710.10
80_C83_C0.5710.10
165_G170_D0.5700.10
33_S169_E0.5690.10
123_A191_A0.5680.10
27_D35_R0.5650.10
79_C83_C0.5640.10
20_A125_W0.5640.10
57_D133_P0.5630.10
151_A200_L0.5630.10
92_D119_T0.5620.10
127_Q163_I0.5620.10
5_I46_K0.5600.10
39_E124_V0.5560.09
110_L113_R0.5530.09
43_L207_V0.5470.09
7_E32_P0.5440.09
7_E208_R0.5440.09
7_E204_R0.5440.09
7_E34_A0.5440.09
110_L201_N0.5430.09
36_E77_Q0.5430.09
93_T173_R0.5420.09
207_V228_P0.5410.09
131_A188_V0.5410.09
105_K201_N0.5400.09
91_P176_H0.5360.09
151_A207_V0.5320.09
103_V234_L0.5320.09
91_P117_D0.5270.09
24_L230_I0.5260.09
13_N40_S0.5220.09
95_T105_K0.5210.09
103_V227_R0.5210.09
207_V223_F0.5200.09
109_R201_N0.5180.09
115_V167_S0.5170.09
30_L45_I0.5170.09
22_I198_A0.5150.09
147_N203_L0.5140.09
130_L151_A0.5130.09
65_P167_S0.5110.09
142_R172_H0.5110.09
135_Q248_S0.5100.09
91_P211_E0.5080.09
131_A136_P0.5060.09
152_D171_L0.5060.09
58_D65_P0.5040.09
54_L57_D0.5010.09
186_H233_A0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ah6A 3 0.5805 99.9 0.78 Contact Map
1wy1A 3 0.5318 99.9 0.792 Contact Map
2zhyA 3 0.6217 99.9 0.794 Contact Map
1wozA 3 0.573 99.9 0.794 Contact Map
1wvtA 3 0.5431 99.9 0.798 Contact Map
2idxA 3 0.6442 99.9 0.799 Contact Map
2g2dA 3 0.5655 99.9 0.799 Contact Map
1rtyA 3 0.5843 99.8 0.801 Contact Map
2nt8A 3 0.6404 99.8 0.801 Contact Map
3ke4A 3 0.6067 99.8 0.801 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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