GREMLIN Database
YFCD - Uncharacterized Nudix hydrolase YfcD
UniProt: P65556 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14107
Length: 180 (157)
Sequences: 2753 (1899)
Seq/√Len: 151.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_N20_E5.9071.00
46_D50_K5.1051.00
58_E65_G4.4301.00
55_R137_E3.8291.00
47_G125_H3.5091.00
55_R136_S2.8541.00
141_L146_I2.8211.00
42_I85_A2.7931.00
80_Q83_E2.6741.00
58_E136_S2.3611.00
142_T145_E2.2771.00
71_A89_A2.2291.00
11_W24_Q2.0611.00
149_R153_F1.9361.00
81_L118_A1.9241.00
79_E87_R1.9121.00
29_Q33_Q1.8771.00
50_K142_T1.8111.00
15_V38_R1.7841.00
19_N38_R1.7741.00
26_S29_Q1.7601.00
88_E91_E1.7401.00
65_G136_S1.7381.00
25_A29_Q1.7301.00
63_L155_P1.7191.00
52_L138_V1.6471.00
47_G123_V1.6121.00
128_F138_V1.5921.00
67_L139_C1.5871.00
25_A30_M1.5701.00
45_H51_I1.5681.00
31_R74_V1.4561.00
84_S87_R1.4551.00
25_A35_L1.4461.00
139_C149_R1.4461.00
12_V30_M1.3911.00
148_A152_E1.3751.00
55_R65_G1.3731.00
93_L138_V1.3661.00
90_E96_A1.3581.00
130_L135_V1.3571.00
52_L140_W1.3361.00
31_R37_H1.3321.00
31_R115_V1.3221.00
146_I157_S1.2771.00
66_M154_T1.2601.00
44_V122_C1.2581.00
68_D154_T1.2571.00
13_D77_A1.2361.00
54_Q68_D1.2081.00
86_R90_E1.2031.00
95_I124_S1.1791.00
130_L138_V1.1701.00
74_V115_V1.1571.00
44_V95_I1.1441.00
24_Q77_A1.1361.00
81_L120_F1.1220.99
9_T26_S1.1220.99
11_W26_S1.1170.99
42_I89_A1.1140.99
67_L137_E1.1110.99
45_H123_V1.1070.99
100_F122_C1.0650.99
12_V37_H1.0620.99
68_D72_G1.0410.99
86_R96_A1.0360.99
51_I146_I1.0340.99
109_E114_R1.0330.99
14_I25_A1.0290.99
91_E131_Q1.0250.99
53_V141_L1.0220.99
139_C145_E1.0140.99
150_C161_L1.0010.99
145_E148_A1.0010.99
36_R107_Y0.9960.99
104_G119_L0.9930.99
27_R88_E0.9790.99
55_R67_L0.9760.99
10_E76_Q0.9690.99
95_I128_F0.9670.98
93_L135_V0.9640.98
45_H121_S0.9620.98
75_V84_S0.9530.98
69_A72_G0.9530.98
46_D140_W0.9450.98
107_Y116_W0.9380.98
10_E87_R0.9380.98
105_Q118_A0.9250.98
16_N22_I0.9210.98
51_I70_T0.9180.98
143_P147_T0.9140.98
135_V138_V0.9110.98
101_A121_S0.9070.98
10_E27_R0.9030.98
14_I35_L0.8880.97
55_R58_E0.8820.97
40_T84_S0.8740.97
73_G88_E0.8700.97
41_Y69_A0.8670.97
37_H74_V0.8650.97
54_Q138_V0.8590.97
9_T28_E0.8560.97
44_V89_A0.8480.97
12_V74_V0.8470.97
17_E107_Y0.8410.96
13_D78_D0.8360.96
148_A151_D0.8360.96
141_L149_R0.8300.96
109_E112_N0.8290.96
147_T151_D0.8180.96
14_I23_A0.8140.96
19_N116_W0.8120.96
41_Y115_V0.8060.95
54_Q93_L0.8050.95
42_I122_C0.8040.95
99_P124_S0.8020.95
147_T162_A0.7960.95
79_E84_S0.7810.95
82_L86_R0.7740.94
19_N81_L0.7670.94
117_G160_A0.7650.94
96_A99_P0.7620.94
60_K134_E0.7600.94
153_F157_S0.7570.94
19_N105_Q0.7530.93
10_E88_E0.7470.93
31_R113_C0.7440.93
124_S128_F0.7420.93
41_Y68_D0.7400.93
102_E105_Q0.7370.93
160_A164_W0.7310.92
149_R152_E0.7220.92
41_Y117_G0.7210.92
89_A97_G0.7160.92
41_Y156_D0.7120.91
50_K145_E0.7080.91
105_Q116_W0.7060.91
75_V88_E0.7050.91
159_K163_L0.7040.91
43_V160_A0.6920.90
82_L85_A0.6900.90
12_V76_Q0.6870.90
30_M74_V0.6830.90
106_F160_A0.6820.90
56_R60_K0.6800.89
51_I143_P0.6690.89
63_L66_M0.6650.88
104_G160_A0.6560.88
39_A113_C0.6550.88
19_N118_A0.6520.87
27_R61_D0.6510.87
54_Q71_A0.6500.87
71_A93_L0.6460.87
10_E73_G0.6420.87
13_D52_L0.6410.86
27_R75_V0.6400.86
76_Q79_E0.6370.86
59_T132_E0.6320.86
17_E109_E0.6310.86
40_T85_A0.6300.86
30_M35_L0.6250.85
53_V153_F0.6250.85
101_A129_A0.6230.85
21_V77_A0.6220.85
30_M73_G0.6210.85
15_V19_N0.6130.84
19_N22_I0.6070.83
41_Y72_G0.6060.83
21_V24_Q0.6050.83
49_G123_V0.6040.83
46_D123_V0.5990.83
26_S30_M0.5980.82
90_E99_P0.5980.82
85_A120_F0.5940.82
72_G75_V0.5930.82
25_A33_Q0.5870.81
59_T133_D0.5780.80
32_A35_L0.5770.80
147_T161_L0.5760.80
37_H115_V0.5750.80
27_R76_Q0.5740.80
121_S164_W0.5710.79
103_H121_S0.5690.79
41_Y54_Q0.5680.79
158_L162_A0.5670.79
41_Y74_V0.5670.79
49_G143_P0.5650.79
11_W77_A0.5640.79
13_D21_V0.5630.79
43_V89_A0.5630.79
151_D158_L0.5620.78
74_V113_C0.5610.78
50_K144_E0.5590.78
72_G88_E0.5560.78
39_A74_V0.5560.78
108_F117_G0.5560.78
106_F110_D0.5550.78
83_E86_R0.5540.77
12_V61_D0.5530.77
70_T93_L0.5490.77
72_G113_C0.5490.77
98_V122_C0.5460.76
15_V36_R0.5440.76
141_L153_F0.5430.76
82_L148_A0.5390.75
36_R114_R0.5390.75
43_V157_S0.5380.75
95_I98_V0.5360.75
46_D125_H0.5350.75
104_G118_A0.5330.75
31_R35_L0.5320.75
69_A113_C0.5310.74
154_T157_S0.5280.74
40_T75_V0.5270.74
11_W129_A0.5260.74
69_A156_D0.5250.74
43_V51_I0.5210.73
27_R62_F0.5190.73
130_L133_D0.5180.73
146_I153_F0.5170.72
143_P146_I0.5160.72
41_Y113_C0.5160.72
19_N107_Y0.5150.72
92_E134_E0.5140.72
27_R91_E0.5130.72
53_V139_C0.5120.72
52_L128_F0.5090.71
26_S62_F0.5080.71
12_V27_R0.5060.71
104_G164_W0.5050.71
38_R75_V0.5030.70
33_Q140_W0.5030.70
31_R39_A0.5030.70
13_D19_N0.5010.70
101_A123_V0.5000.70
143_P157_S0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dhoA 1 0.9833 100 0.339 Contact Map
2pnyA 1 1 100 0.339 Contact Map
2fkbA 1 0.9278 100 0.445 Contact Map
1hztA 1 0.7944 100 0.454 Contact Map
3dupA 2 1 100 0.468 Contact Map
1q27A 1 0.9389 100 0.492 Contact Map
3e57A 2 0.8722 99.9 0.607 Contact Map
2xsqA 2 0.8333 99.9 0.611 Contact Map
1sjyA 2 0.8111 99.8 0.645 Contact Map
3grnA 2 0.7611 99.8 0.646 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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