GREMLIN Database
YQCA - Uncharacterized protein YqcA
UniProt: P65367 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13170
Length: 149 (140)
Sequences: 4022 (2703)
Seq/√Len: 228.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
108_D118_R3.9511.00
91_A104_G3.7741.00
105_K124_L3.4081.00
11_M66_D2.9301.00
86_R117_Q2.6651.00
112_Q118_R2.6231.00
102_N106_Q2.5011.00
110_L113_E2.4491.00
110_L114_Q2.2701.00
87_Y108_D2.1871.00
90_I125_I2.1391.00
4_I26_L2.0241.00
64_L103_G1.9761.00
23_E35_V1.9661.00
87_Y112_Q1.9581.00
41_L49_D1.9461.00
26_L145_G1.9321.00
7_F38_D1.7991.00
9_G68_I1.7991.00
51_Y86_R1.7711.00
89_V104_G1.7621.00
6_I23_E1.7451.00
54_V107_F1.7141.00
120_G143_Q1.6731.00
3_E32_K1.5901.00
15_S55_V1.5791.00
108_D112_Q1.5781.00
38_D71_L1.5681.00
16_L20_E1.5621.00
56_T107_F1.5401.00
54_V111_L1.5261.00
87_Y118_R1.5251.00
53_L144_W1.4781.00
10_T67_S1.4751.00
87_Y116_A1.4351.00
108_D122_M1.4311.00
18_V137_S1.4131.00
7_F41_L1.4111.00
105_K122_M1.3981.00
23_E33_A1.3931.00
72_F107_F1.3731.00
9_G56_T1.3681.00
60_G63_D1.3511.00
23_E27_T1.3261.00
15_S92_L1.3191.00
111_L116_A1.3161.00
18_V92_L1.3131.00
72_F106_Q1.2801.00
76_K110_L1.2751.00
90_I137_S1.2661.00
52_V85_L1.2631.00
101_C124_L1.2291.00
71_L107_F1.2201.00
53_L88_G1.1951.00
88_G120_G1.1571.00
91_A101_C1.1161.00
118_R121_E1.1061.00
22_A55_V1.1051.00
25_I141_V1.1041.00
57_S65_P1.0961.00
109_A113_E1.0801.00
90_I123_L1.0681.00
7_F52_V1.0591.00
56_T103_G1.0531.00
5_G36_F1.0501.00
38_D68_I1.0421.00
22_A141_V1.0271.00
37_E67_S1.0261.00
64_L68_I1.0251.00
64_L72_F1.0151.00
125_I137_S1.0021.00
9_G67_S0.9991.00
120_G144_W0.9861.00
20_E35_V0.9831.00
88_G144_W0.9751.00
56_T65_P0.9741.00
72_F110_L0.9711.00
58_T101_C0.9691.00
56_T68_I0.9691.00
72_F103_G0.9651.00
84_N117_Q0.9581.00
36_F40_E0.9491.00
102_N105_K0.9331.00
142_E146_T0.9100.99
26_L33_A0.8990.99
82_Q116_A0.8940.99
8_V16_L0.8750.99
118_R122_M0.8700.99
49_D52_V0.8670.99
3_E50_K0.8590.99
74_G78_S0.8400.99
18_V55_V0.8380.99
101_C104_G0.8300.99
25_I29_Q0.8290.99
10_T15_S0.8190.99
42_S45_L0.8120.99
88_G119_V0.8110.99
37_E40_E0.8100.99
31_H51_Y0.8100.99
139_P143_Q0.7980.99
39_P67_S0.7950.99
66_D69_V0.7940.99
121_E143_Q0.7940.99
125_I129_E0.7890.99
12_Y61_Q0.7880.99
21_E138_N0.7830.98
139_P142_E0.7830.98
61_Q99_N0.7730.98
89_V108_D0.7700.98
5_G34_T0.7700.98
109_A112_Q0.7680.98
22_A53_L0.7630.98
9_G38_D0.7630.98
72_F76_K0.7620.98
80_G83_P0.7550.98
17_L21_E0.7530.98
4_I51_Y0.7480.98
5_G50_K0.7420.98
104_G122_M0.7400.98
120_G123_L0.7400.98
4_I31_H0.7350.98
41_L74_G0.7300.98
24_A27_T0.7250.98
25_I142_E0.7210.97
95_S128_S0.7110.97
137_S141_V0.7080.97
92_L127_A0.7030.97
55_V90_I0.7010.97
34_T49_D0.6950.97
76_K106_Q0.6940.97
58_T104_G0.6880.97
3_E34_T0.6860.97
80_G114_Q0.6780.96
123_L136_E0.6780.96
12_Y127_A0.6720.96
54_V65_P0.6700.96
11_M15_S0.6700.96
56_T104_G0.6690.96
7_F54_V0.6630.96
85_L111_L0.6600.96
6_I26_L0.6570.96
25_I145_G0.6550.95
62_G65_P0.6510.95
24_A28_A0.6500.95
10_T17_L0.6470.95
99_N102_N0.6450.95
136_E139_P0.6420.95
5_G49_D0.6420.95
6_I19_A0.6350.95
3_E49_D0.6340.95
16_L67_S0.6320.95
143_Q146_T0.6300.94
27_T33_A0.6240.94
15_S57_S0.6240.94
8_V35_V0.6110.93
81_F114_Q0.6080.93
73_Q77_D0.6040.93
59_T127_A0.6030.93
9_G65_P0.5980.93
4_I53_L0.5960.93
75_I114_Q0.5960.93
44_W79_L0.5950.93
45_L48_Q0.5890.92
6_I34_T0.5860.92
87_Y111_L0.5850.92
138_N142_E0.5810.92
7_F36_F0.5800.92
135_T139_P0.5780.91
135_T138_N0.5720.91
82_Q85_L0.5700.91
29_Q120_G0.5640.90
61_Q98_V0.5620.90
104_G124_L0.5600.90
17_L20_E0.5600.90
36_F41_L0.5590.90
94_D97_Y0.5580.90
64_L106_Q0.5580.90
6_I35_V0.5570.90
93_G97_Y0.5530.90
39_P70_P0.5530.90
90_I144_W0.5510.89
105_K109_A0.5500.89
64_L107_F0.5460.89
43_D74_G0.5450.89
100_F122_M0.5450.89
24_A29_Q0.5450.89
58_T65_P0.5440.89
8_V37_E0.5440.89
8_V55_V0.5330.88
79_L114_Q0.5300.88
15_S134_E0.5290.88
63_D106_Q0.5290.88
97_Y101_C0.5240.87
9_G103_G0.5230.87
94_D128_S0.5220.87
129_E135_T0.5170.86
16_L66_D0.5160.86
25_I138_N0.5150.86
14_N17_L0.5120.86
61_Q69_V0.5110.86
95_S126_D0.5100.86
19_A35_V0.5100.86
48_Q84_N0.5080.85
12_Y59_T0.5070.85
6_I53_L0.5050.85
63_D134_E0.5020.85
91_A122_M0.5010.85
78_S114_Q0.5010.85
18_V65_P0.5000.84
53_L119_V0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tllA 2 0.9732 100 0.154 Contact Map
2bpoA 1 0.9933 100 0.213 Contact Map
3qe2A 1 0.9866 100 0.215 Contact Map
3hr4A 2 0.9799 100 0.286 Contact Map
1bvyF 1 0.9732 100 0.362 Contact Map
4h2dA 1 0.9933 100 0.384 Contact Map
1ykgA 1 0.953 100 0.392 Contact Map
4oxxA 1 0.9866 100 0.397 Contact Map
2m6rA 1 0.9866 100 0.401 Contact Map
2hnaA 1 0.9866 100 0.406 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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