GREMLIN Database
YRFG - GMP/IMP nucleotidase YrfG
UniProt: P64636 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12928
Length: 222 (205)
Sequences: 29895 (24547)
Seq/√Len: 1714.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_D168_R4.0671.00
128_E133_D2.9951.00
147_Y151_D2.8721.00
157_A161_A2.7771.00
120_P124_A2.6871.00
182_A189_Y2.5361.00
103_E135_H2.4761.00
12_T164_L2.4611.00
99_I103_E2.4081.00
113_I138_L2.3971.00
111_Q137_D2.3151.00
10_V188_R2.2401.00
138_L161_A2.2331.00
157_A160_E2.2131.00
15_L112_R2.2091.00
115_L154_L2.1901.00
120_P144_T2.1421.00
159_A169_T2.0881.00
147_Y153_R2.0841.00
183_A208_H2.0361.00
179_L189_Y1.9751.00
212_N216_R1.9421.00
165_K168_R1.9151.00
180_D184_Q1.9101.00
13_V110_K1.8891.00
106_K135_H1.8051.00
116_T123_L1.7871.00
159_A187_I1.7751.00
104_A108_S1.7741.00
188_R208_H1.7621.00
171_F182_A1.7451.00
170_L190_C1.6911.00
106_K137_D1.6631.00
14_L158_V1.6511.00
98_T214_Y1.6501.00
124_A133_D1.6131.00
14_L171_F1.6051.00
173_D178_I1.5981.00
112_R136_L1.5791.00
176_E180_D1.5521.00
12_T162_T1.5491.00
159_A166_A1.5441.00
193_V212_N1.5281.00
14_L115_L1.4891.00
10_V170_L1.4651.00
113_I162_T1.4631.00
28_N31_W1.4631.00
164_L169_T1.4561.00
17_M114_L1.4411.00
46_T49_E1.3941.00
83_A87_E1.3921.00
152_Q156_H1.3841.00
101_F214_Y1.3611.00
13_V172_I1.3431.00
190_C211_L1.3421.00
193_V210_S1.3301.00
13_V105_L1.3211.00
27_D31_W1.3201.00
17_M22_L1.3011.00
177_A180_D1.2851.00
140_L161_A1.2781.00
190_C209_P1.2781.00
95_R194_T1.2741.00
20_T172_I1.2671.00
104_A107_A1.2641.00
124_A128_E1.2561.00
12_T169_T1.2421.00
57_Q61_V1.2391.00
213_D216_R1.2191.00
17_M123_L1.2141.00
73_W76_Q1.2111.00
21_L98_T1.2031.00
27_D32_Q1.2031.00
30_F33_K1.1811.00
14_L169_T1.1771.00
140_L158_V1.1731.00
12_T111_Q1.1641.00
106_K112_R1.1631.00
153_R157_A1.1531.00
155_W171_F1.1481.00
114_L136_L1.1451.00
123_L141_S1.1361.00
12_T113_I1.1301.00
97_D100_P1.1301.00
155_W181_A1.0991.00
76_Q80_D1.0981.00
28_N32_Q1.0851.00
125_V129_H1.0851.00
100_P215_R1.0831.00
169_T187_I1.0721.00
155_W187_I1.0661.00
94_L132_L1.0561.00
156_H160_E1.0551.00
145_F157_A1.0461.00
158_V162_T1.0461.00
131_G134_A1.0431.00
75_E79_L1.0421.00
181_A185_F1.0391.00
77_L81_I1.0321.00
35_V39_W1.0251.00
17_M118_A1.0181.00
156_H185_F1.0181.00
153_R156_H1.0181.00
120_P141_S1.0141.00
82_C86_T1.0021.00
51_M55_R1.0021.00
103_E107_A0.9841.00
183_A189_Y0.9821.00
99_I135_H0.9801.00
125_V128_E0.9771.00
115_L158_V0.9731.00
56_Q60_D0.9701.00
74_S78_G0.9681.00
83_A86_T0.9671.00
27_D30_F0.9661.00
171_F187_I0.9661.00
94_L99_I0.9621.00
97_D215_R0.9601.00
138_L162_T0.9591.00
188_R209_P0.9501.00
14_L187_I0.9501.00
62_Q66_N0.9481.00
58_Y61_V0.9341.00
102_L136_L0.9311.00
100_P103_E0.9311.00
116_T141_S0.9291.00
29_Y33_K0.9281.00
31_W34_L0.9261.00
55_R61_V0.9241.00
30_F34_L0.9221.00
97_D213_D0.9141.00
140_L157_A0.9101.00
69_C72_Y0.9011.00
38_T80_D0.8911.00
155_W173_D0.8901.00
55_R59_H0.8861.00
56_Q61_V0.8811.00
18_D24_L0.8771.00
179_L207_R0.8771.00
18_D116_T0.8761.00
120_P143_H0.8751.00
189_Y208_H0.8741.00
113_I158_V0.8691.00
172_I190_C0.8571.00
18_D118_A0.8571.00
63_H66_N0.8511.00
183_A206_Q0.8501.00
14_L162_T0.8491.00
103_E134_A0.8431.00
146_G153_R0.8431.00
95_R192_G0.8381.00
34_L37_E0.8371.00
105_L110_K0.8351.00
87_E90_P0.8331.00
17_M126_K0.8321.00
112_R135_H0.8311.00
156_H166_A0.8311.00
105_L112_R0.8241.00
36_P40_G0.8181.00
95_R98_T0.8171.00
200_I204_Q0.8171.00
80_D83_A0.8031.00
164_L168_R0.7971.00
34_L38_T0.7941.00
22_L130_T0.7931.00
118_A123_L0.7921.00
166_A187_I0.7881.00
11_D110_K0.7871.00
22_L126_K0.7861.00
211_L217_L0.7831.00
33_K37_E0.7821.00
84_M88_M0.7801.00
57_Q60_D0.7741.00
45_V49_E0.7711.00
31_W35_V0.7671.00
170_L188_R0.7661.00
66_N69_C0.7601.00
99_I131_G0.7591.00
123_L126_K0.7561.00
117_N148_P0.7551.00
141_S144_T0.7551.00
152_Q184_Q0.7531.00
100_P104_A0.7501.00
180_D183_A0.7441.00
53_Y56_Q0.7381.00
38_T41_A0.7341.00
191_L210_S0.7321.00
155_W178_I0.7321.00
127_L133_D0.7291.00
76_Q79_L0.7281.00
13_V170_L0.7221.00
78_G81_I0.7191.00
190_C217_L0.7171.00
84_M87_E0.7161.00
79_L83_A0.7131.00
10_V110_K0.7101.00
179_L191_L0.7071.00
201_A204_Q0.7051.00
112_R137_D0.7051.00
117_N150_E0.7041.00
89_G125_V0.7031.00
99_I134_A0.7021.00
31_W36_P0.7001.00
60_D63_H0.6981.00
102_L135_H0.6971.00
192_G214_Y0.6901.00
202_E206_Q0.6891.00
11_D111_Q0.6871.00
36_P41_A0.6821.00
66_N70_L0.6811.00
10_V168_R0.6801.00
23_D93_V0.6801.00
194_T214_Y0.6791.00
51_M54_M0.6631.00
111_Q164_L0.6591.00
138_L158_V0.6581.00
74_S80_D0.6551.00
64_T67_W0.6551.00
38_T83_A0.6551.00
52_E55_R0.6531.00
29_Y32_Q0.6531.00
11_D164_L0.6501.00
211_L214_Y0.6491.00
123_L127_L0.6471.00
82_C85_T0.6471.00
124_A139_L0.6461.00
23_D95_R0.6441.00
171_F181_A0.6431.00
118_A122_N0.6431.00
37_E44_G0.6421.00
62_Q67_W0.6411.00
80_D84_M0.6381.00
54_M58_Y0.6361.00
98_T102_L0.6361.00
94_L130_T0.6351.00
172_I217_L0.6351.00
14_L113_I0.6351.00
175_S178_I0.6341.00
40_G43_N0.6331.00
144_T161_A0.6331.00
75_E78_G0.6221.00
159_A164_L0.6191.00
15_L101_F0.6191.00
202_E205_Y0.6171.00
76_Q81_I0.6161.00
178_I181_A0.6151.00
27_D33_K0.6151.00
78_G82_C0.6151.00
52_E56_Q0.6121.00
121_H125_V0.6101.00
74_S81_I0.6081.00
77_L80_D0.6081.00
18_D126_K0.6061.00
20_T173_D0.6041.00
40_G44_G0.6021.00
55_R58_Y0.5981.00
50_A54_M0.5931.00
103_E106_K0.5901.00
142_T154_L0.5881.00
154_L158_V0.5861.00
145_F154_L0.5851.00
26_F93_V0.5801.00
123_L139_L0.5801.00
115_L171_F0.5801.00
156_H159_A0.5791.00
119_H122_N0.5781.00
97_D101_F0.5751.00
166_A169_T0.5741.00
18_D174_D0.5721.00
67_W70_L0.5721.00
171_F178_I0.5711.00
106_K109_G0.5691.00
81_I85_T0.5661.00
159_A185_F0.5661.00
101_F172_I0.5661.00
10_V13_V0.5661.00
36_P39_W0.5651.00
98_T101_F0.5651.00
64_T68_Y0.5641.00
53_Y57_Q0.5621.00
140_L154_L0.5611.00
20_T192_G0.5591.00
19_G25_A0.5541.00
21_L102_L0.5531.00
39_W43_N0.5521.00
24_L118_A0.5511.00
70_L73_W0.5491.00
140_L162_T0.5451.00
136_L139_L0.5431.00
54_M57_Q0.5411.00
176_E191_L0.5411.00
101_F104_A0.5381.00
122_N126_K0.5351.00
117_N142_T0.5331.00
118_A178_I0.5311.00
63_H67_W0.5281.00
118_A141_S0.5251.00
22_L92_A0.5251.00
64_T69_C0.5231.00
118_A173_D0.5201.00
154_L181_A0.5201.00
96_E215_R0.5201.00
138_L141_S0.5151.00
89_G129_H0.5151.00
191_L202_E0.5071.00
13_V112_R0.5061.00
180_D206_Q0.5021.00
159_A165_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d6jA 1 0.9414 100 0.324 Contact Map
4uw9A 1 0.8874 100 0.327 Contact Map
3l5kA 1 0.982 100 0.327 Contact Map
3qxgA 3 0.9595 100 0.329 Contact Map
4eekA 2 0.9505 100 0.33 Contact Map
3s6jA 2 0.955 100 0.331 Contact Map
3iruA 4 0.9865 100 0.333 Contact Map
3sd7A 1 0.9414 100 0.333 Contact Map
1swvA 2 0.9505 100 0.336 Contact Map
3mc1A 2 0.9459 100 0.337 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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