GREMLIN Database
HOFN - Putative DNA utilization protein HofN
UniProt: P64634 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12924
Length: 179 (171)
Sequences: 927 (712)
Seq/√Len: 54.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_A60_Q5.9991.00
16_T20_R4.0021.00
109_H133_A3.4211.00
66_Q69_K3.1431.00
83_S87_R2.9011.00
23_L27_V2.7291.00
70_P74_E2.6931.00
124_I169_L2.6701.00
3_P10_W2.5601.00
73_L76_Q2.4801.00
125_K166_E2.4721.00
63_R66_Q2.3991.00
123_E166_E2.3291.00
75_Q79_R2.2891.00
52_A55_L2.2871.00
72_L156_Q2.2621.00
97_S146_S2.1521.00
138_E167_Y2.1201.00
59_Q62_A2.0761.00
89_R92_T1.9371.00
16_T19_L1.8370.99
122_L169_L1.7640.99
138_E152_R1.7140.99
54_L107_P1.6990.99
14_R18_F1.6970.99
31_L35_G1.6940.99
47_E51_D1.5850.98
98_A171_R1.5700.98
55_L59_Q1.5670.98
17_A21_F1.4770.97
52_A59_Q1.4710.97
20_R24_L1.4690.97
142_R150_N1.4670.97
134_L158_D1.4570.97
96_Q117_W1.4340.97
56_Q59_Q1.4320.97
124_I141_L1.4170.96
27_V31_L1.4120.96
156_Q164_Q1.4010.96
28_A31_L1.3960.96
47_E50_I1.3940.96
53_V57_A1.3910.96
96_Q100_E1.3600.95
31_L41_R1.3520.95
101_A104_A1.3480.95
17_A36_I1.3250.95
88_Q138_E1.3220.95
86_Q93_R1.3190.94
88_Q92_T1.3180.94
72_L102_L1.3170.94
79_R95_W1.3150.94
45_S48_A1.3100.94
103_A169_L1.3070.94
120_G170_T1.2800.94
94_D171_R1.2700.93
73_L77_Q1.2500.93
62_A65_L1.2460.93
9_P12_Q1.2240.92
99_L152_R1.2110.91
10_W22_W1.2110.91
85_R88_Q1.2050.91
107_P137_L1.1520.89
10_W14_R1.1510.89
79_R82_R1.1480.89
6_N9_P1.1460.89
37_T103_A1.1380.89
56_Q60_Q1.1210.88
11_R22_W1.1160.88
33_A111_W1.1060.87
149_L170_T1.1040.87
88_Q135_N1.0990.87
114_T125_K1.0970.87
45_S73_L1.0960.87
164_Q167_Y1.0940.87
71_R89_R1.0730.86
141_L167_Y1.0710.86
113_T121_T1.0620.85
82_R86_Q1.0500.84
62_A73_L1.0390.84
151_Q168_Q1.0360.84
27_V30_L1.0260.83
122_L147_F1.0120.82
126_G165_F1.0120.82
7_F126_G0.9960.81
93_R97_S0.9900.81
50_I92_T0.9730.80
124_I168_Q0.9700.79
85_R131_I0.9550.78
52_A56_Q0.9450.77
130_S135_N0.9390.77
134_L152_R0.9290.76
15_R113_T0.9260.76
98_A146_S0.9180.75
82_R129_T0.9170.75
28_A43_T0.9160.75
134_L153_G0.9080.75
35_G55_L0.9050.74
71_R75_Q0.9020.74
76_Q80_E0.9020.74
59_Q66_Q0.8990.74
19_L23_L0.8950.74
26_F48_A0.8950.74
98_A122_L0.8920.73
93_R96_Q0.8900.73
24_L124_I0.8870.73
75_Q91_F0.8870.73
117_W132_T0.8820.72
102_L143_Q0.8820.72
137_L154_A0.8730.72
5_I95_W0.8660.71
93_R128_T0.8570.70
72_L76_Q0.8560.70
10_W47_E0.8530.70
158_D161_G0.8520.70
49_R59_Q0.8430.69
64_S77_Q0.8340.68
122_L156_Q0.8340.68
69_K114_T0.8230.67
76_Q121_T0.8200.67
10_W81_Q0.8100.66
19_L111_W0.8040.65
157_Q163_W0.8010.65
75_Q139_T0.7970.65
44_G78_L0.7890.64
95_W163_W0.7870.64
6_N11_R0.7870.64
79_R86_Q0.7830.63
131_I152_R0.7820.63
113_T166_E0.7800.63
76_Q102_L0.7760.63
112_L166_E0.7700.62
95_W132_T0.7670.62
15_R90_Q0.7640.61
25_M160_Q0.7600.61
97_S158_D0.7590.61
22_W26_F0.7560.61
110_A133_A0.7500.60
28_A46_A0.7490.60
48_A52_A0.7430.59
134_L157_Q0.7430.59
9_P139_T0.7430.59
89_R155_T0.7420.59
22_W71_R0.7410.59
22_W51_D0.7390.59
24_L28_A0.7390.59
22_W99_L0.7370.59
96_Q134_L0.7330.58
18_F21_F0.7330.58
110_A167_Y0.7310.58
32_L50_I0.7280.58
16_T44_G0.7270.58
16_T40_L0.7180.57
150_N155_T0.7160.56
28_A38_L0.7150.56
80_E97_S0.7140.56
111_W137_L0.7090.56
150_N169_L0.7020.55
148_H172_K0.7020.55
14_R17_A0.6960.54
90_Q97_S0.6900.54
98_A132_T0.6890.54
69_K87_R0.6880.53
152_R156_Q0.6870.53
106_L137_L0.6830.53
75_Q82_R0.6830.53
98_A112_L0.6820.53
53_V103_A0.6720.52
114_T142_R0.6650.51
121_T168_Q0.6640.51
101_A144_D0.6640.51
108_E129_T0.6590.50
37_T136_A0.6570.50
98_A147_F0.6560.50
122_L148_H0.6550.50
112_L137_L0.6520.50
64_S72_L0.6510.49
42_L56_Q0.6500.49
126_G130_S0.6470.49
95_W111_W0.6390.48
63_R69_K0.6380.48
82_R94_D0.6350.48
11_R47_E0.6310.47
96_Q128_T0.6260.47
47_E58_E0.6250.47
36_I52_A0.6250.47
46_A122_L0.6250.47
82_R93_R0.6220.46
60_Q119_Q0.6210.46
31_L114_T0.6190.46
36_I164_Q0.6180.46
61_L73_L0.6160.46
10_W75_Q0.6150.46
24_L31_L0.6140.46
55_L145_A0.6140.46
85_R91_F0.6140.46
101_A105_L0.6120.45
18_F89_R0.6120.45
141_L147_F0.6070.45
87_R122_L0.6050.45
62_A66_Q0.5990.44
20_R118_Q0.5960.44
127_L141_L0.5940.43
102_L115_I0.5840.42
65_L68_T0.5830.42
54_L69_K0.5800.42
58_E85_R0.5780.42
80_E143_Q0.5770.42
47_E54_L0.5740.41
94_D139_T0.5730.41
95_W146_S0.5730.41
133_A157_Q0.5710.41
95_W99_L0.5710.41
27_V166_E0.5700.41
130_S133_A0.5690.41
21_F106_L0.5660.40
74_E78_L0.5620.40
8_L130_S0.5620.40
131_I138_E0.5610.40
95_W131_I0.5470.39
121_T170_T0.5460.38
99_L111_W0.5460.38
86_Q137_L0.5450.38
28_A77_Q0.5440.38
37_T106_L0.5440.38
10_W160_Q0.5410.38
95_W128_T0.5390.38
17_A38_L0.5380.38
117_W135_N0.5370.38
12_Q111_W0.5360.37
166_E169_L0.5360.37
38_L42_L0.5350.37
32_L56_Q0.5340.37
10_W103_A0.5330.37
28_A60_Q0.5310.37
48_A56_Q0.5290.37
41_R45_S0.5280.37
43_T164_Q0.5270.37
85_R142_R0.5250.36
56_Q145_A0.5230.36
139_T150_N0.5220.36
51_D71_R0.5160.35
134_L169_L0.5150.35
8_L11_R0.5120.35
73_L123_E0.5120.35
113_T159_A0.5110.35
98_A138_E0.5090.35
129_T132_T0.5080.35
101_A155_T0.5060.34
34_V124_I0.5060.34
158_D164_Q0.5030.34
17_A132_T0.5020.34
34_V37_T0.5020.34
29_P33_A0.5010.34
95_W153_G0.5010.34
163_W171_R0.5010.34
99_L136_A0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bhqA 2 0.486 99.9 0.467 Contact Map
2rjzA 2 0.648 90 0.88 Contact Map
2w7vA 2 0.419 78.2 0.897 Contact Map
4q4gX 1 0 35 0.922 Contact Map
4bgnA 3 0.3184 25.3 0.928 Contact Map
4c4vA 1 0.3855 23.8 0.929 Contact Map
4cbcA 3 0.2123 19.6 0.931 Contact Map
2j5uA 4 0.6648 18.4 0.932 Contact Map
4cgkA 3 0.6872 15.3 0.935 Contact Map
3kypA 2 0.581 12.7 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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