GREMLIN Database
YHFU - Uncharacterized protein YhfU
UniProt: P64631 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12916
Length: 117 (114)
Sequences: 130 (87)
Seq/√Len: 8.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_V18_I3.2030.91
71_K96_V3.0590.89
9_L53_N2.9380.87
53_N103_E2.5970.79
9_L103_E2.5860.79
49_I112_L2.4950.76
58_A61_S2.4500.75
108_A111_M2.3690.72
15_K19_E2.1930.66
95_K110_P2.0950.62
58_A65_A2.0840.62
75_I112_L2.0730.61
40_V67_I2.0340.60
76_A104_H1.9950.58
16_K20_A1.9810.58
6_V93_E1.9760.57
6_V28_V1.9550.57
5_G45_L1.9540.56
26_F82_A1.8380.52
84_D88_A1.8280.51
75_I109_I1.7830.49
51_A87_I1.5600.40
23_P26_F1.5470.40
40_V113_I1.4870.37
4_I112_L1.4640.37
10_Q102_V1.4590.36
22_A26_F1.4190.35
83_K87_I1.4130.35
81_K108_A1.4070.34
54_T78_P1.4060.34
82_A103_E1.4060.34
18_I67_I1.3930.34
7_A11_R1.3630.33
17_T105_V1.3600.33
84_D111_M1.3040.31
16_K84_D1.2840.30
63_A97_A1.2830.30
36_A54_T1.2700.30
88_A92_A1.2200.28
22_A113_I1.2170.28
40_V49_I1.2020.27
3_K35_E1.2010.27
56_A77_K1.1780.26
27_E42_S1.1680.26
40_V63_A1.1600.26
3_K44_Q1.1590.26
13_Q105_V1.1210.25
42_S49_I1.1170.25
27_E34_M1.1070.24
14_I60_L1.1000.24
56_A101_S1.0990.24
63_A78_P1.0710.23
82_A90_M1.0310.22
58_A101_S1.0240.22
28_V89_K1.0110.21
51_A79_G1.0100.21
56_A79_G1.0000.21
16_K105_V0.9830.21
30_I34_M0.9750.20
35_E60_L0.9680.20
19_E24_G0.9670.20
87_I95_K0.9610.20
82_A109_I0.9610.20
9_L76_A0.9480.20
6_V10_Q0.9310.19
39_K65_A0.9270.19
68_G86_H0.9070.19
12_E20_A0.9040.19
90_M113_I0.9020.19
32_N45_L0.8630.18
23_P69_Y0.8620.18
74_T101_S0.8570.17
65_A78_P0.8540.17
38_M54_T0.8500.17
58_A97_A0.8430.17
61_S77_K0.8390.17
67_I70_N0.8260.17
92_A106_E0.8220.17
65_A77_K0.8160.16
87_I108_A0.8110.16
91_I115_H0.8070.16
12_E53_N0.8050.16
15_K84_D0.7980.16
9_L87_I0.7920.16
23_P67_I0.7920.16
58_A77_K0.7880.16
72_S109_I0.7860.16
6_V41_K0.7840.16
40_V114_N0.7770.16
103_E108_A0.7740.16
61_S102_V0.7670.15
49_I111_M0.7640.15
86_H89_K0.7610.15
16_K19_E0.7590.15
20_A85_E0.7590.15
45_L112_L0.7580.15
54_T100_L0.7580.15
58_A93_E0.7490.15
44_Q67_I0.7470.15
9_L104_H0.7390.15
86_H91_I0.7210.14
75_I89_K0.7120.14
51_A59_A0.7090.14
31_H54_T0.7070.14
38_M48_Y0.7070.14
88_A114_N0.7030.14
26_F103_E0.6990.14
61_S100_L0.6990.14
49_I83_K0.6940.14
31_H62_I0.6920.14
15_K28_V0.6920.14
67_I114_N0.6830.14
53_N87_I0.6810.14
9_L77_K0.6760.14
91_I102_V0.6720.13
62_I65_A0.6620.13
18_I111_M0.6500.13
54_T104_H0.6490.13
65_A101_S0.6480.13
40_V43_G0.6460.13
73_C82_A0.6430.13
66_V106_E0.6390.13
30_I35_E0.6340.13
74_T77_K0.6320.13
46_D52_C0.6250.13
82_A108_A0.6230.13
19_E26_F0.6160.12
42_S113_I0.6090.12
5_G59_A0.6060.12
49_I96_V0.5950.12
6_V62_I0.5950.12
6_V59_A0.5940.12
58_A63_A0.5910.12
46_D54_T0.5880.12
19_E70_N0.5870.12
36_A96_V0.5850.12
4_I35_E0.5820.12
58_A102_V0.5770.12
48_Y52_C0.5760.12
18_I110_P0.5740.12
69_Y105_V0.5730.12
77_K102_V0.5730.12
43_G85_E0.5700.12
45_L49_I0.5690.12
75_I110_P0.5690.12
58_A100_L0.5670.12
53_N77_K0.5620.11
2_K82_A0.5620.11
32_N115_H0.5560.11
32_N111_M0.5530.11
9_L56_A0.5520.11
18_I80_I0.5490.11
38_M100_L0.5480.11
47_Y88_A0.5440.11
6_V79_G0.5440.11
53_N74_T0.5380.11
3_K13_Q0.5340.11
34_M69_Y0.5320.11
30_I40_V0.5240.11
20_A87_I0.5210.11
18_I45_L0.5210.11
4_I13_Q0.5200.11
29_F70_N0.5190.11
41_K59_A0.5180.11
84_D114_N0.5170.11
77_K103_E0.5150.11
42_S88_A0.5140.11
7_A100_L0.5110.11
65_A74_T0.5050.11
13_Q66_V0.5030.11
32_N37_A0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lflA 2 0.9316 70.7 0.92 Contact Map
2vvrA 2 0.9744 67.4 0.922 Contact Map
3k7pA 4 0.9829 63.6 0.924 Contact Map
3ph3A 2 0.9744 52.2 0.929 Contact Map
3onoA 4 0.9915 51.5 0.929 Contact Map
4lflB 3 0.9658 49.2 0.93 Contact Map
3he8A 2 0.9829 44.6 0.932 Contact Map
3s5pA 4 0.906 44.5 0.932 Contact Map
3sgwA 4 0.9829 43.2 0.932 Contact Map
3c5yA 5 0.9829 42.5 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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