GREMLIN Database
YHEO - Uncharacterized protein YheO
UniProt: P64624 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12899
Length: 240 (207)
Sequences: 987 (739)
Seq/√Len: 51.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_V51_L5.2891.00
139_S143_S4.6691.00
39_L49_I3.9551.00
198_Y231_K3.8681.00
61_A76_S3.5811.00
47_C132_M3.4931.00
218_I223_V3.4391.00
37_D65_A3.3701.00
38_G115_I3.2551.00
190_N226_Y3.1031.00
37_D63_R2.8071.00
30_K33_E2.6991.00
43_I47_C2.6101.00
36_V63_R2.5221.00
220_K225_L2.4291.00
202_I212_V2.3931.00
79_T157_V2.3231.00
108_V135_D2.2381.00
118_R124_V2.1211.00
116_A124_V1.9551.00
32_Y126_G1.9050.99
73_K76_S1.8690.99
69_H110_M1.8560.99
119_N123_R1.8220.99
218_I222_T1.7550.99
35_V128_L1.7470.99
108_V133_N1.7390.99
221_H225_L1.6880.99
36_V39_L1.6780.98
182_R189_K1.6760.98
38_G225_L1.5790.98
45_S144_T1.5770.98
52_H131_N1.5720.98
57_L78_I1.5400.97
51_L128_L1.5270.97
174_T196_N1.4860.97
69_H133_N1.4690.96
188_A208_A1.4580.96
138_F142_M1.4480.96
100_Y114_T1.4420.96
36_V65_A1.4140.96
52_H129_C1.4020.95
172_E215_R1.3950.95
61_A64_I1.3840.95
193_I216_L1.3840.95
63_R74_I1.3790.95
80_D157_V1.3740.95
56_D59_C1.3720.95
213_A223_V1.3710.95
185_S193_I1.3660.95
36_V128_L1.3470.94
53_S57_L1.3340.94
79_T197_L1.3060.93
192_Q195_L1.3060.93
206_K209_I1.2920.93
184_V189_K1.2860.93
33_E62_I1.2840.93
36_V82_A1.2660.92
177_E196_N1.2580.92
193_I217_N1.2520.92
198_Y204_D1.2440.91
112_S129_C1.2270.91
170_T202_I1.2210.91
51_L63_R1.2060.90
100_Y159_F1.2030.90
31_S35_V1.1970.90
91_G118_R1.1910.89
79_T83_L1.1910.89
216_L227_I1.1890.89
99_C118_R1.1870.89
78_I82_A1.1800.89
57_L60_S1.1650.88
49_I229_Q1.1570.88
70_T159_F1.1500.88
39_L130_I1.1440.87
40_A63_R1.1210.86
60_S78_I1.1140.86
38_G220_K1.1110.86
187_N225_L1.1100.86
50_V217_N1.1090.86
39_L47_C1.0960.85
53_S75_G1.0650.83
29_L125_I1.0630.83
187_N229_Q1.0570.83
79_T129_C1.0530.83
79_T102_T1.0420.82
218_I225_L1.0350.82
181_D185_S1.0340.82
26_F55_Q1.0310.81
77_P159_F1.0280.81
52_H72_R1.0270.81
50_V61_A1.0240.81
72_R129_C1.0210.81
119_N125_I1.0050.80
90_T93_D1.0000.79
117_I145_F0.9940.79
208_A212_V0.9920.79
129_C206_K0.9850.78
98_K113_L0.9740.77
99_C113_L0.9670.77
226_Y229_Q0.9630.77
83_L197_L0.9580.76
95_S118_R0.9560.76
130_I194_V0.9550.76
206_K226_Y0.9450.75
187_N191_R0.9440.75
46_H221_H0.9410.75
52_H83_L0.9310.74
174_T193_I0.9310.74
29_L51_L0.9290.74
74_I208_A0.9270.74
181_D184_V0.9250.74
52_H60_S0.9220.73
183_N217_N0.9110.73
36_V49_I0.9070.72
89_M92_A0.9060.72
194_V226_Y0.9060.72
92_A95_S0.9060.72
167_V202_I0.9050.72
30_K117_I0.9050.72
36_V176_E0.9020.72
38_G221_H0.8950.71
175_I231_K0.8880.71
163_V166_L0.8880.71
37_D40_A0.8870.71
104_A108_V0.8870.71
58_K107_G0.8840.70
27_D30_K0.8780.70
155_S158_N0.8660.69
221_H228_R0.8630.68
189_K192_Q0.8610.68
74_I173_F0.8600.68
195_L230_F0.8550.68
77_P157_V0.8530.68
32_Y38_G0.8480.67
114_T127_L0.8440.67
41_M217_N0.8410.66
139_S146_V0.8360.66
197_L212_V0.8320.66
180_A184_V0.8290.65
37_D41_M0.8280.65
218_I228_R0.8210.65
53_S189_K0.8200.64
113_L163_V0.8190.64
90_T118_R0.8130.64
175_I216_L0.8100.63
88_D91_G0.8070.63
137_P181_D0.8040.63
205_I211_Q0.7990.62
80_D84_R0.7990.62
102_T112_S0.7980.62
125_I230_F0.7970.62
77_P216_L0.7930.62
100_Y129_C0.7930.62
72_R131_N0.7900.62
217_N220_K0.7900.62
210_N227_I0.7890.61
138_F208_A0.7890.61
50_V76_S0.7880.61
162_S165_D0.7840.61
83_L87_H0.7840.61
33_E126_G0.7790.60
209_I226_Y0.7670.59
140_Q144_T0.7630.59
40_A44_G0.7610.59
181_D229_Q0.7600.59
32_Y140_Q0.7570.58
79_T159_F0.7570.58
32_Y117_I0.7510.58
38_G113_L0.7370.56
175_I194_V0.7370.56
115_I225_L0.7320.56
182_R187_N0.7320.56
101_F109_L0.7290.55
142_M153_V0.7270.55
111_K134_L0.7260.55
40_A66_N0.7250.55
35_V63_R0.7230.55
39_L43_I0.7180.54
84_R88_D0.7150.54
202_I205_I0.7100.53
171_L210_N0.7090.53
41_M149_E0.7050.53
210_N220_K0.7040.53
193_I197_L0.7020.53
185_S190_N0.7000.52
69_H191_R0.6980.52
80_D129_C0.6970.52
144_T147_P0.6960.52
32_Y125_I0.6950.52
138_F141_I0.6950.52
100_Y112_S0.6950.52
162_S218_I0.6920.52
32_Y35_V0.6910.51
168_T223_V0.6910.51
141_I146_V0.6890.51
102_T163_V0.6880.51
111_K132_M0.6880.51
109_L136_V0.6880.51
171_L211_Q0.6850.51
173_F200_K0.6820.51
180_A189_K0.6770.50
46_H165_D0.6760.50
74_I105_K0.6740.50
43_I104_A0.6700.49
104_A110_M0.6690.49
207_D225_L0.6680.49
81_L182_R0.6620.48
160_A166_L0.6600.48
205_I219_S0.6580.48
203_F212_V0.6570.48
142_M145_F0.6570.48
47_C189_K0.6520.47
194_V223_V0.6510.47
119_N204_D0.6460.47
209_I215_R0.6460.47
194_V218_I0.6410.46
127_L210_N0.6410.46
129_C157_V0.6350.46
35_V38_G0.6270.45
37_D75_G0.6270.45
161_S213_A0.6250.45
171_L215_R0.6240.45
30_K145_F0.6170.44
40_A65_A0.6170.44
194_V203_F0.6160.44
31_S34_A0.6150.44
44_G219_S0.6130.43
45_S136_V0.6130.43
79_T228_R0.6130.43
27_D120_R0.6130.43
121_E147_P0.6100.43
170_T174_T0.6080.43
29_L35_V0.6040.42
117_I126_G0.6040.42
120_R199_E0.5990.42
174_T227_I0.5970.42
36_V40_A0.5960.42
42_L80_D0.5960.42
112_S131_N0.5940.41
98_K115_I0.5940.41
160_A205_I0.5930.41
30_K177_E0.5910.41
43_I46_H0.5890.41
79_T100_Y0.5890.41
211_Q215_R0.5870.41
168_T211_Q0.5870.41
173_F196_N0.5850.41
57_L207_D0.5820.40
189_K219_S0.5800.40
125_I157_V0.5790.40
159_F228_R0.5780.40
195_L199_E0.5750.40
114_T190_N0.5740.39
75_G112_S0.5740.39
105_K130_I0.5730.39
127_L221_H0.5720.39
135_D190_N0.5720.39
60_S75_G0.5710.39
179_N217_N0.5670.39
219_S223_V0.5670.39
91_G116_A0.5660.39
26_F165_D0.5640.38
33_E63_R0.5630.38
73_K155_S0.5630.38
74_I150_T0.5620.38
110_M219_S0.5600.38
49_I140_Q0.5580.38
38_G70_T0.5570.38
81_L157_V0.5560.38
73_K108_V0.5550.38
102_T110_M0.5500.37
102_T115_I0.5500.37
34_A126_G0.5490.37
28_I125_I0.5470.37
33_E125_I0.5450.37
156_S188_A0.5450.37
62_I180_A0.5440.37
79_T82_A0.5440.37
46_H132_M0.5420.36
169_Q188_A0.5400.36
121_E214_D0.5400.36
162_S187_N0.5390.36
179_N192_Q0.5380.36
220_K229_Q0.5360.36
69_H109_L0.5360.36
60_S80_D0.5330.35
113_L116_A0.5290.35
172_E212_V0.5250.35
222_T226_Y0.5230.35
58_K205_I0.5220.34
86_L124_V0.5220.34
178_V181_D0.5220.34
194_V222_T0.5210.34
72_R79_T0.5210.34
38_G102_T0.5200.34
54_L217_N0.5190.34
177_E192_Q0.5190.34
86_L180_A0.5180.34
204_D228_R0.5170.34
142_M176_E0.5160.34
198_Y230_F0.5140.34
39_L42_L0.5120.34
115_I124_V0.5110.33
50_V80_D0.5070.33
154_G199_E0.5060.33
45_S148_P0.5050.33
52_H82_A0.5020.33
46_H160_A0.5010.32
44_G126_G0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x48A 1 0.225 97.2 0.901 Contact Map
2elhA 1 0.2958 96.8 0.905 Contact Map
1jkoC 1 0.1917 96.6 0.908 Contact Map
4l5eA 2 0.1917 96.5 0.909 Contact Map
2jn6A 1 0.2333 96.3 0.91 Contact Map
2gloA 1 0.2458 96.2 0.911 Contact Map
1umqA 1 0.25 96.2 0.912 Contact Map
2m8eA 1 0.2375 96.1 0.912 Contact Map
1tc3C 1 0.2125 95.8 0.915 Contact Map
4dyqA 5 0.2208 95.7 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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