GREMLIN Database
YHCO - Uncharacterized protein YhcO
UniProt: P64616 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12821
Length: 90 (86)
Sequences: 126 (75)
Seq/√Len: 8.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_V37_S3.4720.94
31_K37_S2.7720.83
47_L51_L2.7180.82
16_D24_T2.5050.76
8_F66_F2.4020.73
34_D66_F2.3710.72
37_S74_D2.1140.63
4_Y47_L2.0970.62
58_L70_I2.0610.61
4_Y32_V1.9090.55
55_F86_F1.7900.50
20_D23_Q1.7650.49
37_S44_N1.7130.46
13_S16_D1.7020.46
13_S44_N1.6480.44
80_L84_L1.6200.43
57_H63_R1.6180.43
75_E82_G1.5880.41
15_E66_F1.5690.41
20_D40_D1.4360.35
28_A81_E1.3850.34
31_K34_D1.3610.33
14_Q25_F1.3300.32
5_T63_R1.3070.31
65_R85_R1.2720.30
43_M80_L1.2680.29
4_Y14_Q1.2520.29
21_F70_I1.2450.29
28_A33_R1.2430.29
48_P51_L1.2290.28
20_D61_K1.2200.28
6_F21_F1.2030.27
6_F17_F1.1930.27
79_E86_F1.1520.26
12_E62_T1.1420.25
13_S26_G1.1290.25
35_L86_F1.1280.25
71_L78_E1.1180.25
31_K40_D1.0700.23
76_A80_L1.0620.23
25_F39_W1.0520.23
37_S47_L1.0490.22
20_D62_T1.0430.22
53_I81_E1.0230.22
60_E63_R1.0020.21
21_F73_F1.0010.21
32_V40_D0.9930.21
2_N43_M0.9670.20
63_R68_A0.9570.20
4_Y29_K0.9500.20
67_G70_I0.9270.19
15_E26_G0.8740.18
26_G51_L0.8680.18
48_P68_A0.8670.18
19_R48_P0.8660.18
34_D81_E0.8630.18
13_S75_E0.8590.17
71_L87_N0.8590.17
4_Y34_D0.8470.17
23_Q45_D0.8430.17
78_E82_G0.8350.17
65_R68_A0.8340.17
31_K47_L0.8330.17
82_G87_N0.8270.17
52_E72_L0.8240.17
77_E82_G0.8180.17
11_I86_F0.8050.16
51_L55_F0.7980.16
65_R71_L0.7950.16
21_F53_I0.7930.16
12_E29_K0.7920.16
31_K44_N0.7880.16
26_G44_N0.7670.15
16_D62_T0.7660.15
48_P86_F0.7650.15
4_Y31_K0.7550.15
39_W76_A0.7520.15
78_E84_L0.7470.15
4_Y37_S0.7390.15
49_L80_L0.7290.15
6_F76_A0.7240.14
11_I68_A0.7180.14
35_L84_L0.7010.14
9_D57_H0.6960.14
23_Q81_E0.6960.14
21_F25_F0.6900.14
54_E86_F0.6850.14
32_V47_L0.6830.14
9_D43_M0.6750.13
16_D66_F0.6650.13
72_L84_L0.6620.13
13_S19_R0.6620.13
47_L74_D0.6590.13
52_E87_N0.6480.13
24_T66_F0.6440.13
58_L67_G0.6360.13
20_D43_M0.6350.13
35_L80_L0.6200.12
12_E34_D0.6130.12
31_K43_M0.6110.12
15_E28_A0.6110.12
31_K83_H0.6020.12
1_M7_D0.5960.12
27_L51_L0.5890.12
33_R37_S0.5880.12
3_I10_E0.5840.12
31_K61_K0.5820.12
42_L71_L0.5720.12
42_L78_E0.5710.12
3_I58_L0.5700.12
1_M74_D0.5690.12
16_D61_K0.5660.12
52_E71_L0.5590.11
40_D44_N0.5540.11
55_F71_L0.5540.11
68_A72_L0.5520.11
19_R75_E0.5480.11
56_V69_L0.5420.11
20_D24_T0.5350.11
16_D59_G0.5350.11
68_A77_E0.5340.11
10_E45_D0.5240.11
5_T57_H0.5190.11
6_F79_E0.5180.11
12_E66_F0.5170.11
59_G66_F0.5160.11
34_D37_S0.5100.11
11_I70_I0.5100.11
72_L87_N0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cx6A 1 1 99.9 0.384 Contact Map
2za4B 1 0.9667 99.8 0.513 Contact Map
4ui9N 1 0.4333 39.9 0.916 Contact Map
3hbeX 1 0.3778 34.7 0.919 Contact Map
1wvvA 5 0.3889 28.1 0.922 Contact Map
2cjlA 1 0.3889 26.8 0.923 Contact Map
4mckA 1 0.3778 23.5 0.925 Contact Map
3wh1A 1 0.3889 19.5 0.928 Contact Map
2dkvA 1 0.4667 13.5 0.933 Contact Map
4pddA 1 0.4444 10.2 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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