GREMLIN Database
YHCN - Uncharacterized protein YhcN
UniProt: P64614 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12820
Length: 87 (74)
Sequences: 304 (146)
Seq/√Len: 17.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_L83_A3.5451.00
39_T71_T3.2020.99
48_S51_D2.6620.97
57_N61_E2.5520.96
32_Q85_L1.9440.85
21_F25_S1.8640.82
52_M79_W1.8340.81
41_S82_T1.8330.81
53_R58_K1.6280.73
42_V83_A1.5940.71
48_S67_A1.5780.70
26_I53_R1.5450.69
25_S57_N1.5110.67
39_T82_T1.4790.65
34_R67_A1.4750.65
44_G78_T1.4720.65
58_K62_E1.4500.64
62_E68_Y1.4280.62
24_D30_Q1.4260.62
47_S52_M1.4260.62
50_M85_L1.3860.60
25_S28_A1.3820.60
16_L85_L1.2930.55
24_D67_A1.2920.54
36_A44_G1.2890.54
37_I46_A1.2610.53
23_A57_N1.2550.52
69_Q84_E1.2480.52
24_D37_I1.2420.51
26_I55_M1.2100.50
45_V81_A1.2080.49
70_I77_D1.2030.49
42_V81_A1.2020.49
16_L21_F1.1790.48
27_D57_N1.1550.46
51_D62_E1.1490.46
42_V56_L1.1450.46
55_M79_W1.1440.46
36_A76_G1.1290.45
76_G87_K1.0940.43
60_A65_A1.0660.41
40_V61_E1.0610.41
18_F38_G0.9970.37
72_E80_H0.9800.36
62_E85_L0.9730.36
46_A58_K0.9670.35
35_E82_T0.9490.34
34_R44_G0.9090.32
26_I34_R0.9010.32
75_S79_W0.8760.31
44_G52_M0.8680.30
53_R68_Y0.8630.30
52_M64_G0.8560.30
33_N38_G0.8320.28
28_A36_A0.8280.28
33_N53_R0.8050.27
45_V86_Y0.7990.27
39_T84_E0.7860.26
21_F51_D0.7860.26
54_E58_K0.7690.26
63_K85_L0.7690.26
15_V74_R0.7640.25
41_S86_Y0.7640.25
79_W86_Y0.7620.25
46_A81_A0.7480.25
23_A72_E0.7200.23
31_A62_E0.7040.23
28_A68_Y0.6950.22
21_F87_K0.6940.22
25_S37_I0.6900.22
43_S78_T0.6840.22
34_R61_E0.6820.22
16_L63_K0.6750.21
17_S21_F0.6720.21
45_V78_T0.6710.21
49_P73_A0.6660.21
19_G41_S0.6620.21
49_P52_M0.6550.21
55_M75_S0.6380.20
29_A40_V0.6310.20
66_T71_T0.6290.20
66_T69_Q0.6270.20
26_I35_E0.6140.19
17_S70_I0.5970.19
36_A84_E0.5940.18
22_A61_E0.5920.18
43_S83_A0.5840.18
57_N70_I0.5820.18
17_S35_E0.5800.18
37_I81_A0.5790.18
32_Q66_T0.5770.18
35_E48_S0.5650.17
77_D82_T0.5600.17
19_G72_E0.5600.17
50_M87_K0.5600.17
29_A33_N0.5540.17
43_S62_E0.5520.17
44_G77_D0.5500.17
15_V31_A0.5480.17
54_E70_I0.5450.17
15_V18_F0.5450.17
15_V24_D0.5340.16
43_S56_L0.5290.16
23_A59_K0.5290.16
46_A62_E0.5260.16
55_M86_Y0.5250.16
59_K84_E0.5120.16
68_Y71_T0.5070.15
61_E78_T0.5070.15
15_V19_G0.5000.15
16_L46_A0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jnaA 2 0.9885 99.9 0.267 Contact Map
2nocA 1 0.977 99.9 0.268 Contact Map
2m2jA 1 0.7701 99.9 0.39 Contact Map
2ma4A 1 0.7356 99.8 0.411 Contact Map
4evuA 2 0.7586 99.8 0.428 Contact Map
3tdgA 2 0.6667 59.3 0.89 Contact Map
3layA 5 0.6782 39.7 0.902 Contact Map
1xr4A 2 0.977 35.6 0.904 Contact Map
3gk7A 2 0.8161 25.4 0.911 Contact Map
3qliA 2 0.8391 19.4 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0045 seconds.