GREMLIN Database
ZAPE - Cell division protein ZapE
UniProt: P64612 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12819
Length: 375 (354)
Sequences: 1927 (1213)
Seq/√Len: 64.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
179_D199_K9.7561.00
95_L139_V5.6411.00
131_D166_R4.6871.00
269_Q296_H4.6841.00
303_V333_V4.3771.00
34_I38_E4.1611.00
33_E37_Q3.6911.00
31_R203_D3.5631.00
115_E132_R3.5221.00
274_S302_D3.5141.00
280_V313_E3.4241.00
92_Y100_K3.3101.00
236_M299_M3.1971.00
305_V337_V3.0071.00
6_P36_Y2.9911.00
180_E183_R2.9551.00
291_L298_V2.9541.00
21_P26_K2.9381.00
196_D199_K2.9011.00
229_H232_T2.8911.00
11_L26_K2.7901.00
272_A301_F2.7171.00
274_S277_T2.5741.00
300_L331_L2.5131.00
134_K168_I2.5041.00
328_H370_R2.4571.00
320_L324_F2.3611.00
192_L196_D2.2881.00
276_T280_V2.2341.00
101_Q111_R2.1751.00
255_E260_P2.1651.00
236_M334_S2.1631.00
142_F172_A2.0931.00
115_E136_E2.0691.00
182_Y185_G2.0631.00
224_W333_V2.0561.00
124_D158_G2.0341.00
253_T260_P2.0091.00
233_R302_D1.9541.00
261_L291_L1.9531.00
111_R115_E1.9501.00
289_I323_E1.9481.00
176_I350_F1.9421.00
338_P341_E1.9291.00
55_R58_K1.9151.00
72_R203_D1.8861.00
7_T30_S1.8781.00
185_G188_R1.8741.00
42_S71_V1.8711.00
71_V169_T1.8691.00
146_F176_I1.8271.00
263_T273_V1.8161.00
279_C320_L1.7551.00
163_L168_I1.7371.00
292_S324_F1.7260.99
224_W335_A1.7170.99
160_M194_A1.7130.99
7_T11_L1.7110.99
9_Q13_A1.7020.99
170_L202_C1.6720.99
99_R138_D1.6490.99
277_T281_D1.6150.99
111_R136_E1.6130.99
225_L232_T1.5870.99
137_T140_L1.5850.99
315_R351_E1.5780.99
34_I203_D1.5720.99
28_A76_M1.5490.99
54_A57_G1.5430.99
101_Q136_E1.5230.99
339_L356_L1.5150.99
338_P363_Q1.5080.99
300_L320_L1.5030.99
266_V295_F1.5030.99
298_V324_F1.4860.98
147_V191_F1.4700.98
85_T326_E1.4700.98
235_Q239_L1.4690.98
112_V155_L1.4560.98
55_R60_W1.4510.98
88_M141_C1.4270.98
147_V156_L1.4140.98
364_S367_Y1.4140.98
237_D272_A1.4090.98
77_W177_P1.4000.98
113_H152_D1.3980.98
7_T33_E1.3970.98
116_L126_L1.3890.98
26_K30_S1.3860.97
261_L277_T1.3710.97
42_S138_D1.3670.97
265_G272_A1.3670.97
178_P204_V1.3590.97
118_A132_R1.3510.97
11_L15_N1.3400.97
7_T26_K1.3320.97
253_T262_A1.3250.97
182_Y188_R1.3240.97
335_A342_I1.3040.96
13_A86_W1.2890.96
237_D301_F1.2870.96
54_A58_K1.2800.96
297_T330_K1.2800.96
177_P180_E1.2730.96
337_V341_E1.2700.96
145_F172_A1.2640.96
101_Q140_L1.2640.96
264_M277_T1.2410.95
11_L21_P1.2390.95
304_P313_E1.2280.95
39_L169_T1.2270.95
236_M301_F1.2250.95
33_E36_Y1.2150.95
270_T296_H1.2080.94
252_P295_F1.1980.94
227_P232_T1.1910.94
88_M173_T1.1890.94
251_S262_A1.1640.93
54_A59_L1.1620.93
12_K16_E1.1590.93
85_T176_I1.1560.93
335_A339_L1.1490.93
269_Q297_T1.1470.93
290_A293_R1.1470.93
164_F202_C1.1440.93
36_Y94_S1.1430.93
27_E30_S1.1410.93
188_R192_L1.1400.93
31_R34_I1.1390.92
13_A19_H1.1330.92
243_L299_M1.1330.92
112_V129_I1.1320.92
237_D241_L1.1250.92
206_N210_G1.1240.92
321_V331_L1.1220.92
300_L333_V1.1080.91
263_T271_L1.1020.91
249_E265_G1.1000.91
224_W227_P1.0990.91
105_F142_F1.0920.91
85_T201_H1.0850.91
252_P263_T1.0840.90
307_T310_M1.0740.90
106_H197_A1.0730.90
35_I171_V1.0720.90
97_G100_K1.0670.90
31_R205_M1.0630.90
35_I169_T1.0520.89
326_E355_C1.0520.89
77_W206_N1.0520.89
9_Q94_S1.0490.89
232_T334_S1.0470.89
254_L295_F1.0440.89
219_T365_E1.0340.88
275_F313_E1.0310.88
185_G192_L1.0280.88
27_E31_R1.0280.88
285_Q319_A1.0280.88
101_Q115_E1.0240.88
176_I351_E1.0230.88
142_F170_L1.0230.88
161_K165_A1.0080.87
30_S33_E1.0050.87
9_Q93_Q0.9960.86
91_F141_C0.9940.86
97_G139_V0.9920.86
343_Y351_E0.9920.86
40_I96_P0.9900.86
103_L111_R0.9870.86
119_L129_I0.9850.86
228_L232_T0.9790.85
305_V344_Q0.9780.85
157_G160_M0.9690.85
229_H233_R0.9560.84
131_D162_A0.9550.84
110_L289_I0.9520.84
300_L303_V0.9440.83
211_V216_R0.9420.83
278_L300_L0.9350.83
32_L315_R0.9310.82
150_I154_M0.9280.82
315_R318_I0.9160.81
162_A166_R0.9160.81
198_I202_C0.9040.80
239_L299_M0.9030.80
92_Y142_F0.9000.80
110_L286_H0.8960.80
153_A182_Y0.8940.80
272_A326_E0.8930.80
246_G249_E0.8760.78
264_M271_L0.8750.78
124_D127_E0.8710.78
310_M313_E0.8690.78
97_G138_D0.8680.78
172_A202_C0.8660.78
13_A35_I0.8630.77
8_S11_L0.8610.77
127_E162_A0.8610.77
176_I318_I0.8580.77
28_A205_M0.8570.77
318_I352_F0.8540.77
23_D27_E0.8520.76
270_T299_M0.8490.76
365_E369_K0.8460.76
251_S266_V0.8460.76
13_A18_S0.8410.75
225_L235_Q0.8410.75
73_G172_A0.8380.75
228_L236_M0.8350.75
14_L21_P0.8350.75
293_R327_R0.8340.75
232_T236_M0.8310.75
244_A268_N0.8290.74
354_R357_S0.8260.74
116_L121_G0.8250.74
196_D200_Q0.8220.74
222_H235_Q0.8210.74
356_L360_Q0.8180.73
182_Y187_Q0.8120.73
146_F319_A0.8090.73
89_D102_R0.8080.72
354_R358_R0.8040.72
57_G61_G0.8040.72
161_K198_I0.8040.72
252_P266_V0.8030.72
306_M314_A0.8000.72
29_V87_L0.7970.71
77_W317_F0.7940.71
238_K242_A0.7920.71
19_H86_W0.7900.71
271_L278_L0.7890.71
236_M272_A0.7880.71
307_T346_D0.7870.70
35_I74_L0.7840.70
6_P94_S0.7840.70
37_Q40_I0.7750.69
308_R311_E0.7700.69
35_I71_V0.7680.69
155_L182_Y0.7600.68
117_T121_G0.7570.68
233_R264_M0.7570.68
128_I132_R0.7560.67
230_D234_A0.7550.67
353_Q356_L0.7550.67
176_I319_A0.7540.67
340_Y360_Q0.7520.67
116_L125_P0.7510.67
13_A90_L0.7470.66
225_L239_L0.7460.66
121_G126_L0.7420.66
197_A273_V0.7370.65
74_L205_M0.7370.65
41_N138_D0.7360.65
92_Y141_C0.7340.65
150_I164_F0.7340.65
55_R59_L0.7330.65
7_T29_V0.7320.65
308_R345_G0.7310.65
201_H323_E0.7300.65
292_S326_E0.7300.65
127_E166_R0.7280.64
277_T283_R0.7280.64
107_R323_E0.7270.64
263_T302_D0.7250.64
215_L360_Q0.7240.64
57_G60_W0.7240.64
186_L317_F0.7200.64
59_L62_K0.7190.64
273_V300_L0.7180.63
306_M310_M0.7140.63
80_V167_G0.7130.63
342_I352_F0.7110.63
237_D265_G0.7070.62
103_L142_F0.7060.62
304_P336_E0.7050.62
305_V336_E0.7040.62
266_V271_L0.7030.62
82_R351_E0.7030.62
31_R35_I0.7020.62
56_V59_L0.7010.62
222_H225_L0.7000.61
190_R197_A0.6980.61
282_A326_E0.6970.61
303_V342_I0.6960.61
233_R301_F0.6960.61
78_G81_G0.6920.61
307_T344_Q0.6920.61
88_M91_F0.6910.60
13_A93_Q0.6900.60
103_L107_R0.6900.60
308_R346_D0.6870.60
115_E156_L0.6870.60
75_Y152_D0.6850.60
243_L270_T0.6840.60
29_V33_E0.6800.59
311_E347_R0.6750.59
10_Y29_V0.6720.58
280_V310_M0.6700.58
36_Y95_L0.6700.58
215_L367_Y0.6690.58
301_F334_S0.6690.58
311_E346_D0.6690.58
119_L132_R0.6690.58
17_G21_P0.6670.58
92_Y98_E0.6660.58
151_T326_E0.6660.58
81_G84_K0.6650.58
343_Y355_C0.6640.57
146_F326_E0.6640.57
148_S351_E0.6620.57
110_L326_E0.6610.57
148_S185_G0.6600.57
238_K339_L0.6600.57
306_M346_D0.6590.57
327_R367_Y0.6590.57
343_Y362_M0.6590.57
101_Q137_T0.6580.57
30_S34_I0.6540.56
182_Y192_L0.6540.56
76_M210_G0.6530.56
35_I39_L0.6510.56
346_D349_K0.6500.56
133_F367_Y0.6490.56
42_S46_A0.6480.56
273_V278_L0.6470.55
299_M332_V0.6460.55
38_E203_D0.6460.55
240_W272_A0.6450.55
318_I355_C0.6450.55
188_R193_P0.6430.55
160_M289_I0.6410.55
321_V355_C0.6400.55
264_M274_S0.6390.55
263_T266_V0.6380.54
340_Y356_L0.6380.54
187_Q190_R0.6370.54
69_T169_T0.6350.54
36_Y40_I0.6340.54
82_R209_A0.6340.54
133_F136_E0.6320.54
77_W272_A0.6310.54
13_A16_E0.6300.53
124_D160_M0.6300.53
287_D352_F0.6290.53
332_V347_R0.6290.53
228_L231_E0.6280.53
235_Q238_K0.6280.53
270_T328_H0.6270.53
107_R329_V0.6270.53
112_V133_F0.6250.53
330_K368_L0.6250.53
118_A276_T0.6250.53
56_V61_G0.6240.53
296_H368_L0.6230.53
333_V359_L0.6220.53
298_V320_L0.6210.52
182_Y362_M0.6200.52
176_I323_E0.6200.52
242_A268_N0.6190.52
244_A270_T0.6190.52
233_R237_D0.6180.52
82_R343_Y0.6180.52
262_A277_T0.6170.52
254_L288_Y0.6150.52
228_L233_R0.6150.52
157_G343_Y0.6140.52
262_A281_D0.6140.52
15_N21_P0.6140.52
254_L271_L0.6130.52
346_D352_F0.6120.51
95_L141_C0.6110.51
57_G62_K0.6090.51
228_L334_S0.6090.51
323_E350_F0.6080.51
38_E72_R0.6070.51
298_V329_V0.6070.51
176_I180_E0.6060.51
28_A41_N0.6050.51
192_L195_I0.6040.50
303_V340_Y0.6040.50
315_R343_Y0.6020.50
319_A326_E0.6000.50
38_E41_N0.6000.50
234_A238_K0.5990.50
134_K138_D0.5940.49
318_I350_F0.5930.49
12_K15_N0.5910.49
111_R132_R0.5900.49
122_Q128_I0.5880.49
244_A248_R0.5860.48
254_L262_A0.5860.48
183_R289_I0.5850.48
19_H90_L0.5850.48
176_I202_C0.5840.48
91_F126_L0.5840.48
218_L364_S0.5830.48
251_S265_G0.5820.48
82_R150_I0.5800.48
314_A343_Y0.5790.48
225_L229_H0.5790.48
154_M195_I0.5780.47
39_L139_V0.5770.47
22_D25_Q0.5760.47
79_G206_N0.5760.47
160_M164_F0.5750.47
82_R176_I0.5750.47
318_I348_L0.5740.47
250_N254_L0.5740.47
70_P200_Q0.5740.47
253_T268_N0.5730.47
335_A363_Q0.5730.47
241_L249_E0.5720.47
329_V333_V0.5710.47
55_R62_K0.5700.47
42_S169_T0.5700.47
239_L332_V0.5700.47
85_T146_F0.5680.46
76_M207_V0.5680.46
93_Q266_V0.5670.46
148_S176_I0.5660.46
75_Y78_G0.5660.46
105_F172_A0.5660.46
157_G194_A0.5650.46
109_M362_M0.5650.46
323_E327_R0.5630.46
85_T356_L0.5630.46
211_V217_T0.5630.46
106_H319_A0.5590.45
288_Y336_E0.5590.45
117_T120_Q0.5590.45
257_N261_L0.5570.45
18_S23_D0.5570.45
8_S33_E0.5560.45
110_L355_C0.5550.45
56_V62_K0.5550.45
226_S338_P0.5540.45
119_L122_Q0.5510.44
194_A197_A0.5500.44
164_F320_L0.5490.44
114_E118_A0.5490.44
230_D233_R0.5470.44
263_T295_F0.5460.44
343_Y352_F0.5450.44
95_L100_K0.5450.44
276_T304_P0.5440.44
152_D188_R0.5440.44
8_S72_R0.5440.44
91_F125_P0.5440.44
250_N266_V0.5440.44
78_G84_K0.5430.43
78_G83_G0.5430.43
155_L160_M0.5430.43
352_F355_C0.5420.43
206_N303_V0.5400.43
27_E205_M0.5390.43
281_D288_Y0.5390.43
113_H185_G0.5390.43
85_T156_L0.5380.43
20_Q211_V0.5370.43
150_I182_Y0.5350.42
239_L242_A0.5350.42
312_S323_E0.5340.42
301_F355_C0.5340.42
88_M160_M0.5320.42
194_A284_S0.5310.42
15_N26_K0.5310.42
112_V182_Y0.5290.42
6_P11_L0.5280.42
154_M186_L0.5280.42
133_F163_L0.5280.42
26_K37_Q0.5270.42
28_A343_Y0.5260.41
12_K37_Q0.5260.41
145_F318_I0.5250.41
43_T46_A0.5230.41
113_H182_Y0.5230.41
99_R137_T0.5230.41
344_Q349_K0.5230.41
247_K267_E0.5220.41
264_M301_F0.5220.41
115_E285_Q0.5220.41
13_A286_H0.5210.41
130_A352_F0.5210.41
130_A162_A0.5210.41
82_R316_R0.5200.41
172_A290_A0.5200.41
95_L318_I0.5200.41
155_L255_E0.5190.41
281_D285_Q0.5190.41
162_A184_N0.5190.41
76_M87_L0.5180.41
154_M185_G0.5180.41
154_M191_F0.5180.41
21_P30_S0.5170.40
169_T251_S0.5160.40
325_Y361_E0.5160.40
194_A283_R0.5150.40
237_D250_N0.5150.40
321_V356_L0.5140.40
9_Q12_K0.5140.40
160_M355_C0.5140.40
244_A265_G0.5140.40
94_S100_K0.5120.40
11_L30_S0.5110.40
319_A355_C0.5110.40
91_F95_L0.5100.40
186_L190_R0.5090.40
15_N18_S0.5080.39
219_T242_A0.5080.39
17_G20_Q0.5080.39
42_S45_P0.5070.39
117_T286_H0.5070.39
14_L17_G0.5060.39
41_N268_N0.5060.39
217_T366_E0.5060.39
141_C173_T0.5060.39
138_D355_C0.5050.39
184_N317_F0.5040.39
112_V185_G0.5040.39
295_F345_G0.5040.39
34_I37_Q0.5030.39
146_F351_E0.5030.39
58_K62_K0.5020.39
113_H147_V0.5020.39
19_H29_V0.5010.39
182_Y193_P0.5010.39
14_L29_V0.5000.39
305_V341_E0.5000.39
256_I312_S0.5000.39
142_F207_V0.5000.39
85_T351_E0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w58A 2 0.48 99.7 0.87 Contact Map
4m4wJ 3 0.5173 99.7 0.873 Contact Map
2qgzA 1 0.44 99.6 0.88 Contact Map
3ec2A 1 0.4507 99.6 0.881 Contact Map
3bosA 2 0.568 99.2 0.904 Contact Map
1u0jA 1 0.5467 99.1 0.906 Contact Map
1tueA 1 0.512 98.9 0.915 Contact Map
1lv7A 2 0.5947 98.9 0.915 Contact Map
2qz4A 1 0.5787 98.8 0.917 Contact Map
4qosA 1 0.56 98.8 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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