GREMLIN Database
YRBL - Uncharacterized protein YrbL
UniProt: P64610 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12807
Length: 210 (183)
Sequences: 159 (138)
Seq/√Len: 10.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_I77_G7.1521.00
2_I29_I3.4750.97
85_D91_S3.2460.96
42_E153_N3.0690.94
28_C82_V3.0340.94
129_M153_N2.8700.91
66_Y78_Y2.2660.78
117_L124_N2.2370.77
66_Y170_C2.2330.77
24_D27_R2.1760.75
136_I148_P2.1310.73
3_R172_R2.1280.73
18_C28_C2.0720.71
14_R134_Q2.0700.71
67_H81_D2.0280.69
72_T75_G2.0160.69
131_L136_I1.9330.65
21_H75_G1.9260.65
129_M132_K1.9130.64
120_Y124_N1.8630.62
91_S139_H1.8050.60
15_H42_E1.7960.59
64_P176_R1.7260.56
139_H147_I1.7230.56
64_P173_K1.7160.56
53_L103_Y1.7130.56
138_C148_P1.7130.56
83_I109_Q1.7040.55
42_E129_M1.6960.55
125_R170_C1.6860.54
117_L173_K1.6600.53
15_H153_N1.6440.52
18_C114_L1.6300.52
130_S153_N1.6170.51
20_A82_V1.6040.51
43_I78_Y1.5730.49
18_C154_I1.5680.49
42_E49_Y1.5510.48
94_L98_A1.5310.47
150_V153_N1.4720.44
126_I181_F1.4340.43
64_P133_P1.3940.41
41_K87_D1.3930.41
4_L16_R1.3660.40
75_G88_G1.3640.40
117_L136_I1.3330.38
71_E76_T1.3230.38
109_Q180_R1.3130.37
70_V140_R1.3000.37
21_H74_C1.2910.36
34_H62_G1.2900.36
19_Y31_I1.2830.36
42_E132_K1.2820.36
148_P174_Q1.2820.36
4_L75_G1.2770.36
31_I166_S1.2660.35
46_E85_D1.2280.34
44_R137_L1.2210.33
38_G117_L1.2190.33
16_R152_D1.2180.33
28_C128_T1.2150.33
10_L102_R1.2080.33
19_Y81_D1.2040.33
55_R174_Q1.2030.33
28_C170_C1.1980.32
30_K152_D1.1960.32
123_D167_K1.1810.32
44_R113_L1.1780.32
28_C66_Y1.1710.31
41_K172_R1.1690.31
20_A45_R1.1670.31
21_H73_D1.1660.31
16_R135_N1.1650.31
101_C112_Q1.1480.30
135_N148_P1.1460.30
83_I88_G1.1450.30
56_R171_L1.1440.30
22_P68_G1.1420.30
69_T78_Y1.1360.30
122_Q162_L1.1160.29
113_L138_C1.0980.29
13_G46_E1.0940.28
10_L178_W1.0930.28
18_C176_R1.0810.28
78_Y130_S1.0810.28
29_I79_V1.0800.28
41_K160_I1.0650.27
83_I126_I1.0640.27
129_M154_I1.0550.27
14_R153_N1.0530.27
173_K176_R1.0400.26
128_T153_N1.0350.26
4_L21_H1.0280.26
127_V174_Q1.0200.26
10_L18_C1.0060.25
80_Y170_C1.0020.25
38_G149_V1.0010.25
91_S140_R0.9960.25
64_P91_S0.9950.25
165_W169_C0.9940.25
90_P115_K0.9740.24
91_S124_N0.9660.24
62_G120_Y0.9640.24
45_R76_T0.9600.24
21_H50_Y0.9540.23
115_K137_L0.9530.23
43_I170_C0.9510.23
126_I141_I0.9410.23
161_P165_W0.9410.23
26_Q145_E0.9390.23
18_C82_V0.9380.23
82_V151_C0.9330.23
31_I115_K0.9260.23
45_R161_P0.9120.22
42_E150_V0.9120.22
87_D171_L0.9080.22
120_Y136_I0.9020.22
60_W110_L0.9020.22
11_G44_R0.9010.22
5_S167_K0.8980.22
20_A151_C0.8950.22
86_F148_P0.8830.21
31_I104_E0.8810.21
2_I179_K0.8790.21
156_E177_L0.8780.21
114_L134_Q0.8700.21
36_G171_L0.8630.21
18_C137_L0.8600.20
156_E161_P0.8570.20
128_T157_S0.8460.20
97_F118_K0.8460.20
54_G172_R0.8280.20
78_Y128_T0.8270.19
94_L128_T0.8200.19
12_T112_Q0.8180.19
6_E116_Q0.8170.19
110_L176_R0.8150.19
19_Y51_A0.8130.19
137_L153_N0.8120.19
30_K72_T0.8100.19
13_G22_P0.8070.19
83_I91_S0.8040.19
26_Q99_E0.8020.19
15_H49_Y0.7990.19
114_L177_L0.7930.19
57_L186_A0.7920.18
9_P73_D0.7920.18
31_I167_K0.7920.18
11_G148_P0.7910.18
18_C90_P0.7870.18
99_E114_L0.7860.18
154_I183_A0.7860.18
11_G154_I0.7770.18
27_R67_H0.7760.18
45_R129_M0.7750.18
6_E160_I0.7690.18
21_H27_R0.7660.18
136_I167_K0.7640.18
117_L120_Y0.7610.18
91_S120_Y0.7560.17
10_L138_C0.7540.17
27_R79_V0.7530.17
48_K131_L0.7480.17
28_C174_Q0.7260.17
11_G91_S0.7250.17
56_R151_C0.7230.17
49_Y52_H0.7190.17
28_C91_S0.7180.17
11_G15_H0.7160.16
77_G152_D0.7160.16
23_E162_L0.7150.16
63_I136_I0.7050.16
58_K89_K0.7000.16
149_V180_R0.6960.16
97_F181_F0.6930.16
176_R184_Q0.6860.16
78_Y132_K0.6860.16
18_C97_F0.6830.16
52_H137_L0.6800.16
67_H154_I0.6790.16
19_Y79_V0.6770.15
70_V84_A0.6720.15
24_D87_D0.6650.15
28_C80_Y0.6640.15
43_I154_I0.6580.15
9_P14_R0.6540.15
45_R66_Y0.6500.15
38_G142_S0.6490.15
2_I87_D0.6410.15
99_E159_L0.6390.15
8_S26_Q0.6390.15
43_I82_V0.6360.15
169_C173_K0.6220.14
108_A123_D0.6220.14
89_K123_D0.6200.14
31_I59_D0.6150.14
182_I185_P0.6140.14
110_L138_C0.6130.14
141_I147_I0.6080.14
29_I125_R0.6070.14
101_C144_S0.6050.14
98_A122_Q0.6030.14
60_W181_F0.6000.14
16_R158_T0.5970.14
117_L121_L0.5920.14
92_I97_F0.5860.13
60_W63_I0.5860.13
19_Y22_P0.5840.13
33_Y149_V0.5830.13
22_P46_E0.5830.13
24_D73_D0.5820.13
126_I138_C0.5790.13
52_H178_W0.5780.13
81_D131_L0.5780.13
30_K135_N0.5770.13
159_L162_L0.5770.13
3_R73_D0.5760.13
14_R128_T0.5750.13
116_Q182_I0.5730.13
11_G16_R0.5690.13
35_R99_E0.5690.13
19_Y63_I0.5690.13
29_I130_S0.5690.13
36_G63_I0.5650.13
138_C146_V0.5640.13
132_K153_N0.5620.13
159_L170_C0.5600.13
10_L42_E0.5560.13
28_C133_P0.5560.13
126_I179_K0.5560.13
88_G186_A0.5550.13
25_A183_A0.5520.13
13_G21_H0.5480.13
171_L184_Q0.5480.13
13_G135_N0.5450.13
69_T90_P0.5440.13
29_I75_G0.5440.13
49_Y66_Y0.5440.13
129_M173_K0.5430.12
31_I74_C0.5430.12
97_F122_Q0.5400.12
111_R175_E0.5380.12
98_A127_V0.5360.12
16_R64_P0.5360.12
93_T167_K0.5350.12
94_L131_L0.5330.12
57_L108_A0.5310.12
71_E136_I0.5310.12
13_G30_K0.5300.12
72_T152_D0.5290.12
34_H153_N0.5280.12
19_Y86_F0.5250.12
53_L136_I0.5240.12
139_H170_C0.5240.12
125_R172_R0.5230.12
68_G150_V0.5210.12
58_K181_F0.5190.12
45_R160_I0.5180.12
61_S96_E0.5180.12
123_D175_E0.5170.12
8_S19_Y0.5150.12
19_Y122_Q0.5130.12
121_L184_Q0.5110.12
165_W178_W0.5110.12
85_D114_L0.5100.12
42_E176_R0.5100.12
12_T84_A0.5070.12
23_E183_A0.5060.12
131_L181_F0.5020.12
27_R103_Y0.5010.12
4_L72_T0.5010.12
146_V179_K0.5010.12
132_K154_I0.5010.12
13_G16_R0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ci6B 1 0.8048 98 0.871 Contact Map
4bvuA 1 0.7905 98 0.871 Contact Map
2x4fA 1 0.8857 98 0.871 Contact Map
1zarA 1 0.8048 97.9 0.873 Contact Map
2qkwB 1 0.881 97.9 0.875 Contact Map
1zthA 1 0.8524 97.9 0.875 Contact Map
4u6rA 1 0.8905 97.9 0.875 Contact Map
4ix3A 2 0.9095 97.8 0.876 Contact Map
2w4oA 1 0.7476 97.8 0.876 Contact Map
3utoA 1 0.8952 97.8 0.876 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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