GREMLIN Database
MLAE - Probable phospholipid ABC transporter permease protein MlaE
UniProt: P64606 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12800
Length: 260 (245)
Sequences: 3560 (2050)
Seq/√Len: 131.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
212_T249_L7.6631.00
216_I245_A4.7651.00
48_L154_S4.3671.00
44_L149_W3.9191.00
224_A234_A3.6001.00
151_G214_T3.0911.00
60_V161_I2.9911.00
63_G162_F2.9881.00
44_L153_I2.6361.00
98_E205_K2.6191.00
95_L166_G2.5991.00
30_A148_F2.5341.00
98_E250_D2.3931.00
49_Y54_L2.3281.00
120_I143_V2.2831.00
148_F211_I2.2771.00
64_V169_G2.1841.00
51_V116_L2.1681.00
50_N54_L2.1551.00
60_V165_V2.1101.00
208_V249_L2.0941.00
106_L243_S2.0861.00
152_V211_I2.0081.00
124_R129_L2.0021.00
171_S182_S1.9891.00
205_K250_D1.9761.00
26_M140_L1.9251.00
220_N237_R1.9021.00
212_T216_I1.8751.00
220_N241_H1.8651.00
208_V253_L1.8551.00
113_G217_S1.8191.00
117_T238_T1.8121.00
22_R223_D1.7281.00
171_S186_W1.7231.00
167_I189_M1.6831.00
100_G163_V1.6731.00
159_T163_V1.6511.00
17_L21_G1.6301.00
25_L29_N1.6171.00
44_L48_L1.6131.00
152_V210_A1.6111.00
56_M161_I1.5921.00
43_L46_R1.5821.00
70_L94_S1.5811.00
140_L144_I1.5741.00
170_G185_F1.5731.00
209_F250_D1.5621.00
48_L153_I1.5551.00
160_V203_L1.5361.00
159_T202_C1.5241.00
139_P222_Y1.4421.00
96_L167_I1.4151.00
124_R222_Y1.3951.00
125_A231_I1.3901.00
171_S175_V1.3841.00
47_Q147_R1.3751.00
194_D197_M1.3721.00
79_T84_E1.3661.00
23_A219_F1.3591.00
227_T231_I1.3551.00
55_S112_A1.3531.00
26_M219_F1.3521.00
152_V207_V1.3491.00
229_A233_R1.3391.00
138_D141_R1.3321.00
159_T206_S1.3241.00
200_V204_I1.3231.00
47_Q50_N1.3131.00
23_A27_L1.3041.00
155_L210_A1.3021.00
128_Q243_S1.2931.00
92_A193_V1.2891.00
20_F24_G1.2771.00
204_I257_M1.2721.00
30_A144_I1.2711.00
27_L215_W1.2681.00
19_T26_M1.2421.00
108_F155_L1.2361.00
155_L159_T1.2321.00
74_G90_L1.2311.00
26_M144_I1.2281.00
91_V170_G1.2181.00
29_N32_V1.2141.00
59_I162_F1.2131.00
129_L143_V1.2090.99
104_A162_F1.2060.99
61_V244_L1.1900.99
39_K44_L1.1900.99
137_V142_R1.1680.99
133_E139_P1.1670.99
19_T219_F1.1550.99
217_S242_S1.1490.99
116_L218_L1.1430.99
199_L203_L1.1380.99
163_V202_C1.1260.99
112_A115_A1.1250.99
124_R223_D1.1220.99
52_G55_S1.1210.99
175_V182_S1.1030.99
19_T22_R1.1020.99
16_T20_F1.0960.99
248_G252_V1.0950.99
98_E209_F1.0930.99
201_N257_M1.0900.99
121_G224_A1.0870.99
124_R133_E1.0840.99
108_F213_V1.0700.99
30_A140_L1.0690.99
32_V36_E1.0560.99
33_G141_R1.0550.99
197_M204_I1.0460.99
105_A246_V1.0430.99
132_M142_R1.0420.98
219_F223_D1.0350.98
30_A145_S1.0300.98
220_N223_D1.0280.98
65_F102_V1.0210.98
122_L231_I1.0210.98
26_M34_K1.0200.98
87_L174_G1.0190.98
224_A230_G1.0190.98
110_G240_V1.0140.98
207_V211_I1.0050.98
89_M188_A1.0050.98
38_R141_R1.0000.98
71_G91_V0.9910.98
211_I215_W0.9860.98
92_A189_M0.9830.98
24_G28_F0.9820.98
29_N140_L0.9820.98
253_L257_M0.9780.98
111_R235_T0.9720.98
185_F189_M0.9660.98
172_L176_S0.9530.97
30_A215_W0.9470.97
122_L228_S0.9470.97
122_L125_A0.9440.97
109_A242_S0.9370.97
239_V250_D0.9320.97
89_M192_A0.9240.97
12_K15_K0.9240.97
212_T245_A0.9220.97
66_I103_V0.9190.97
14_I18_R0.9160.97
49_Y53_V0.9020.96
27_L31_L0.8990.96
132_M135_M0.8880.96
128_Q137_V0.8830.96
164_A252_V0.8710.95
21_G24_G0.8670.95
187_S191_N0.8580.95
228_S231_I0.8570.95
41_A45_V0.8570.95
46_R229_A0.8500.95
12_K16_T0.8440.95
109_A246_V0.8420.95
96_L202_C0.8400.94
114_S239_V0.8330.94
217_S238_T0.8260.94
21_G25_L0.8230.94
53_V56_M0.8210.94
252_V256_L0.8170.94
88_G188_A0.8150.94
33_G138_D0.8130.93
120_I147_R0.8100.93
109_A254_T0.8060.93
213_V246_V0.8060.93
205_K209_F0.8040.93
216_I241_H0.8020.93
19_T220_N0.8020.93
119_E147_R0.8020.93
47_Q119_E0.8000.93
21_G26_M0.8000.93
25_L28_F0.7970.93
97_R198_D0.7970.93
29_N138_D0.7960.93
19_T32_V0.7950.93
18_R22_R0.7930.93
189_M193_V0.7930.93
121_G226_P0.7880.92
233_R237_R0.7840.92
183_G187_S0.7830.92
13_G16_T0.7830.92
96_L163_V0.7800.92
157_L160_V0.7790.92
73_Q254_T0.7780.92
106_L247_L0.7750.92
16_T19_T0.7740.92
195_W200_V0.7740.92
119_E123_M0.7740.92
213_V242_S0.7710.92
31_L35_P0.7630.91
19_T29_N0.7610.91
75_Y178_K0.7600.91
74_G78_L0.7580.91
62_S128_Q0.7560.91
22_R219_F0.7540.91
51_V150_A0.7530.91
78_L90_L0.7500.90
147_R232_S0.7450.90
26_M29_N0.7420.90
238_T244_L0.7390.90
69_V209_F0.7340.89
14_I17_L0.7330.89
33_G145_S0.7320.89
93_L97_R0.7310.89
186_W190_Q0.7270.89
23_A215_W0.7250.89
81_Y84_E0.7170.88
125_A227_T0.7160.88
34_K145_S0.7090.88
41_A44_L0.7080.88
22_R26_M0.7070.88
95_L100_G0.7020.87
166_G170_G0.7010.87
198_D231_I0.7000.87
134_M232_S0.6950.87
160_V207_V0.6930.87
104_A155_L0.6850.86
34_K37_F0.6850.86
69_V251_F0.6850.86
73_Q107_L0.6820.86
100_G166_G0.6810.86
117_T220_N0.6810.86
133_E136_A0.6800.86
17_L31_L0.6790.85
227_T230_G0.6740.85
143_V232_S0.6730.85
104_A110_G0.6720.85
14_I149_W0.6710.85
126_T136_A0.6700.85
87_L101_P0.6700.85
66_I114_S0.6700.85
105_A250_D0.6670.84
50_N119_E0.6650.84
204_I208_V0.6640.84
83_A93_L0.6640.84
118_A232_S0.6620.84
110_G236_T0.6620.84
136_A139_P0.6610.84
96_L193_V0.6570.84
71_G185_F0.6570.84
243_S247_L0.6550.83
106_L109_A0.6510.83
73_Q179_G0.6510.83
111_R115_A0.6510.83
97_R193_V0.6500.83
27_L211_I0.6500.83
204_I253_L0.6470.83
13_G204_I0.6450.82
181_D184_F0.6440.82
13_G17_L0.6430.82
155_L213_V0.6430.82
20_F153_I0.6400.82
68_M218_L0.6340.81
148_F215_W0.6330.81
61_V245_A0.6330.81
51_V154_S0.6320.81
93_L193_V0.6310.81
129_L222_Y0.6290.81
58_I123_M0.6280.81
116_L217_S0.6260.81
56_M165_V0.6260.81
236_T240_V0.6240.80
86_S89_M0.6190.80
108_F112_A0.6180.80
105_A209_F0.6160.79
144_I222_Y0.6150.79
227_T232_S0.6140.79
47_Q116_L0.6130.79
119_E126_T0.6060.78
173_V177_W0.6050.78
117_T217_S0.6050.78
66_I99_L0.6040.78
64_V165_V0.6020.78
131_S231_I0.6020.78
71_G174_G0.6000.78
223_D234_A0.5990.78
109_A217_S0.5930.77
121_G217_S0.5930.77
15_K19_T0.5890.76
25_L32_V0.5870.76
128_Q251_F0.5850.76
162_F232_S0.5820.76
20_F23_A0.5810.75
24_G164_A0.5810.75
56_M100_G0.5790.75
107_L243_S0.5780.75
132_M210_A0.5770.75
72_L255_A0.5770.75
114_S202_C0.5760.75
33_G36_E0.5760.75
57_L61_V0.5750.75
78_L87_L0.5740.75
58_I75_Y0.5730.74
39_K149_W0.5730.74
26_M30_A0.5720.74
132_M228_S0.5700.74
87_L180_I0.5690.74
245_A249_L0.5680.74
225_I230_G0.5670.74
122_L232_S0.5640.73
144_I218_L0.5640.73
109_A232_S0.5630.73
19_T28_F0.5630.73
75_Y106_L0.5630.73
94_S110_G0.5600.73
208_V212_T0.5590.73
29_N33_G0.5580.72
71_G173_V0.5570.72
143_V218_L0.5480.71
104_A159_T0.5470.71
207_V210_A0.5470.71
91_V185_F0.5460.71
171_S176_S0.5460.71
123_M235_T0.5440.71
22_R152_V0.5440.71
63_G100_G0.5430.70
43_L119_E0.5410.70
174_G180_I0.5400.70
44_L74_G0.5380.70
176_S179_G0.5370.70
224_A227_T0.5360.69
12_K31_L0.5350.69
101_P139_P0.5340.69
165_V180_I0.5330.69
51_V151_G0.5330.69
115_A236_T0.5310.69
37_F145_S0.5290.68
251_F255_A0.5290.68
72_L94_S0.5270.68
69_V73_Q0.5260.68
32_V203_L0.5250.68
48_L52_G0.5250.68
250_D254_T0.5240.68
83_A94_S0.5220.67
160_V164_A0.5210.67
55_S90_L0.5200.67
62_S247_L0.5160.67
181_D191_N0.5150.66
19_T34_K0.5150.66
17_L20_F0.5140.66
102_V128_Q0.5140.66
65_F99_L0.5130.66
42_P45_V0.5120.66
124_R237_R0.5120.66
12_K17_L0.5110.66
58_I107_L0.5110.66
47_Q51_V0.5110.66
94_S99_L0.5110.66
12_K208_V0.5100.66
68_M102_V0.5090.66
230_G234_A0.5090.66
234_A237_R0.5080.65
55_S107_L0.5070.65
21_G34_K0.5070.65
237_R241_H0.5070.65
156_P236_T0.5060.65
154_S162_F0.5050.65
88_G237_R0.5050.65
111_R123_M0.5040.65
125_A224_A0.5040.65
128_Q247_L0.5040.65
166_G169_G0.5030.65
14_I153_I0.5010.64
126_T228_S0.5010.64
38_R41_A0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mgyA 1 0.3885 14.6 0.96 Contact Map
2zy9A 2 0.5269 10.2 0.963 Contact Map
1rh5C 1 0.1231 4.3 0.969 Contact Map
3wu2T 1 0.0962 3.5 0.97 Contact Map
4wv4B 1 0.2192 1.8 0.974 Contact Map
2ls2A 1 0.0962 1.8 0.975 Contact Map
4uc1A 3 0.3577 1.3 0.976 Contact Map
4f35D 2 0.4385 1.3 0.977 Contact Map
2kncB 1 0.1308 1.3 0.977 Contact Map
2q2kA 3 0.1154 1.3 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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