GREMLIN Database
MLAD - Probable phospholipid ABC transporter-binding protein MlaD
UniProt: P64604 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12799
Length: 183 (151)
Sequences: 6248 (4771)
Seq/√Len: 388.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_A84_L4.7781.00
43_Y81_R3.9001.00
45_T81_R3.8491.00
97_S114_L3.3311.00
69_A85_E3.2461.00
43_Y83_T2.7181.00
70_D83_T2.6721.00
41_T83_T2.6171.00
74_D81_R2.5181.00
72_T83_T2.3031.00
42_L84_L2.2551.00
57_P64_V2.2251.00
45_T79_L2.2031.00
99_L114_L2.1161.00
129_K132_D2.0981.00
72_T81_R1.9861.00
39_T85_E1.9641.00
43_Y133_T1.9331.00
45_T133_T1.9301.00
150_F154_S1.9281.00
100_S115_N1.8221.00
41_T85_E1.7401.00
64_V67_R1.7321.00
84_L112_L1.7251.00
41_T69_A1.7101.00
52_L82_V1.6951.00
52_L56_S1.6941.00
96_T117_G1.6691.00
91_N127_I1.6591.00
54_A70_D1.6581.00
59_S111_Y1.6221.00
69_A83_T1.5511.00
102_R113_A1.5141.00
60_I65_V1.4491.00
56_S68_V1.4301.00
13_F24_V1.4291.00
151_L155_K1.4191.00
46_F82_V1.4171.00
156_G161_N1.3751.00
74_D79_L1.3491.00
41_T130_D1.3431.00
142_V145_D1.3061.00
28_A31_V1.2851.00
95_D126_A1.2661.00
98_S115_N1.2621.00
38_P88_Q1.2521.00
71_I82_V1.2381.00
158_D161_N1.2231.00
59_S64_V1.2091.00
23_F27_K1.2001.00
54_A71_I1.1881.00
46_F137_T1.1861.00
96_T118_F1.1861.00
8_I12_I1.1651.00
46_F101_I1.1601.00
25_C29_A1.1491.00
98_S138_K1.1471.00
56_S109_E1.1451.00
45_T74_D1.1351.00
161_N164_D1.0921.00
162_S165_A1.0871.00
65_V86_I1.0691.00
44_A112_L1.0681.00
22_L26_L1.0651.00
13_F17_A1.0631.00
93_I97_S1.0561.00
145_D149_Q1.0411.00
76_K79_L1.0221.00
99_L112_L1.0171.00
47_D79_L0.9931.00
55_R67_R0.9931.00
65_V114_L0.9821.00
160_K163_G0.9711.00
128_L132_D0.9651.00
29_A32_T0.9581.00
105_G109_E0.9571.00
42_L86_I0.9541.00
157_D161_N0.9541.00
67_R85_E0.9431.00
14_L17_A0.9411.00
150_F153_G0.9311.00
60_I93_I0.9291.00
6_N9_W0.9291.00
40_Y130_D0.9281.00
27_K31_V0.9221.00
28_A32_T0.9031.00
104_S109_E0.9021.00
57_P104_S0.9011.00
26_L29_A0.8841.00
32_T35_R0.8811.00
22_L25_C0.8801.00
90_Y93_I0.8721.00
49_I52_L0.8671.00
9_W12_I0.8631.00
39_T88_Q0.8611.00
49_I71_I0.8511.00
144_E148_G0.8451.00
94_P116_V0.8441.00
42_L130_D0.8391.00
149_Q153_G0.8351.00
21_A24_V0.8341.00
95_D132_D0.8331.00
153_G157_D0.8281.00
22_L29_A0.8271.00
25_C28_A0.8241.00
86_I90_Y0.8181.00
47_D139_S0.8131.00
24_V29_A0.8111.00
96_T121_P0.7911.00
94_P97_S0.7901.00
143_L146_L0.7831.00
40_Y88_Q0.7801.00
61_G80_P0.7791.00
50_G110_Q0.7711.00
95_D119_E0.7661.00
149_Q154_S0.7651.00
27_K30_N0.7631.00
159_N163_G0.7541.00
160_K164_D0.7541.00
14_L21_A0.7521.00
156_G160_K0.7451.00
148_G152_Y0.7411.00
104_S111_Y0.7381.00
49_I80_P0.7291.00
104_S147_I0.7271.00
7_E10_V0.7261.00
75_P79_L0.7261.00
149_Q155_K0.7231.00
44_A99_L0.7171.00
14_L18_L0.7121.00
51_G105_G0.7101.00
7_E11_G0.7061.00
65_V93_I0.7021.00
60_I116_V0.7001.00
154_S157_D0.6971.00
39_T87_E0.6930.99
120_D126_A0.6920.99
146_L149_Q0.6750.99
68_V112_L0.6750.99
49_I101_I0.6720.99
97_S116_V0.6710.99
13_F29_A0.6700.99
46_F49_I0.6690.99
24_V30_N0.6670.99
100_S138_K0.6630.99
87_E90_Y0.6590.99
127_I132_D0.6550.99
127_I131_G0.6490.99
94_P117_G0.6490.99
50_G59_S0.6480.99
101_I112_L0.6470.99
56_S110_Q0.6470.99
21_A25_C0.6450.99
47_D137_T0.6450.99
105_G111_Y0.6420.99
17_A107_L0.6410.99
17_A28_A0.6400.99
88_Q91_N0.6350.99
16_A23_F0.6260.99
98_S117_G0.6230.99
144_E147_I0.6230.99
101_I139_S0.6220.99
43_Y72_T0.6200.99
51_G62_G0.6200.99
145_D148_G0.6140.99
24_V32_T0.6120.99
17_A25_C0.6110.99
142_V148_G0.6110.99
96_T120_D0.6100.99
153_G156_G0.6100.99
73_L80_P0.6090.99
56_S103_T0.6090.99
141_M146_L0.6010.99
102_R111_Y0.6000.99
65_V90_Y0.5990.99
61_G101_I0.5970.98
12_I15_L0.5880.98
26_L32_T0.5880.98
101_I110_Q0.5840.98
54_A57_P0.5810.98
131_G134_I0.5810.98
160_K165_A0.5800.98
24_V27_K0.5760.98
152_Y155_K0.5710.98
10_V21_A0.5650.98
27_K32_T0.5650.98
161_N165_A0.5650.98
24_V28_A0.5640.98
157_D160_K0.5640.98
20_A23_F0.5620.98
13_F28_A0.5590.98
59_S113_A0.5590.98
7_E21_A0.5580.98
44_A97_S0.5540.98
104_S107_L0.5530.98
19_L22_L0.5520.97
141_M144_E0.5500.97
143_L147_I0.5470.97
134_I137_T0.5460.97
23_F26_L0.5460.97
108_G111_Y0.5440.97
45_T135_Q0.5440.97
128_L134_I0.5420.97
69_A84_L0.5400.97
40_Y86_I0.5390.97
156_G162_S0.5380.97
61_G117_G0.5360.97
97_S128_L0.5320.97
12_I16_A0.5260.97
26_L30_N0.5240.97
63_V106_L0.5240.97
29_A35_R0.5230.97
86_I93_I0.5190.96
40_Y90_Y0.5170.96
25_C31_V0.5130.96
86_I99_L0.5080.96
142_V151_L0.5060.96
71_I118_F0.5060.96
40_Y89_R0.5060.96
15_L18_L0.5050.96
100_S113_A0.5050.96
7_E107_L0.5040.96
141_M149_Q0.5040.96
101_I106_L0.5030.96
71_I80_P0.5010.96
20_A24_V0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mc7A 1 0.1639 10 0.934 Contact Map
4tkoB 1 0.5082 6.8 0.939 Contact Map
3s8fC 1 0.1694 6.5 0.939 Contact Map
2lk9A 1 0.1257 5.1 0.942 Contact Map
4n4rB 1 0.6885 4.3 0.944 Contact Map
3girA 1 0.6557 3.8 0.946 Contact Map
4b4aA 1 0.2514 3.7 0.946 Contact Map
3w5aC 1 0.1694 3.5 0.946 Contact Map
1wsrA 2 0.6284 3.5 0.947 Contact Map
1yx2A 1 0.623 3.4 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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