GREMLIN Database
MLAB - Probable phospholipid ABC transporter-binding protein MlaB
UniProt: P64602 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12797
Length: 97 (94)
Sequences: 134 (95)
Seq/√Len: 9.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_R53_G2.4690.82
77_V82_Y2.4460.81
83_T95_L2.3500.79
28_L57_L2.2850.77
5_L32_R2.2660.76
31_M35_A2.1040.70
49_R89_N2.0440.68
28_L61_L2.0310.67
50_V81_V2.0170.67
9_Q39_I1.9690.65
91_P94_V1.9070.62
74_L85_A1.8780.61
52_T91_P1.8140.58
24_V47_V1.7750.56
80_K83_T1.6670.52
26_L30_E1.6460.51
61_L95_L1.5580.47
11_G83_T1.5470.46
53_G78_N1.5300.45
47_V55_L1.5240.45
12_D15_A1.5240.45
86_K91_P1.5170.45
60_H90_L1.4780.43
9_Q23_D1.4740.43
81_V85_A1.4640.42
57_L90_L1.4540.42
60_H89_N1.4310.41
13_T21_D1.4310.41
3_E71_N1.4140.40
42_I77_V1.4130.40
49_R58_L1.4060.40
49_R90_L1.3640.38
77_V94_V1.3640.38
1_M5_L1.3560.38
8_M68_Q1.3510.38
72_V95_L1.3220.36
9_Q89_N1.2940.35
40_T70_N1.2820.35
22_Q35_A1.2400.33
3_E34_E1.1250.29
81_V94_V1.1220.28
44_L94_V1.0930.27
23_D27_P1.0850.27
12_D67_K1.0830.27
72_V83_T1.0820.27
74_L83_T1.0700.27
59_L62_I1.0190.25
53_G62_I1.0130.25
15_A79_D1.0040.24
4_S42_I1.0030.24
28_L69_G0.9950.24
11_G95_L0.9910.24
16_L69_G0.9910.24
3_E79_D0.9910.24
2_S73_T0.9780.23
36_V61_L0.9630.23
65_A72_V0.9530.23
41_C79_D0.9470.22
43_D68_Q0.9310.22
13_T17_S0.9270.22
42_I62_I0.9080.21
39_I74_L0.8800.20
70_N77_V0.8790.20
19_E49_R0.8750.20
8_M91_P0.8740.20
53_G89_N0.8650.20
58_L89_N0.8530.20
48_S74_L0.8510.20
4_S12_D0.8300.19
31_M57_L0.8160.19
46_R78_N0.7910.18
32_R43_D0.7880.18
53_G70_N0.7880.18
52_T85_A0.7800.18
15_A39_I0.7800.18
74_L95_L0.7770.18
53_G79_D0.7670.17
45_S78_N0.7660.17
21_D27_P0.7650.17
67_K70_N0.7550.17
50_V58_L0.7530.17
61_L75_Q0.7510.17
22_Q52_T0.7360.16
25_L55_L0.7320.16
28_L91_P0.7300.16
35_A43_D0.7250.16
22_Q44_L0.7230.16
78_N82_Y0.7140.16
62_I91_P0.7130.16
57_L69_G0.6950.15
72_V86_K0.6940.15
44_L91_P0.6910.15
6_S17_S0.6870.15
24_V81_V0.6830.15
3_E30_E0.6820.15
49_R60_H0.6770.15
9_Q78_N0.6750.15
19_E53_G0.6740.15
49_R62_I0.6700.15
28_L90_L0.6650.15
19_E66_K0.6610.15
22_Q47_V0.6600.15
19_E92_A0.6590.15
23_D48_S0.6520.14
43_D79_D0.6520.14
32_R89_N0.6510.14
66_K82_Y0.6500.14
13_T73_T0.6490.14
66_K71_N0.6350.14
36_V64_L0.6330.14
33_E69_G0.6310.14
6_S19_E0.6280.14
2_S45_S0.6240.14
5_L79_D0.6200.14
11_G45_S0.6150.14
38_G46_R0.6150.14
39_I65_A0.6040.13
46_R80_K0.6020.13
27_P38_G0.5940.13
57_L60_H0.5900.13
77_V92_A0.5770.13
2_S17_S0.5690.13
63_D85_A0.5680.13
4_S17_S0.5640.13
35_A70_N0.5610.13
17_S73_T0.5500.12
22_Q43_D0.5440.12
38_G68_Q0.5320.12
55_L70_N0.5250.12
43_D73_T0.5240.12
1_M68_Q0.5200.12
27_P64_L0.5190.12
9_Q35_A0.5170.12
86_K95_L0.5140.12
83_T92_A0.5140.12
77_V95_L0.5120.12
58_L79_D0.5110.12
46_R61_L0.5110.12
66_K92_A0.5080.12
26_L74_L0.5040.11
39_I95_L0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1th8B 1 0.9794 98.8 0.736 Contact Map
1sboA 1 0.9897 98.7 0.742 Contact Map
4hylA 2 0.9794 98.6 0.752 Contact Map
4qtpA 2 0.9794 98.6 0.755 Contact Map
4xs5A 1 0.9691 98.5 0.755 Contact Map
1h4xA 1 0.9897 98.5 0.758 Contact Map
3t6oA 5 0.9794 98.5 0.76 Contact Map
3zxnA 1 0.9691 98.5 0.761 Contact Map
2klnA 1 0.9897 98.4 0.763 Contact Map
2ka5A 1 0.9897 98.4 0.764 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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