GREMLIN Database
YHBT - Uncharacterized protein YhbT
UniProt: P64599 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12789
Length: 174 (144)
Sequences: 309 (192)
Seq/√Len: 16.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_P129_K3.4710.99
90_F97_L3.3840.99
56_R60_I3.0340.98
63_R93_D2.9640.98
72_S79_V2.6790.96
36_V75_N2.4730.94
103_R133_D2.4290.94
48_G51_E2.2800.91
58_L96_D2.2550.91
40_Q140_M2.1920.90
29_K69_W2.1810.90
40_Q132_M2.1310.88
93_D96_D2.0530.86
63_R91_S1.9890.85
103_R115_R1.9340.83
45_L73_V1.9300.83
20_P143_A1.9180.82
119_E134_A1.8230.79
30_R34_E1.7790.77
96_D115_R1.7760.77
114_R122_T1.7350.75
136_E148_L1.7350.75
102_A152_A1.6760.73
92_A134_A1.6450.71
113_Q127_Y1.5880.68
132_M154_F1.5830.68
57_W88_V1.5480.66
97_L100_I1.5340.66
92_A135_I1.5140.64
69_W99_M1.4640.62
56_R87_D1.3960.58
14_P50_L1.3790.57
81_S84_A1.3490.55
45_L137_L1.3480.55
45_L103_R1.3210.54
99_M104_K1.3110.53
61_H68_Q1.3110.53
49_E96_D1.3080.53
41_F78_L1.2910.52
24_T48_G1.2890.52
121_D131_L1.2880.52
53_L128_V1.2840.52
62_V151_L1.2660.51
50_L94_A1.2530.50
111_F114_R1.2520.50
115_R133_D1.2450.49
88_V113_Q1.2430.49
45_L78_L1.2360.49
55_G77_K1.2150.48
14_P145_R1.2110.47
50_L73_V1.1980.47
80_V145_R1.1790.46
143_A150_Q1.1780.45
96_D99_M1.1770.45
107_P123_E1.1760.45
111_F130_N1.1690.45
29_K49_E1.1660.45
17_L65_I1.1630.45
55_G85_Q1.1620.45
85_Q93_D1.1530.44
24_T27_A1.1480.44
99_M105_Q1.1170.42
53_L129_K1.1170.42
111_F122_T1.1160.42
58_L78_L1.0960.41
38_S97_L1.0720.39
35_Q93_D1.0660.39
20_P23_L1.0500.38
99_M152_A1.0460.38
34_E92_A1.0420.38
52_F60_I1.0300.37
95_S115_R1.0200.37
15_S63_R1.0190.37
40_Q47_D1.0140.36
90_F95_S0.9970.35
52_F113_Q0.9880.35
45_L66_D0.9880.35
94_A98_L0.9880.35
114_R130_N0.9840.35
22_K32_V0.9640.34
60_I94_A0.9610.33
80_V95_S0.9600.33
17_L23_L0.9530.33
36_V109_T0.9520.33
36_V43_Q0.9510.33
60_I104_K0.9490.33
59_S89_S0.9430.33
46_D155_V0.9420.33
107_P131_L0.9400.32
58_L71_T0.9380.32
60_I98_L0.9340.32
57_W118_I0.9230.32
138_E145_R0.9220.32
33_L109_T0.9180.31
61_H89_S0.9170.31
76_G79_V0.9100.31
55_G76_G0.9100.31
43_Q59_S0.9090.31
83_N117_V0.9050.31
44_A47_D0.9030.31
20_P105_Q0.9000.30
69_W138_E0.8760.29
24_T39_W0.8720.29
41_F47_D0.8510.28
39_W134_A0.8470.28
57_W101_A0.8430.28
22_K66_D0.8290.27
111_F125_G0.8250.27
119_E151_L0.8250.27
51_E135_I0.8250.27
122_T130_N0.8230.27
68_Q91_S0.8170.27
16_L22_K0.8160.26
52_F97_L0.8080.26
63_R83_N0.8080.26
28_L78_L0.8020.26
18_S75_N0.7990.26
69_W95_S0.7970.26
107_P130_N0.7900.25
52_F127_Y0.7870.25
24_T150_Q0.7730.25
77_K115_R0.7710.24
107_P136_E0.7530.24
44_A101_A0.7510.24
67_L94_A0.7490.24
42_R132_M0.7430.23
75_N136_E0.7410.23
77_K84_A0.7400.23
33_L147_M0.7390.23
49_E131_L0.7390.23
106_D112_F0.7270.23
108_D120_G0.7270.23
108_D112_F0.7270.23
106_D120_G0.7270.23
112_F120_G0.7270.23
28_L46_D0.7260.23
36_V143_A0.7180.22
38_S100_I0.7170.22
71_T150_Q0.7150.22
144_L147_M0.7050.22
24_T154_F0.6930.21
90_F113_Q0.6870.21
95_S118_I0.6810.21
15_S117_V0.6810.21
48_G101_A0.6780.21
47_D118_I0.6720.20
22_K137_L0.6700.20
16_L20_P0.6660.20
71_T79_V0.6650.20
59_S86_A0.6630.20
119_E136_E0.6620.20
114_R125_G0.6530.20
80_V100_I0.6520.20
133_D147_M0.6520.20
92_A155_V0.6490.20
56_R121_D0.6420.19
21_V152_A0.6410.19
52_F78_L0.6400.19
134_A151_L0.6380.19
12_L15_S0.6370.19
12_L147_M0.6310.19
80_V152_A0.6310.19
50_L127_Y0.6280.19
66_D105_Q0.6270.19
35_Q40_Q0.6260.19
107_P116_L0.6250.19
63_R137_L0.6240.19
88_V107_P0.6230.19
60_I100_I0.6210.19
95_S104_K0.6190.19
33_L80_V0.6190.19
37_L155_V0.6120.18
95_S99_M0.6090.18
25_P108_D0.6080.18
25_P120_G0.6080.18
25_P112_F0.6080.18
25_P106_D0.6080.18
42_R153_D0.6070.18
16_L85_Q0.6050.18
13_G100_I0.6020.18
19_V74_V0.5980.18
35_Q132_M0.5950.18
32_V81_S0.5900.18
29_K136_E0.5860.17
88_V119_E0.5860.17
41_F133_D0.5790.17
18_S150_Q0.5770.17
75_N93_D0.5730.17
102_A134_A0.5700.17
14_P97_L0.5690.17
107_P121_D0.5570.16
119_E126_L0.5530.16
68_Q77_K0.5530.16
35_Q87_D0.5440.16
20_P102_A0.5410.16
146_M150_Q0.5410.16
125_G130_N0.5340.16
26_F36_V0.5310.16
54_E79_V0.5310.16
66_D146_M0.5300.16
88_V148_L0.5300.16
56_R79_V0.5290.16
27_A71_T0.5280.16
30_R93_D0.5280.16
67_L98_L0.5240.15
43_Q86_A0.5150.15
97_L154_F0.5150.15
37_L44_A0.5120.15
38_S153_D0.5120.15
122_T125_G0.5110.15
18_S146_M0.5110.15
146_M153_D0.5080.15
29_K70_F0.5040.15
116_L126_L0.5030.15
19_V22_K0.5010.15
45_L72_S0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jgxA 2 0.6782 99.3 0.774 Contact Map
1iktA 1 0.6264 99.2 0.783 Contact Map
2qztA 2 0.6264 99.1 0.788 Contact Map
1pz4A 1 0.6322 99.1 0.792 Contact Map
3cnuA 2 0.6092 98.9 0.805 Contact Map
1c44A 1 0.6724 98.9 0.805 Contact Map
4nurA 2 0.7989 98.7 0.817 Contact Map
3bkrA 1 0.6092 98.7 0.818 Contact Map
2yheA 3 0.7989 98.7 0.819 Contact Map
4pdxA 2 0.7931 98.6 0.824 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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