GREMLIN Database
YRAP - Uncharacterized protein YraP
UniProt: P64596 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12781
Length: 191 (181)
Sequences: 1145 (804)
Seq/√Len: 59.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_T151_T6.0001.00
54_V98_A4.5101.00
51_E74_A3.3931.00
73_T82_V2.9731.00
127_W131_K2.6761.00
95_K109_N2.5661.00
42_G46_D2.5241.00
50_L79_V2.3631.00
128_I151_T2.3181.00
171_A185_T2.2791.00
147_V170_A2.2461.00
98_A101_V2.2111.00
85_S111_I2.1521.00
137_L144_S2.1151.00
81_L94_A2.0391.00
79_V104_A2.0141.00
147_V162_V2.0061.00
171_A175_S1.9931.00
164_E168_K1.9581.00
162_V187_F1.9541.00
93_R96_Q1.9471.00
50_L74_A1.9141.00
185_T189_F1.9031.00
81_L98_A1.8411.00
69_R117_I1.8201.00
167_A189_F1.8141.00
132_V174_A1.7820.99
135_Q177_V1.7360.99
61_D93_R1.7140.99
139_S173_I1.7130.99
167_A187_F1.6280.99
26_G29_A1.6060.99
167_A171_A1.6020.99
48_G51_E1.5940.99
139_S169_A1.5800.99
112_R157_F1.5680.99
95_K99_M1.5270.98
22_A25_V1.5000.98
78_K106_E1.4750.98
142_V169_A1.4600.98
69_R122_A1.4500.98
88_A92_A1.4320.97
54_V101_V1.4300.97
73_T148_K1.4110.97
50_L104_A1.4080.97
18_G21_A1.4080.97
91_S95_K1.3760.97
37_D44_Q1.3750.97
149_V158_L1.3670.97
70_I94_A1.3310.96
129_T133_R1.3060.96
75_Y159_M1.2980.95
167_A185_T1.2920.95
117_I122_A1.2840.95
155_E184_T1.2740.95
130_T134_S1.2700.95
164_E189_F1.2690.95
34_A41_V1.2660.95
142_V170_A1.2640.95
40_S46_D1.2580.94
112_R155_E1.2540.94
11_I14_L1.2370.94
142_V147_V1.2320.94
20_V25_V1.2280.94
39_R75_Y1.2260.94
80_L157_F1.2250.94
88_A91_S1.2230.94
80_L159_M1.2130.93
104_A107_V1.1860.93
127_W130_T1.1380.91
121_E124_N1.1360.91
172_D175_S1.1310.91
29_A32_T1.1280.91
132_V156_V1.1240.90
12_S15_L1.1140.90
133_R149_V1.1050.90
132_V177_V1.1010.89
84_Q153_N1.0970.89
141_L169_A1.0960.89
154_G181_K1.0920.89
135_Q173_I1.0900.89
98_A107_V1.0780.88
94_A111_I1.0760.88
157_F184_T1.0740.88
54_V79_V1.0740.88
131_K179_G1.0650.88
174_A183_V1.0560.87
7_I12_S1.0390.87
38_P166_E1.0340.86
48_G74_A1.0320.86
87_N113_Q1.0260.86
180_V183_V1.0250.86
27_T30_V1.0170.85
58_L94_A1.0110.85
77_G103_G1.0070.85
158_L174_A1.0040.85
131_K135_Q1.0040.85
69_R84_Q1.0030.85
127_W134_S1.0020.84
168_K185_T0.9980.84
87_N90_L0.9750.83
69_R152_E0.9680.82
70_I81_L0.9660.82
46_D49_T0.9630.82
27_T35_A0.9530.81
8_A13_A0.9370.80
161_L188_T0.9140.79
147_V187_F0.9120.78
55_N72_V0.9110.78
128_I154_G0.9070.78
172_D176_R0.9060.78
85_S113_Q0.9050.78
162_V167_A0.8950.77
42_G101_V0.8890.77
68_A85_S0.8870.76
86_P90_L0.8830.76
77_G105_N0.8710.75
32_T35_A0.8710.75
55_N59_S0.8610.74
71_N152_E0.8570.74
57_A97_I0.8570.74
81_L111_I0.8490.73
8_A14_L0.8430.73
50_L103_G0.8420.73
10_L13_A0.8400.72
85_S94_A0.8340.72
151_T156_V0.8130.70
76_Q161_L0.8130.70
31_G34_A0.8130.70
71_N82_V0.8110.70
43_T76_Q0.8070.69
11_I15_L0.8050.69
25_V29_A0.8010.69
9_V13_A0.8000.69
83_G160_G0.7900.68
155_E182_R0.7860.67
135_Q176_R0.7760.66
53_R101_V0.7700.66
156_V180_V0.7690.66
46_D103_G0.7680.66
136_L142_V0.7640.65
131_K178_S0.7590.65
7_I10_L0.7540.64
17_Q20_V0.7530.64
34_A44_Q0.7480.63
7_I13_A0.7460.63
124_N154_G0.7450.63
49_T53_R0.7420.63
10_L14_L0.7410.63
95_K113_Q0.7400.63
92_A96_Q0.7370.62
72_V98_A0.7350.62
81_L95_K0.7270.61
78_K108_Y0.7250.61
91_S111_I0.7250.61
156_V183_V0.7100.59
136_L170_A0.7030.59
57_A100_G0.7020.59
158_L170_A0.7010.58
115_Q118_G0.6980.58
147_V158_L0.6980.58
92_A165_R0.6980.58
77_G177_V0.6950.58
42_G49_T0.6920.58
67_E90_L0.6850.57
10_L15_L0.6830.57
124_N131_K0.6800.56
57_A60_K0.6790.56
31_G35_A0.6790.56
133_R144_S0.6760.56
13_A113_Q0.6760.56
171_A183_V0.6760.56
56_S133_R0.6750.56
99_M106_E0.6730.55
84_Q121_E0.6720.55
15_L20_V0.6710.55
54_V72_V0.6650.55
28_A32_T0.6620.54
144_S169_A0.6620.54
73_T150_T0.6610.54
84_Q152_E0.6600.54
159_M184_T0.6600.54
13_A120_G0.6570.54
134_S168_K0.6510.53
64_I68_A0.6510.53
25_V32_T0.6480.53
21_A25_V0.6470.53
56_S59_S0.6450.52
60_K79_V0.6430.52
121_E154_G0.6400.52
128_I131_K0.6380.52
129_T148_K0.6370.51
123_S134_S0.6350.51
125_D151_T0.6340.51
21_A24_V0.6320.51
54_V111_I0.6300.51
42_G166_E0.6300.51
42_G53_R0.6200.49
34_A114_G0.6180.49
30_V33_K0.6160.49
128_I156_V0.6130.49
159_M186_A0.6120.49
90_L93_R0.6120.49
171_A187_F0.6120.49
94_A97_I0.6120.49
84_Q117_I0.6100.48
170_A183_V0.6090.48
113_Q116_P0.6060.48
9_V12_S0.6030.48
134_S138_T0.6020.47
37_D183_V0.6020.47
64_I90_L0.5960.47
129_T156_V0.5930.46
96_Q99_M0.5880.46
126_T130_T0.5880.46
87_N119_L0.5880.46
117_I153_N0.5870.46
84_Q112_R0.5850.46
157_F186_A0.5840.45
9_V25_V0.5830.45
175_S182_R0.5820.45
167_A177_V0.5780.45
39_R42_G0.5750.44
20_V77_G0.5730.44
95_K107_V0.5660.43
27_T31_G0.5660.43
61_D64_I0.5640.43
75_Y84_Q0.5630.43
108_Y186_A0.5630.43
170_A180_V0.5630.43
17_Q22_A0.5610.43
32_T37_D0.5610.43
149_V183_V0.5590.43
107_V169_A0.5570.42
93_R97_I0.5530.42
7_I14_L0.5510.42
18_G22_A0.5490.42
51_E55_N0.5450.41
80_L186_A0.5440.41
113_Q157_F0.5410.41
66_K107_V0.5400.41
54_V81_L0.5400.41
139_S146_N0.5360.40
110_E184_T0.5360.40
19_C184_T0.5350.40
13_A168_K0.5320.40
26_G32_T0.5310.40
126_T151_T0.5280.39
169_A173_I0.5280.39
10_L17_Q0.5260.39
30_V77_G0.5220.39
20_V27_T0.5220.39
14_L165_R0.5210.39
25_V28_A0.5200.38
85_S91_S0.5180.38
31_G37_D0.5180.38
78_K99_M0.5180.38
13_A16_L0.5170.38
20_V28_A0.5160.38
76_Q177_V0.5150.38
59_S97_I0.5130.38
8_A15_L0.5120.38
148_K152_E0.5120.38
11_I107_V0.5110.38
132_V149_V0.5080.37
9_V15_L0.5050.37
74_A79_V0.5050.37
15_L171_A0.5040.37
113_Q184_T0.5020.37
78_K107_V0.5010.36
78_K105_N0.5010.36
110_E158_L0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4alzA 1 0.6545 99.9 0.573 Contact Map
2kgsA 1 0.6387 99.8 0.584 Contact Map
2l26A 1 0.6283 98.3 0.809 Contact Map
4qq0A 1 0.9005 96.3 0.866 Contact Map
2qgmA 1 0.733 73.9 0.915 Contact Map
4uu4A 1 0.712 50.5 0.927 Contact Map
3tlkA 1 0.7644 40.2 0.931 Contact Map
3zbiC 1 0.1466 34.6 0.933 Contact Map
3b55A 1 0.6597 25 0.938 Contact Map
4n01A 1 0.7696 22 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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