GREMLIN Database
YHAV - Toxin YhaV
UniProt: P64594 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12761
Length: 154 (144)
Sequences: 183 (117)
Seq/√Len: 9.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_D39_N5.9431.00
12_L108_L3.1070.94
56_I121_G2.9620.92
119_T122_K2.8200.90
44_A48_L2.8080.89
81_K84_S2.5820.85
92_R119_T2.3990.80
28_E45_A2.3640.79
48_L89_G2.3110.77
21_T51_V2.2620.76
142_D145_T2.1420.72
44_A89_G2.1400.71
120_Y126_A2.0940.70
32_L128_T2.0060.66
59_H66_S2.0030.66
100_S117_L1.9530.64
65_S69_F1.7890.57
89_G92_R1.7660.56
93_Y117_L1.7660.56
91_G119_T1.7440.55
92_R126_A1.7370.55
145_T149_E1.7360.55
43_K119_T1.7340.55
52_V92_R1.7090.53
73_K81_K1.6640.51
55_V89_G1.6560.51
27_A128_T1.6440.50
32_L43_K1.5940.48
65_S84_S1.5780.47
52_V89_G1.5770.47
104_K131_S1.5630.47
29_V40_Y1.4930.44
30_E104_K1.4620.42
17_C29_V1.4600.42
8_N58_E1.4370.41
142_D147_T1.4190.40
48_L93_Y1.3960.39
72_G76_G1.3870.39
66_S107_I1.3690.38
118_R127_Y1.3680.38
43_K92_R1.3480.37
57_E84_S1.3440.37
24_A93_Y1.3320.37
56_I117_L1.3310.37
16_P35_K1.3300.37
56_I69_F1.3270.36
88_F91_G1.2900.35
14_A23_D1.2890.35
43_K46_T1.2730.34
52_V144_E1.2660.34
118_R140_P1.2600.34
80_N131_S1.2380.33
21_T98_R1.2240.32
74_S112_N1.1950.31
19_Q80_N1.1920.31
8_N13_Y1.1800.31
43_K120_Y1.1660.30
116_T128_T1.1290.29
31_T42_R1.1140.28
28_E79_K1.1030.28
27_A148_R1.0830.27
71_H122_K1.0670.26
32_L40_Y1.0390.25
52_V111_M1.0370.25
89_G100_S1.0320.25
7_V17_C1.0270.25
40_Y143_W0.9950.24
7_V13_Y0.9850.24
44_A92_R0.9820.24
6_R135_K0.9630.23
48_L55_V0.9610.23
20_E150_T0.9590.23
19_Q23_D0.9500.22
66_S128_T0.9490.22
48_L92_R0.9390.22
92_R121_G0.9380.22
14_A19_Q0.9300.22
20_E41_Q0.9300.22
138_H149_E0.9280.22
33_K81_K0.9190.22
62_V69_F0.9130.21
117_L132_K0.9020.21
51_V60_I0.9010.21
7_V12_L0.8980.21
28_E93_Y0.8930.21
79_K115_N0.8890.21
57_E99_Y0.8870.21
72_G134_L0.8820.20
70_R139_P0.8790.20
56_I132_K0.8780.20
80_N135_K0.8750.20
107_I135_K0.8740.20
83_W109_G0.8480.19
14_A20_E0.8440.19
76_G86_V0.8430.19
34_G149_E0.8430.19
44_A93_Y0.8330.19
57_E65_S0.8280.19
55_V100_S0.8240.19
56_I108_L0.8220.19
46_T124_T0.8160.19
52_V60_I0.8100.18
88_F120_Y0.8080.18
12_L102_K0.8070.18
38_E151_E0.8060.18
18_F56_I0.8020.18
51_V82_D0.8010.18
55_V103_E0.7980.18
76_G134_L0.7970.18
43_K126_A0.7910.18
39_N67_P0.7900.18
22_Y116_T0.7900.18
83_W112_N0.7800.18
18_F52_V0.7790.18
112_N116_T0.7740.17
99_Y132_K0.7720.17
59_H114_E0.7650.17
125_D130_F0.7650.17
44_A119_T0.7570.17
62_V142_D0.7540.17
83_W134_L0.7530.17
96_F110_W0.7460.17
28_E52_V0.7460.17
72_G112_N0.7430.17
72_G83_W0.7430.17
11_A105_V0.7390.17
54_K107_I0.7380.16
17_C51_V0.7360.16
74_S134_L0.7340.16
74_S122_K0.7330.16
59_H68_A0.7320.16
55_V63_N0.7310.16
52_V55_V0.7290.16
101_E121_G0.7290.16
57_E69_F0.7270.16
122_K141_A0.7240.16
28_E32_L0.7200.16
22_Y31_T0.7120.16
80_N99_Y0.7100.16
42_R128_T0.7020.16
67_P147_T0.6990.16
80_N102_K0.6780.15
68_A151_E0.6770.15
69_F114_E0.6710.15
91_G126_A0.6710.15
98_R140_P0.6650.15
59_H102_K0.6600.15
33_K41_Q0.6600.15
59_H128_T0.6590.15
29_V93_Y0.6590.15
51_V84_S0.6490.14
7_V67_P0.6490.14
17_C21_T0.6480.14
44_A55_V0.6460.14
22_Y107_I0.6340.14
49_L107_I0.6280.14
137_G140_P0.6280.14
56_I123_K0.6210.14
107_I148_R0.6100.14
143_W146_L0.6100.14
26_V144_E0.6090.14
67_P80_N0.6040.13
9_G133_M0.6000.13
86_V139_P0.6000.13
58_E135_K0.5960.13
46_T49_L0.5950.13
49_L88_F0.5930.13
10_W21_T0.5910.13
21_T111_M0.5870.13
38_E67_P0.5860.13
33_K144_E0.5850.13
102_K132_K0.5830.13
72_G133_M0.5800.13
88_F111_M0.5740.13
126_A139_P0.5720.13
17_C23_D0.5710.13
50_A88_F0.5700.13
22_Y66_S0.5670.13
39_N104_K0.5660.13
27_A151_E0.5650.13
20_E105_V0.5640.13
14_A51_V0.5610.13
112_N134_L0.5600.13
66_S69_F0.5600.13
89_G93_Y0.5580.12
43_K48_L0.5580.12
48_L100_S0.5570.12
91_G111_M0.5530.12
12_L126_A0.5480.12
6_R53_H0.5470.12
123_K131_S0.5460.12
19_Q111_M0.5380.12
89_G117_L0.5380.12
27_A102_K0.5370.12
20_E36_D0.5360.12
88_F126_A0.5330.12
12_L26_V0.5290.12
73_K79_K0.5250.12
44_A100_S0.5230.12
38_E73_K0.5220.12
128_T147_T0.5210.12
15_H82_D0.5210.12
38_E136_R0.5180.12
14_A30_E0.5150.12
37_P141_A0.5140.12
32_L75_L0.5140.12
136_R148_R0.5090.12
58_E102_K0.5080.12
28_E62_V0.5070.12
127_Y130_F0.5070.12
42_R108_L0.5060.11
41_Q105_V0.5060.11
48_L119_T0.5040.11
52_V91_G0.5020.11
10_W16_P0.5020.11
139_P143_W0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3g5oB 1 0.526 94.7 0.919 Contact Map
4ml2A 1 0.5779 94.4 0.92 Contact Map
2kheA 1 0.5779 93.8 0.922 Contact Map
4lttA 1 0.5909 93.6 0.922 Contact Map
4fxiA 2 0.6039 91.3 0.928 Contact Map
4nrnA 2 0.5844 90.7 0.929 Contact Map
3bpqB 1 0.5519 90.6 0.929 Contact Map
1wmiA 2 0.5649 90.5 0.929 Contact Map
2a6sA 1 0.5455 74.9 0.941 Contact Map
3oeiC 2 0.5519 59.6 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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