GREMLIN Database
YHAI - Inner membrane protein YhaI
UniProt: P64592 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12748
Length: 118 (110)
Sequences: 1610 (1401)
Seq/√Len: 133.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_N13_G4.0681.00
6_S10_N2.6381.00
12_V61_L2.5691.00
93_V97_F2.4651.00
21_K25_M2.3851.00
55_Y59_T2.3481.00
75_D103_T2.2611.00
92_L96_V2.0601.00
68_I81_A2.0461.00
18_A22_E2.0271.00
30_N55_Y2.0081.00
19_R101_E1.9941.00
4_Y8_L1.8811.00
7_V26_F1.7961.00
67_A98_F1.7931.00
87_P90_G1.7741.00
72_H78_G1.7661.00
14_F65_A1.7601.00
75_D108_R1.6851.00
4_Y30_N1.6841.00
79_A82_L1.6741.00
107_N110_G1.6711.00
5_L9_K1.5631.00
3_W21_K1.5481.00
101_E112_D1.4721.00
68_I78_G1.4711.00
41_Q45_G1.4111.00
75_D109_Y1.3901.00
11_Y62_P1.3751.00
102_G112_D1.3701.00
19_R112_D1.3421.00
4_Y29_I1.3181.00
3_W25_M1.3041.00
94_L98_F1.2701.00
23_Y98_F1.2681.00
104_S112_D1.2571.00
71_L94_L1.2461.00
26_F66_L1.2421.00
8_L59_T1.2171.00
95_L99_C1.2081.00
85_F90_G1.1950.99
7_V66_L1.1940.99
39_V43_I1.1710.99
32_I36_I1.1670.99
18_A66_L1.1590.99
74_T100_T1.1490.99
10_N18_A1.1300.99
105_G112_D1.1230.99
78_G81_A1.1230.99
96_V100_T1.1050.99
6_S18_A1.0860.99
37_I55_Y1.0810.99
61_L65_A1.0690.99
41_Q47_E1.0310.98
106_S110_G1.0240.98
4_Y55_Y1.0200.98
95_L98_F1.0010.98
11_Y58_A0.9970.98
4_Y7_V0.9890.98
101_E104_S0.9760.98
41_Q49_P0.9730.98
34_G52_S0.9710.98
84_F94_L0.9700.98
14_F64_L0.9700.98
106_S111_N0.9490.97
82_L90_G0.9180.97
37_I41_Q0.9170.97
4_Y33_V0.9160.97
76_R93_V0.8990.96
38_N42_L0.8970.96
86_V90_G0.8940.96
3_W6_S0.8820.96
96_V99_C0.8640.96
83_L94_L0.8570.95
67_A81_A0.8530.95
76_R97_F0.8440.95
83_L93_V0.8360.95
81_A84_F0.8350.95
6_S22_E0.8290.94
82_L87_P0.8220.94
29_I33_V0.8120.94
30_N59_T0.8080.94
35_A39_V0.7930.93
89_I93_V0.7860.93
29_I32_I0.7820.92
3_W7_V0.7810.92
74_T97_F0.7790.92
28_L32_I0.7790.92
84_F87_P0.7770.92
18_A26_F0.7760.92
97_F100_T0.7710.92
106_S112_D0.7680.92
33_V55_Y0.7600.91
18_A69_R0.7510.91
41_Q52_S0.7500.91
4_Y25_M0.7490.91
64_L68_I0.7360.90
102_G109_Y0.7310.90
5_L8_L0.7230.89
93_V96_V0.7130.89
41_Q44_L0.7040.88
53_M57_L0.7030.88
11_Y14_F0.6980.87
30_N34_G0.6970.87
91_W95_L0.6960.87
80_W83_L0.6920.87
59_T63_V0.6910.87
103_T112_D0.6890.87
102_G110_G0.6880.87
11_Y65_A0.6800.86
6_S13_G0.6760.86
41_Q51_L0.6730.86
74_T98_F0.6720.85
56_L59_T0.6670.85
34_G56_L0.6650.85
8_L30_N0.6630.85
71_L97_F0.6610.85
76_R80_W0.6550.84
49_P52_S0.6490.83
27_T31_A0.6380.82
44_L48_L0.6370.82
80_W86_V0.6360.82
8_L29_I0.6350.82
58_A65_A0.6350.82
60_F64_L0.6350.82
72_H77_S0.6280.81
7_V18_A0.6240.81
86_V93_V0.6130.80
13_G18_A0.6110.80
7_V10_N0.6100.79
8_L58_A0.6030.79
102_G107_N0.6010.78
68_I77_S0.6010.78
77_S80_W0.6000.78
68_I79_A0.5970.78
17_R110_G0.5950.78
109_Y112_D0.5940.78
3_W66_L0.5930.78
74_T102_G0.5930.78
26_F30_N0.5920.77
77_S82_L0.5910.77
19_R22_E0.5900.77
47_E50_Y0.5850.77
56_L60_F0.5830.76
30_N63_V0.5720.75
12_V62_P0.5710.75
64_L81_A0.5700.75
30_N33_V0.5600.73
40_I43_I0.5500.72
3_W19_R0.5480.72
61_L69_R0.5420.71
50_Y54_L0.5410.71
13_G65_A0.5410.71
27_T30_N0.5400.71
72_H75_D0.5400.71
71_L74_T0.5360.70
38_N52_S0.5340.70
4_Y21_K0.5260.69
19_R110_G0.5230.68
32_I35_A0.5110.67
52_S56_L0.5080.66
84_F91_W0.5050.66
71_L98_F0.5030.65
8_L26_F0.5020.65
31_A52_S0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mgyA 1 0.8814 14.6 0.929 Contact Map
2ww9B 1 0.4746 13.2 0.93 Contact Map
2m8rA 1 0.3814 11.7 0.932 Contact Map
4w252 1 0.4915 7.2 0.938 Contact Map
3mp7B 1 0.4322 7 0.938 Contact Map
1fftB 1 0.6186 5.7 0.941 Contact Map
3bo0B 1 0.4746 5.1 0.942 Contact Map
1rh5B 1 0.4492 4.6 0.943 Contact Map
3l1lA 2 0.9322 4 0.945 Contact Map
2nwlA 3 0.8051 3.9 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0051 seconds.