GREMLIN Database
YHAH - Inner membrane protein YhaH
UniProt: P64590 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12747
Length: 121 (110)
Sequences: 1666 (1436)
Seq/√Len: 136.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_N13_G4.1241.00
97_I101_F2.7261.00
12_V65_L2.5931.00
6_K10_N2.5931.00
21_K25_M2.5161.00
72_F85_A2.4281.00
79_D107_T2.4071.00
96_L100_V2.3561.00
59_Y63_V2.2891.00
91_P94_G2.1331.00
18_A22_E2.0731.00
30_N59_Y2.0361.00
14_F69_A1.9161.00
19_R105_A1.9081.00
83_W86_L1.8711.00
4_Y8_L1.8541.00
76_H82_A1.8231.00
7_V26_F1.7201.00
71_Q102_N1.6841.00
79_D112_R1.6721.00
5_L9_K1.6671.00
4_Y30_N1.6611.00
111_N114_G1.6591.00
72_F82_A1.5681.00
3_W21_K1.4951.00
105_A116_D1.4541.00
11_Y66_P1.4021.00
99_I103_C1.3461.00
82_A85_A1.3371.00
79_D113_F1.3011.00
26_F70_V1.2981.00
4_Y29_V1.2981.00
41_D45_G1.2931.00
98_I102_N1.2891.00
106_G116_D1.2791.00
108_P116_D1.2251.00
19_R116_D1.2101.00
3_W25_M1.2051.00
23_Y102_N1.2031.00
39_L43_M1.1931.00
65_L69_A1.1780.99
75_L98_I1.1710.99
32_I36_V1.1580.99
8_L63_V1.1550.99
100_V104_Q1.1410.99
18_A70_V1.1250.99
7_V70_V1.1040.99
78_T104_Q1.1010.99
37_L59_Y1.0910.99
6_K18_A1.0850.99
71_Q85_A1.0760.99
4_Y7_V1.0710.99
10_N18_A1.0580.99
41_D53_G1.0380.99
105_A108_P1.0120.98
88_F98_I1.0070.98
110_E114_G0.9970.98
85_A88_F0.9810.98
11_Y62_L0.9770.98
4_Y59_Y0.9660.98
37_L41_D0.9450.98
109_G116_D0.9350.97
18_A73_R0.9280.97
86_L94_G0.9150.97
84_W87_L0.9150.97
110_E115_P0.9020.97
3_W6_K0.8960.97
93_I97_I0.8790.96
99_I102_N0.8780.96
14_F68_W0.8720.96
41_D44_L0.8650.96
34_T56_T0.8640.96
4_Y33_F0.8600.96
30_N63_V0.8590.96
80_R97_I0.8520.95
87_L98_I0.8500.95
29_V33_F0.8490.95
35_F39_L0.8370.95
78_T101_F0.8370.95
41_D56_T0.8190.94
6_K22_E0.8180.94
18_A26_F0.8110.94
5_L8_L0.8100.94
68_W85_A0.8020.94
38_G42_K0.8000.94
97_I100_V0.7990.94
34_T60_G0.7960.94
30_N34_T0.7930.93
95_W99_I0.7800.93
86_L91_P0.7730.93
90_I94_G0.7690.92
28_L32_I0.7680.92
63_V67_W0.7560.92
3_W7_V0.7550.92
65_L73_R0.7450.91
101_F104_Q0.7410.91
100_V103_C0.7330.90
114_G117_P0.7310.90
80_R84_W0.7270.90
110_E116_D0.7200.90
106_G113_F0.7160.89
4_Y25_M0.7120.89
80_R101_F0.7110.89
81_S86_L0.7050.89
75_L101_F0.6960.88
106_G114_G0.6940.88
19_R22_E0.6870.87
27_I31_I0.6790.87
53_G56_T0.6760.86
64_F68_W0.6760.86
33_F59_Y0.6680.86
41_D55_L0.6680.86
29_V32_I0.6660.86
60_G63_V0.6630.85
89_L94_G0.6560.85
68_W72_F0.6550.85
8_L62_L0.6480.84
11_Y14_F0.6420.84
11_Y69_A0.6410.83
78_T106_G0.6380.83
6_K13_G0.6370.83
107_T116_D0.6310.82
13_G18_A0.6290.82
41_D46_W0.6180.81
57_T61_I0.6170.81
93_I96_L0.6130.81
81_S84_W0.5960.79
8_L30_N0.5960.79
76_H81_S0.5940.79
78_T102_N0.5910.78
87_L91_P0.5870.78
72_F83_W0.5850.78
87_L94_G0.5750.76
90_I97_I0.5710.76
54_I58_I0.5690.76
12_V66_P0.5690.76
106_G111_N0.5640.75
26_F30_N0.5600.74
3_W70_V0.5530.73
8_L29_V0.5520.73
94_G98_I0.5510.73
38_G56_T0.5480.73
85_A92_F0.5480.73
7_V18_A0.5450.72
88_F94_G0.5450.72
7_V10_N0.5420.72
95_W100_V0.5400.72
72_F81_S0.5340.71
72_F86_L0.5330.71
22_E70_V0.5320.71
91_P98_I0.5240.69
22_E26_F0.5230.69
17_R114_G0.5230.69
58_I62_L0.5220.69
31_I56_T0.5220.69
87_L90_I0.5200.69
62_L69_A0.5160.68
113_F116_D0.5150.68
9_K87_L0.5120.68
30_N33_F0.5110.68
27_I30_N0.5050.67
24_W28_L0.5040.67
75_L85_A0.5020.66
23_Y60_G0.5000.66
76_H79_D0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mgyA 1 0.876 10.6 0.932 Contact Map
2m8rA 1 0.3719 8.6 0.935 Contact Map
3mk7A 1 0.7603 7.4 0.937 Contact Map
4ryoA 1 0.7769 4.1 0.944 Contact Map
1fftB 1 0.6281 3.9 0.945 Contact Map
2ww9B 1 0.4628 3.5 0.946 Contact Map
2qjyA 2 0.9917 3.1 0.948 Contact Map
3d31C 2 0.8099 3 0.948 Contact Map
3s8fA 1 0.7851 3 0.948 Contact Map
3ayfA 2 0.3554 3 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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