GREMLIN Database
YQJI - Transcriptional regulator YqjI
UniProt: P64588 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12954
Length: 207 (173)
Sequences: 752 (527)
Seq/√Len: 40.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
198_R202_D6.5201.00
67_I81_L4.6241.00
192_I203_I4.5381.00
129_E132_A4.0611.00
105_D109_E3.3341.00
114_T126_A3.2991.00
195_V206_L3.2801.00
195_V199_A3.1941.00
73_R88_L2.7901.00
166_R197_D2.7071.00
118_E121_G2.4741.00
39_H43_C2.4591.00
115_I125_I2.2231.00
139_R143_E2.1470.99
74_D80_E2.0780.99
170_N197_D1.9680.99
194_A201_F1.9360.99
84_A87_N1.7640.97
103_T107_L1.6870.97
134_W137_E1.6540.96
175_L203_I1.5680.95
35_H38_E1.5150.94
134_W138_N1.4780.93
67_I100_I1.4710.93
58_F148_R1.4700.93
166_R170_N1.4670.93
199_A203_I1.4280.92
89_T174_V1.4030.91
103_T106_F1.3920.91
99_V103_T1.3910.91
138_N141_Q1.3840.90
111_S130_Q1.3660.90
38_E44_G1.3620.90
185_S188_Q1.3610.90
36_Q39_H1.3600.90
58_F93_Y1.3570.90
108_Q115_I1.3470.89
71_L127_L1.3410.89
167_A193_I1.3350.89
133_Q136_E1.3250.88
61_G64_R1.3220.88
39_H44_G1.3070.88
33_H38_E1.3020.87
99_V105_D1.2950.87
88_L150_K1.2920.87
191_K203_I1.2740.86
104_L125_I1.2730.86
135_L138_N1.2510.85
168_L172_K1.2410.85
31_C35_H1.2310.84
140_E150_K1.2290.84
196_I199_A1.2230.84
33_H39_H1.1890.82
167_A197_D1.1880.82
184_I188_Q1.1800.82
164_M179_V1.1750.81
43_C119_E1.1670.81
108_Q175_L1.1630.81
110_Q127_L1.1590.81
77_H106_F1.1580.80
76_S81_L1.1570.80
112_L172_K1.1490.80
57_F60_H1.1380.79
94_T100_I1.1300.79
30_H33_H1.1190.78
30_H187_A1.1190.78
45_G49_R1.1020.77
63_L204_T1.0960.77
35_H39_H1.0810.76
103_T200_A1.0770.75
120_G124_Q1.0720.75
135_L142_V1.0600.74
105_D125_I1.0600.74
143_E147_E1.0460.73
112_L134_W1.0360.72
31_C34_G1.0350.72
171_F199_A1.0260.72
77_H80_E1.0240.72
44_G140_E1.0230.72
53_R122_K1.0230.72
30_H37_H1.0220.71
85_I103_T1.0110.71
40_G43_C1.0000.70
178_R192_I0.9990.70
87_N107_L0.9980.70
132_A136_E0.9850.69
133_Q137_E0.9720.68
48_G129_E0.9600.67
30_H34_G0.9580.66
184_I192_I0.9440.65
109_E112_L0.9410.65
69_D73_R0.9410.65
164_M176_D0.9360.65
72_S139_R0.9300.64
189_I193_I0.9270.64
170_N200_A0.9240.64
32_G35_H0.9220.63
30_H35_H0.9210.63
36_Q41_Q0.9140.63
30_H147_E0.9140.63
71_L76_S0.9130.63
195_V198_R0.9120.63
33_H36_Q0.9120.63
115_I122_K0.9050.62
88_L94_T0.9030.62
38_E41_Q0.9030.62
59_G67_I0.8990.61
57_F94_T0.8990.61
32_G39_H0.8950.61
37_H41_Q0.8940.61
32_G36_Q0.8940.61
106_F134_W0.8870.60
164_M184_I0.8830.60
76_S83_K0.8810.60
130_Q161_N0.8740.59
70_I75_D0.8730.59
92_N164_M0.8640.58
58_F67_I0.8590.58
114_T120_G0.8530.57
76_S84_A0.8400.56
166_R175_L0.8380.56
110_Q146_E0.8340.56
61_G128_T0.8300.55
87_N133_Q0.8280.55
84_A88_L0.8250.55
163_Q166_R0.8230.55
74_D81_L0.8190.54
41_Q44_G0.8150.54
49_R52_G0.8040.53
66_V146_E0.7970.52
126_A132_A0.7960.52
80_E191_K0.7950.52
81_L103_T0.7940.52
93_Y148_R0.7930.52
112_L135_L0.7930.52
64_R89_T0.7900.52
66_V164_M0.7870.51
191_K202_D0.7840.51
168_L196_I0.7790.51
55_Q80_E0.7740.50
62_E127_L0.7740.50
59_G122_K0.7690.50
127_L135_L0.7620.49
184_I204_T0.7580.49
78_G101_Y0.7580.49
129_E133_Q0.7540.48
44_G48_G0.7530.48
54_R198_R0.7530.48
56_R93_Y0.7440.47
72_S132_A0.7400.47
62_E190_K0.7390.47
40_G44_G0.7380.47
34_G188_Q0.7360.47
50_G198_R0.7340.46
60_H63_L0.7230.45
31_C37_H0.7220.45
32_G43_C0.7190.45
60_H88_L0.7140.45
37_H42_C0.7130.45
163_Q193_I0.7110.44
53_R159_R0.7110.44
39_H138_N0.7080.44
113_I125_I0.6910.43
90_Q176_D0.6880.42
72_S162_P0.6860.42
71_L113_I0.6840.42
114_T129_E0.6830.42
93_Y127_L0.6800.42
136_E139_R0.6780.41
76_S80_E0.6740.41
198_R201_F0.6710.41
178_R184_I0.6700.41
66_V93_Y0.6700.41
32_G194_A0.6670.40
34_G42_C0.6600.40
67_I130_Q0.6560.39
93_Y204_T0.6530.39
188_Q191_K0.6520.39
180_N196_I0.6480.39
146_E156_A0.6470.39
178_R203_I0.6470.39
74_D113_I0.6450.39
172_K193_I0.6420.38
62_E144_M0.6390.38
200_A204_T0.6360.38
113_I118_E0.6330.37
37_H147_E0.6320.37
99_V106_F0.6300.37
58_F63_L0.6300.37
44_G129_E0.6290.37
34_G37_H0.6220.37
34_G38_E0.6220.37
129_E147_E0.6200.36
64_R103_T0.6180.36
67_I145_I0.6160.36
97_P120_G0.6150.36
55_Q111_S0.6100.36
36_Q129_E0.6090.35
103_T170_N0.6070.35
64_R184_I0.6060.35
133_Q185_S0.6050.35
85_I196_I0.6040.35
84_A114_T0.6040.35
86_E91_G0.5990.35
58_F205_Q0.5990.35
64_R110_Q0.5980.35
83_K170_N0.5940.34
60_H99_V0.5890.34
94_T150_K0.5890.34
45_G48_G0.5890.34
35_H43_C0.5880.34
93_Y178_R0.5880.34
177_L204_T0.5860.34
80_E122_K0.5840.33
167_A196_I0.5840.33
94_T204_T0.5830.33
125_I135_L0.5820.33
82_I93_Y0.5800.33
34_G169_D0.5780.33
195_V202_D0.5750.33
77_H165_K0.5740.33
65_L135_L0.5730.32
74_D191_K0.5660.32
82_I100_I0.5640.32
161_N164_M0.5630.32
163_Q197_D0.5610.32
60_H121_G0.5600.31
121_G184_I0.5590.31
166_R205_Q0.5560.31
117_E124_Q0.5530.31
194_A203_I0.5460.30
183_D192_I0.5440.30
34_G39_H0.5440.30
130_Q193_I0.5420.30
66_V163_Q0.5400.30
65_L93_Y0.5390.30
94_T123_K0.5390.30
61_G87_N0.5360.30
114_T147_E0.5350.30
89_T124_Q0.5350.30
115_I123_K0.5340.29
71_L144_M0.5330.29
72_S129_E0.5330.29
106_F110_Q0.5270.29
101_Y104_L0.5270.29
85_I193_I0.5260.29
80_E99_V0.5260.29
83_K112_L0.5220.29
31_C41_Q0.5220.29
147_E150_K0.5200.28
93_Y110_Q0.5200.28
38_E43_C0.5180.28
59_G168_L0.5170.28
86_E104_L0.5160.28
77_H167_A0.5110.28
30_H136_E0.5040.27
178_R204_T0.5030.27
80_E104_L0.5010.27
63_L81_L0.5000.27
112_L128_T0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1bm9A 2 0.5459 99.8 0.694 Contact Map
2rkhA 2 0.5942 99.8 0.702 Contact Map
3l9fA 2 0.6329 99.8 0.714 Contact Map
1yg2A 2 0.6522 99.7 0.733 Contact Map
1xmaA 2 0.4879 99.6 0.752 Contact Map
2eshA 2 0.5314 99.6 0.754 Contact Map
2e1nA 2 0.5169 99.6 0.755 Contact Map
2zfwA 2 0.5169 99.6 0.761 Contact Map
2dqlA 2 0.5314 99.5 0.763 Contact Map
3f8bA 2 0.4879 99.5 0.771 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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