GREMLIN Database
YQJE - Inner membrane protein YqjE
UniProt: P64585 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12744
Length: 134 (119)
Sequences: 333 (222)
Seq/√Len: 20.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_A113_L3.2421.00
119_E122_N3.0930.99
26_V84_A2.8690.99
61_A96_A2.6410.98
87_A91_V2.5470.98
64_G93_L2.5330.98
80_Y83_N2.4100.97
74_W78_P2.3390.96
34_R41_E2.0840.93
72_I116_T2.0690.93
124_R128_E2.0160.92
76_V84_A1.9480.90
32_R64_G1.9160.89
17_I58_M1.7270.84
57_T100_G1.6930.82
83_N87_A1.6340.80
71_L86_I1.5920.78
104_L108_R1.5590.77
59_L84_A1.5310.75
58_M88_T1.5020.74
73_I85_M1.4930.73
32_R123_D1.4770.73
44_K110_S1.4540.71
53_M110_S1.4480.71
21_I31_T1.4360.70
28_M112_L1.4280.70
36_A116_T1.4170.69
43_E46_N1.3900.68
69_M92_L1.3640.66
52_L110_S1.3270.64
87_A108_R1.3160.63
37_V74_W1.2900.62
50_L58_M1.2800.61
55_G58_M1.2750.61
73_I119_E1.2630.60
90_V98_I1.2440.59
74_W77_D1.2380.59
56_L75_A1.2310.58
94_L105_R1.2240.58
71_L108_R1.2130.57
31_T69_M1.1990.56
78_P109_K1.1970.56
18_G22_V1.1960.56
87_A94_L1.1920.56
27_E99_G1.1880.55
60_F92_L1.1800.55
83_N86_I1.1610.54
29_V93_L1.1450.53
82_L124_R1.1380.52
36_A72_I1.1370.52
84_A93_L1.1280.51
78_P95_L1.1000.50
89_T117_R1.0990.50
57_T78_P1.0990.50
65_L97_L1.0900.49
24_I116_T1.0750.48
27_E63_F1.0710.48
42_E75_A1.0470.46
38_V116_T1.0220.45
32_R47_L1.0190.44
92_L99_G1.0140.44
69_M73_I1.0030.43
43_E112_L0.9870.42
102_W105_R0.9800.42
52_L55_G0.9740.41
22_V94_L0.9630.41
115_H119_E0.9600.41
38_V121_A0.9600.41
22_V37_V0.9510.40
113_L116_T0.9400.39
44_K66_M0.9390.39
101_I105_R0.9380.39
101_I104_L0.9210.38
30_E124_R0.9200.38
43_E62_A0.9120.38
33_L43_E0.9110.38
29_V119_E0.9090.37
72_I90_V0.9090.37
18_G103_T0.9080.37
53_M84_A0.9030.37
64_G82_L0.9020.37
44_K106_K0.9010.37
92_L112_L0.8950.37
73_I103_T0.8950.37
37_V89_T0.8890.36
82_L86_I0.8740.35
74_W82_L0.8700.35
34_R44_K0.8690.35
67_S99_G0.8670.35
54_L68_L0.8660.35
80_Y111_T0.8640.35
55_G65_L0.8430.33
90_V95_L0.8420.33
28_M38_V0.8380.33
28_M36_A0.8330.33
30_E34_R0.8320.33
27_E115_H0.8310.33
40_L106_K0.8270.33
18_G118_H0.8260.33
42_E46_N0.8250.32
67_S70_V0.8240.32
90_V114_R0.8230.32
56_L59_L0.8200.32
110_S122_N0.8140.32
71_L75_A0.8100.32
32_R35_L0.8000.31
46_N54_L0.7920.31
50_L107_S0.7800.30
40_L78_P0.7730.30
78_P87_A0.7710.29
52_L58_M0.7710.29
49_Q106_K0.7690.29
37_V113_L0.7580.29
41_E82_L0.7510.28
20_R56_L0.7500.28
19_Q117_R0.7470.28
19_Q52_L0.7390.28
28_M115_H0.7200.27
21_I44_K0.7170.27
34_R37_V0.7110.26
33_L85_M0.7090.26
32_R126_L0.7010.26
16_G100_G0.6970.26
40_L88_T0.6890.25
55_G110_S0.6880.25
46_N60_F0.6840.25
41_E92_L0.6780.25
43_E110_S0.6740.24
49_Q102_W0.6740.24
43_E114_R0.6680.24
28_M119_E0.6660.24
14_V95_L0.6660.24
53_M71_L0.6600.24
75_A91_V0.6510.23
97_L108_R0.6360.23
28_M39_E0.6260.22
104_L116_T0.6250.22
51_L69_M0.6250.22
12_K87_A0.6230.22
72_I94_L0.6200.22
59_L97_L0.6070.21
72_I105_R0.6010.21
81_R84_A0.5940.21
17_I127_L0.5930.21
13_S49_Q0.5910.21
68_L71_L0.5900.21
85_M89_T0.5870.20
25_M65_L0.5860.20
25_M63_F0.5750.20
82_L85_M0.5740.20
40_L61_A0.5730.20
23_S95_L0.5720.20
29_V121_A0.5710.20
69_M78_P0.5700.20
33_L36_A0.5690.20
19_Q61_A0.5690.20
15_L63_F0.5680.20
87_A128_E0.5640.20
76_V95_L0.5630.19
87_A107_S0.5590.19
26_V98_I0.5540.19
72_I114_R0.5510.19
72_I83_N0.5470.19
21_I89_T0.5450.19
101_I125_Q0.5390.19
55_G116_T0.5390.19
90_V94_L0.5240.18
79_Q114_R0.5210.18
62_A66_M0.5190.18
44_K52_L0.5110.17
56_L93_L0.5110.17
54_L107_S0.5090.17
61_A92_L0.5080.17
46_N104_L0.5070.17
23_S91_V0.5050.17
22_V54_L0.5030.17
11_G22_V0.5030.17
21_I117_R0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ev6A 3 0.7761 7.6 0.938 Contact Map
4bw5A 2 0.4254 5.4 0.942 Contact Map
3ar4A 1 0.9328 4.6 0.944 Contact Map
4i0uA 4 0.709 4.6 0.944 Contact Map
3ukmA 2 0.4328 3.4 0.948 Contact Map
2m20A 2 0.3433 2.8 0.95 Contact Map
2kluA 1 0.3955 2.4 0.951 Contact Map
3pjzA 2 0.5149 2.3 0.952 Contact Map
4l9uA 2 0.1567 2.3 0.952 Contact Map
2f95B 2 0.3433 2.2 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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