GREMLIN Database
CPTB - Antitoxin CptB
UniProt: P64559 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13075
Length: 88 (77)
Sequences: 387 (229)
Seq/√Len: 26.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_C43_F4.6031.00
6_K33_D4.0811.00
39_E71_M2.8701.00
27_F35_L2.8351.00
37_D40_K2.6870.99
66_D69_L2.5890.99
45_R66_D2.2300.98
39_E75_L2.1850.97
10_H29_E2.0130.96
52_P61_H1.8650.93
63_K74_R1.6290.88
42_I68_E1.5980.87
72_M75_L1.5410.84
58_L77_Q1.5160.83
56_N62_G1.4460.80
63_K70_E1.4370.80
69_L73_V1.3750.77
7_A12_A1.3530.76
23_S80_N1.3470.75
68_E71_M1.3160.74
36_S42_I1.2780.71
31_E80_N1.2770.71
45_R69_L1.2460.69
74_R78_T1.2300.68
45_R68_E1.2270.68
9_I47_L1.1820.65
53_D62_G1.1610.64
42_I72_M1.1290.62
56_N61_H1.1200.61
64_P72_M1.1070.60
60_N77_Q1.1070.60
32_Y40_K1.0250.54
22_I52_P1.0210.54
24_I64_P1.0140.53
27_F55_F0.9940.52
6_K28_F0.9810.51
64_P70_E0.9810.51
29_E38_D0.9720.50
5_N44_I0.9690.50
25_M47_L0.9550.49
17_M55_F0.9380.48
41_R44_I0.9370.48
23_S29_E0.9350.47
10_H43_F0.9340.47
31_E79_R0.9130.46
30_H45_R0.9110.46
32_Y44_I0.9080.45
64_P73_V0.9060.45
26_P40_K0.8790.43
18_R22_I0.8770.43
70_E74_R0.8730.43
9_I44_I0.8650.42
46_L69_L0.8400.41
22_I30_H0.8390.40
12_A28_F0.8370.40
18_R35_L0.7940.37
52_P56_N0.7840.37
36_S39_E0.7770.36
9_I28_F0.7730.36
28_F80_N0.7620.35
44_I47_L0.7580.35
18_R27_F0.7520.34
8_R67_A0.7460.34
7_A29_E0.7450.34
23_S30_H0.7380.33
9_I77_Q0.7200.32
62_G78_T0.7190.32
13_C25_M0.7180.32
25_M29_E0.7150.32
70_E75_L0.7100.32
20_L59_M0.6980.31
52_P59_M0.6970.31
26_P55_F0.6950.31
36_S70_E0.6820.30
34_S40_K0.6730.29
58_L65_A0.6700.29
24_I80_N0.6690.29
22_I56_N0.6560.28
34_S65_A0.6530.28
17_M20_L0.6510.28
63_K68_E0.6490.28
18_R52_P0.6460.28
41_R62_G0.6440.28
39_E74_R0.6420.27
30_H36_S0.6190.26
7_A33_D0.6160.26
12_A33_D0.6100.26
10_H54_L0.6030.25
62_G65_A0.5990.25
34_S68_E0.5860.24
7_A25_M0.5850.24
31_E58_L0.5820.24
75_L79_R0.5810.24
38_D41_R0.5750.24
9_I48_E0.5730.24
77_Q80_N0.5640.23
9_I71_M0.5530.23
45_R72_M0.5470.22
18_R21_D0.5470.22
38_D48_E0.5420.22
36_S72_M0.5370.22
48_E67_A0.5300.21
11_W16_G0.5270.21
11_W15_R0.5270.21
11_W14_R0.5270.21
24_I60_N0.5260.21
18_R56_N0.5220.21
7_A13_C0.5190.21
34_S41_R0.5190.21
10_H13_C0.5180.21
36_S49_C0.5170.21
39_E42_I0.5170.21
6_K44_I0.5070.20
48_E64_P0.5060.20
17_M21_D0.5030.20
22_I58_L0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1x6iA 2 1 100 0.276 Contact Map
2jr5A 1 1 99.9 0.313 Contact Map
1puzA 1 0.8977 99.9 0.337 Contact Map
2lm4A 1 0.9886 99.9 0.366 Contact Map
1zzgA 2 0.7841 22 0.917 Contact Map
4gicA 2 0.5795 16.2 0.922 Contact Map
1kaeA 2 0.5795 13.9 0.924 Contact Map
2r2yA 1 0.8864 13.7 0.924 Contact Map
2kr0A 1 0.9886 12.8 0.925 Contact Map
4g09A 2 0.4886 10.2 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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