GREMLIN Database
YGFM - Uncharacterized protein YgfM
UniProt: P64557 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13063
Length: 259 (246)
Sequences: 5958 (4071)
Seq/√Len: 259.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_E134_T3.8611.00
201_R206_E3.7051.00
65_R151_E3.4951.00
128_V153_I3.4651.00
129_F135_L3.1551.00
128_V151_E3.1191.00
133_E147_R3.0211.00
56_W70_S2.7001.00
18_K27_W2.5581.00
108_A149_L2.5531.00
128_V132_G2.4941.00
134_T153_I2.4051.00
63_A153_I2.2491.00
136_S139_D2.1661.00
220_A241_G2.1651.00
55_D74_P2.1131.00
59_W156_D2.0771.00
128_V134_T1.9711.00
6_F45_I1.9701.00
7_R51_D1.9481.00
70_S75_L1.9201.00
10_S13_Q1.8811.00
130_G150_T1.8791.00
73_Q99_N1.8601.00
12_E130_G1.8221.00
65_R153_I1.8141.00
127_L149_L1.8041.00
9_D13_Q1.7751.00
183_T187_G1.7631.00
124_D138_E1.7391.00
21_Y45_I1.7381.00
16_E20_R1.7161.00
126_E153_I1.7041.00
15_L131_N1.6941.00
177_T193_D1.6931.00
49_L69_M1.6901.00
71_R74_P1.6741.00
210_L215_L1.6521.00
104_G149_L1.6451.00
58_D65_R1.6411.00
73_Q77_D1.6251.00
164_R250_D1.6151.00
66_I75_L1.6041.00
216_E245_A1.5751.00
126_E136_S1.5641.00
6_F17_L1.5631.00
18_K47_I1.5571.00
132_G150_T1.5561.00
192_L202_L1.5381.00
182_M188_M1.5381.00
63_A156_D1.4701.00
27_W148_L1.4661.00
138_E203_H1.4641.00
59_W80_F1.4381.00
17_L47_I1.4371.00
28_F46_A1.4331.00
115_V165_K1.4231.00
180_V247_L1.4191.00
127_L137_I1.4191.00
27_W49_L1.4171.00
64_L81_I1.4151.00
212_G249_A1.3961.00
118_P193_D1.3881.00
204_D207_K1.3731.00
204_D222_A1.3711.00
238_Y242_V1.3701.00
208_Q214_A1.3511.00
14_A148_L1.3471.00
24_E44_K1.3391.00
180_V190_I1.3311.00
164_R246_D1.3251.00
26_V41_T1.3241.00
212_G216_E1.3241.00
219_V244_V1.3111.00
11_V148_L1.3041.00
211_E214_A1.2941.00
25_A47_I1.2941.00
192_L240_T1.2881.00
11_V130_G1.2881.00
29_A69_M1.2801.00
103_I152_I1.2661.00
50_Q71_R1.2661.00
121_L137_I1.2591.00
15_L130_G1.2481.00
223_I240_T1.2381.00
65_R128_V1.2331.00
72_L101_S1.2321.00
107_I152_I1.2251.00
62_G156_D1.2241.00
72_L116_L1.2211.00
15_L148_L1.2151.00
202_L205_V1.2121.00
114_S117_L1.1891.00
245_A249_A1.1741.00
8_P49_L1.1731.00
66_I154_I1.1691.00
166_I239_I1.1671.00
203_H207_K1.1591.00
7_R48_S1.1581.00
8_P13_Q1.1571.00
122_A191_A1.1551.00
13_Q16_E1.1511.00
208_Q217_Q1.1401.00
79_R83_A1.1351.00
85_L116_L1.1321.00
88_A119_V1.1281.00
142_A146_D1.1251.00
75_L103_I1.1231.00
55_D71_R1.1141.00
5_F48_S1.1071.00
227_E233_V1.1061.00
11_V15_L1.1031.00
107_I120_L1.1021.00
192_L195_V1.0951.00
68_A104_G1.0901.00
29_A102_T1.0791.00
209_N214_A1.0651.00
27_W47_I1.0641.00
60_D65_R1.0631.00
108_A140_Y1.0631.00
57_V70_S1.0601.00
117_L141_L1.0531.00
73_Q76_R1.0511.00
129_F147_R1.0481.00
160_T183_T1.0461.00
218_A221_N1.0431.00
72_L92_V1.0341.00
233_V237_R1.0311.00
92_V101_S1.0291.00
131_N147_R1.0081.00
120_L127_L1.0031.00
13_Q17_L0.9991.00
85_L119_V0.9971.00
56_W151_E0.9951.00
87_E250_D0.9941.00
28_F31_G0.9931.00
31_G35_N0.9931.00
174_T177_T0.9881.00
242_V246_D0.9861.00
205_V222_A0.9761.00
202_L222_A0.9751.00
63_A155_K0.9571.00
247_L251_C0.9501.00
9_D51_D0.9481.00
55_D69_M0.9421.00
238_Y241_G0.9421.00
181_A189_R0.9361.00
71_R102_T0.9241.00
59_W64_L0.9211.00
229_L237_R0.9181.00
215_L248_Y0.9161.00
210_L214_A0.9131.00
158_Y183_T0.9091.00
121_L138_E0.9071.00
165_K239_I0.9071.00
33_K109_A0.9031.00
164_R247_L0.8941.00
121_L141_L0.8911.00
73_Q95_R0.8811.00
127_L140_Y0.8801.00
12_E53_E0.8801.00
138_E201_R0.8771.00
72_L89_L0.8721.00
120_L125_A0.8661.00
80_F83_A0.8661.00
203_H206_E0.8661.00
213_N217_Q0.8651.00
190_I205_V0.8641.00
66_I103_I0.8621.00
195_V240_T0.8551.00
79_R82_P0.8470.99
178_A243_L0.8460.99
214_A217_Q0.8460.99
59_W63_A0.8450.99
120_L154_I0.8430.99
60_D63_A0.8420.99
228_D236_K0.8410.99
128_V150_T0.8400.99
21_Y24_E0.8360.99
49_L148_L0.8330.99
192_L244_V0.8320.99
28_F34_L0.8310.99
157_P160_T0.8290.99
103_I116_L0.8290.99
231_G236_K0.8260.99
11_V53_E0.8260.99
137_I141_L0.8230.99
129_F133_E0.8180.99
124_D201_R0.8150.99
22_Q25_A0.8140.99
21_Y25_A0.8120.99
70_S103_I0.8120.99
166_I243_L0.8120.99
54_L69_M0.8100.99
164_R243_L0.8070.99
204_D221_N0.8060.99
87_E161_C0.8040.99
76_R90_G0.7960.99
84_A161_C0.7960.99
87_E162_A0.7960.99
12_E16_E0.7960.99
11_V54_L0.7950.99
50_Q69_M0.7940.99
106_E116_L0.7870.99
118_P177_T0.7860.99
190_I202_L0.7860.99
19_R131_N0.7830.99
57_V78_A0.7820.99
233_V236_K0.7800.99
37_T94_S0.7790.99
14_A52_L0.7780.99
89_L92_V0.7750.99
122_A179_A0.7680.99
115_V163_T0.7630.99
163_T177_T0.7610.99
191_A201_R0.7590.99
205_V218_A0.7550.99
237_R241_G0.7540.99
124_D189_R0.7510.99
18_K21_Y0.7510.99
33_K111_Q0.7500.99
209_N212_G0.7490.99
227_E234_A0.7450.99
64_L156_D0.7430.99
70_S74_P0.7330.98
143_C146_D0.7250.98
231_G234_A0.7220.98
6_F21_Y0.7210.98
14_A27_W0.7170.98
109_A114_S0.7150.98
17_L21_Y0.7070.98
153_I156_D0.7070.98
123_L154_I0.7050.98
168_R172_G0.7050.98
228_D232_S0.7020.98
143_C197_S0.7010.98
138_E189_R0.6990.98
75_L116_L0.6980.98
78_A82_P0.6970.98
25_A45_I0.6960.98
58_D151_E0.6960.98
32_S106_E0.6950.98
161_C181_A0.6950.98
28_F35_N0.6930.98
84_A181_A0.6880.98
137_I140_Y0.6870.98
76_R89_L0.6870.98
103_I120_L0.6850.98
208_Q211_E0.6840.98
55_D70_S0.6840.98
124_D136_S0.6790.98
60_D156_D0.6770.97
56_W74_P0.6710.97
93_Y97_V0.6700.97
229_L234_A0.6700.97
111_Q173_L0.6680.97
57_V66_I0.6670.97
228_D231_G0.6650.97
61_N156_D0.6650.97
63_A154_I0.6620.97
26_V34_L0.6620.97
107_I117_L0.6600.97
196_A200_L0.6600.97
11_V27_W0.6600.97
107_I137_I0.6580.97
125_A152_I0.6570.97
18_K22_Q0.6540.97
168_R173_L0.6450.97
76_R95_R0.6440.97
141_L199_A0.6420.97
8_P11_V0.6410.96
84_A123_L0.6400.96
94_S165_K0.6340.96
125_A154_I0.6320.96
200_L223_I0.6260.96
176_V195_V0.6240.96
11_V14_A0.6230.96
70_S104_G0.6190.96
29_A49_L0.6180.96
189_R201_R0.6180.96
72_L93_Y0.6160.96
53_E56_W0.6140.96
87_E91_F0.6130.95
113_E194_G0.6120.95
49_L54_L0.6100.95
219_V222_A0.6080.95
12_E132_G0.6070.95
33_K172_G0.5990.95
135_L140_Y0.5980.95
102_T105_G0.5960.95
242_V245_A0.5930.95
196_A199_A0.5920.95
32_S94_S0.5910.94
54_L68_A0.5900.94
21_Y47_I0.5890.94
76_R86_R0.5880.94
26_V109_A0.5860.94
66_I70_S0.5840.94
75_L89_L0.5840.94
225_P228_D0.5830.94
218_A222_A0.5830.94
59_W62_G0.5830.94
72_L75_L0.5830.94
162_A250_D0.5810.94
234_A238_Y0.5800.94
188_M206_E0.5800.94
109_A145_C0.5790.94
239_I243_L0.5780.94
212_G245_A0.5770.94
6_F13_Q0.5740.94
94_S171_A0.5720.93
72_L103_I0.5680.93
121_L199_A0.5670.93
74_P77_D0.5650.93
109_A173_L0.5630.93
124_D187_G0.5620.93
15_L19_R0.5580.93
119_V179_A0.5540.92
111_Q145_C0.5530.92
173_L194_G0.5520.92
37_T115_V0.5520.92
157_P181_A0.5510.92
114_S173_L0.5510.92
48_S100_Q0.5500.92
210_L251_C0.5490.92
134_T151_E0.5470.92
78_A81_I0.5460.92
74_P78_A0.5460.92
33_K173_L0.5450.92
106_E173_L0.5440.92
124_D155_K0.5440.92
110_R141_L0.5430.92
121_L191_A0.5430.92
53_E69_M0.5400.91
93_Y171_A0.5390.91
143_C198_K0.5380.91
234_A237_R0.5380.91
21_Y44_K0.5370.91
86_R90_G0.5360.91
167_S175_V0.5360.91
216_E241_G0.5350.91
182_M251_C0.5350.91
88_A92_V0.5330.91
239_I242_V0.5310.91
107_I127_L0.5240.90
18_K25_A0.5230.90
50_Q100_Q0.5220.90
64_L80_F0.5220.90
63_A126_E0.5220.90
75_L120_L0.5190.90
15_L18_K0.5180.90
127_L135_L0.5170.90
127_L152_I0.5160.89
169_S172_G0.5150.89
97_V171_A0.5150.89
18_K26_V0.5140.89
228_D233_V0.5130.89
138_E141_L0.5120.89
161_C165_K0.5120.89
212_G215_L0.5120.89
114_S174_T0.5100.89
129_F140_Y0.5100.89
43_K46_A0.5070.89
142_A197_S0.5060.89
144_P196_A0.5050.88
94_S97_V0.5020.88
141_L198_K0.5010.88
127_L141_L0.5000.88
112_E228_D0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1n62C 1 0.9846 100 0.2 Contact Map
1t3qC 1 0.9884 100 0.209 Contact Map
1rm6B 1 0.9691 100 0.218 Contact Map
1ffvC 1 0.9884 100 0.236 Contact Map
3hrdC 1 0.9884 100 0.246 Contact Map
3zyvA 3 0.9923 100 0.252 Contact Map
2w3sA 1 0.9807 100 0.258 Contact Map
3nvzB 1 0.9846 100 0.273 Contact Map
3uncA 2 0.9923 100 0.291 Contact Map
3tx1A 1 0.7722 98 0.872 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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