QUEE - ECOLI - GREMLIN Contacts

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QUEE - 7-carboxy-7-deazaguanine synthase

UniProt:	P64554	Sequences: MQYPINEMFQTLQGEGYFTGVPAIFIRLQGCPVGCAWCDTKHTWEKLEDREVSLFSILAKTKESDKWGAASSEDLLAVIGRQGYTARHVVITGGEPCIHDLLPLTDLLEKNGFSCQIETSGTHEVRCTPNTWVTVSPKLNMRGGYEVLSQALERANEIKHPVGRVRDIEALDELLATLTDDKPRVIALQPISQKDDATRLCIETCIARNWRLSMQTHKYLNIA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13034
Length:	223 (191)
Sequences:	2498 (1665)
Seq/√Len:	120.4

ECOLI - QUEE
BACSU - QUEE
HALSA - Q9HHN7
SULSO - Q97ZQ9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
32_P	120_S	2.993	1.00
91_I	100_D	2.647	1.00
72_S	79_I	2.513	1.00
21_V	114_S	2.422	1.00
156_N	184_R	2.358	1.00
119_T	135_V	2.242	1.00
204_T	208_R	2.234	1.00
172_D	208_R	2.226	1.00
37_W	163_G	2.149	1.00
23_A	88_H	2.138	1.00
73_E	107_L	2.076	1.00
109_E	131_T	2.066	1.00
23_A	90_V	2.036	1.00
72_S	76_L	2.035	1.00
97_C	125_V	2.034	1.00
91_I	108_L	2.005	1.00
187_A	211_R	1.949	1.00
51_E	54_L	1.949	1.00
17_Y	187_A	1.947	1.00
199_R	203_E	1.935	1.00
76_L	79_I	1.901	1.00
8_M	75_L	1.875	1.00
78_V	83_G	1.863	1.00
203_E	207_A	1.845	1.00
18_F	88_H	1.828	1.00
10_Q	86_A	1.825	1.00
163_G	191_I	1.794	1.00
19_T	216_T	1.777	1.00
203_E	206_I	1.762	1.00
21_V	211_R	1.759	1.00
40_T	43_T	1.739	1.00
75_L	79_I	1.738	1.00
28_L	91_I	1.727	1.00
125_V	133_V	1.689	1.00
6_N	46_K	1.687	1.00
8_M	24_I	1.667	1.00
125_V	152_L	1.667	1.00
109_E	115_C	1.667	1.00
72_S	75_L	1.658	1.00
32_P	122_T	1.646	1.00
41_K	44_W	1.629	1.00
214_M	219_Y	1.615	1.00
8_M	78_V	1.606	1.00
74_D	77_A	1.580	1.00
10_Q	22_P	1.566	1.00
106_D	110_K	1.556	1.00
165_V	169_E	1.531	1.00
202_I	206_I	1.526	1.00
215_Q	218_K	1.514	1.00
4_P	99_H	1.495	1.00
24_I	79_I	1.489	1.00
141_M	164_R	1.487	1.00
73_E	77_A	1.466	1.00
32_P	98_I	1.464	1.00
88_H	116_Q	1.446	1.00
173_E	177_T	1.444	1.00
74_D	78_V	1.426	1.00
33_V	120_S	1.421	1.00
88_H	114_S	1.401	1.00
205_C	212_L	1.392	1.00
169_E	172_D	1.379	1.00
189_Q	215_Q	1.377	1.00
168_I	172_D	1.369	1.00
17_Y	157_E	1.354	1.00
173_E	176_A	1.344	1.00
23_A	116_Q	1.323	1.00
201_C	204_T	1.308	1.00
106_D	109_E	1.306	1.00
26_I	79_I	1.304	1.00
28_L	101_L	1.294	1.00
32_P	123_H	1.285	1.00
37_W	139_L	1.259	0.99
119_T	133_V	1.251	0.99
87_R	113_F	1.230	0.99
140_N	166_R	1.228	0.99
199_R	202_I	1.228	0.99
198_T	202_I	1.198	0.99
26_I	89_V	1.186	0.99
82_Q	111_N	1.180	0.99
167_D	170_A	1.174	0.99
17_Y	185_V	1.172	0.99
162_V	188_L	1.164	0.99
73_E	111_N	1.160	0.99
89_V	108_L	1.156	0.99
8_M	26_I	1.131	0.99
90_V	116_Q	1.118	0.99
116_Q	134_T	1.118	0.99
171_L	188_L	1.109	0.99
101_L	105_T	1.085	0.98
91_I	101_L	1.083	0.98
76_L	107_L	1.073	0.98
91_I	115_C	1.053	0.98
21_V	88_H	1.053	0.98
18_F	114_S	1.049	0.98
128_T	133_V	1.042	0.98
3_Y	28_L	1.041	0.98
172_D	176_A	1.026	0.98
141_M	163_G	1.024	0.98
167_D	178_L	1.018	0.98
105_T	115_C	1.002	0.97
75_L	78_V	0.999	0.97
51_E	55_F	0.997	0.97
202_I	220_L	0.986	0.97
34_G	44_W	0.981	0.97
194_K	197_A	0.981	0.97
11_T	90_V	0.966	0.97
109_E	130_N	0.964	0.97
6_N	42_H	0.964	0.97
158_I	180_D	0.960	0.97
5_I	28_L	0.955	0.97
175_L	186_I	0.945	0.96
117_I	128_T	0.934	0.96
26_I	91_I	0.928	0.96
19_T	214_M	0.926	0.96
160_H	188_L	0.918	0.96
189_Q	213_S	0.914	0.96
174_L	177_T	0.912	0.96
200_L	204_T	0.908	0.95
151_A	154_R	0.904	0.95
117_I	130_N	0.895	0.95
202_I	205_C	0.889	0.95
189_Q	192_S	0.878	0.95
13_Q	137_P	0.870	0.94
75_L	84_Y	0.867	0.94
97_C	123_H	0.864	0.94
3_Y	104_L	0.863	0.94
97_C	117_I	0.861	0.94
16_G	90_V	0.859	0.94
88_H	117_I	0.857	0.94
188_L	204_T	0.853	0.94
107_L	111_N	0.851	0.94
105_T	128_T	0.847	0.93
52_V	55_F	0.843	0.93
10_Q	206_I	0.840	0.93
3_Y	101_L	0.838	0.93
6_N	29_Q	0.832	0.93
137_P	174_L	0.832	0.93
18_F	134_T	0.830	0.93
139_L	170_A	0.830	0.93
90_V	136_S	0.827	0.93
166_R	169_E	0.826	0.93
123_H	152_L	0.824	0.92
102_L	106_D	0.821	0.92
155_A	183_P	0.810	0.92
200_L	203_E	0.805	0.92
117_I	133_V	0.805	0.92
102_L	127_C	0.803	0.91
179_T	209_N	0.801	0.91
5_I	52_V	0.800	0.91
125_V	135_V	0.798	0.91
189_Q	212_L	0.795	0.91
48_E	51_E	0.794	0.91
148_L	155_A	0.794	0.91
169_E	173_E	0.790	0.91
135_V	152_L	0.788	0.91
103_P	107_L	0.787	0.91
98_I	123_H	0.786	0.91
161_P	191_I	0.783	0.90
140_N	170_A	0.780	0.90
36_A	140_N	0.774	0.90
100_D	103_P	0.774	0.90
162_V	204_T	0.768	0.90
17_Y	134_T	0.768	0.90
125_V	130_N	0.765	0.89
72_S	77_A	0.764	0.89
26_I	75_L	0.762	0.89
162_V	167_D	0.757	0.89
18_F	116_Q	0.756	0.89
105_T	109_E	0.752	0.89
73_E	110_K	0.749	0.88
19_T	213_S	0.748	0.88
134_T	157_E	0.740	0.88
13_Q	116_Q	0.736	0.87
18_F	21_V	0.735	0.87
168_I	204_T	0.728	0.87
149_S	177_T	0.717	0.86
103_P	106_D	0.716	0.86
29_Q	99_H	0.709	0.85
168_I	208_R	0.708	0.85
89_V	115_C	0.708	0.85
107_L	110_K	0.705	0.85
6_N	43_T	0.701	0.85
186_I	209_N	0.701	0.85
151_A	155_A	0.697	0.84
78_V	84_Y	0.692	0.84
48_E	78_V	0.691	0.84
148_L	152_L	0.689	0.84
33_V	122_T	0.686	0.84
34_G	141_M	0.686	0.84
24_I	84_Y	0.684	0.83
10_Q	84_Y	0.681	0.83
110_K	180_D	0.680	0.83
143_G	148_L	0.677	0.83
8_M	74_D	0.675	0.83
133_V	153_E	0.663	0.81
139_L	160_H	0.663	0.81
90_V	213_S	0.659	0.81
3_Y	103_P	0.657	0.81
192_S	218_K	0.657	0.81
168_I	207_A	0.652	0.80
36_A	143_G	0.650	0.80
72_S	107_L	0.650	0.80
12_L	205_C	0.649	0.80
172_D	210_W	0.648	0.80
72_S	104_L	0.643	0.79
4_P	30_G	0.643	0.79
111_N	207_A	0.642	0.79
204_T	207_A	0.641	0.79
174_L	178_L	0.641	0.79
11_T	92_T	0.639	0.79
167_D	171_L	0.634	0.78
214_M	218_K	0.633	0.78
189_Q	218_K	0.631	0.78
210_W	213_S	0.630	0.78
89_V	113_F	0.630	0.78
83_G	86_A	0.629	0.78
21_V	113_F	0.629	0.78
132_W	157_E	0.626	0.78
30_G	104_L	0.626	0.78
139_L	191_I	0.623	0.77
201_C	206_I	0.620	0.77
44_W	47_L	0.614	0.76
29_Q	47_L	0.613	0.76
151_A	156_N	0.610	0.76
165_V	203_E	0.609	0.76
33_V	95_E	0.608	0.76
29_Q	187_A	0.601	0.75
188_L	205_C	0.601	0.75
28_L	99_H	0.598	0.74
76_L	111_N	0.597	0.74
135_V	155_A	0.596	0.74
77_A	110_K	0.593	0.74
55_F	74_D	0.588	0.73
76_L	82_Q	0.585	0.73
90_V	132_W	0.585	0.73
160_H	186_I	0.580	0.72
167_D	177_T	0.577	0.72
79_I	113_F	0.574	0.71
162_V	201_C	0.573	0.71
23_A	92_T	0.572	0.71
124_E	127_C	0.571	0.71
119_T	152_L	0.569	0.71
82_Q	113_F	0.568	0.71
18_F	219_Y	0.565	0.70
201_C	207_A	0.564	0.70
196_D	199_R	0.561	0.70
95_E	120_S	0.560	0.69
115_C	128_T	0.560	0.69
189_Q	202_I	0.559	0.69
18_F	132_W	0.556	0.69
5_I	26_I	0.554	0.69
201_C	205_C	0.553	0.69
97_C	124_E	0.551	0.68
125_V	156_N	0.549	0.68
165_V	200_L	0.543	0.67
10_Q	85_T	0.542	0.67
90_V	134_T	0.540	0.67
55_F	78_V	0.539	0.67
159_K	189_Q	0.538	0.66
42_H	46_K	0.537	0.66
108_L	115_C	0.535	0.66
12_L	202_I	0.535	0.66
16_G	21_V	0.534	0.66
164_R	172_D	0.533	0.66
24_I	113_F	0.532	0.66
91_I	104_L	0.531	0.65
192_S	215_Q	0.529	0.65
8_M	84_Y	0.528	0.65
162_V	200_L	0.528	0.65
9_F	14_G	0.527	0.65
166_R	196_D	0.525	0.65
124_E	151_A	0.524	0.64
17_Y	88_H	0.524	0.64
212_L	220_L	0.524	0.64
172_D	207_A	0.518	0.64
201_C	208_R	0.517	0.63
167_D	201_C	0.515	0.63
21_V	87_R	0.513	0.63
9_F	216_T	0.511	0.62
44_W	120_S	0.510	0.62
37_W	43_T	0.509	0.62
173_E	183_P	0.509	0.62
7_E	11_T	0.508	0.62
73_E	179_T	0.506	0.62
23_A	136_S	0.506	0.62
72_S	103_P	0.500	0.61

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4njhA	2	0.8475	100	0.396	Contact Map
3c8fA	1	0.8475	99.8	0.716	Contact Map
3rfaA	1	0.9013	99.6	0.776	Contact Map
2yx0A	1	0.9148	99.5	0.786	Contact Map
1tv8A	2	0.8655	99.5	0.786	Contact Map
2z2uA	1	0.8296	99.5	0.793	Contact Map
4k36A	1	0.8117	99.4	0.803	Contact Map
2a5hA	4	0.9013	99.3	0.806	Contact Map
2qgqA	1	0.7399	99.1	0.823	Contact Map
3canA	2	0.5785	99.1	0.825	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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