GREMLIN Database
QUEE - 7-carboxy-7-deazaguanine synthase
UniProt: P64554 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13034
Length: 223 (191)
Sequences: 2498 (1665)
Seq/√Len: 120.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_P120_S2.9931.00
91_I100_D2.6471.00
72_S79_I2.5131.00
21_V114_S2.4221.00
156_N184_R2.3581.00
119_T135_V2.2421.00
204_T208_R2.2341.00
172_D208_R2.2261.00
37_W163_G2.1491.00
23_A88_H2.1381.00
73_E107_L2.0761.00
109_E131_T2.0661.00
23_A90_V2.0361.00
72_S76_L2.0351.00
97_C125_V2.0341.00
91_I108_L2.0051.00
187_A211_R1.9491.00
51_E54_L1.9491.00
17_Y187_A1.9471.00
199_R203_E1.9351.00
76_L79_I1.9011.00
8_M75_L1.8751.00
78_V83_G1.8631.00
203_E207_A1.8451.00
18_F88_H1.8281.00
10_Q86_A1.8251.00
163_G191_I1.7941.00
19_T216_T1.7771.00
203_E206_I1.7621.00
21_V211_R1.7591.00
40_T43_T1.7391.00
75_L79_I1.7381.00
28_L91_I1.7271.00
125_V133_V1.6891.00
6_N46_K1.6871.00
8_M24_I1.6671.00
125_V152_L1.6671.00
109_E115_C1.6671.00
72_S75_L1.6581.00
32_P122_T1.6461.00
41_K44_W1.6291.00
214_M219_Y1.6151.00
8_M78_V1.6061.00
74_D77_A1.5801.00
10_Q22_P1.5661.00
106_D110_K1.5561.00
165_V169_E1.5311.00
202_I206_I1.5261.00
215_Q218_K1.5141.00
4_P99_H1.4951.00
24_I79_I1.4891.00
141_M164_R1.4871.00
73_E77_A1.4661.00
32_P98_I1.4641.00
88_H116_Q1.4461.00
173_E177_T1.4441.00
74_D78_V1.4261.00
33_V120_S1.4211.00
88_H114_S1.4011.00
205_C212_L1.3921.00
169_E172_D1.3791.00
189_Q215_Q1.3771.00
168_I172_D1.3691.00
17_Y157_E1.3541.00
173_E176_A1.3441.00
23_A116_Q1.3231.00
201_C204_T1.3081.00
106_D109_E1.3061.00
26_I79_I1.3041.00
28_L101_L1.2941.00
32_P123_H1.2851.00
37_W139_L1.2590.99
119_T133_V1.2510.99
87_R113_F1.2300.99
140_N166_R1.2280.99
199_R202_I1.2280.99
198_T202_I1.1980.99
26_I89_V1.1860.99
82_Q111_N1.1800.99
167_D170_A1.1740.99
17_Y185_V1.1720.99
162_V188_L1.1640.99
73_E111_N1.1600.99
89_V108_L1.1560.99
8_M26_I1.1310.99
90_V116_Q1.1180.99
116_Q134_T1.1180.99
171_L188_L1.1090.99
101_L105_T1.0850.98
91_I101_L1.0830.98
76_L107_L1.0730.98
91_I115_C1.0530.98
21_V88_H1.0530.98
18_F114_S1.0490.98
128_T133_V1.0420.98
3_Y28_L1.0410.98
172_D176_A1.0260.98
141_M163_G1.0240.98
167_D178_L1.0180.98
105_T115_C1.0020.97
75_L78_V0.9990.97
51_E55_F0.9970.97
202_I220_L0.9860.97
34_G44_W0.9810.97
194_K197_A0.9810.97
11_T90_V0.9660.97
109_E130_N0.9640.97
6_N42_H0.9640.97
158_I180_D0.9600.97
5_I28_L0.9550.97
175_L186_I0.9450.96
117_I128_T0.9340.96
26_I91_I0.9280.96
19_T214_M0.9260.96
160_H188_L0.9180.96
189_Q213_S0.9140.96
174_L177_T0.9120.96
200_L204_T0.9080.95
151_A154_R0.9040.95
117_I130_N0.8950.95
202_I205_C0.8890.95
189_Q192_S0.8780.95
13_Q137_P0.8700.94
75_L84_Y0.8670.94
97_C123_H0.8640.94
3_Y104_L0.8630.94
97_C117_I0.8610.94
16_G90_V0.8590.94
88_H117_I0.8570.94
188_L204_T0.8530.94
107_L111_N0.8510.94
105_T128_T0.8470.93
52_V55_F0.8430.93
10_Q206_I0.8400.93
3_Y101_L0.8380.93
6_N29_Q0.8320.93
137_P174_L0.8320.93
18_F134_T0.8300.93
139_L170_A0.8300.93
90_V136_S0.8270.93
166_R169_E0.8260.93
123_H152_L0.8240.92
102_L106_D0.8210.92
155_A183_P0.8100.92
200_L203_E0.8050.92
117_I133_V0.8050.92
102_L127_C0.8030.91
179_T209_N0.8010.91
5_I52_V0.8000.91
125_V135_V0.7980.91
189_Q212_L0.7950.91
48_E51_E0.7940.91
148_L155_A0.7940.91
169_E173_E0.7900.91
135_V152_L0.7880.91
103_P107_L0.7870.91
98_I123_H0.7860.91
161_P191_I0.7830.90
140_N170_A0.7800.90
36_A140_N0.7740.90
100_D103_P0.7740.90
162_V204_T0.7680.90
17_Y134_T0.7680.90
125_V130_N0.7650.89
72_S77_A0.7640.89
26_I75_L0.7620.89
162_V167_D0.7570.89
18_F116_Q0.7560.89
105_T109_E0.7520.89
73_E110_K0.7490.88
19_T213_S0.7480.88
134_T157_E0.7400.88
13_Q116_Q0.7360.87
18_F21_V0.7350.87
168_I204_T0.7280.87
149_S177_T0.7170.86
103_P106_D0.7160.86
29_Q99_H0.7090.85
168_I208_R0.7080.85
89_V115_C0.7080.85
107_L110_K0.7050.85
6_N43_T0.7010.85
186_I209_N0.7010.85
151_A155_A0.6970.84
78_V84_Y0.6920.84
48_E78_V0.6910.84
148_L152_L0.6890.84
33_V122_T0.6860.84
34_G141_M0.6860.84
24_I84_Y0.6840.83
10_Q84_Y0.6810.83
110_K180_D0.6800.83
143_G148_L0.6770.83
8_M74_D0.6750.83
133_V153_E0.6630.81
139_L160_H0.6630.81
90_V213_S0.6590.81
3_Y103_P0.6570.81
192_S218_K0.6570.81
168_I207_A0.6520.80
36_A143_G0.6500.80
72_S107_L0.6500.80
12_L205_C0.6490.80
172_D210_W0.6480.80
72_S104_L0.6430.79
4_P30_G0.6430.79
111_N207_A0.6420.79
204_T207_A0.6410.79
174_L178_L0.6410.79
11_T92_T0.6390.79
167_D171_L0.6340.78
214_M218_K0.6330.78
189_Q218_K0.6310.78
210_W213_S0.6300.78
89_V113_F0.6300.78
83_G86_A0.6290.78
21_V113_F0.6290.78
132_W157_E0.6260.78
30_G104_L0.6260.78
139_L191_I0.6230.77
201_C206_I0.6200.77
44_W47_L0.6140.76
29_Q47_L0.6130.76
151_A156_N0.6100.76
165_V203_E0.6090.76
33_V95_E0.6080.76
29_Q187_A0.6010.75
188_L205_C0.6010.75
28_L99_H0.5980.74
76_L111_N0.5970.74
135_V155_A0.5960.74
77_A110_K0.5930.74
55_F74_D0.5880.73
76_L82_Q0.5850.73
90_V132_W0.5850.73
160_H186_I0.5800.72
167_D177_T0.5770.72
79_I113_F0.5740.71
162_V201_C0.5730.71
23_A92_T0.5720.71
124_E127_C0.5710.71
119_T152_L0.5690.71
82_Q113_F0.5680.71
18_F219_Y0.5650.70
201_C207_A0.5640.70
196_D199_R0.5610.70
95_E120_S0.5600.69
115_C128_T0.5600.69
189_Q202_I0.5590.69
18_F132_W0.5560.69
5_I26_I0.5540.69
201_C205_C0.5530.69
97_C124_E0.5510.68
125_V156_N0.5490.68
165_V200_L0.5430.67
10_Q85_T0.5420.67
90_V134_T0.5400.67
55_F78_V0.5390.67
159_K189_Q0.5380.66
42_H46_K0.5370.66
108_L115_C0.5350.66
12_L202_I0.5350.66
16_G21_V0.5340.66
164_R172_D0.5330.66
24_I113_F0.5320.66
91_I104_L0.5310.65
192_S215_Q0.5290.65
8_M84_Y0.5280.65
162_V200_L0.5280.65
9_F14_G0.5270.65
166_R196_D0.5250.65
124_E151_A0.5240.64
17_Y88_H0.5240.64
212_L220_L0.5240.64
172_D207_A0.5180.64
201_C208_R0.5170.63
167_D201_C0.5150.63
21_V87_R0.5130.63
9_F216_T0.5110.62
44_W120_S0.5100.62
37_W43_T0.5090.62
173_E183_P0.5090.62
7_E11_T0.5080.62
73_E179_T0.5060.62
23_A136_S0.5060.62
72_S103_P0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4njhA 2 0.8475 100 0.396 Contact Map
3c8fA 1 0.8475 99.8 0.716 Contact Map
3rfaA 1 0.9013 99.6 0.776 Contact Map
2yx0A 1 0.9148 99.5 0.786 Contact Map
1tv8A 2 0.8655 99.5 0.786 Contact Map
2z2uA 1 0.8296 99.5 0.793 Contact Map
4k36A 1 0.8117 99.4 0.803 Contact Map
2a5hA 4 0.9013 99.3 0.806 Contact Map
2qgqA 1 0.7399 99.1 0.823 Contact Map
3canA 2 0.5785 99.1 0.825 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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