GREMLIN Database
CBTA - Cytoskeleton-binding toxin CbtA
UniProt: P64524 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13389
Length: 124 (107)
Sequences: 139 (57)
Seq/√Len: 5.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_L12_A4.1570.94
58_S89_I3.0600.76
42_P70_Y2.7630.68
92_I104_M2.5020.60
42_P63_V2.3540.55
5_P15_R2.3350.55
51_Q78_P2.2480.52
28_R46_E2.1910.50
3_T16_P2.0080.43
3_T11_A1.9120.40
79_G85_R1.7900.36
96_R101_T1.7420.35
18_P94_I1.6930.33
2_K13_S1.5880.30
44_A50_E1.5810.30
8_P28_R1.5750.30
19_V65_F1.5460.29
2_K5_P1.5360.29
2_K24_I1.5100.28
46_E71_A1.5000.28
75_T92_I1.4790.27
75_T101_T1.4640.27
22_W43_F1.4600.27
19_V61_D1.4420.26
11_A44_A1.4410.26
14_S19_V1.4170.26
92_I106_R1.3970.25
63_V82_A1.3870.25
27_S44_A1.3800.25
11_A17_S1.3800.25
58_S94_I1.3440.24
45_D60_C1.3060.23
52_H65_F1.3030.23
84_T88_L1.2830.22
61_D81_S1.2790.22
5_P10_Q1.2580.22
15_R27_S1.2270.21
48_V57_I1.2060.20
2_K28_R1.1990.20
4_L7_L1.1940.20
46_E66_L1.1920.20
6_V32_Q1.1850.20
95_L101_T1.1800.20
46_E61_D1.1670.20
32_Q105_T1.1200.19
12_A45_D1.1110.18
22_W59_L1.0670.18
43_F59_L1.0670.18
82_A91_S1.0370.17
73_V86_S1.0360.17
4_L9_G1.0350.17
95_L98_R1.0310.17
77_Q91_S1.0220.17
63_V70_Y1.0210.17
43_F62_A1.0070.16
22_W62_A1.0070.16
12_A31_D1.0010.16
73_V96_R0.9920.16
11_A24_I0.9910.16
3_T10_Q0.9900.16
10_Q13_S0.9630.16
101_T104_M0.9530.15
58_S87_Q0.9490.15
2_K8_P0.9470.15
47_R75_T0.9460.15
18_P21_I0.9290.15
13_S20_E0.9240.15
77_Q85_R0.9180.15
4_L12_A0.9090.15
3_T14_S0.9030.14
10_Q27_S0.8940.14
70_Y84_T0.8830.14
13_S24_I0.8820.14
28_R66_L0.8810.14
17_S37_T0.8630.14
3_T8_P0.8620.14
9_G20_E0.8500.14
23_Q94_I0.8390.13
77_Q87_Q0.8380.13
78_P82_A0.8350.13
6_V9_G0.8160.13
70_Y105_T0.8030.13
6_V21_I0.8000.13
7_L28_R0.7990.13
5_P31_D0.7940.13
9_G13_S0.7910.13
60_C89_I0.7810.13
66_L83_C0.7800.13
32_Q44_A0.7680.12
52_H67_V0.7640.12
31_D107_D0.7620.12
65_F84_T0.7610.12
39_N54_E0.7560.12
2_K6_V0.7510.12
88_L100_A0.7470.12
12_A20_E0.7470.12
1_M5_P0.7470.12
68_E78_P0.7410.12
55_A59_L0.7410.12
83_C88_L0.7400.12
69_K105_T0.7320.12
26_L68_E0.7290.12
98_R101_T0.7290.12
60_C99_R0.7250.12
7_L15_R0.7230.12
82_A92_I0.7120.12
71_A75_T0.6940.11
16_P94_I0.6920.11
80_F85_R0.6910.11
15_R20_E0.6910.11
69_K73_V0.6880.11
100_A103_L0.6780.11
100_A104_M0.6750.11
9_G63_V0.6690.11
7_L44_A0.6630.11
95_L100_A0.6620.11
15_R32_Q0.6580.11
70_Y82_A0.6570.11
7_L20_E0.6550.11
97_A100_A0.6540.11
69_K104_M0.6490.11
71_A78_P0.6470.11
51_Q94_I0.6440.11
42_P89_I0.6380.11
33_H43_F0.6360.11
22_W33_H0.6360.11
5_P12_A0.6340.11
45_D89_I0.6280.10
24_I28_R0.6210.10
70_Y96_R0.6190.10
90_N105_T0.6190.10
69_K106_R0.6170.10
21_I69_K0.6160.10
10_Q16_P0.6060.10
91_S99_R0.6030.10
55_A71_A0.6020.10
63_V107_D0.6000.10
46_E105_T0.5980.10
15_R21_I0.5950.10
7_L10_Q0.5920.10
7_L13_S0.5840.10
63_V66_L0.5810.10
2_K16_P0.5790.10
55_A65_F0.5650.10
45_D63_V0.5630.10
100_A106_R0.5560.10
60_C91_S0.5540.10
57_I98_R0.5520.10
10_Q20_E0.5400.09
59_L62_A0.5380.09
63_V90_N0.5280.09
47_R91_S0.5270.09
32_Q69_K0.5260.09
4_L50_E0.5220.09
57_I69_K0.5220.09
86_S101_T0.5210.09
42_P53_I0.5170.09
17_S21_I0.5050.09
16_P48_V0.5020.09
17_S84_T0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d3lA 1 0.6371 22.5 0.954 Contact Map
4wbdA 2 0.9435 16 0.957 Contact Map
1vejA 1 0.5323 14.4 0.958 Contact Map
3fg1A 4 0.7339 13.6 0.959 Contact Map
1at3A 3 0.6532 12.5 0.959 Contact Map
2knzA 1 0.4194 11.7 0.96 Contact Map
2pbkA 2 0.621 11.2 0.96 Contact Map
3v98A 1 0.7339 11.2 0.96 Contact Map
1o6eA 4 0.621 11.1 0.96 Contact Map
3vf1A 1 0.7339 10.8 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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