GREMLIN Database
YEAK - Uncharacterized protein YeaK
UniProt: P64483 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13497
Length: 167 (147)
Sequences: 5175 (3527)
Seq/√Len: 290.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_E146_I3.2431.00
65_Q120_K2.7101.00
151_D154_R2.6091.00
86_I122_V2.4421.00
19_S25_F2.4061.00
57_K98_E2.3931.00
99_V110_I2.3061.00
148_K151_D2.2421.00
153_L160_L2.2261.00
81_Q162_N2.1831.00
128_F160_L2.1511.00
85_H161_V2.0611.00
37_E41_E2.0271.00
125_P162_N2.0191.00
69_A82_L1.9851.00
58_V88_G1.9721.00
17_L21_E1.9721.00
66_H102_L1.8861.00
26_R146_I1.8521.00
135_A146_I1.8511.00
95_S98_E1.7901.00
28_V146_I1.7381.00
16_A20_Q1.6721.00
21_E155_I1.6651.00
49_Q131_F1.6411.00
125_P129_E1.5581.00
100_D106_V1.5321.00
118_K157_Q1.5301.00
56_C82_L1.5291.00
96_P107_F1.4971.00
55_V119_L1.4731.00
48_G131_F1.4331.00
78_D81_Q1.3991.00
58_V65_Q1.3921.00
67_V82_L1.3921.00
115_F121_L1.3501.00
46_A49_Q1.3411.00
51_A70_I1.3321.00
69_A163_F1.3051.00
153_L158_P1.2991.00
38_A42_I1.2981.00
85_H159_E1.2911.00
26_R133_E1.2851.00
122_V163_F1.2781.00
75_Q126_L1.2681.00
16_A19_S1.2661.00
51_A127_L1.2411.00
56_C77_A1.2391.00
150_A153_L1.2391.00
48_G74_D1.2361.00
128_F150_A1.2101.00
125_P128_F1.2061.00
98_E101_E1.2001.00
27_V143_K1.1901.00
58_V91_A1.1891.00
98_E102_L1.1771.00
57_K92_S1.1711.00
15_I27_V1.1641.00
15_I19_S1.1571.00
12_Q16_A1.1481.00
59_K88_G1.1441.00
23_A155_I1.1381.00
80_S84_S1.1271.00
122_V161_V1.1211.00
38_A41_E1.1201.00
66_H119_L1.1161.00
49_Q146_I1.1091.00
56_C67_V1.0961.00
68_L115_F1.0751.00
60_G88_G1.0681.00
49_Q133_E1.0671.00
120_K159_E1.0431.00
57_K66_H1.0391.00
30_H33_V1.0371.00
127_L160_L1.0341.00
126_L129_E1.0321.00
66_H94_A1.0291.00
28_V135_A1.0271.00
88_G91_A1.0241.00
94_A102_L1.0241.00
54_L77_A1.0211.00
67_V86_I1.0071.00
128_F149_T1.0021.00
127_L134_I1.0021.00
45_T135_A0.9971.00
17_L20_Q0.9871.00
71_L77_A0.9811.00
18_L145_V0.9781.00
32_A35_K0.9741.00
99_V107_F0.9741.00
124_D162_N0.9641.00
132_D148_K0.9621.00
150_A154_R0.9561.00
54_L93_L0.9511.00
138_A144_S0.9401.00
31_E42_I0.9381.00
43_R135_A0.9271.00
32_A38_A0.9261.00
81_Q84_S0.9251.00
136_F152_Y0.9231.00
21_E154_R0.9221.00
29_T143_K0.9151.00
67_V88_G0.9151.00
57_K60_G0.9131.00
58_V67_V0.9091.00
102_L119_L0.9071.00
112_P152_Y0.9011.00
13_R116_H0.9001.00
41_E47_L0.8911.00
55_V99_V0.8841.00
138_A145_V0.8811.00
128_F153_L0.8461.00
24_D151_D0.8381.00
131_F134_I0.8361.00
123_A153_L0.8341.00
123_A127_L0.8331.00
65_Q88_G0.8311.00
147_L151_D0.8291.00
136_F147_L0.8291.00
41_E44_G0.8131.00
32_A36_C0.8131.00
106_V141_L0.8020.99
18_L25_F0.8000.99
37_E47_L0.7960.99
100_D107_F0.7900.99
59_K89_L0.7900.99
70_I121_L0.7850.99
97_A100_D0.7830.99
13_R16_A0.7750.99
33_V38_A0.7710.99
92_S95_S0.7670.99
71_L163_F0.7630.99
122_V159_E0.7550.99
19_S24_D0.7480.99
140_M143_K0.7360.99
45_T50_G0.7360.99
51_A134_I0.7190.99
67_V91_A0.7110.99
55_V110_I0.7110.99
34_G38_A0.7080.99
43_R144_S0.7080.99
123_A160_L0.7010.99
105_C111_P0.7000.99
71_L75_Q0.6990.99
30_H142_D0.6950.99
56_C69_A0.6890.98
58_V86_I0.6880.98
55_V94_A0.6860.98
47_L74_D0.6850.98
82_L91_A0.6730.98
123_A152_Y0.6690.98
113_F156_A0.6670.98
56_C91_A0.6620.98
96_P100_D0.6480.98
53_A68_L0.6470.98
30_H43_R0.6450.98
23_A151_D0.6450.98
68_L119_L0.6440.98
82_L86_I0.6420.98
102_L117_P0.6410.98
24_D148_K0.6400.97
66_H98_E0.6380.97
137_N144_S0.6380.97
33_V42_I0.6360.97
40_S73_A0.6360.97
18_L23_A0.6360.97
39_V144_S0.6340.97
150_A160_L0.6300.97
113_F152_Y0.6250.97
35_K38_A0.6220.97
57_K95_S0.6190.97
14_L145_V0.6140.97
75_Q124_D0.6140.97
51_A126_L0.6110.97
96_P99_V0.6080.97
50_G73_A0.6030.96
37_E74_D0.6020.96
82_L122_V0.6000.96
81_Q85_H0.5970.96
15_I25_F0.5970.96
69_A122_V0.5940.96
115_F119_L0.5900.96
70_I123_A0.5900.96
80_S89_L0.5890.96
56_C93_L0.5860.96
113_F145_V0.5850.96
51_A131_F0.5840.96
23_A147_L0.5770.95
50_G144_S0.5770.95
60_G65_Q0.5770.95
123_A158_P0.5730.95
77_A163_F0.5700.95
46_A131_F0.5660.95
103_T116_H0.5650.95
30_H144_S0.5640.95
58_V89_L0.5630.95
32_A142_D0.5600.95
39_V50_G0.5540.94
33_V36_C0.5470.94
135_A144_S0.5430.94
129_E162_N0.5370.93
105_C114_S0.5330.93
23_A26_R0.5320.93
112_P136_F0.5320.93
45_T146_I0.5290.93
25_F145_V0.5290.93
40_S43_R0.5260.93
70_I136_F0.5260.93
25_F151_D0.5260.93
36_C40_S0.5210.92
104_G116_H0.5200.92
56_C79_L0.5130.92
149_T160_L0.5120.92
29_T140_M0.5080.91
14_L111_P0.5070.91
132_D150_A0.5060.91
49_Q132_D0.5030.91
128_F131_F0.5010.91
39_V73_A0.5010.91
147_L152_Y0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vjfA 1 0.9281 100 0.208 Contact Map
2z0xA 1 0.9281 100 0.21 Contact Map
1dbuA 1 0.8922 100 0.211 Contact Map
1vkiA 2 0.9341 100 0.216 Contact Map
3op6A 2 0.8982 100 0.219 Contact Map
2dxaA 1 0.9222 100 0.22 Contact Map
1wdvA 1 0.8922 100 0.226 Contact Map
3memA 1 0.8323 100 0.376 Contact Map
2j3lA 2 0.9701 97.9 0.803 Contact Map
2kpjA 1 0.5629 47.8 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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