GREMLIN Database
LSRG - Autoinducer 2-degrading protein LsrG
UniProt: P64461 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13811
Length: 96 (84)
Sequences: 422 (308)
Seq/√Len: 33.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_G61_A3.1521.00
56_Y71_Y3.0811.00
59_E63_A2.9121.00
24_Q73_T2.6781.00
14_K17_E2.6571.00
36_L57_K2.2160.99
43_D51_Y2.1030.99
26_H52_I2.0900.98
58_D61_A2.0150.98
25_N70_H1.7100.95
25_N29_S1.6810.94
15_V48_S1.6760.94
22_F52_I1.5920.92
22_F35_N1.5770.92
9_N84_G1.5590.92
32_E70_H1.5220.91
17_E20_E1.4990.90
16_D20_E1.4420.88
21_V77_K1.4380.88
63_A66_K1.4320.88
21_V78_L1.3540.85
76_A79_E1.3270.83
22_F26_H1.3190.83
32_E65_H1.2980.82
52_I74_C1.2670.80
8_I74_C1.2530.80
57_K73_T1.2530.80
66_K71_Y1.2500.79
42_Q50_F1.2320.78
4_T62_V1.2300.78
22_F74_C1.2200.78
15_V42_Q1.2070.77
15_V50_F1.1690.75
13_D81_L1.1630.74
6_V38_F1.1600.74
35_N53_Y1.1590.74
4_T35_N1.1420.73
10_V50_F1.1330.72
64_F67_T1.1190.71
4_T26_H1.1090.71
26_H35_N1.1040.70
53_Y58_D1.0930.70
73_T77_K1.0720.68
7_E51_Y1.0710.68
78_L81_L1.0690.68
6_V52_I1.0630.67
8_I41_L1.0600.67
68_T78_L1.0500.66
82_M86_R1.0100.63
30_V56_Y0.9820.61
35_N62_V0.9820.61
33_E77_K0.9800.61
37_R74_C0.9780.61
28_G69_P0.9280.57
8_I82_M0.9220.56
65_H70_H0.9170.56
29_S66_K0.9150.56
28_G31_Q0.9100.55
29_S32_E0.9050.55
61_A64_F0.8750.52
10_V48_S0.8740.52
26_H40_V0.8460.50
17_E67_T0.8390.49
72_K82_M0.7980.46
47_N80_S0.7960.46
14_K44_P0.7860.45
12_E69_P0.7830.45
28_G40_V0.7830.45
17_E51_Y0.7740.44
23_R27_L0.7730.44
75_V85_P0.7690.43
5_L30_V0.7630.43
16_D19_I0.7540.42
9_N46_V0.7250.40
15_V47_N0.7160.39
22_F25_N0.7150.39
4_T85_P0.7110.39
46_V49_R0.7050.38
33_E45_E0.7030.38
60_D80_S0.6930.37
40_V57_K0.6830.37
3_V35_N0.6770.36
45_E51_Y0.6630.35
12_E33_E0.6570.35
67_T72_K0.6440.34
36_L67_T0.6380.33
35_N56_Y0.6310.33
14_K81_L0.6270.32
7_E14_K0.6260.32
60_D63_A0.6240.32
7_E49_R0.6230.32
19_I38_F0.6210.32
6_V53_Y0.6200.32
26_H50_F0.6090.31
22_F85_P0.6010.30
60_D73_T0.5960.30
9_N45_E0.5940.30
9_N43_D0.5840.29
52_I85_P0.5820.29
32_E78_L0.5780.29
51_Y67_T0.5660.28
35_N38_F0.5640.28
41_L50_F0.5630.28
31_Q49_R0.5620.28
42_Q49_R0.5610.28
56_Y74_C0.5570.27
19_I42_Q0.5550.27
6_V25_N0.5530.27
78_L82_M0.5510.27
8_I37_R0.5500.27
67_T76_A0.5480.27
6_V35_N0.5440.26
17_E79_E0.5430.26
38_F52_I0.5300.26
33_E64_F0.5260.25
81_L84_G0.5250.25
35_N39_D0.5250.25
44_P57_K0.5190.25
41_L71_Y0.5180.25
74_C78_L0.5160.25
45_E60_D0.5160.25
31_Q42_Q0.5130.25
50_F74_C0.5120.24
83_T86_R0.5100.24
8_I11_H0.5050.24
71_Y82_M0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2omoA 2 1 99.8 0.345 Contact Map
3mcsA 1 0.9896 99.7 0.376 Contact Map
2gffA 2 1 99.7 0.379 Contact Map
3f44A 1 1 99.7 0.381 Contact Map
3kkfA 3 0.9896 99.7 0.387 Contact Map
4zosA 2 1 99.7 0.395 Contact Map
3gz7A 2 0.9896 99.7 0.397 Contact Map
1tuvA 2 0.9688 99.7 0.398 Contact Map
3e8oA 2 1 99.7 0.398 Contact Map
2pd1A 5 0.9792 99.7 0.402 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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