GREMLIN Database
YDDW - UPF0748 lipoprotein YddW
UniProt: P64426 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13794
Length: 439 (354)
Sequences: 1549 (1108)
Seq/√Len: 58.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
206_D252_T4.4481.00
148_E151_K4.3641.00
337_A414_I4.0561.00
91_M145_M3.9611.00
160_F223_V3.7081.00
213_Q277_K3.5111.00
228_P286_K3.3881.00
96_D152_R3.3831.00
250_N263_K3.2351.00
108_F156_V3.0221.00
107_F231_G2.9701.00
351_Y404_N2.9351.00
214_D218_S2.8231.00
269_N273_Q2.8121.00
56_M105_T2.7801.00
143_Q147_D2.7221.00
145_M156_V2.7021.00
92_I144_F2.6161.00
326_R330_Q2.6051.00
55_P405_D2.5861.00
275_I293_V2.5591.00
56_M107_F2.4401.00
222_E226_R2.4071.00
91_M156_V2.3841.00
276_A280_H2.3691.00
95_L106_V2.3331.00
214_D277_K2.3301.00
71_P90_A2.3031.00
163_Y274_L2.2781.00
108_F145_M2.2681.00
234_F278_V2.2331.00
221_A285_I2.2321.00
98_L103_I2.2291.00
213_Q273_Q2.2021.00
272_Q332_L2.1611.00
91_M108_F2.1211.00
221_A281_T2.0941.00
98_L154_M2.0491.00
150_H230_D2.0251.00
269_N272_Q2.0161.00
99_Q154_M2.0051.00
197_R247_L1.9701.00
304_H315_A1.9581.00
163_Y271_T1.9461.00
144_F148_E1.9251.00
340_I355_A1.9071.00
122_I218_S1.9041.00
59_I98_L1.8951.00
225_S285_I1.8821.00
424_P430_V1.8671.00
58_G107_F1.8581.00
224_V289_V1.8471.00
87_Q139_Y1.8381.00
132_K135_E1.8301.00
272_Q326_R1.7940.99
279_S283_K1.7870.99
373_I413_T1.7850.99
344_F403_L1.7800.99
290_E368_R1.7670.99
340_I354_L1.7420.99
67_L417_R1.7400.99
224_V282_I1.7310.99
356_K403_L1.6930.99
142_L156_V1.6490.99
92_I148_E1.6430.99
223_V232_V1.6390.99
155_K290_E1.5970.99
114_G205_L1.5960.99
404_N413_T1.5920.99
362_V367_T1.5840.99
297_G342_W1.5780.99
123_L222_E1.5780.99
58_G414_I1.5720.99
356_K360_D1.5700.99
292_G335_Y1.5380.98
229_V232_V1.5370.98
69_W87_Q1.5180.98
276_A332_L1.5140.98
241_E296_A1.5120.98
84_A88_Q1.5020.98
276_A330_Q1.4880.98
249_D256_Y1.4850.98
149_A156_V1.4820.98
300_R318_D1.4810.98
316_A324_T1.4670.98
401_L405_D1.4480.97
209_I212_V1.4480.97
95_L145_M1.4430.97
107_F414_I1.4410.97
233_Q372_G1.4350.97
221_A225_S1.4330.97
250_N254_R1.4210.97
236_D339_Q1.4150.97
257_G260_F1.4140.97
95_L152_R1.3910.97
121_K143_Q1.3850.97
344_F350_R1.3680.96
356_K407_V1.3630.96
286_K289_V1.3600.96
197_R206_D1.3480.96
208_G252_T1.3340.96
121_K226_R1.3030.95
105_T155_K1.2960.95
85_R88_Q1.2950.95
210_P214_D1.2910.95
192_H195_W1.2830.95
65_S167_V1.2830.95
89_Q93_D1.2810.95
427_Q430_V1.2740.95
223_V229_V1.2680.94
139_Y144_F1.2650.94
217_T281_T1.2610.94
217_T278_V1.2580.94
345_S350_R1.2580.94
355_A407_V1.2500.94
148_E152_R1.2440.94
94_K418_E1.2340.94
118_W223_V1.2310.94
88_Q144_F1.2250.93
61_L94_K1.2200.93
231_G293_V1.2200.93
183_Q186_A1.2180.93
97_H100_R1.2160.93
180_T186_A1.2120.93
206_D419_D1.2060.93
143_Q146_L1.1970.93
238_F339_Q1.1930.92
279_S291_F1.1830.92
106_V154_M1.1810.92
369_L410_I1.1730.92
83_R86_V1.1610.91
265_D321_Y1.1590.91
123_L219_I1.1590.91
262_S265_D1.1460.91
251_E255_K1.1370.91
91_M149_A1.1260.90
277_K281_T1.1230.90
160_F232_V1.1200.90
237_Y339_Q1.1180.90
315_A318_D1.1180.90
266_W270_N1.1110.90
162_P237_Y1.1090.89
146_L154_M1.1070.89
103_I154_M1.1050.89
217_T274_L1.0990.89
120_S222_E1.0960.89
293_V333_L1.0920.89
314_A377_K1.0910.89
97_H422_N1.0890.89
217_T277_K1.0890.89
252_T263_K1.0800.88
110_V223_V1.0750.88
268_R323_D1.0740.88
324_T336_I1.0690.88
218_S281_T1.0600.87
325_R329_E1.0480.87
325_R361_V1.0360.86
268_R317_Y1.0350.86
110_V158_A1.0320.86
279_S331_G1.0290.86
220_V232_V1.0260.85
195_W212_V1.0160.85
231_G414_I1.0140.85
253_Y261_A1.0120.85
220_V278_V1.0110.85
125_W137_P1.0100.84
210_P213_Q1.0080.84
160_F221_A1.0060.84
271_T316_A0.9960.84
260_F269_N0.9950.84
352_D403_L0.9930.83
359_A409_E0.9920.83
362_V369_L0.9920.83
326_R332_L0.9810.83
58_G313_G0.9810.83
111_K123_L0.9800.83
355_A410_I0.9760.82
314_A319_E0.9750.82
85_R89_Q0.9740.82
61_L106_V0.9690.82
329_E365_T0.9670.82
206_D209_I0.9650.82
205_L212_V0.9630.82
298_V314_A0.9620.81
210_P256_Y0.9530.81
161_N164_R0.9450.80
307_L361_V0.9410.80
279_S332_L0.9410.80
220_V234_F0.9410.80
375_F415_L0.9390.80
180_T183_Q0.9350.80
208_G266_W0.9340.80
236_D295_P0.9300.79
149_A154_M0.9260.79
316_A320_S0.9260.79
328_V362_V0.9240.79
164_R236_D0.9200.78
299_W357_W0.9180.78
219_I222_E0.9140.78
161_N236_D0.9120.78
197_R252_T0.9080.78
251_E254_R0.9050.77
229_V286_K0.9020.77
153_G290_E0.8970.77
316_A322_A0.8930.76
343_P346_R0.8930.76
265_D268_R0.8920.76
417_R420_Y0.8920.76
164_R238_F0.8900.76
344_F352_D0.8890.76
147_D151_K0.8840.76
424_P427_Q0.8840.76
228_P288_G0.8810.75
162_P238_F0.8800.75
295_P339_Q0.8790.75
98_L418_E0.8780.75
108_F117_L0.8770.75
63_T117_L0.8760.75
234_F291_F0.8750.75
88_Q147_D0.8690.74
198_T203_F0.8650.74
301_N311_T0.8590.74
298_V319_E0.8590.74
373_I404_N0.8560.73
70_P87_Q0.8510.73
114_G165_V0.8480.73
55_P401_L0.8450.72
142_L223_V0.8420.72
221_A232_V0.8390.72
164_R339_Q0.8380.72
181_L184_Q0.8380.72
281_T285_I0.8360.71
260_F263_K0.8230.70
166_S203_F0.8190.70
428_Q432_Y0.8160.70
211_E255_K0.8130.69
304_H307_L0.8120.69
167_V202_R0.8120.69
209_I252_T0.8080.69
144_F151_K0.8060.69
113_D165_V0.8020.68
238_F322_A0.7980.68
161_N339_Q0.7960.68
114_G204_V0.7960.68
198_T201_D0.7910.67
249_D270_N0.7900.67
180_T184_Q0.7890.67
162_P236_D0.7860.67
224_V229_V0.7840.67
397_L401_L0.7830.66
162_P339_Q0.7810.66
131_G134_G0.7760.66
70_P90_A0.7750.66
208_G270_N0.7750.66
424_P428_Q0.7750.66
97_H101_L0.7730.65
298_V354_L0.7730.65
146_L156_V0.7720.65
261_A269_N0.7710.65
342_W354_L0.7700.65
218_S221_A0.7690.65
208_G256_Y0.7670.65
68_D416_F0.7650.65
161_N237_Y0.7630.64
269_N280_H0.7620.64
296_A354_L0.7560.64
93_D97_H0.7530.63
164_R237_Y0.7520.63
221_A284_S0.7500.63
205_L215_W0.7500.63
224_V281_T0.7460.63
273_Q276_A0.7440.62
376_Y416_F0.7430.62
402_D406_A0.7390.62
119_P416_F0.7390.62
282_I289_V0.7390.62
196_I203_F0.7390.62
62_A67_L0.7380.62
67_L167_V0.7360.62
353_V356_K0.7360.62
125_W134_G0.7360.62
54_Q288_G0.7340.61
244_G417_R0.7330.61
121_K222_E0.7320.61
429_A432_Y0.7310.61
298_V312_R0.7300.61
228_P289_V0.7260.61
99_Q153_G0.7240.60
278_V282_I0.7220.60
359_A410_I0.7200.60
328_V367_T0.7190.60
229_V289_V0.7170.60
258_G261_A0.7160.60
274_L278_V0.7100.59
280_H284_S0.7070.59
119_P222_E0.7060.58
191_Q195_W0.7030.58
186_A189_Y0.7030.58
300_R305_D0.7020.58
61_L108_F0.7000.58
279_S334_D0.7000.58
59_I421_L0.6990.58
312_R348_A0.6990.58
205_L418_E0.6990.58
399_K402_D0.6980.58
355_A403_L0.6980.58
103_I415_L0.6970.57
322_A339_Q0.6970.57
282_I291_F0.6950.57
340_I371_I0.6940.57
110_V160_F0.6940.57
157_H233_Q0.6930.57
343_P350_R0.6920.57
377_K380_E0.6910.57
242_S314_A0.6840.56
231_G289_V0.6840.56
63_T66_R0.6820.56
206_D271_T0.6800.56
111_K115_T0.6760.55
161_N292_G0.6760.55
294_S339_Q0.6740.55
217_T284_S0.6740.55
97_H418_E0.6720.55
204_V240_T0.6720.55
159_W327_W0.6720.55
68_D400_Q0.6700.54
157_H335_Y0.6700.54
88_Q148_E0.6700.54
196_I205_L0.6670.54
359_A373_I0.6660.54
195_W209_I0.6660.54
62_A68_D0.6640.54
160_F219_I0.6640.54
335_Y370_Y0.6630.54
301_N349_A0.6620.54
52_S405_D0.6610.53
122_I214_D0.6510.52
287_P403_L0.6510.52
249_D263_K0.6510.52
404_N414_I0.6480.52
60_W372_G0.6480.52
375_F420_Y0.6480.52
161_N238_F0.6470.52
120_S223_V0.6470.52
247_L263_K0.6470.52
238_F295_P0.6470.52
55_P104_N0.6460.52
56_M370_Y0.6460.52
84_A138_G0.6450.52
166_S170_K0.6440.52
166_S371_I0.6440.52
395_P399_K0.6440.52
316_A319_E0.6440.52
373_I400_Q0.6410.51
114_G123_L0.6410.51
374_A377_K0.6380.51
377_K383_K0.6380.51
109_Q237_Y0.6370.51
94_K97_H0.6330.50
183_Q189_Y0.6330.50
68_D419_D0.6330.50
249_D252_T0.6330.50
241_E320_S0.6310.50
67_L420_Y0.6310.50
236_D294_S0.6300.50
312_R421_L0.6300.50
69_W139_Y0.6280.50
168_N201_D0.6270.50
191_Q198_T0.6250.49
117_L128_L0.6210.49
122_I219_I0.6190.49
142_L229_V0.6180.49
184_Q189_Y0.6170.49
68_D417_R0.6170.49
224_V286_K0.6170.49
371_I404_N0.6160.48
212_V416_F0.6160.48
101_L429_A0.6150.48
374_A416_F0.6140.48
297_G354_L0.6140.48
224_V232_V0.6130.48
160_F220_V0.6120.48
105_T157_H0.6120.48
396_E400_Q0.6110.48
99_Q102_G0.6100.48
420_Y425_Q0.6100.48
146_L228_P0.6090.48
63_T112_P0.6040.47
311_T349_A0.6010.47
62_A416_F0.5990.47
86_V89_Q0.5980.46
212_V216_I0.5970.46
212_V274_L0.5970.46
113_D202_R0.5960.46
238_F293_V0.5930.46
191_Q218_S0.5920.46
204_V415_L0.5920.46
135_E360_D0.5920.46
63_T71_P0.5920.46
258_G269_N0.5900.46
237_Y322_A0.5890.46
105_T414_I0.5890.46
139_Y417_R0.5880.45
281_T284_S0.5870.45
152_R230_D0.5860.45
131_G321_Y0.5860.45
221_A224_V0.5850.45
236_D322_A0.5840.45
323_D327_W0.5830.45
154_M180_T0.5830.45
305_D311_T0.5820.45
189_Y196_I0.5820.45
292_G354_L0.5820.45
264_A321_Y0.5820.45
55_P413_T0.5800.45
92_I151_K0.5800.45
101_L421_L0.5800.45
308_G311_T0.5800.45
296_A342_W0.5790.44
379_G426_T0.5770.44
89_Q92_I0.5760.44
359_A408_P0.5750.44
146_L430_V0.5750.44
95_L149_A0.5730.44
99_Q152_R0.5720.44
91_M205_L0.5720.44
213_Q274_L0.5720.44
428_Q433_L0.5710.44
301_N305_D0.5700.43
346_R353_V0.5680.43
57_R405_D0.5670.43
105_T337_A0.5670.43
253_Y263_K0.5670.43
253_Y256_Y0.5670.43
54_Q154_M0.5660.43
284_S287_P0.5660.43
378_V426_T0.5650.43
314_A320_S0.5630.43
206_D246_R0.5590.42
350_R373_I0.5590.42
298_V313_G0.5590.42
68_D87_Q0.5590.42
125_W130_T0.5580.42
155_K288_G0.5570.42
106_V152_R0.5570.42
199_S248_N0.5560.42
210_P255_K0.5550.42
127_D168_N0.5550.42
162_P295_P0.5540.42
62_A109_Q0.5540.42
206_D248_N0.5530.42
430_V433_L0.5520.41
51_Q276_A0.5500.41
61_L107_F0.5490.41
92_I99_Q0.5480.41
118_W222_E0.5470.41
94_K422_N0.5460.41
355_A359_A0.5450.41
160_F278_V0.5450.41
298_V349_A0.5430.40
116_A162_P0.5420.40
201_D284_S0.5410.40
157_H372_G0.5410.40
96_D146_L0.5400.40
119_P143_Q0.5390.40
282_I286_K0.5350.40
69_W417_R0.5350.40
292_G337_A0.5340.40
123_L215_W0.5330.39
221_A257_G0.5330.39
223_V281_T0.5310.39
379_G425_Q0.5300.39
234_F293_V0.5300.39
87_Q123_L0.5290.39
163_Y217_T0.5280.39
239_Y358_W0.5280.39
282_I333_L0.5270.39
64_V340_I0.5260.39
265_D269_N0.5260.39
116_A126_S0.5260.39
103_I216_I0.5250.39
62_A65_S0.5240.38
427_Q431_S0.5230.38
142_L227_Y0.5230.38
331_G367_T0.5210.38
343_P383_K0.5210.38
236_D293_V0.5200.38
261_A265_D0.5200.38
374_A417_R0.5190.38
217_T223_V0.5180.38
95_L146_L0.5170.38
61_L145_M0.5170.38
109_Q134_G0.5170.38
338_P360_D0.5170.38
111_K297_G0.5160.38
51_Q251_E0.5160.38
134_G137_P0.5150.38
138_G222_E0.5150.38
106_V114_G0.5150.38
179_S186_A0.5150.38
297_G340_I0.5150.38
181_L185_P0.5150.38
87_Q90_A0.5140.37
103_I288_G0.5140.37
151_K356_K0.5140.37
374_A400_Q0.5140.37
237_Y295_P0.5140.37
374_A420_Y0.5130.37
59_I418_E0.5130.37
256_Y270_N0.5120.37
159_W339_Q0.5110.37
368_R411_S0.5090.37
127_D133_I0.5090.37
100_R433_L0.5080.37
333_L409_E0.5080.37
119_P280_H0.5080.37
167_V216_I0.5080.37
63_T67_L0.5070.37
272_Q323_D0.5060.37
243_P319_E0.5060.37
164_R322_A0.5060.37
265_D272_Q0.5060.37
111_K164_R0.5040.36
59_I416_F0.5030.36
68_D374_A0.5030.36
301_N313_G0.5030.36
99_Q209_I0.5010.36
362_V365_T0.5010.36
95_L156_V0.5010.36
66_R69_W0.5000.36
207_P239_Y0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p7oA 1 0.7289 100 0.535 Contact Map
4f9dA 1 0.7882 100 0.612 Contact Map
3vmnA 1 0.8633 100 0.645 Contact Map
3wnoA 2 0.8041 100 0.649 Contact Map
4h41A 3 0.7039 100 0.66 Contact Map
4s1aA 2 0.4282 100 0.701 Contact Map
3mi6A 4 0.8656 99.7 0.866 Contact Map
4uozA 3 0.738 99.6 0.871 Contact Map
2yfoA 4 0.861 99.6 0.872 Contact Map
2xn2A 4 0.8337 99.6 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0109 seconds.