GREMLIN Database
ZNTB - Zinc transport protein ZntB
UniProt: P64423 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13356
Length: 327 (292)
Sequences: 5384 (3749)
Seq/√Len: 219.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
292_G298_G9.4931.00
112_D115_L4.1391.00
296_G303_F4.0751.00
307_C311_V3.3381.00
304_S308_I3.0531.00
66_V110_Y2.9981.00
305_I309_L2.7841.00
286_L307_C2.7631.00
42_W118_S2.7581.00
301_F305_I2.6391.00
109_V116_I2.5101.00
44_H120_R2.4961.00
90_L151_C2.4501.00
175_N186_F2.4481.00
302_G306_F2.4311.00
319_L323_R2.4181.00
315_G319_L2.4171.00
54_Q58_T2.4091.00
301_F304_S2.4061.00
277_F282_F2.3081.00
291_L297_G2.2681.00
60_P117_V2.2461.00
57_A67_R2.2371.00
168_K186_F2.2311.00
283_L306_F2.2231.00
294_I303_F2.2101.00
109_V118_S2.1831.00
282_F286_L2.1761.00
293_G300_Q2.1691.00
294_I297_G2.1691.00
299_W305_I2.1681.00
45_L56_L2.1231.00
155_T230_I1.9961.00
300_Q304_S1.9491.00
156_D233_R1.9431.00
264_A267_T1.9011.00
116_I146_W1.8971.00
299_W302_G1.8421.00
66_V85_G1.8111.00
286_L310_L1.7711.00
304_S307_C1.7481.00
291_L294_I1.7361.00
49_H52_S1.7231.00
287_F294_I1.7141.00
116_I147_L1.6881.00
198_R242_D1.6711.00
88_I147_L1.6561.00
316_G320_W1.6221.00
287_F303_F1.5941.00
66_V82_L1.5881.00
78_R232_D1.5851.00
70_L110_Y1.5811.00
306_F310_L1.5721.00
287_F297_G1.5541.00
274_A278_L1.5431.00
93_I197_M1.5321.00
303_F307_C1.4941.00
289_V306_F1.4871.00
176_L251_M1.4831.00
75_T89_T1.4591.00
268_Y272_L1.4531.00
51_D54_Q1.4421.00
152_D233_R1.4361.00
62_L110_Y1.4321.00
287_F296_G1.4141.00
152_D156_D1.4091.00
169_I248_T1.3831.00
307_C310_L1.3801.00
306_F309_L1.3691.00
283_L287_F1.3501.00
69_A78_R1.3411.00
65_N68_D1.3341.00
296_G299_W1.3281.00
75_T106_A1.3281.00
111_M147_L1.3271.00
291_L303_F1.3261.00
318_A322_H1.3151.00
294_I304_S1.3131.00
88_I109_V1.3131.00
63_P82_L1.3121.00
116_I143_C1.3101.00
107_M154_L1.3011.00
297_G303_F1.2911.00
291_L302_G1.2861.00
148_V227_M1.2841.00
293_G304_S1.2841.00
278_L282_F1.2671.00
299_W303_F1.2581.00
50_H54_Q1.2411.00
87_L110_Y1.2381.00
62_L117_V1.2251.00
280_S310_L1.2151.00
40_P143_C1.2091.00
54_Q57_A1.1951.00
279_P282_F1.1911.00
40_P146_W1.1861.00
142_D145_G1.1841.00
320_W324_S1.1801.00
155_T233_R1.1741.00
265_R268_Y1.1721.00
200_Y204_Q1.1661.00
231_A235_G1.1631.00
209_A231_A1.1581.00
165_L190_L1.1551.00
212_A228_Q1.1541.00
133_D149_D1.1531.00
277_F280_S1.1461.00
48_V52_S1.1421.00
130_V153_A1.1411.00
317_V321_L1.1401.00
191_R253_D1.1361.00
34_V37_E1.1351.00
260_Q263_L1.1311.00
266_R271_S1.1251.00
191_R245_I1.1241.00
130_V146_W1.1211.00
229_D232_D1.1131.00
280_S283_L1.1111.00
271_S274_A1.1021.00
314_I318_A1.0981.00
312_V316_G1.0911.00
81_R86_T1.0911.00
205_R235_G1.0861.00
267_T274_A1.0831.00
284_T307_C1.0831.00
308_I312_V1.0711.00
280_S306_F1.0631.00
81_R214_E1.0541.00
291_L306_F1.0541.00
296_G304_S1.0531.00
208_Y234_L1.0471.00
68_D156_D1.0461.00
155_T234_L1.0451.00
184_R255_I1.0421.00
46_N123_K1.0411.00
305_I308_I1.0341.00
302_G305_I1.0291.00
55_W59_T1.0291.00
286_L289_V1.0251.00
271_S278_L1.0221.00
290_N295_P1.0151.00
291_L296_G1.0131.00
266_R270_M1.0131.00
286_L303_F1.0121.00
75_T229_D1.0121.00
194_L244_C1.0081.00
76_R239_D1.0071.00
259_M263_L1.0061.00
131_V135_E0.9981.00
109_V147_L0.9931.00
173_E192_K0.9921.00
287_F299_W0.9861.00
191_R252_A0.9811.00
295_P302_G0.9811.00
127_L150_V0.9741.00
51_D55_W0.9741.00
70_L108_R0.9721.00
169_I244_C0.9701.00
194_L248_T0.9681.00
76_R203_P0.9651.00
168_K193_Q0.9651.00
202_A239_D0.9601.00
188_A252_A0.9591.00
132_S135_E0.9531.00
205_R242_D0.9431.00
61_L64_N0.9431.00
132_S136_E0.9411.00
287_F321_L0.9401.00
129_D153_A0.9361.00
235_G239_D0.9190.99
79_V88_I0.9170.99
73_E121_Q0.9140.99
36_D39_H0.9140.99
220_S223_Q0.9090.99
287_F306_F0.9090.99
69_A229_D0.9090.99
284_T303_F0.9010.99
159_S237_G0.8940.99
287_F290_N0.8920.99
296_G302_G0.8910.99
114_R143_C0.8890.99
94_N103_Q0.8890.99
287_F295_P0.8870.99
281_T285_G0.8860.99
89_T108_R0.8820.99
195_I247_R0.8810.99
311_V315_G0.8770.99
63_P66_V0.8740.99
162_I165_L0.8730.99
55_W58_T0.8720.99
274_A277_F0.8650.99
166_H244_C0.8650.99
91_R106_A0.8620.99
175_N183_P0.8580.99
53_A57_A0.8570.99
275_M278_L0.8560.99
69_A233_R0.8550.99
92_C124_V0.8520.99
190_L248_T0.8500.99
281_T286_L0.8490.99
47_Y121_Q0.8460.99
254_E268_Y0.8400.99
282_F310_L0.8390.99
88_I111_M0.8370.99
262_N271_S0.8330.99
294_I302_G0.8300.99
107_M127_L0.8270.99
294_I299_W0.8240.99
260_Q267_T0.8210.99
273_M279_P0.8170.99
242_D246_A0.8140.99
80_S228_Q0.8100.99
177_L258_V0.8070.99
133_D153_A0.8050.99
38_A41_C0.7960.98
141_T222_D0.7960.98
258_V261_E0.7960.98
105_V120_R0.7960.98
294_I306_F0.7930.98
68_D152_D0.7910.98
293_G298_G0.7910.98
280_S314_I0.7840.98
296_G307_C0.7840.98
272_L279_P0.7830.98
215_R219_M0.7820.98
35_I38_A0.7810.98
275_M280_S0.7800.98
249_G253_D0.7800.98
261_E268_Y0.7750.98
201_M237_G0.7740.98
265_R278_L0.7690.98
65_N80_S0.7660.98
44_H118_S0.7630.98
130_V149_D0.7630.98
104_L196_V0.7600.98
260_Q264_A0.7560.98
310_L314_I0.7560.98
250_V253_D0.7530.98
293_G299_W0.7530.98
279_P313_L0.7460.98
289_V294_I0.7440.98
293_G303_F0.7380.97
63_P69_A0.7310.97
128_D132_S0.7280.97
283_L310_L0.7280.97
39_H114_R0.7270.97
69_A232_D0.7270.97
48_V120_R0.7270.97
302_G309_L0.7240.97
188_A254_E0.7230.97
276_V314_I0.7200.97
65_N226_R0.7180.97
142_D223_Q0.7170.97
303_F306_F0.7160.97
45_L119_T0.7130.97
280_S313_L0.7100.97
281_T306_F0.7070.97
79_V207_V0.7070.97
287_F291_L0.7040.97
280_S284_T0.7030.97
316_G319_L0.6970.96
96_S101_P0.6970.96
90_L154_L0.6950.96
201_M238_L0.6950.96
44_H131_V0.6940.96
205_R209_A0.6900.96
102_D193_Q0.6900.96
293_G296_G0.6880.96
63_P85_G0.6840.96
293_G302_G0.6830.96
148_V229_D0.6830.96
286_L294_I0.6830.96
63_P226_R0.6820.96
65_N69_A0.6810.96
145_G226_R0.6810.96
88_I207_V0.6790.96
95_G98_D0.6790.96
76_R156_D0.6770.96
35_I39_H0.6770.96
309_L313_L0.6760.96
262_N266_R0.6710.96
168_K171_D0.6690.95
144_G223_Q0.6690.95
240_E244_C0.6690.95
297_G307_C0.6660.95
263_L267_T0.6650.95
267_T285_G0.6600.95
90_L109_V0.6560.95
141_T145_G0.6510.95
289_V310_L0.6510.95
120_R131_V0.6500.95
269_T273_M0.6490.95
86_T111_M0.6460.95
299_W304_S0.6460.95
245_I253_D0.6450.95
70_L85_G0.6420.94
277_F284_T0.6400.94
239_D245_I0.6400.94
296_G305_I0.6320.94
319_L322_H0.6320.94
96_S103_Q0.6320.94
287_F293_G0.6310.94
187_L199_R0.6290.94
273_M317_V0.6260.94
92_C125_L0.6260.94
284_T310_L0.6260.94
46_N120_R0.6250.94
69_A80_S0.6230.93
204_Q236_R0.6220.93
269_T320_W0.6210.93
300_Q319_L0.6190.93
262_N265_R0.6180.93
231_A234_L0.6160.93
282_F285_G0.6130.93
178_D181_I0.6130.93
36_D114_R0.6120.93
308_I315_G0.6100.93
175_N181_I0.6100.93
221_D224_R0.6070.93
92_C105_V0.6070.93
202_A238_L0.6060.92
205_R238_L0.6060.92
128_D186_F0.6060.92
91_R104_L0.6060.92
48_V119_T0.6050.92
284_T289_V0.6050.92
263_L266_R0.6030.92
164_Q168_K0.6030.92
283_L313_L0.6020.92
58_T61_L0.6020.92
118_S150_V0.6020.92
276_V280_S0.6000.92
67_R70_L0.5990.92
46_N122_R0.5970.92
183_P187_L0.5940.92
34_V38_A0.5930.92
195_I224_R0.5930.92
322_H325_K0.5930.92
194_L241_I0.5920.92
140_P145_G0.5920.92
209_A235_G0.5920.92
151_C230_I0.5910.92
50_H315_G0.5910.92
152_D155_T0.5900.91
65_N82_L0.5900.91
43_L117_V0.5870.91
64_N68_D0.5850.91
268_Y306_F0.5830.91
92_C107_M0.5820.91
269_T277_F0.5810.91
246_A250_V0.5800.91
319_L325_K0.5770.91
205_R231_A0.5750.90
79_V86_T0.5730.90
106_A121_Q0.5720.90
296_G301_F0.5700.90
72_G233_R0.5690.90
137_G311_V0.5670.90
275_M279_P0.5670.90
148_V223_Q0.5660.90
320_W325_K0.5660.90
118_S127_L0.5660.90
170_I199_R0.5640.90
291_L299_W0.5640.90
51_D315_G0.5630.89
272_L318_A0.5620.89
282_F314_I0.5620.89
87_L91_R0.5610.89
227_M286_L0.5610.89
160_E237_G0.5610.89
152_D226_R0.5610.89
276_V318_A0.5590.89
177_L185_G0.5570.89
301_F307_C0.5570.89
263_L268_Y0.5560.89
185_G258_V0.5540.89
198_R205_R0.5530.89
289_V297_G0.5530.89
94_N97_T0.5530.89
65_N78_R0.5520.89
253_D256_A0.5520.89
112_D143_C0.5500.88
212_A224_R0.5500.88
158_S237_G0.5480.88
98_D171_D0.5480.88
65_N230_I0.5480.88
230_I233_R0.5460.88
192_K247_R0.5450.88
159_S236_R0.5450.88
158_S200_Y0.5450.88
146_W150_V0.5440.88
95_G102_D0.5430.88
148_V230_I0.5420.88
53_A71_A0.5410.88
34_V39_H0.5410.88
148_V226_R0.5410.88
70_L119_T0.5400.87
36_D201_M0.5390.87
246_A251_M0.5380.87
95_G103_Q0.5370.87
144_G218_W0.5360.87
188_A192_K0.5360.87
45_L52_S0.5360.87
269_T295_P0.5350.87
98_D165_L0.5340.87
293_G297_G0.5330.87
82_L232_D0.5290.86
68_D78_R0.5290.86
91_R200_Y0.5290.86
201_M241_I0.5280.86
36_D55_W0.5280.86
173_E251_M0.5280.86
83_G118_S0.5270.86
184_R200_Y0.5230.86
219_M223_Q0.5210.86
53_A119_T0.5210.86
311_V314_I0.5200.85
249_G252_A0.5200.85
124_V127_L0.5170.85
83_G132_S0.5150.85
282_F317_V0.5150.85
92_C126_A0.5140.85
130_V150_V0.5130.85
140_P222_D0.5120.85
76_R235_G0.5110.84
271_S280_S0.5100.84
159_S233_R0.5090.84
288_G294_I0.5080.84
52_S127_L0.5070.84
284_T321_L0.5060.84
92_C120_R0.5030.84
274_A282_F0.5030.84
206_D209_A0.5030.84
249_G254_E0.5030.84
272_L278_L0.5020.83
79_V214_E0.5010.83
285_G288_G0.5000.83
130_V133_D0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i0uA 4 0.9878 100 0.148 Contact Map
4ev6A 3 0.948 100 0.167 Contact Map
3nvoA 2 0.7706 100 0.487 Contact Map
4egwA 1 0.7431 100 0.49 Contact Map
3ck6A 3 0.7462 100 0.497 Contact Map
2bbhA 2 0.6239 100 0.557 Contact Map
2hn1A 2 0.7064 100 0.565 Contact Map
3rkgA 1 0.6789 88.9 0.93 Contact Map
4aurA 1 0.9664 32.9 0.954 Contact Map
4jo7E 2 0.2722 18.8 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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