ZNTB - ECOLI - GREMLIN Contacts

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ZNTB - Zinc transport protein ZntB

UniProt:	P64423	Sequences: MEAIKGSDVNVPDAVFAWMLDGRGGVKPLENTDVIDEAHPCWLHLNYVHHDSAQWLATTPLLPNNVRDALAGESTRPRVSRLGEGTLITLRCINGSTDERPDQLVAMRVYMDGRLIVSTRQRKVLALDDVVSDLEEGTGPTDCGGWLVDVCDALTDHSSEFIEQLHDKIIDLEDNLLDQQIPPRGFLALLRKQLIVMRRYMAPQRDVYARLASERLPWMSDDQRRRMQDIADRLGRGLDEIDACIARTGVMADEIAQVMQENLARRTYTMSLMAMVFLPSTFLTGLFGVNLGGIPGGGWQFGFSIFCILLVVLIGGVALWLHRSKWL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13356
Length:	327 (292)
Sequences:	5384 (3749)
Seq/√Len:	219.4

ECOLI - ZNTB CORA
BACSU - YFJQ CORA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
292_G	298_G	9.493	1.00
112_D	115_L	4.139	1.00
296_G	303_F	4.075	1.00
307_C	311_V	3.338	1.00
304_S	308_I	3.053	1.00
66_V	110_Y	2.998	1.00
305_I	309_L	2.784	1.00
286_L	307_C	2.763	1.00
42_W	118_S	2.758	1.00
301_F	305_I	2.639	1.00
109_V	116_I	2.510	1.00
44_H	120_R	2.496	1.00
90_L	151_C	2.450	1.00
175_N	186_F	2.448	1.00
302_G	306_F	2.431	1.00
319_L	323_R	2.418	1.00
315_G	319_L	2.417	1.00
54_Q	58_T	2.409	1.00
301_F	304_S	2.406	1.00
277_F	282_F	2.308	1.00
291_L	297_G	2.268	1.00
60_P	117_V	2.246	1.00
57_A	67_R	2.237	1.00
168_K	186_F	2.231	1.00
283_L	306_F	2.223	1.00
294_I	303_F	2.210	1.00
109_V	118_S	2.183	1.00
282_F	286_L	2.176	1.00
293_G	300_Q	2.169	1.00
294_I	297_G	2.169	1.00
299_W	305_I	2.168	1.00
45_L	56_L	2.123	1.00
155_T	230_I	1.996	1.00
300_Q	304_S	1.949	1.00
156_D	233_R	1.943	1.00
264_A	267_T	1.901	1.00
116_I	146_W	1.897	1.00
299_W	302_G	1.842	1.00
66_V	85_G	1.811	1.00
286_L	310_L	1.771	1.00
304_S	307_C	1.748	1.00
291_L	294_I	1.736	1.00
49_H	52_S	1.723	1.00
287_F	294_I	1.714	1.00
116_I	147_L	1.688	1.00
198_R	242_D	1.671	1.00
88_I	147_L	1.656	1.00
316_G	320_W	1.622	1.00
287_F	303_F	1.594	1.00
66_V	82_L	1.588	1.00
78_R	232_D	1.585	1.00
70_L	110_Y	1.581	1.00
306_F	310_L	1.572	1.00
287_F	297_G	1.554	1.00
274_A	278_L	1.543	1.00
93_I	197_M	1.532	1.00
303_F	307_C	1.494	1.00
289_V	306_F	1.487	1.00
176_L	251_M	1.483	1.00
75_T	89_T	1.459	1.00
268_Y	272_L	1.453	1.00
51_D	54_Q	1.442	1.00
152_D	233_R	1.436	1.00
62_L	110_Y	1.432	1.00
287_F	296_G	1.414	1.00
152_D	156_D	1.409	1.00
169_I	248_T	1.383	1.00
307_C	310_L	1.380	1.00
306_F	309_L	1.369	1.00
283_L	287_F	1.350	1.00
69_A	78_R	1.341	1.00
65_N	68_D	1.334	1.00
296_G	299_W	1.328	1.00
75_T	106_A	1.328	1.00
111_M	147_L	1.327	1.00
291_L	303_F	1.326	1.00
318_A	322_H	1.315	1.00
294_I	304_S	1.313	1.00
88_I	109_V	1.313	1.00
63_P	82_L	1.312	1.00
116_I	143_C	1.310	1.00
107_M	154_L	1.301	1.00
297_G	303_F	1.291	1.00
291_L	302_G	1.286	1.00
148_V	227_M	1.284	1.00
293_G	304_S	1.284	1.00
278_L	282_F	1.267	1.00
299_W	303_F	1.258	1.00
50_H	54_Q	1.241	1.00
87_L	110_Y	1.238	1.00
62_L	117_V	1.225	1.00
280_S	310_L	1.215	1.00
40_P	143_C	1.209	1.00
54_Q	57_A	1.195	1.00
279_P	282_F	1.191	1.00
40_P	146_W	1.186	1.00
142_D	145_G	1.184	1.00
320_W	324_S	1.180	1.00
155_T	233_R	1.174	1.00
265_R	268_Y	1.172	1.00
200_Y	204_Q	1.166	1.00
231_A	235_G	1.163	1.00
209_A	231_A	1.158	1.00
165_L	190_L	1.155	1.00
212_A	228_Q	1.154	1.00
133_D	149_D	1.153	1.00
277_F	280_S	1.146	1.00
48_V	52_S	1.142	1.00
130_V	153_A	1.141	1.00
317_V	321_L	1.140	1.00
191_R	253_D	1.136	1.00
34_V	37_E	1.135	1.00
260_Q	263_L	1.131	1.00
266_R	271_S	1.125	1.00
191_R	245_I	1.124	1.00
130_V	146_W	1.121	1.00
229_D	232_D	1.113	1.00
280_S	283_L	1.111	1.00
271_S	274_A	1.102	1.00
314_I	318_A	1.098	1.00
312_V	316_G	1.091	1.00
81_R	86_T	1.091	1.00
205_R	235_G	1.086	1.00
267_T	274_A	1.083	1.00
284_T	307_C	1.083	1.00
308_I	312_V	1.071	1.00
280_S	306_F	1.063	1.00
81_R	214_E	1.054	1.00
291_L	306_F	1.054	1.00
296_G	304_S	1.053	1.00
208_Y	234_L	1.047	1.00
68_D	156_D	1.046	1.00
155_T	234_L	1.045	1.00
184_R	255_I	1.042	1.00
46_N	123_K	1.041	1.00
305_I	308_I	1.034	1.00
302_G	305_I	1.029	1.00
55_W	59_T	1.029	1.00
286_L	289_V	1.025	1.00
271_S	278_L	1.022	1.00
290_N	295_P	1.015	1.00
291_L	296_G	1.013	1.00
266_R	270_M	1.013	1.00
286_L	303_F	1.012	1.00
75_T	229_D	1.012	1.00
194_L	244_C	1.008	1.00
76_R	239_D	1.007	1.00
259_M	263_L	1.006	1.00
131_V	135_E	0.998	1.00
109_V	147_L	0.993	1.00
173_E	192_K	0.992	1.00
287_F	299_W	0.986	1.00
191_R	252_A	0.981	1.00
295_P	302_G	0.981	1.00
127_L	150_V	0.974	1.00
51_D	55_W	0.974	1.00
70_L	108_R	0.972	1.00
169_I	244_C	0.970	1.00
194_L	248_T	0.968	1.00
76_R	203_P	0.965	1.00
168_K	193_Q	0.965	1.00
202_A	239_D	0.960	1.00
188_A	252_A	0.959	1.00
132_S	135_E	0.953	1.00
205_R	242_D	0.943	1.00
61_L	64_N	0.943	1.00
132_S	136_E	0.941	1.00
287_F	321_L	0.940	1.00
129_D	153_A	0.936	1.00
235_G	239_D	0.919	0.99
79_V	88_I	0.917	0.99
73_E	121_Q	0.914	0.99
36_D	39_H	0.914	0.99
220_S	223_Q	0.909	0.99
287_F	306_F	0.909	0.99
69_A	229_D	0.909	0.99
284_T	303_F	0.901	0.99
159_S	237_G	0.894	0.99
287_F	290_N	0.892	0.99
296_G	302_G	0.891	0.99
114_R	143_C	0.889	0.99
94_N	103_Q	0.889	0.99
287_F	295_P	0.887	0.99
281_T	285_G	0.886	0.99
89_T	108_R	0.882	0.99
195_I	247_R	0.881	0.99
311_V	315_G	0.877	0.99
63_P	66_V	0.874	0.99
162_I	165_L	0.873	0.99
55_W	58_T	0.872	0.99
274_A	277_F	0.865	0.99
166_H	244_C	0.865	0.99
91_R	106_A	0.862	0.99
175_N	183_P	0.858	0.99
53_A	57_A	0.857	0.99
275_M	278_L	0.856	0.99
69_A	233_R	0.855	0.99
92_C	124_V	0.852	0.99
190_L	248_T	0.850	0.99
281_T	286_L	0.849	0.99
47_Y	121_Q	0.846	0.99
254_E	268_Y	0.840	0.99
282_F	310_L	0.839	0.99
88_I	111_M	0.837	0.99
262_N	271_S	0.833	0.99
294_I	302_G	0.830	0.99
107_M	127_L	0.827	0.99
294_I	299_W	0.824	0.99
260_Q	267_T	0.821	0.99
273_M	279_P	0.817	0.99
242_D	246_A	0.814	0.99
80_S	228_Q	0.810	0.99
177_L	258_V	0.807	0.99
133_D	153_A	0.805	0.99
38_A	41_C	0.796	0.98
141_T	222_D	0.796	0.98
258_V	261_E	0.796	0.98
105_V	120_R	0.796	0.98
294_I	306_F	0.793	0.98
68_D	152_D	0.791	0.98
293_G	298_G	0.791	0.98
280_S	314_I	0.784	0.98
296_G	307_C	0.784	0.98
272_L	279_P	0.783	0.98
215_R	219_M	0.782	0.98
35_I	38_A	0.781	0.98
275_M	280_S	0.780	0.98
249_G	253_D	0.780	0.98
261_E	268_Y	0.775	0.98
201_M	237_G	0.774	0.98
265_R	278_L	0.769	0.98
65_N	80_S	0.766	0.98
44_H	118_S	0.763	0.98
130_V	149_D	0.763	0.98
104_L	196_V	0.760	0.98
260_Q	264_A	0.756	0.98
310_L	314_I	0.756	0.98
250_V	253_D	0.753	0.98
293_G	299_W	0.753	0.98
279_P	313_L	0.746	0.98
289_V	294_I	0.744	0.98
293_G	303_F	0.738	0.97
63_P	69_A	0.731	0.97
128_D	132_S	0.728	0.97
283_L	310_L	0.728	0.97
39_H	114_R	0.727	0.97
69_A	232_D	0.727	0.97
48_V	120_R	0.727	0.97
302_G	309_L	0.724	0.97
188_A	254_E	0.723	0.97
276_V	314_I	0.720	0.97
65_N	226_R	0.718	0.97
142_D	223_Q	0.717	0.97
303_F	306_F	0.716	0.97
45_L	119_T	0.713	0.97
280_S	313_L	0.710	0.97
281_T	306_F	0.707	0.97
79_V	207_V	0.707	0.97
287_F	291_L	0.704	0.97
280_S	284_T	0.703	0.97
316_G	319_L	0.697	0.96
96_S	101_P	0.697	0.96
90_L	154_L	0.695	0.96
201_M	238_L	0.695	0.96
44_H	131_V	0.694	0.96
205_R	209_A	0.690	0.96
102_D	193_Q	0.690	0.96
293_G	296_G	0.688	0.96
63_P	85_G	0.684	0.96
293_G	302_G	0.683	0.96
148_V	229_D	0.683	0.96
286_L	294_I	0.683	0.96
63_P	226_R	0.682	0.96
65_N	69_A	0.681	0.96
145_G	226_R	0.681	0.96
88_I	207_V	0.679	0.96
95_G	98_D	0.679	0.96
76_R	156_D	0.677	0.96
35_I	39_H	0.677	0.96
309_L	313_L	0.676	0.96
262_N	266_R	0.671	0.96
168_K	171_D	0.669	0.95
144_G	223_Q	0.669	0.95
240_E	244_C	0.669	0.95
297_G	307_C	0.666	0.95
263_L	267_T	0.665	0.95
267_T	285_G	0.660	0.95
90_L	109_V	0.656	0.95
141_T	145_G	0.651	0.95
289_V	310_L	0.651	0.95
120_R	131_V	0.650	0.95
269_T	273_M	0.649	0.95
86_T	111_M	0.646	0.95
299_W	304_S	0.646	0.95
245_I	253_D	0.645	0.95
70_L	85_G	0.642	0.94
277_F	284_T	0.640	0.94
239_D	245_I	0.640	0.94
296_G	305_I	0.632	0.94
319_L	322_H	0.632	0.94
96_S	103_Q	0.632	0.94
287_F	293_G	0.631	0.94
187_L	199_R	0.629	0.94
273_M	317_V	0.626	0.94
92_C	125_L	0.626	0.94
284_T	310_L	0.626	0.94
46_N	120_R	0.625	0.94
69_A	80_S	0.623	0.93
204_Q	236_R	0.622	0.93
269_T	320_W	0.621	0.93
300_Q	319_L	0.619	0.93
262_N	265_R	0.618	0.93
231_A	234_L	0.616	0.93
282_F	285_G	0.613	0.93
178_D	181_I	0.613	0.93
36_D	114_R	0.612	0.93
308_I	315_G	0.610	0.93
175_N	181_I	0.610	0.93
221_D	224_R	0.607	0.93
92_C	105_V	0.607	0.93
202_A	238_L	0.606	0.92
205_R	238_L	0.606	0.92
128_D	186_F	0.606	0.92
91_R	104_L	0.606	0.92
48_V	119_T	0.605	0.92
284_T	289_V	0.605	0.92
263_L	266_R	0.603	0.92
164_Q	168_K	0.603	0.92
283_L	313_L	0.602	0.92
58_T	61_L	0.602	0.92
118_S	150_V	0.602	0.92
276_V	280_S	0.600	0.92
67_R	70_L	0.599	0.92
46_N	122_R	0.597	0.92
183_P	187_L	0.594	0.92
34_V	38_A	0.593	0.92
195_I	224_R	0.593	0.92
322_H	325_K	0.593	0.92
194_L	241_I	0.592	0.92
140_P	145_G	0.592	0.92
209_A	235_G	0.592	0.92
151_C	230_I	0.591	0.92
50_H	315_G	0.591	0.92
152_D	155_T	0.590	0.91
65_N	82_L	0.590	0.91
43_L	117_V	0.587	0.91
64_N	68_D	0.585	0.91
268_Y	306_F	0.583	0.91
92_C	107_M	0.582	0.91
269_T	277_F	0.581	0.91
246_A	250_V	0.580	0.91
319_L	325_K	0.577	0.91
205_R	231_A	0.575	0.90
79_V	86_T	0.573	0.90
106_A	121_Q	0.572	0.90
296_G	301_F	0.570	0.90
72_G	233_R	0.569	0.90
137_G	311_V	0.567	0.90
275_M	279_P	0.567	0.90
148_V	223_Q	0.566	0.90
320_W	325_K	0.566	0.90
118_S	127_L	0.566	0.90
170_I	199_R	0.564	0.90
291_L	299_W	0.564	0.90
51_D	315_G	0.563	0.89
272_L	318_A	0.562	0.89
282_F	314_I	0.562	0.89
87_L	91_R	0.561	0.89
227_M	286_L	0.561	0.89
160_E	237_G	0.561	0.89
152_D	226_R	0.561	0.89
276_V	318_A	0.559	0.89
177_L	185_G	0.557	0.89
301_F	307_C	0.557	0.89
263_L	268_Y	0.556	0.89
185_G	258_V	0.554	0.89
198_R	205_R	0.553	0.89
289_V	297_G	0.553	0.89
94_N	97_T	0.553	0.89
65_N	78_R	0.552	0.89
253_D	256_A	0.552	0.89
112_D	143_C	0.550	0.88
212_A	224_R	0.550	0.88
158_S	237_G	0.548	0.88
98_D	171_D	0.548	0.88
65_N	230_I	0.548	0.88
230_I	233_R	0.546	0.88
192_K	247_R	0.545	0.88
159_S	236_R	0.545	0.88
158_S	200_Y	0.545	0.88
146_W	150_V	0.544	0.88
95_G	102_D	0.543	0.88
148_V	230_I	0.542	0.88
53_A	71_A	0.541	0.88
34_V	39_H	0.541	0.88
148_V	226_R	0.541	0.88
70_L	119_T	0.540	0.87
36_D	201_M	0.539	0.87
246_A	251_M	0.538	0.87
95_G	103_Q	0.537	0.87
144_G	218_W	0.536	0.87
188_A	192_K	0.536	0.87
45_L	52_S	0.536	0.87
269_T	295_P	0.535	0.87
98_D	165_L	0.534	0.87
293_G	297_G	0.533	0.87
82_L	232_D	0.529	0.86
68_D	78_R	0.529	0.86
91_R	200_Y	0.529	0.86
201_M	241_I	0.528	0.86
36_D	55_W	0.528	0.86
173_E	251_M	0.528	0.86
83_G	118_S	0.527	0.86
184_R	200_Y	0.523	0.86
219_M	223_Q	0.521	0.86
53_A	119_T	0.521	0.86
311_V	314_I	0.520	0.85
249_G	252_A	0.520	0.85
124_V	127_L	0.517	0.85
83_G	132_S	0.515	0.85
282_F	317_V	0.515	0.85
92_C	126_A	0.514	0.85
130_V	150_V	0.513	0.85
140_P	222_D	0.512	0.85
76_R	235_G	0.511	0.84
271_S	280_S	0.510	0.84
159_S	233_R	0.509	0.84
288_G	294_I	0.508	0.84
52_S	127_L	0.507	0.84
284_T	321_L	0.506	0.84
92_C	120_R	0.503	0.84
274_A	282_F	0.503	0.84
206_D	209_A	0.503	0.84
249_G	254_E	0.503	0.84
272_L	278_L	0.502	0.83
79_V	214_E	0.501	0.83
285_G	288_G	0.500	0.83
130_V	133_D	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i0uA	4	0.9878	100	0.148	Contact Map
4ev6A	3	0.948	100	0.167	Contact Map
3nvoA	2	0.7706	100	0.487	Contact Map
4egwA	1	0.7431	100	0.49	Contact Map
3ck6A	3	0.7462	100	0.497	Contact Map
2bbhA	2	0.6239	100	0.557	Contact Map
2hn1A	2	0.7064	100	0.565	Contact Map
3rkgA	1	0.6789	88.9	0.93	Contact Map
4aurA	1	0.9664	32.9	0.954	Contact Map
4jo7E	2	0.2722	18.8	0.959	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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