GREMLIN Database
AMIC - N-acetylmuramoyl-L-alanine amidase AmiC
UniProt: P63883 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13086
Length: 417 (368)
Sequences: 1519 (1084)
Seq/√Len: 56.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
339_V370_I5.3801.00
223_R227_E4.2281.00
210_R213_D4.1481.00
227_E234_V3.9991.00
218_I374_T3.5541.00
262_V403_I3.4451.00
226_I232_M3.4371.00
194_P219_A3.4181.00
221_R393_Q3.3761.00
225_L397_E3.0381.00
229_E404_K2.9751.00
209_T383_E2.9641.00
226_I234_V2.9101.00
194_P237_T2.6481.00
372_V399_I2.6331.00
221_R392_Q2.6081.00
74_D112_R2.5151.00
209_T387_K2.5041.00
102_R114_V2.4961.00
223_R236_M2.4041.00
71_V117_L2.3921.00
40_R53_E2.3051.00
219_A264_I2.2961.00
189_V233_K2.2691.00
281_A336_G2.1871.00
217_Q392_Q2.1731.00
102_R116_E2.1521.00
232_M404_K2.1481.00
107_D110_T2.1181.00
205_G383_E2.1021.00
49_R141_D2.0821.00
260_L403_I2.0761.00
65_L70_R2.0561.00
358_G363_K2.0511.00
63_F72_V2.0461.00
204_V210_R2.0441.00
268_A378_S2.0291.00
191_M237_T1.9981.00
279_V340_L1.9891.00
219_A236_M1.9541.00
217_Q221_R1.9461.00
226_I400_L1.9351.00
296_A300_N1.9301.00
277_S347_N1.8781.00
248_V251_A1.8781.00
70_R114_V1.8661.00
51_T137_R1.8661.00
66_S69_E1.8460.99
254_Q366_D1.8390.99
218_I395_V1.8350.99
137_R141_D1.7840.99
65_L114_V1.7820.99
275_S385_K1.7680.99
288_T296_A1.7650.99
225_L393_Q1.7600.99
128_L137_R1.7540.99
49_R137_R1.7460.99
65_L68_P1.7430.99
223_R234_V1.7420.99
315_Y319_T1.7380.99
74_D102_R1.7150.99
130_P136_E1.7070.99
65_L74_D1.6940.99
267_D278_S1.6840.99
192_L219_A1.6820.99
229_E400_L1.6730.99
104_G114_V1.6640.99
50_V115_F1.6600.99
40_R49_R1.6400.99
192_L234_V1.6320.99
221_R389_A1.6160.99
102_R112_R1.6070.99
225_L228_K1.5960.98
335_F370_I1.5860.98
191_M252_K1.5760.98
126_F141_D1.5660.98
70_R74_D1.5610.98
245_P248_V1.5610.98
70_R112_R1.5520.98
72_V114_V1.5350.98
40_R137_R1.5230.98
191_M234_V1.5200.98
281_A333_L1.5180.98
52_V113_M1.5130.98
40_R141_D1.4950.98
275_S381_E1.4940.98
53_E137_R1.4830.97
51_T139_V1.4810.97
73_V140_M1.4590.97
106_F110_T1.4560.97
269_F274_P1.4520.97
224_S228_K1.4480.97
189_V235_Y1.4450.97
68_P114_V1.4250.97
74_D114_V1.4240.97
221_R224_S1.4110.97
49_R139_V1.4080.97
264_I374_T1.4080.97
333_L336_G1.4010.96
289_S355_E1.3980.96
190_I260_L1.3970.96
391_F395_V1.3950.96
40_R139_V1.3930.96
291_A325_Q1.3810.96
382_E391_F1.3800.96
235_Y252_K1.3660.96
40_R51_T1.3650.96
53_E139_V1.3640.96
70_R102_R1.3610.96
65_L112_R1.3570.96
280_F292_A1.3230.95
342_K405_A1.2830.94
340_L349_L1.2830.94
186_R259_D1.2790.94
246_L360_A1.2790.94
54_S58_L1.2790.94
207_Y383_E1.2590.94
250_V364_A1.2560.94
30_L33_V1.2510.93
74_D104_G1.2420.93
53_E141_D1.2410.93
296_A299_Q1.2380.93
292_A296_A1.2360.93
44_A199_E1.2330.93
333_L356_Q1.2260.93
383_E387_K1.2250.93
42_W199_E1.2150.92
271_S274_P1.2150.92
205_G214_V1.2080.92
130_P141_D1.2030.92
42_W45_S1.2000.92
63_F114_V1.1890.92
192_L223_R1.1880.91
68_P74_D1.1840.91
126_F139_V1.1810.91
278_S391_F1.1800.91
187_P233_K1.1770.91
300_N359_F1.1760.91
344_G349_L1.1720.91
260_L335_F1.1710.91
187_P230_G1.1660.91
49_R126_F1.1650.91
40_R130_P1.1590.90
26_S33_V1.1550.90
65_L102_R1.1510.90
68_P102_R1.1500.90
40_R128_L1.1480.90
286_G289_S1.1430.90
329_I356_Q1.1380.90
188_I407_F1.1290.89
75_I78_V1.1290.89
96_P118_K1.1250.89
363_K367_I1.1200.89
343_L395_V1.1140.89
191_M258_A1.1000.88
254_Q364_A1.0960.88
73_V115_F1.0950.88
225_L400_L1.0920.88
28_V32_A1.0890.87
65_L104_G1.0880.87
292_A300_N1.0870.87
220_R239_N1.0850.87
342_K345_K1.0730.87
381_E385_K1.0730.87
215_V236_M1.0720.87
49_R128_L1.0710.87
104_G112_R1.0670.86
385_K391_F1.0660.86
117_L121_V1.0540.86
192_L222_L1.0490.85
267_D277_S1.0460.85
52_V75_I1.0390.85
194_P215_V1.0380.85
191_M194_P1.0380.85
269_F272_R1.0280.84
70_R104_G1.0230.84
70_R116_E1.0200.84
128_L141_D1.0200.84
243_F246_L1.0190.84
124_Q264_I1.0170.84
281_A288_T1.0150.83
225_L229_E1.0130.83
51_T141_D1.0120.83
281_A356_Q1.0090.83
347_N375_A1.0050.83
296_A359_F1.0040.83
247_Q360_A1.0040.83
281_A354_V1.0020.83
379_N383_E0.9930.82
115_F142_L0.9890.82
274_P350_H0.9880.82
63_F74_D0.9830.81
71_V121_V0.9810.81
319_T323_M0.9770.81
29_S33_V0.9760.81
385_K388_T0.9720.81
40_R126_F0.9660.80
63_F70_R0.9640.80
42_W141_D0.9600.80
62_Q125_L0.9590.80
235_Y256_Q0.9580.80
126_F137_R0.9580.80
206_K383_E0.9570.80
261_F359_F0.9560.80
254_Q365_P0.9540.79
288_T300_N0.9530.79
63_F112_R0.9520.79
27_Q32_A0.9490.79
215_V266_A0.9490.79
27_Q30_L0.9490.79
247_Q290_T0.9470.79
74_D116_E0.9460.79
44_A47_Y0.9380.78
170_V173_A0.9340.78
323_M366_D0.9320.78
350_H377_I0.9300.78
203_A377_I0.9270.77
246_L359_F0.9250.77
80_L98_I0.9180.77
325_Q328_T0.9170.77
53_E126_F0.9120.76
248_V252_K0.9070.76
250_V360_A0.9030.76
48_T141_D0.8990.75
190_I232_M0.8980.75
338_A402_G0.8870.74
42_W134_F0.8820.74
128_L139_V0.8790.74
31_A55_N0.8770.73
205_G382_E0.8730.73
288_T356_Q0.8680.73
232_M375_A0.8670.73
222_L399_I0.8660.73
130_P135_K0.8640.72
224_S393_Q0.8630.72
40_R48_T0.8620.72
331_D406_Y0.8590.72
42_W126_F0.8520.71
91_I101_A0.8510.71
123_P143_Y0.8500.71
342_K401_A0.8480.71
77_D109_Q0.8470.71
220_R240_E0.8410.70
284_T326_S0.8400.70
104_G116_E0.8360.70
213_D387_K0.8350.70
71_V398_S0.8330.70
393_Q397_E0.8330.70
100_S116_E0.8320.69
23_L26_S0.8300.69
350_H355_E0.8290.69
277_S375_A0.8290.69
28_V31_A0.8270.69
97_F121_V0.8230.69
292_A299_Q0.8220.69
134_F199_E0.8210.68
223_R239_N0.8180.68
38_A53_E0.8170.68
112_R116_E0.8140.68
207_Y380_V0.8140.68
250_V367_I0.8130.68
232_M407_F0.8120.68
175_S183_G0.8100.67
192_L226_I0.8080.67
281_A329_I0.8070.67
19_A26_S0.8020.67
269_F350_H0.8010.67
26_S30_L0.7960.66
314_R318_H0.7940.66
148_Q177_P0.7890.65
220_R223_R0.7890.65
253_A367_I0.7880.65
294_Y367_I0.7830.65
25_V29_S0.7780.64
179_P182_A0.7780.64
296_A303_D0.7760.64
375_A391_F0.7610.63
218_I392_Q0.7600.62
242_I245_P0.7590.62
330_A375_A0.7570.62
358_G365_P0.7570.62
254_Q278_S0.7550.62
39_V50_V0.7550.62
355_E375_A0.7530.62
339_V399_I0.7520.62
354_V359_F0.7510.61
261_F300_N0.7510.61
267_D350_H0.7490.61
213_D217_Q0.7460.61
146_N149_D0.7460.61
300_N303_D0.7400.60
390_T394_E0.7400.60
327_L331_D0.7370.60
336_G356_Q0.7370.60
201_S210_R0.7360.60
218_I391_F0.7330.60
254_Q367_I0.7330.60
325_Q375_A0.7320.60
47_Y141_D0.7290.59
347_N391_F0.7290.59
222_L400_L0.7290.59
53_E130_P0.7280.59
303_D307_G0.7260.59
290_T294_Y0.7260.59
204_V383_E0.7250.59
113_M237_T0.7250.59
374_T399_I0.7240.59
103_V113_M0.7240.59
27_Q31_A0.7230.59
72_V112_R0.7230.59
334_K410_G0.7180.58
251_A255_K0.7180.58
62_Q71_V0.7170.58
189_V389_A0.7170.58
73_V93_A0.7110.57
50_V73_V0.7110.57
232_M402_G0.7100.57
47_Y143_Y0.7090.57
262_V372_V0.7040.57
23_L341_N0.7030.56
130_P134_F0.7030.56
248_V255_K0.7000.56
29_S32_A0.7000.56
355_E377_I0.6990.56
335_F407_F0.6980.56
277_S343_L0.6970.56
290_T293_K0.6960.56
53_E135_K0.6940.55
385_K394_E0.6940.55
218_I396_A0.6940.55
325_Q365_P0.6900.55
69_E120_N0.6900.55
268_A272_R0.6890.55
344_G348_K0.6870.55
65_L72_V0.6860.55
218_I264_I0.6860.55
24_S190_I0.6850.54
296_A378_S0.6830.54
311_S314_R0.6820.54
250_V365_P0.6790.54
130_P137_R0.6770.54
22_L26_S0.6750.53
289_S296_A0.6740.53
23_L33_V0.6730.53
332_S354_V0.6730.53
252_K256_Q0.6730.53
43_P47_Y0.6720.53
63_F102_R0.6720.53
175_S190_I0.6700.53
68_P112_R0.6690.53
254_Q267_D0.6660.52
342_K402_G0.6650.52
42_W137_R0.6630.52
346_I398_S0.6620.52
49_R53_E0.6580.52
28_V33_V0.6580.52
190_I222_L0.6570.51
218_I222_L0.6540.51
224_S227_E0.6520.51
25_V28_V0.6510.51
20_M28_V0.6500.51
295_L359_F0.6480.50
127_A262_V0.6480.50
179_P185_D0.6470.50
328_T365_P0.6460.50
176_G180_G0.6460.50
381_E388_T0.6450.50
19_A29_S0.6440.50
194_P223_R0.6420.50
324_V328_T0.6410.50
288_T292_A0.6400.50
340_L344_G0.6390.49
331_D402_G0.6390.49
43_P144_P0.6380.49
296_A354_V0.6370.49
61_K65_L0.6360.49
227_E399_I0.6310.49
262_V370_I0.6310.49
75_I138_L0.6300.49
251_A310_K0.6300.49
336_G349_L0.6290.48
27_Q33_V0.6290.48
36_V52_V0.6240.48
221_R225_L0.6240.48
239_N375_A0.6240.48
267_D364_A0.6230.48
206_K272_R0.6230.48
399_I403_I0.6190.47
42_W49_R0.6170.47
300_N332_S0.6140.47
205_G377_I0.6110.46
293_K297_Q0.6110.46
21_W37_V0.6110.46
309_S324_V0.6090.46
205_G380_V0.6090.46
61_K76_E0.6080.46
172_P183_G0.6080.46
340_L351_K0.6080.46
250_V290_T0.6070.46
375_A400_L0.6060.46
317_D324_V0.6060.46
175_S182_A0.6060.46
236_M264_I0.6050.46
267_D366_D0.6030.46
30_L34_S0.6010.45
36_V78_V0.6010.45
272_R391_F0.5990.45
105_Q110_T0.5990.45
300_N354_V0.5960.45
277_S391_F0.5960.45
63_F68_P0.5940.45
184_R189_V0.5930.45
24_S27_Q0.5910.44
67_N147_A0.5890.44
123_P126_F0.5890.44
250_V358_G0.5890.44
62_Q122_K0.5870.44
321_F325_Q0.5850.44
42_W128_L0.5840.44
209_T214_V0.5820.43
42_W47_Y0.5810.43
131_V134_F0.5810.43
140_M401_A0.5810.43
67_N251_A0.5790.43
72_V102_R0.5780.43
300_N305_I0.5760.43
140_M409_D0.5760.43
280_F355_E0.5760.43
71_V75_I0.5740.42
329_I406_Y0.5730.42
31_A34_S0.5730.42
250_V261_F0.5700.42
342_K398_S0.5700.42
279_V351_K0.5700.42
335_F398_S0.5690.42
60_Y317_D0.5690.42
173_A182_A0.5680.42
278_S364_A0.5680.42
229_E232_M0.5680.42
277_S349_L0.5680.42
122_K145_A0.5670.42
236_M330_A0.5660.42
128_L136_E0.5640.41
377_I383_E0.5630.41
319_T364_A0.5630.41
232_M400_L0.5630.41
377_I380_V0.5610.41
335_F339_V0.5610.41
188_I406_Y0.5590.41
22_L29_S0.5560.41
400_L404_K0.5560.41
324_V327_L0.5560.41
374_T386_L0.5560.41
397_E401_A0.5550.40
280_F300_N0.5540.40
174_Q177_P0.5530.40
323_M327_L0.5530.40
243_F303_D0.5510.40
358_G367_I0.5500.40
389_A392_Q0.5500.40
301_A305_I0.5500.40
237_T244_I0.5490.40
312_G326_S0.5490.40
32_A55_N0.5450.39
247_Q311_S0.5450.39
57_Q75_I0.5440.39
99_K118_K0.5440.39
170_V179_P0.5440.39
282_L321_F0.5430.39
269_F294_Y0.5420.39
25_V30_L0.5420.39
355_E376_F0.5420.39
77_D341_N0.5420.39
219_A222_L0.5410.39
176_G179_P0.5410.39
106_F114_V0.5400.39
77_D108_P0.5400.39
68_P104_G0.5390.39
179_P190_I0.5390.39
239_N341_N0.5380.39
289_S293_K0.5380.39
329_I354_V0.5370.39
169_Q175_S0.5350.38
22_L27_Q0.5340.38
283_S321_F0.5330.38
73_V221_R0.5320.38
304_L321_F0.5320.38
40_R143_Y0.5320.38
268_A377_I0.5320.38
113_M136_E0.5310.38
64_A69_E0.5300.38
230_G234_V0.5300.38
174_Q181_K0.5300.38
103_V111_V0.5300.38
80_L111_V0.5290.38
126_F130_P0.5290.38
175_S178_Q0.5290.38
280_F359_F0.5290.38
205_G209_T0.5280.38
20_M26_S0.5280.38
68_P369_S0.5280.38
178_Q390_T0.5270.38
280_F356_Q0.5270.38
45_S199_E0.5270.38
121_V142_L0.5250.37
292_A357_A0.5240.37
210_R393_Q0.5240.37
320_M336_G0.5230.37
143_Y252_K0.5230.37
60_Y335_F0.5230.37
317_D366_D0.5200.37
49_R130_P0.5190.37
261_F354_V0.5190.37
281_A355_E0.5190.37
212_K300_N0.5190.37
172_P405_A0.5190.37
41_V91_I0.5180.37
140_M251_A0.5180.37
299_Q359_F0.5170.37
100_S104_G0.5170.37
180_G183_G0.5160.36
46_S51_T0.5150.36
398_S405_A0.5150.36
26_S35_Q0.5140.36
220_R236_M0.5140.36
333_L358_G0.5140.36
56_R394_E0.5130.36
261_F361_V0.5130.36
98_I117_L0.5130.36
326_S354_V0.5120.36
254_Q328_T0.5110.36
68_P116_E0.5110.36
187_P247_Q0.5090.36
244_I318_H0.5090.36
191_M235_Y0.5080.36
206_K380_V0.5080.36
69_E121_V0.5080.36
289_S359_F0.5070.36
268_A350_H0.5070.36
278_S350_H0.5070.36
321_F366_D0.5060.35
174_Q179_P0.5050.35
283_S288_T0.5050.35
193_D249_R0.5050.35
286_G327_L0.5050.35
214_V326_S0.5040.35
228_K389_A0.5020.35
110_T150_M0.5020.35
305_I309_S0.5020.35
212_K241_D0.5010.35
94_D215_V0.5000.35
378_S383_E0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4binA 1 0.8345 100 0.227 Contact Map
3ne8A 2 0.5396 100 0.438 Contact Map
4rn7A 1 0.4388 100 0.519 Contact Map
1jwqA 1 0.4245 100 0.522 Contact Map
4lq6A 1 0.4412 100 0.527 Contact Map
1xovA 1 0.4365 100 0.533 Contact Map
3czxA 2 0.4197 100 0.55 Contact Map
3qayA 1 0.4101 100 0.566 Contact Map
4av2A 3 0.4604 99.1 0.894 Contact Map
4aqzA 1 0.3213 97.7 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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