GREMLIN Database
YHBS - Uncharacterized N-acetyltransferase YhbS
UniProt: P63417 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12788
Length: 167 (157)
Sequences: 2200 (1598)
Seq/√Len: 127.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_F96_G5.3871.00
77_L93_V3.3631.00
97_L108_V3.3551.00
15_D32_H3.1281.00
97_L122_F3.0491.00
18_L78_A2.8191.00
113_D118_S2.6931.00
71_W107_A2.6451.00
4_R47_T2.4611.00
99_S102_E2.1531.00
95_E99_S2.1181.00
56_Y78_A2.0971.00
17_L53_V2.0721.00
20_R80_D2.0151.00
64_V156_G1.9941.00
81_E84_R1.9871.00
6_E43_G1.9731.00
83_Y86_Q1.9361.00
106_A147_A1.9271.00
90_R119_R1.9231.00
48_D83_Y1.9081.00
15_D19_R1.8181.00
90_R94_Y1.7821.00
6_E35_R1.7401.00
44_L95_E1.7231.00
72_V105_Y1.6871.00
4_R10_D1.6841.00
47_T51_G1.6831.00
95_E98_D1.6821.00
57_V96_G1.6061.00
145_R149_D1.5971.00
74_M93_V1.5781.00
54_I88_L1.5661.00
45_V53_V1.5111.00
18_L56_Y1.4941.00
90_R120_F1.4291.00
44_L96_G1.4021.00
114_P140_A1.4001.00
79_V88_L1.3941.00
25_D28_A1.3901.00
73_G160_Y1.3861.00
111_L160_Y1.3831.00
131_R157_L1.3631.00
5_V99_S1.3571.00
72_V100_L1.3251.00
118_S142_Q1.3081.00
80_D83_Y1.3071.00
126_A138_E1.3021.00
74_M110_T1.2861.00
40_L58_A1.2841.00
109_V130_L1.2821.00
52_Q80_D1.2671.00
39_F161_H1.2361.00
123_E127_H1.2301.00
62_V158_V1.2120.99
46_A88_L1.1910.99
3_I44_L1.1880.99
55_G92_L1.1470.99
97_L144_H1.1460.99
48_D54_I1.1450.99
16_A19_R1.1430.99
57_V92_L1.1400.99
74_M108_V1.1360.99
19_R28_A1.1230.99
25_D29_K1.1110.99
101_N144_H1.0750.99
125_A143_V1.0620.99
18_L31_V1.0570.99
37_D161_H1.0540.98
111_L141_F1.0530.98
98_D101_N1.0520.98
99_S103_F1.0480.98
145_R148_D1.0410.98
44_L99_S1.0400.98
12_P16_A1.0330.98
10_D47_T1.0320.98
15_D29_K1.0200.98
89_A116_L1.0170.98
34_L60_S1.0150.98
94_Y98_D0.9940.98
113_D142_Q0.9900.98
93_V120_F0.9780.98
141_F160_Y0.9560.97
24_S28_A0.9540.97
57_V77_L0.9480.97
91_Q94_Y0.9320.97
73_G141_F0.9320.97
113_D140_A0.9230.96
62_V71_W0.9160.96
15_D28_A0.9140.96
14_I40_L0.9110.96
54_I83_Y0.9020.96
64_V154_V0.8980.96
46_A79_V0.8850.96
145_R150_A0.8830.95
64_V71_W0.8670.95
62_V73_G0.8630.95
59_F74_M0.8570.95
30_L75_A0.8480.94
128_H143_V0.8440.94
120_F144_H0.8400.94
123_E128_H0.8380.94
73_G109_V0.8360.94
63_D68_D0.8350.94
110_T142_Q0.8350.94
65_Q157_L0.8330.94
100_L130_L0.8330.94
61_P70_Q0.8210.93
37_D40_L0.8210.93
61_P105_Y0.8180.93
149_D152_N0.8170.93
98_D102_E0.8160.93
44_L92_L0.8100.93
19_R25_D0.8020.93
20_R81_E0.8000.92
4_R45_V0.7980.92
30_L132_C0.7970.92
79_V116_L0.7960.92
52_Q83_Y0.7950.92
19_R23_E0.7880.92
27_E31_V0.7830.92
118_S124_L0.7780.91
42_L103_F0.7780.91
48_D52_Q0.7750.91
71_W109_V0.7750.91
20_R82_K0.7720.91
13_G52_Q0.7680.91
85_G116_L0.7660.91
76_P117_Y0.7640.91
16_A20_R0.7620.90
65_Q68_D0.7600.90
123_E145_R0.7600.90
55_G79_V0.7580.90
21_S81_E0.7510.90
17_L80_D0.7500.90
116_L120_F0.7490.90
58_A75_A0.7440.89
101_N147_A0.7430.89
72_V108_V0.7360.89
75_A134_W0.7340.89
52_Q82_K0.7280.88
111_L136_G0.7260.88
125_A129_D0.7260.88
27_E30_L0.7250.88
77_L92_L0.7240.88
42_L100_L0.7190.88
23_E26_A0.7140.87
57_V93_V0.7120.87
41_T61_P0.7090.87
5_V44_L0.7050.87
114_P118_S0.7010.86
106_A150_A0.7010.86
59_F100_L0.6850.85
44_L55_G0.6840.85
29_K33_D0.6750.84
66_G115_A0.6690.84
116_L119_R0.6640.83
94_Y144_H0.6600.83
22_F76_P0.6600.83
141_F158_V0.6590.83
73_G117_Y0.6570.83
18_L43_G0.6560.83
11_A35_R0.6360.81
65_Q159_E0.6330.80
110_T141_F0.6290.80
69_L106_A0.6240.79
108_V122_F0.6240.79
100_L108_V0.6200.79
94_Y120_F0.6170.79
138_E142_Q0.6140.78
127_H131_R0.6080.78
22_F84_R0.6070.78
130_L158_V0.6060.77
107_A143_V0.6030.77
63_D159_E0.6020.77
59_F110_T0.6000.77
94_Y101_N0.5960.76
84_R117_Y0.5960.76
113_D117_Y0.5930.76
64_V107_A0.5920.76
48_D86_Q0.5910.76
4_R53_V0.5910.76
112_G117_Y0.5900.76
43_G56_Y0.5850.75
59_F108_V0.5840.75
132_C141_F0.5780.74
87_G91_Q0.5770.74
77_L89_A0.5750.74
23_E28_A0.5740.74
18_L25_D0.5700.73
132_C157_L0.5690.73
150_A154_V0.5690.73
101_N146_L0.5680.73
13_G53_V0.5650.72
17_L21_S0.5640.72
26_A29_K0.5620.72
19_R26_A0.5620.72
136_G139_S0.5620.72
69_L154_V0.5610.72
73_G134_W0.5580.71
76_P112_G0.5580.71
109_V158_V0.5560.71
47_T53_V0.5520.71
66_G159_E0.5490.70
30_L60_S0.5470.70
11_A40_L0.5450.70
60_S140_A0.5420.69
22_F30_L0.5380.69
113_D116_L0.5360.68
11_A14_I0.5350.68
46_A55_G0.5330.68
27_E111_L0.5300.68
111_L158_V0.5280.67
90_R116_L0.5270.67
12_P15_D0.5210.66
110_T144_H0.5200.66
34_L40_L0.5170.66
42_L105_Y0.5160.66
111_L142_Q0.5160.66
118_S140_A0.5150.65
41_T100_L0.5130.65
57_V110_T0.5130.65
124_L138_E0.5120.65
7_I10_D0.5120.65
12_P47_T0.5110.65
75_A110_T0.5080.64
19_R24_S0.5080.64
31_V58_A0.5070.64
13_G16_A0.5060.64
6_E109_V0.5050.64
72_V103_F0.5040.64
75_A111_L0.5030.64
14_I31_V0.5020.63
38_G61_P0.5010.63
55_G88_L0.5000.63
48_D51_G0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4zbgA 1 0.8743 99.9 0.535 Contact Map
4rs2A 1 1 99.9 0.565 Contact Map
1cjwA 1 0.8443 99.7 0.659 Contact Map
3te4A 1 0.8743 99.7 0.66 Contact Map
3sxnA 4 0.994 99.7 0.665 Contact Map
1kuxA 1 0.8443 99.7 0.666 Contact Map
2hv2A 4 0.994 99.7 0.667 Contact Map
1n71A 4 0.8683 99.7 0.668 Contact Map
3n7zA 4 0.994 99.7 0.67 Contact Map
3r1kA 4 0.994 99.7 0.671 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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