YHES - ECOLI - GREMLIN Contacts

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YHES - Uncharacterized ABC transporter ATP-binding protein YheS

UniProt:	P63389	Sequences: MIVFSSLQIRRGVRVLLDNATATINPGQKVGLVGKNGCGKSTLLALLKNEISADGGSYTFPGSWQLAWVNQETPALPQAALEYVIDGDREYRQLEAQLHDANERNDGHAIATIHGKLDAIDAWSIRSRAASLLHGLGFSNEQLERPVSDFSGGWRMRLNLAQALICRSDLLLLDEPTNHLDLDAVIWLEKWLKSYQGTLILISHDRDFLDPIVDKIIHIEQQSMFEYTGNYSSFEVQRATRLAQQQAMYESQQERVAHLQSYIDRFRAKATKAKQAQSRIKMLERMELIAPAHVDNPFRFSFRAPESLPNPLLKMEKVSAGYGDRIILDSIKLNLVPGSRIGLLGRNGAGKSTLIKLLAGELAPVSGEIGLAKGIKLGYFAQHQLEYLRADESPIQHLARLAPQELEQKLRDYLGGFGFQGDKVTEETRRFSGGEKARLVLALIVWQRPNLLLLDEPTNHLDLDMRQALTEALIEFEGALVVVSHDRHLLRSTTDDLYLVHDRKVEPFDGDLEDYQQWLSDVQKQENQTDEAPKENANSAQARKDQKRREAELRAQTQPLRKEIARLEKEMEKLNAQLAQAEEKLGDSELYDQSRKAELTACLQQQASAKSGLEECEMAWLEAQEQLEQMLLEGQSN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12903
Length:	637 (518)
Sequences:	4985 (3545)
Seq/√Len:	155.7

ECOLI - YHES UUP ETTA GSIA YBIT YBHF
BACSU - YDIF YFMR YFMM YKPA EXPZ
SULSO - Q980K5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
577_Q	605_Q	4.791	1.00
210_D	232_S	4.182	1.00
317_K	330_S	4.032	1.00
563_E	619_A	3.997	1.00
260_Q	264_D	3.726	1.00
315_M	318_V	3.455	1.00
391_D	429_R	3.379	1.00
570_E	612_G	3.209	1.00
491_R	513_E	2.998	1.00
263_I	280_I	2.997	1.00
608_S	612_G	2.883	1.00
598_E	601_A	2.876	1.00
215_K	226_E	2.847	1.00
316_E	368_E	2.815	1.00
610_K	614_E	2.797	1.00
389_R	392_E	2.744	1.00
320_A	365_V	2.674	1.00
392_E	400_R	2.626	1.00
318_V	364_P	2.555	1.00
578_L	609_A	2.504	1.00
225_F	241_R	2.440	1.00
326_I	329_D	2.426	1.00
570_E	616_C	2.422	1.00
320_A	357_L	2.414	1.00
233_S	237_Q	2.355	1.00
267_R	280_I	2.288	1.00
145_R	149_D	2.269	1.00
577_Q	580_Q	2.235	1.00
574_L	616_C	2.213	1.00
355_I	483_V	2.209	1.00
582_E	606_Q	2.198	1.00
566_R	570_E	2.193	1.00
321_G	365_V	2.186	1.00
567_L	616_C	2.152	1.00
561_R	565_A	2.151	1.00
213_V	216_I	2.143	1.00
581_A	602_C	2.125	1.00
193_K	211_P	2.122	1.00
584_K	598_E	2.118	1.00
339_S	496_D	2.115	1.00
604_Q	608_S	2.092	1.00
601_A	605_Q	2.091	1.00
121_D	124_S	2.066	1.00
584_K	587_D	2.064	1.00
580_Q	584_K	2.056	1.00
335_L	341_I	2.053	1.00
582_E	610_K	2.044	1.00
249_Y	253_Q	2.032	1.00
571_M	613_L	2.002	1.00
116_K	120_I	2.001	1.00
128_R	167_R	1.981	1.00
233_S	236_V	1.956	1.00
342_G	490_L	1.951	1.00
578_L	606_Q	1.935	1.00
236_V	240_T	1.929	1.00
227_Y	241_R	1.929	1.00
572_E	575_N	1.895	1.00
617_E	621_L	1.878	1.00
605_Q	608_S	1.872	1.00
142_Q	145_R	1.859	1.00
573_K	577_Q	1.857	1.00
269_K	272_K	1.854	1.00
280_I	284_E	1.853	1.00
357_L	364_P	1.841	1.00
117_L	122_A	1.817	1.00
319_S	366_S	1.810	1.00
574_L	609_A	1.804	1.00
255_R	258_H	1.803	1.00
237_Q	240_T	1.803	1.00
581_A	609_A	1.793	1.00
562_K	565_A	1.785	1.00
278_S	281_K	1.762	1.00
277_Q	280_I	1.758	1.00
317_K	332_K	1.747	1.00
315_M	333_L	1.734	1.00
428_T	439_L	1.732	1.00
600_T	604_Q	1.710	1.00
341_I	498_Y	1.699	1.00
189_E	211_P	1.697	1.00
254_E	257_A	1.693	1.00
597_A	601_A	1.657	1.00
577_Q	609_A	1.655	1.00
146_P	149_D	1.654	1.00
239_A	243_A	1.640	1.00
614_E	618_M	1.636	1.00
277_Q	281_K	1.633	1.00
357_L	369_I	1.629	1.00
240_T	244_Q	1.621	1.00
266_F	269_K	1.612	1.00
240_T	243_A	1.603	1.00
564_I	623_A	1.596	1.00
244_Q	248_M	1.592	1.00
572_E	576_A	1.586	1.00
576_A	580_Q	1.579	1.00
606_Q	610_K	1.578	1.00
612_G	616_C	1.559	1.00
569_K	572_E	1.558	1.00
578_L	610_K	1.553	1.00
172_L	202_I	1.549	1.00
618_M	621_L	1.545	1.00
315_M	358_L	1.535	1.00
570_E	573_K	1.527	1.00
323_G	326_I	1.517	1.00
496_D	507_P	1.510	1.00
359_A	453_L	1.504	1.00
263_I	283_L	1.500	1.00
109_A	112_T	1.498	1.00
256_V	288_L	1.498	1.00
356_K	361_E	1.496	1.00
321_G	326_I	1.491	1.00
551_A	554_R	1.486	1.00
511_D	514_D	1.484	1.00
218_H	234_F	1.483	1.00
147_V	158_L	1.481	1.00
562_K	566_R	1.473	1.00
609_A	612_G	1.468	1.00
259_L	282_M	1.464	1.00
605_Q	609_A	1.459	1.00
394_P	439_L	1.435	1.00
328_L	331_I	1.429	1.00
575_N	613_L	1.421	1.00
267_R	270_A	1.420	1.00
261_S	264_D	1.417	1.00
557_T	561_R	1.416	1.00
558_Q	562_K	1.409	1.00
607_A	611_S	1.407	1.00
237_Q	241_R	1.399	1.00
574_L	578_L	1.394	1.00
357_L	365_V	1.393	1.00
578_L	582_E	1.392	1.00
571_M	575_N	1.388	1.00
260_Q	288_L	1.373	1.00
615_E	619_A	1.371	1.00
342_G	494_T	1.362	1.00
217_I	224_M	1.352	1.00
550_E	554_R	1.352	1.00
311_P	370_G	1.348	1.00
548_R	551_A	1.345	1.00
619_A	623_A	1.341	1.00
588_S	591_Y	1.338	1.00
612_G	615_E	1.332	1.00
230_N	233_S	1.326	1.00
618_M	622_E	1.317	1.00
449_P	476_F	1.315	1.00
393_S	396_Q	1.311	1.00
329_D	504_K	1.299	1.00
587_D	590_L	1.296	1.00
112_T	116_K	1.294	1.00
314_K	370_G	1.291	1.00
482_V	494_T	1.290	1.00
584_K	602_C	1.289	1.00
281_K	284_E	1.285	1.00
621_L	625_E	1.282	1.00
405_E	409_K	1.280	1.00
611_S	614_E	1.277	1.00
392_E	397_H	1.276	1.00
619_A	622_E	1.272	1.00
333_L	498_Y	1.264	1.00
397_H	443_L	1.263	1.00
579_A	582_E	1.262	1.00
578_L	613_L	1.259	1.00
598_E	602_C	1.258	1.00
582_E	586_G	1.258	1.00
397_H	428_T	1.255	1.00
577_Q	584_K	1.255	1.00
615_E	618_M	1.255	1.00
473_L	480_L	1.250	1.00
276_A	280_I	1.245	1.00
378_G	449_P	1.244	1.00
557_T	560_L	1.244	1.00
218_H	238_R	1.242	1.00
567_L	623_A	1.240	1.00
266_F	272_K	1.239	1.00
275_Q	283_L	1.233	1.00
396_Q	399_A	1.230	1.00
426_E	430_R	1.226	1.00
579_A	583_E	1.224	1.00
229_G	237_Q	1.217	1.00
574_L	613_L	1.215	1.00
585_L	590_L	1.214	1.00
318_V	369_I	1.211	1.00
318_V	357_L	1.211	1.00
549_R	553_L	1.205	1.00
246_Q	250_E	1.201	1.00
108_H	112_T	1.198	1.00
570_E	574_L	1.197	1.00
556_Q	560_L	1.196	1.00
217_I	226_E	1.195	1.00
604_Q	607_A	1.192	1.00
115_G	118_D	1.189	1.00
560_L	623_A	1.189	1.00
390_A	429_R	1.188	1.00
115_G	119_A	1.186	1.00
201_L	213_V	1.178	1.00
501_H	506_E	1.176	1.00
277_Q	285_R	1.170	1.00
252_Q	289_I	1.168	1.00
564_I	624_Q	1.163	1.00
547_K	550_E	1.163	1.00
555_A	558_Q	1.162	1.00
320_A	362_L	1.161	1.00
516_Q	519_L	1.160	1.00
229_G	233_S	1.155	1.00
155_R	383_H	1.154	1.00
406_L	409_K	1.153	1.00
253_Q	256_V	1.144	1.00
170_L	198_T	1.142	1.00
274_K	280_I	1.142	1.00
603_L	607_A	1.141	1.00
563_E	567_L	1.141	1.00
451_L	481_V	1.141	1.00
394_P	428_T	1.138	1.00
150_F	158_L	1.138	1.00
547_K	551_A	1.137	1.00
601_A	604_Q	1.133	1.00
315_M	369_I	1.130	1.00
609_A	613_L	1.130	1.00
276_A	279_R	1.129	1.00
126_R	130_A	1.129	1.00
560_L	564_I	1.122	1.00
580_Q	583_E	1.120	1.00
107_G	110_I	1.119	1.00
372_A	375_I	1.113	1.00
279_R	283_L	1.113	1.00
249_Y	252_Q	1.112	1.00
473_L	493_T	1.106	0.99
276_A	283_L	1.106	0.99
268_A	272_K	1.104	0.99
275_Q	281_K	1.101	0.99
341_I	481_V	1.087	0.99
219_I	224_M	1.085	0.99
510_G	514_D	1.081	0.99
552_E	556_Q	1.080	0.99
331_I	498_Y	1.076	0.99
585_L	603_L	1.075	0.99
414_L	417_F	1.075	0.99
548_R	552_E	1.073	0.99
139_S	142_Q	1.069	0.99
172_L	200_I	1.066	0.99
190_K	193_K	1.065	0.99
607_A	610_K	1.063	0.99
614_E	621_L	1.060	0.99
567_L	571_M	1.059	0.99
262_Y	275_Q	1.057	0.99
589_E	592_D	1.053	0.99
568_E	572_E	1.051	0.99
392_E	396_Q	1.050	0.99
275_Q	278_S	1.047	0.99
614_E	617_E	1.047	0.99
356_K	362_L	1.046	0.99
376_K	447_Q	1.044	0.99
274_K	278_S	1.044	0.99
292_A	296_N	1.044	0.99
559_P	562_K	1.042	0.99
559_P	563_E	1.039	0.99
124_S	128_R	1.038	0.99
328_L	357_L	1.037	0.99
352_S	356_K	1.035	0.99
109_A	113_I	1.030	0.99
316_E	332_K	1.029	0.99
183_D	346_R	1.027	0.99
371_L	375_I	1.025	0.99
273_A	277_Q	1.025	0.99
274_K	277_Q	1.024	0.99
423_K	426_E	1.024	0.99
106_D	109_A	1.021	0.99
278_S	283_L	1.020	0.99
111_A	115_G	1.017	0.99
554_R	558_Q	1.015	0.99
275_Q	287_E	1.015	0.99
276_A	287_E	1.014	0.99
482_V	490_L	1.014	0.99
565_A	569_K	1.013	0.99
602_C	605_Q	1.011	0.99
167_R	196_Q	1.010	0.99
518_W	522_V	1.008	0.99
408_Q	412_D	1.007	0.99
542_A	545_D	1.001	0.99
286_M	289_I	0.999	0.99
276_A	285_R	0.997	0.99
192_L	199_L	0.996	0.99
514_D	517_Q	0.994	0.99
546_Q	550_E	0.993	0.99
577_Q	581_A	0.990	0.99
546_Q	549_R	0.987	0.99
252_Q	286_M	0.987	0.99
276_A	281_K	0.986	0.99
581_A	606_Q	0.982	0.99
608_S	611_S	0.981	0.99
244_Q	247_A	0.977	0.99
277_Q	283_L	0.970	0.99
293_H	296_N	0.970	0.99
402_A	407_E	0.966	0.99
256_V	283_L	0.965	0.99
524_K	528_Q	0.965	0.99
346_R	349_A	0.964	0.99
558_Q	561_R	0.963	0.99
566_R	569_K	0.962	0.99
281_K	285_R	0.962	0.99
322_Y	327_I	0.960	0.99
243_A	247_A	0.958	0.99
560_L	563_E	0.955	0.99
278_S	285_R	0.954	0.98
453_L	481_V	0.954	0.98
482_V	493_T	0.947	0.98
283_L	286_M	0.947	0.98
290_A	296_N	0.945	0.98
319_S	330_S	0.944	0.98
583_E	587_D	0.944	0.98
519_L	522_V	0.944	0.98
540_A	544_K	0.943	0.98
618_M	625_E	0.941	0.98
544_K	547_K	0.941	0.98
550_E	553_L	0.940	0.98
522_V	525_Q	0.939	0.98
264_D	267_R	0.937	0.98
242_L	246_Q	0.933	0.98
207_D	488_H	0.932	0.98
255_R	286_M	0.930	0.98
523_Q	526_E	0.929	0.98
190_K	194_S	0.929	0.98
599_L	603_L	0.928	0.98
116_K	119_A	0.927	0.98
278_S	286_M	0.925	0.98
391_D	427_E	0.921	0.98
268_A	271_T	0.920	0.98
548_R	554_R	0.919	0.98
285_R	289_I	0.919	0.98
611_S	615_E	0.919	0.98
279_R	286_M	0.919	0.98
546_Q	551_A	0.917	0.98
569_K	573_K	0.917	0.98
482_V	489_L	0.915	0.98
319_S	329_D	0.914	0.98
267_R	271_T	0.909	0.98
515_Y	519_L	0.906	0.98
585_L	599_L	0.902	0.98
571_M	617_E	0.902	0.98
320_A	353_T	0.900	0.98
261_S	265_R	0.897	0.98
525_Q	528_Q	0.896	0.98
267_R	272_K	0.893	0.98
567_L	619_A	0.893	0.98
101_A	105_N	0.892	0.98
552_E	555_A	0.889	0.98
284_E	288_L	0.883	0.98
490_L	494_T	0.876	0.97
308_L	375_I	0.874	0.97
313_L	371_L	0.874	0.97
581_A	605_Q	0.874	0.97
275_Q	285_R	0.874	0.97
513_E	517_Q	0.871	0.97
364_P	369_I	0.868	0.97
528_Q	532_A	0.866	0.97
568_E	575_N	0.866	0.97
269_K	273_A	0.857	0.97
575_N	617_E	0.855	0.97
545_D	548_R	0.852	0.97
321_G	324_D	0.851	0.97
243_A	246_Q	0.850	0.97
590_L	602_C	0.849	0.97
280_I	283_L	0.849	0.97
409_K	412_D	0.848	0.97
412_D	416_G	0.847	0.97
227_Y	234_F	0.846	0.97
310_N	336_V	0.843	0.97
553_L	556_Q	0.843	0.97
322_Y	362_L	0.842	0.97
603_L	606_Q	0.841	0.97
270_A	273_A	0.837	0.97
266_F	273_A	0.836	0.97
504_K	507_P	0.835	0.97
395_I	399_A	0.835	0.97
549_R	552_E	0.835	0.97
266_F	270_A	0.833	0.96
514_D	518_W	0.833	0.96
576_A	579_A	0.833	0.96
314_K	334_N	0.833	0.96
499_L	515_Y	0.831	0.96
255_R	259_L	0.829	0.96
279_R	285_R	0.823	0.96
584_K	605_Q	0.823	0.96
290_A	295_D	0.822	0.96
210_D	230_N	0.822	0.96
523_Q	527_N	0.821	0.96
512_L	515_Y	0.821	0.96
596_K	600_T	0.819	0.96
285_R	288_L	0.818	0.96
147_V	159_N	0.818	0.96
564_I	567_L	0.816	0.96
304_A	477_E	0.815	0.96
501_H	504_K	0.815	0.96
512_L	516_Q	0.814	0.96
427_E	430_R	0.813	0.96
590_L	593_Q	0.811	0.96
600_T	603_L	0.811	0.96
220_E	225_F	0.808	0.96
250_E	254_E	0.807	0.96
395_I	410_L	0.805	0.96
398_L	442_A	0.804	0.96
258_H	261_S	0.803	0.96
278_S	282_M	0.799	0.96
140_N	143_L	0.798	0.95
168_S	195_Y	0.796	0.95
563_E	570_E	0.795	0.95
275_Q	280_I	0.794	0.95
140_N	144_E	0.794	0.95
474_I	492_S	0.792	0.95
515_Y	518_W	0.792	0.95
411_R	424_V	0.791	0.95
134_H	143_L	0.788	0.95
308_L	451_L	0.785	0.95
278_S	287_E	0.785	0.95
415_G	420_Q	0.785	0.95
463_L	467_Q	0.784	0.95
499_L	519_L	0.781	0.95
583_E	586_G	0.779	0.95
273_A	280_I	0.779	0.95
275_Q	282_M	0.778	0.95
389_R	397_H	0.778	0.95
508_F	518_W	0.777	0.95
519_L	523_Q	0.775	0.95
529_T	532_A	0.770	0.95
227_Y	237_Q	0.768	0.94
316_E	370_G	0.766	0.94
209_L	234_F	0.764	0.94
415_G	419_F	0.763	0.94
399_A	410_L	0.763	0.94
139_S	143_L	0.761	0.94
555_A	562_K	0.758	0.94
454_L	480_L	0.756	0.94
127_S	131_S	0.756	0.94
313_L	335_L	0.755	0.94
275_Q	279_R	0.755	0.94
278_S	289_I	0.754	0.94
277_Q	287_E	0.754	0.94
471_E	475_E	0.752	0.94
484_S	489_L	0.752	0.94
121_D	128_R	0.751	0.94
573_K	576_A	0.750	0.94
540_A	545_D	0.749	0.94
125_I	129_A	0.749	0.94
309_P	372_A	0.749	0.94
136_L	161_A	0.747	0.94
527_N	530_D	0.744	0.93
415_G	421_G	0.743	0.93
306_E	376_K	0.743	0.93
319_S	326_I	0.742	0.93
218_H	241_R	0.742	0.93
597_A	600_T	0.738	0.93
593_Q	596_K	0.738	0.93
309_P	312_L	0.737	0.93
396_Q	400_R	0.736	0.93
378_G	444_I	0.735	0.93
585_L	591_Y	0.734	0.93
272_K	280_I	0.734	0.93
528_Q	531_E	0.731	0.93
268_A	273_A	0.731	0.93
574_L	612_G	0.730	0.93
563_E	566_R	0.728	0.93
531_E	534_K	0.727	0.93
590_L	599_L	0.726	0.93
547_K	553_L	0.725	0.93
542_A	546_Q	0.725	0.93
163_A	171_L	0.724	0.93
571_M	616_C	0.723	0.92
203_S	209_L	0.722	0.92
360_G	371_L	0.722	0.92
264_D	269_K	0.721	0.92
105_N	109_A	0.718	0.92
317_K	366_S	0.717	0.92
575_N	579_A	0.715	0.92
560_L	568_E	0.713	0.92
541_Q	545_D	0.712	0.92
357_L	363_A	0.711	0.92
593_Q	598_E	0.709	0.92
216_I	230_N	0.709	0.92
110_I	117_L	0.707	0.92
138_F	150_F	0.706	0.92
344_L	497_L	0.705	0.92
591_Y	599_L	0.705	0.92
329_D	366_S	0.704	0.91
556_Q	559_P	0.704	0.91
108_H	111_A	0.704	0.91
257_A	261_S	0.703	0.91
581_A	585_L	0.702	0.91
553_L	557_T	0.699	0.91
518_W	521_D	0.698	0.91
259_L	262_Y	0.697	0.91
620_W	624_Q	0.696	0.91
574_L	577_Q	0.696	0.91
281_K	286_M	0.696	0.91
262_Y	279_R	0.694	0.91
270_A	277_Q	0.693	0.91
339_S	495_D	0.693	0.91
563_E	623_A	0.692	0.91
308_L	312_L	0.691	0.91
329_D	502_D	0.690	0.91
577_Q	612_G	0.690	0.91
525_Q	529_T	0.690	0.91
276_A	286_M	0.690	0.91
596_K	599_L	0.690	0.91
290_A	294_V	0.689	0.91
210_D	488_H	0.689	0.91
335_L	498_Y	0.686	0.90
293_H	297_P	0.685	0.90
588_S	592_D	0.685	0.90
613_L	616_C	0.684	0.90
543_R	551_A	0.683	0.90
272_K	277_Q	0.678	0.90
358_L	481_V	0.677	0.90
267_R	273_A	0.677	0.90
354_L	358_L	0.677	0.90
290_A	293_H	0.675	0.90
110_I	114_H	0.673	0.90
130_A	140_N	0.670	0.89
273_A	276_A	0.670	0.89
613_L	617_E	0.669	0.89
522_V	526_E	0.668	0.89
524_K	527_N	0.668	0.89
355_I	453_L	0.667	0.89
312_L	479_A	0.667	0.89
277_Q	284_E	0.666	0.89
292_A	295_D	0.664	0.89
543_R	546_Q	0.662	0.89
322_Y	326_I	0.661	0.89
248_M	289_I	0.660	0.89
278_S	284_E	0.659	0.89
114_H	118_D	0.659	0.89
393_S	427_E	0.658	0.89
195_Y	199_L	0.657	0.88
275_Q	289_I	0.657	0.88
335_L	479_A	0.656	0.88
568_E	624_Q	0.654	0.88
422_D	425_T	0.653	0.88
453_L	483_V	0.653	0.88
263_I	267_R	0.652	0.88
281_K	287_E	0.652	0.88
118_D	122_A	0.652	0.88
542_A	551_A	0.652	0.88
510_G	515_Y	0.650	0.88
411_R	421_G	0.650	0.88
555_A	559_P	0.649	0.88
247_A	250_E	0.647	0.88
262_Y	271_T	0.646	0.88
413_Y	416_G	0.645	0.88
291_P	294_V	0.645	0.88
500_V	505_V	0.644	0.87
134_H	140_N	0.644	0.87
405_E	446_W	0.642	0.87
274_K	281_K	0.641	0.87
540_A	543_R	0.641	0.87
241_R	244_Q	0.640	0.87
321_G	357_L	0.637	0.87
402_A	405_E	0.637	0.87
124_S	127_S	0.635	0.87
413_Y	419_F	0.635	0.87
266_F	280_I	0.633	0.87
556_Q	563_E	0.633	0.87
377_L	451_L	0.631	0.86
320_A	328_L	0.630	0.86
125_I	165_I	0.629	0.86
130_A	143_L	0.628	0.86
251_S	255_R	0.627	0.86
268_A	280_I	0.626	0.86
521_D	525_Q	0.626	0.86
581_A	584_K	0.625	0.86
319_S	328_L	0.624	0.86
311_P	314_K	0.624	0.86
276_A	282_M	0.624	0.86
255_R	282_M	0.623	0.86
281_K	289_I	0.623	0.86
349_A	500_V	0.622	0.86
539_S	542_A	0.621	0.85
395_I	425_T	0.620	0.85
199_L	212_I	0.620	0.85
256_V	263_I	0.620	0.85
405_E	410_L	0.619	0.85
547_K	554_R	0.618	0.85
320_A	323_G	0.617	0.85
277_Q	282_M	0.616	0.85
372_A	450_N	0.613	0.85
568_E	581_A	0.613	0.85
294_V	297_P	0.613	0.85
361_E	387_Y	0.613	0.85
358_L	369_I	0.612	0.85
335_L	451_L	0.612	0.85
530_D	533_P	0.612	0.85
270_A	274_K	0.612	0.85
268_A	277_Q	0.612	0.85
556_Q	564_I	0.611	0.85
262_Y	266_F	0.611	0.85
276_A	289_I	0.610	0.84
607_A	614_E	0.609	0.84
571_M	579_A	0.608	0.84
118_D	123_W	0.607	0.84
131_S	135_G	0.605	0.84
182_L	186_I	0.605	0.84
252_Q	256_V	0.605	0.84
413_Y	446_W	0.605	0.84
309_P	373_K	0.605	0.84
117_L	121_D	0.604	0.84
338_G	479_A	0.604	0.84
596_K	603_L	0.604	0.84
605_Q	612_G	0.603	0.84
179_H	442_A	0.602	0.84
189_E	487_R	0.602	0.84
142_Q	150_F	0.602	0.84
539_S	543_R	0.601	0.84
170_L	200_I	0.601	0.84
551_A	559_P	0.600	0.83
269_K	280_I	0.600	0.83
393_S	397_H	0.599	0.83
505_V	508_F	0.599	0.83
216_I	220_E	0.597	0.83
567_L	575_N	0.597	0.83
266_F	277_Q	0.595	0.83
413_Y	442_A	0.595	0.83
265_R	268_A	0.595	0.83
410_L	419_F	0.595	0.83
252_Q	263_I	0.593	0.83
555_A	565_A	0.593	0.83
107_G	111_A	0.593	0.83
520_S	523_Q	0.592	0.83
263_I	284_E	0.592	0.83
145_R	150_F	0.591	0.83
201_L	212_I	0.591	0.83
236_V	239_A	0.591	0.83
504_K	508_F	0.591	0.83
526_E	530_D	0.590	0.82
498_Y	507_P	0.590	0.82
276_A	284_E	0.590	0.82
272_K	278_S	0.589	0.82
358_L	371_L	0.589	0.82
598_E	605_Q	0.589	0.82
508_F	514_D	0.588	0.82
395_I	424_V	0.588	0.82
405_E	408_Q	0.588	0.82
273_A	281_K	0.588	0.82
266_F	275_Q	0.587	0.82
113_I	116_K	0.585	0.82
324_D	327_I	0.583	0.82
533_P	546_Q	0.583	0.82
247_A	251_S	0.582	0.82
359_A	377_L	0.582	0.82
538_N	541_Q	0.580	0.81
503_R	507_P	0.580	0.81
554_R	559_P	0.579	0.81
568_E	574_L	0.578	0.81
235_E	467_Q	0.577	0.81
317_K	320_A	0.575	0.81
312_L	450_N	0.575	0.81
380_F	437_A	0.575	0.81
600_T	607_A	0.574	0.81
260_Q	263_I	0.574	0.81
267_R	276_A	0.574	0.81
390_A	436_K	0.573	0.81
583_E	605_Q	0.572	0.81
274_K	279_R	0.570	0.80
529_T	533_P	0.568	0.80
277_Q	289_I	0.568	0.80
614_E	625_E	0.568	0.80
545_D	580_Q	0.567	0.80
321_G	327_I	0.567	0.80
318_V	328_L	0.566	0.80
275_Q	286_M	0.565	0.80
567_L	570_E	0.564	0.80
110_I	118_D	0.564	0.80
516_Q	520_S	0.562	0.79
543_R	550_E	0.562	0.79
577_Q	608_S	0.561	0.79
578_L	581_A	0.561	0.79
192_L	212_I	0.561	0.79
564_I	568_E	0.560	0.79
331_I	505_V	0.559	0.79
225_F	234_F	0.557	0.79
521_D	524_K	0.557	0.79
537_A	540_A	0.557	0.79
371_L	377_L	0.557	0.79
284_E	287_E	0.556	0.79
265_R	271_T	0.556	0.79
265_R	273_A	0.556	0.79
570_E	577_Q	0.553	0.78
230_N	237_Q	0.552	0.78
272_K	275_Q	0.552	0.78
101_A	106_D	0.552	0.78
246_Q	249_Y	0.550	0.78
343_L	481_V	0.550	0.78
245_Q	289_I	0.548	0.78
551_A	557_T	0.548	0.78
524_K	530_D	0.547	0.78
132_L	191_W	0.547	0.78
256_V	260_Q	0.547	0.78
590_L	598_E	0.546	0.77
542_A	615_E	0.546	0.77
387_Y	440_V	0.545	0.77
559_P	565_A	0.544	0.77
262_Y	270_A	0.544	0.77
232_S	236_V	0.543	0.77
398_L	410_L	0.542	0.77
260_Q	283_L	0.542	0.77
298_F	302_F	0.541	0.77
136_L	187_W	0.541	0.77
271_T	274_K	0.540	0.77
554_R	557_T	0.540	0.77
575_N	578_L	0.540	0.77
262_Y	269_K	0.539	0.76
237_Q	244_Q	0.539	0.76
247_A	439_L	0.538	0.76
303_R	448_R	0.538	0.76
581_A	590_L	0.538	0.76
408_Q	416_G	0.538	0.76
309_P	489_L	0.537	0.76
113_I	117_L	0.537	0.76
541_Q	546_Q	0.537	0.76
359_A	379_Y	0.536	0.76
563_E	616_C	0.536	0.76
272_K	276_A	0.535	0.76
245_Q	248_M	0.534	0.76
147_V	155_R	0.534	0.76
533_P	537_A	0.534	0.76
501_H	519_L	0.532	0.76
271_T	276_A	0.532	0.76
262_Y	268_A	0.531	0.75
274_K	283_L	0.531	0.75
544_K	611_S	0.531	0.75
228_T	233_S	0.531	0.75
207_D	491_R	0.530	0.75
117_L	123_W	0.529	0.75
530_D	534_K	0.529	0.75
245_Q	291_P	0.529	0.75
544_K	550_E	0.528	0.75
568_E	588_S	0.527	0.75
488_H	492_S	0.526	0.75
560_L	565_A	0.525	0.75
129_A	165_I	0.524	0.74
557_T	562_K	0.524	0.74
580_Q	605_Q	0.524	0.74
172_L	617_E	0.523	0.74
321_G	366_S	0.523	0.74
267_R	285_R	0.522	0.74
420_Q	423_K	0.521	0.74
360_G	363_A	0.521	0.74
531_E	535_E	0.520	0.74
262_Y	273_A	0.519	0.74
538_N	543_R	0.519	0.74
280_I	286_M	0.519	0.74
534_K	546_Q	0.517	0.74
193_K	212_I	0.517	0.74
429_R	439_L	0.517	0.74
611_S	618_M	0.516	0.73
268_A	276_A	0.516	0.73
266_F	271_T	0.516	0.73
265_R	269_K	0.515	0.73
606_Q	613_L	0.514	0.73
501_H	508_F	0.514	0.73
534_K	537_A	0.514	0.73
259_L	279_R	0.513	0.73
164_L	187_W	0.511	0.73
251_S	254_E	0.510	0.73
258_H	282_M	0.509	0.72
218_H	227_Y	0.508	0.72
269_K	278_S	0.508	0.72
536_N	543_R	0.508	0.72
542_A	548_R	0.508	0.72
440_V	443_L	0.507	0.72
534_K	544_K	0.507	0.72
291_P	296_N	0.506	0.72
154_W	380_F	0.505	0.72
498_Y	505_V	0.505	0.72
139_S	145_R	0.503	0.71
526_E	529_T	0.503	0.71
543_R	547_K	0.503	0.71
282_M	285_R	0.502	0.71
206_R	470_T	0.500	0.71
273_A	278_S	0.500	0.71
277_Q	286_M	0.500	0.71

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4finA	2	0.8179	100	0.422	Contact Map
2iw3A	2	0.6719	100	0.492	Contact Map
4q9hA	1	0.7708	100	0.505	Contact Map
4f4cA	1	0.73	100	0.51	Contact Map
3bk7A	1	0.7802	100	0.536	Contact Map
1yqtA	1	0.7818	100	0.541	Contact Map
3ozxA	1	0.7739	100	0.553	Contact Map
3j16B	1	0.8006	100	0.561	Contact Map
3ux8A	2	0.6546	100	0.595	Contact Map
2vf7A	2	0.7394	100	0.642	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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