GREMLIN Database
YQEG - Inner membrane transport protein YqeG
UniProt: P63340 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13098
Length: 409 (399)
Sequences: 464 (237)
Seq/√Len: 11.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_W10_T5.2671.00
17_Y244_S5.0371.00
98_F343_I4.8341.00
116_L122_I3.7280.99
113_T124_L3.6690.99
260_Y263_A3.4000.98
339_L343_I3.3460.98
161_I240_I3.2880.97
241_I299_K3.2430.97
105_A138_L2.9550.95
160_L241_I2.9350.95
98_F339_L2.9210.95
160_L299_K2.8840.94
59_C215_A2.7340.93
96_A362_S2.7020.92
70_G219_R2.6470.91
263_A267_E2.4360.87
260_Y278_L2.4150.87
213_T306_F2.3860.86
160_L244_S2.3390.85
65_S76_A2.3080.84
372_I376_L2.2810.83
313_T336_S2.2800.83
198_I402_C2.2760.83
153_M299_K2.2460.82
146_R309_I2.2440.82
139_N301_F2.2330.82
384_L388_R2.2270.82
131_S281_A2.2240.82
385_K388_R2.2170.82
42_I190_T2.2160.82
9_E229_K2.1920.81
64_S80_Y2.1590.80
206_S209_P2.1410.79
136_L341_S2.1400.79
47_A201_M2.1180.78
48_W65_S2.0720.77
375_T391_G2.0680.77
244_S299_K2.0650.77
42_I401_L2.0560.76
355_I387_W1.9530.72
332_N389_S1.9220.71
155_F180_L1.9210.71
317_K336_S1.8990.70
353_N356_S1.8930.70
114_E276_S1.8880.70
160_L168_S1.8110.66
393_L397_I1.8070.66
54_P194_I1.8070.66
219_R229_K1.7940.66
98_F255_S1.7830.65
113_T130_V1.7640.64
132_L232_K1.7440.63
379_Y396_L1.7410.63
346_I407_F1.7240.62
241_I244_S1.7110.62
78_T318_T1.7030.61
70_G135_V1.6770.60
95_I362_S1.6740.60
132_L341_S1.6690.60
297_M394_I1.6690.60
25_T299_K1.6610.59
237_A244_S1.6590.59
336_S346_I1.6510.59
267_E285_L1.6500.59
103_I244_S1.6260.58
18_G297_M1.6140.57
150_I160_L1.5890.56
372_I396_L1.5860.56
218_R230_C1.5830.56
312_A316_V1.5810.55
335_L339_L1.5620.54
229_K232_K1.5570.54
34_S52_Y1.5550.54
117_A124_L1.5500.54
115_Q294_V1.5420.54
153_M241_I1.5370.53
6_S222_Y1.5320.53
15_A163_Y1.5250.53
95_I144_M1.4780.50
113_T117_A1.4740.50
121_V133_G1.4710.50
238_Y244_S1.4700.50
356_S359_Y1.4630.50
169_I350_I1.4460.49
100_V366_I1.4420.49
73_I209_P1.4330.48
132_L136_L1.4160.47
87_N315_V1.4110.47
25_T241_I1.3970.46
57_A144_M1.3930.46
96_A295_V1.3920.46
148_A403_V1.3910.46
262_E266_E1.3830.46
101_V301_F1.3780.45
313_T333_R1.3740.45
73_I358_I1.3720.45
362_S388_R1.3580.44
168_S247_F1.3470.44
153_M209_P1.3400.43
42_I194_I1.3360.43
5_W9_E1.3260.43
215_A230_C1.3170.42
347_V362_S1.3040.42
73_I305_Y1.3010.42
191_L376_L1.2900.41
156_L287_I1.2870.41
301_F305_Y1.2790.40
146_R220_E1.2770.40
162_A166_F1.2720.40
299_K302_L1.2720.40
6_S217_D1.2690.40
223_G392_N1.2670.40
21_V160_L1.2580.39
32_L246_L1.2520.39
115_Q290_I1.2500.39
45_L174_S1.2490.39
141_I400_I1.2430.39
112_L134_V1.2410.39
315_V395_T1.2330.38
153_M160_L1.2330.38
106_V144_M1.2270.38
263_A266_E1.2240.38
129_L178_D1.2230.38
72_G76_A1.2210.38
215_A395_T1.2180.38
292_V300_S1.2170.38
372_I400_I1.2170.38
210_I299_K1.2100.37
204_A315_V1.1950.37
384_L403_V1.1930.36
41_F397_I1.1920.36
114_E285_L1.1850.36
87_N91_T1.1800.36
27_F354_A1.1800.36
106_V354_A1.1760.36
350_I407_F1.1740.36
319_T342_L1.1730.36
105_A237_A1.1660.35
47_A197_S1.1650.35
171_L300_S1.1620.35
379_Y401_L1.1620.35
330_A334_A1.1610.35
81_Y370_L1.1580.35
357_M363_G1.1580.35
167_L245_V1.1520.35
146_R344_T1.1490.34
200_V363_G1.1470.34
160_L300_S1.1370.34
91_T386_P1.1360.34
42_I330_A1.1360.34
379_Y388_R1.1310.34
17_Y299_K1.1280.33
17_Y237_A1.1270.33
166_F247_F1.1270.33
7_K108_I1.1240.33
390_I400_I1.1220.33
57_A108_I1.1200.33
150_I299_K1.1160.33
101_V213_T1.1130.33
241_I302_L1.1130.33
133_G338_M1.1070.33
64_S398_V1.1010.32
17_Y238_Y1.1000.32
342_L346_I1.0990.32
73_I206_S1.0970.32
338_M378_T1.0950.32
284_W357_M1.0930.32
166_F266_E1.0920.32
201_M238_Y1.0910.32
359_Y363_G1.0900.32
45_L67_T1.0840.32
143_L289_G1.0820.31
15_A168_S1.0790.31
27_F109_T1.0760.31
127_R159_P1.0710.31
45_L343_I1.0660.31
238_Y241_I1.0640.31
375_T396_L1.0640.31
172_V401_L1.0640.31
376_L396_L1.0620.31
50_L111_S1.0590.30
270_T302_L1.0580.30
200_V282_P1.0500.30
66_K79_H1.0380.30
376_L389_S1.0350.29
133_G136_L1.0270.29
100_V206_S1.0260.29
88_L91_T1.0260.29
292_V335_L1.0250.29
44_A197_S1.0220.29
169_I221_K1.0210.29
142_F160_L1.0150.29
21_V241_I1.0130.29
48_W204_A1.0110.28
128_M169_I1.0100.28
21_V244_S1.0080.28
140_L169_I1.0080.28
17_Y65_S1.0080.28
32_L311_G1.0070.28
163_Y292_V0.9960.28
133_G137_I0.9930.28
204_A292_V0.9900.28
220_E288_S0.9900.28
208_T246_L0.9890.28
116_L124_L0.9860.27
84_K185_E0.9840.27
366_I406_M0.9780.27
258_P262_E0.9740.27
204_A331_F0.9740.27
52_Y387_W0.9740.27
23_A28_L0.9710.27
196_I289_G0.9590.26
395_T400_I0.9580.26
10_T340_V0.9580.26
76_A363_G0.9580.26
333_R380_L0.9560.26
105_A149_T0.9480.26
64_S357_M0.9430.26
184_V190_T0.9390.26
145_G357_M0.9370.26
269_V295_V0.9370.26
8_E218_R0.9370.26
218_R221_K0.9370.26
362_S403_V0.9350.25
379_Y393_L0.9340.25
95_I287_I0.9320.25
160_L289_G0.9280.25
115_Q274_A0.9260.25
102_L373_M0.9190.25
260_Y305_Y0.9150.25
347_V386_P0.9130.25
34_S166_F0.9100.25
379_Y384_L0.9080.24
375_T392_N0.9080.24
172_V294_V0.9080.24
103_I344_T0.9050.24
73_I96_A0.9030.24
49_P175_W0.9020.24
271_I305_Y0.9020.24
393_L396_L0.9020.24
374_P399_G0.9010.24
96_A209_P0.9000.24
162_A169_I0.8990.24
164_F394_I0.8980.24
17_Y149_T0.8950.24
156_L305_Y0.8920.24
118_K168_S0.8900.24
162_A227_M0.8880.24
341_S406_M0.8850.24
162_A393_L0.8850.24
17_Y59_C0.8830.24
88_L396_L0.8810.24
216_I242_C0.8810.24
116_L237_A0.8800.23
180_L281_A0.8790.23
215_A298_S0.8780.23
367_A370_L0.8760.23
21_V37_A0.8730.23
45_L151_R0.8720.23
18_G104_Y0.8700.23
346_I395_T0.8680.23
346_I350_I0.8660.23
140_L190_T0.8640.23
259_S326_K0.8620.23
160_L238_Y0.8620.23
185_E356_S0.8600.23
373_M404_S0.8590.23
160_L210_I0.8560.23
67_T71_E0.8550.23
32_L201_M0.8540.23
140_L180_L0.8460.22
32_L206_S0.8450.22
168_S237_A0.8450.22
378_T396_L0.8440.22
168_S244_S0.8440.22
228_D401_L0.8430.22
256_I276_S0.8420.22
27_F110_N0.8420.22
357_M365_L0.8400.22
46_V217_D0.8370.22
155_F224_E0.8340.22
168_S289_G0.8330.22
41_F95_I0.8330.22
128_M349_C0.8290.22
75_G332_N0.8280.22
134_V345_F0.8280.22
215_A400_I0.8260.22
169_I266_E0.8240.22
135_V344_T0.8220.21
144_M269_V0.8210.21
110_N127_R0.8190.21
47_A210_I0.8160.21
73_I311_G0.8160.21
91_T315_V0.8140.21
149_T271_I0.8130.21
17_Y160_L0.8130.21
118_K277_M0.8110.21
116_L169_I0.8110.21
366_I370_L0.8060.21
377_S392_N0.8050.21
65_S210_I0.8040.21
147_H167_L0.8030.21
359_Y370_L0.8020.21
51_T364_P0.8010.21
183_Q338_M0.8000.21
154_G197_S0.8000.21
38_V158_F0.8000.21
151_R245_V0.7990.21
316_V329_R0.7980.21
94_F364_P0.7980.21
259_S390_I0.7960.21
352_P363_G0.7960.21
84_K87_N0.7940.21
8_E145_G0.7930.20
154_G210_I0.7930.20
13_S262_E0.7920.20
73_I208_T0.7920.20
160_L292_V0.7910.20
43_T77_V0.7890.20
237_A299_K0.7840.20
154_G160_L0.7840.20
80_Y384_L0.7810.20
321_Q324_G0.7770.20
270_T405_V0.7760.20
65_S244_S0.7720.20
163_Y250_F0.7710.20
237_A242_C0.7710.20
16_L19_T0.7670.20
232_K294_V0.7660.20
91_T177_P0.7650.20
91_T319_T0.7620.19
357_M362_S0.7620.19
363_G404_S0.7600.19
47_A63_L0.7600.19
153_M295_V0.7590.19
104_Y175_W0.7590.19
101_V257_P0.7520.19
15_A150_I0.7510.19
337_I365_L0.7510.19
38_V41_F0.7490.19
113_T125_R0.7490.19
115_Q301_F0.7470.19
42_I354_A0.7460.19
59_C373_M0.7440.19
38_V232_K0.7420.19
65_S150_I0.7410.19
105_A244_S0.7400.19
119_H164_F0.7320.19
11_L48_W0.7310.19
86_G92_L0.7290.18
52_Y240_I0.7280.18
212_S296_A0.7270.18
243_I368_M0.7270.18
152_V384_L0.7250.18
42_I335_L0.7240.18
21_V295_V0.7240.18
246_L347_V0.7220.18
156_L382_P0.7220.18
61_F373_M0.7220.18
34_S230_C0.7210.18
389_S393_L0.7210.18
99_V203_F0.7180.18
16_L370_L0.7150.18
39_V60_Q0.7130.18
48_W150_I0.7110.18
329_R338_M0.7100.18
143_L160_L0.7100.18
315_V319_T0.7080.18
91_T185_E0.7070.18
25_T244_S0.7070.18
202_V206_S0.7060.18
71_E79_H0.7050.18
123_D357_M0.7040.18
92_L245_V0.7030.18
114_E119_H0.7000.18
210_I244_S0.6980.18
100_V203_F0.6980.18
327_K350_I0.6960.18
294_V344_T0.6940.17
131_S345_F0.6920.17
190_T313_T0.6910.17
191_L194_I0.6900.17
246_L302_L0.6890.17
386_P400_I0.6890.17
5_W236_V0.6860.17
104_Y296_A0.6860.17
332_N403_V0.6850.17
321_Q388_R0.6850.17
158_F210_I0.6850.17
74_T94_F0.6850.17
379_Y398_V0.6830.17
162_A381_I0.6820.17
180_L354_A0.6820.17
76_A86_G0.6800.17
135_V151_R0.6780.17
66_K388_R0.6770.17
49_P104_Y0.6760.17
58_L211_I0.6760.17
261_I271_I0.6740.17
6_S221_K0.6720.17
146_R294_V0.6710.17
350_I396_L0.6700.17
366_I383_A0.6700.17
166_F338_M0.6690.17
147_H155_F0.6690.17
11_L17_Y0.6680.17
45_L185_E0.6680.17
54_P57_A0.6670.17
305_Y358_I0.6660.17
347_V359_Y0.6650.17
232_K291_I0.6650.17
21_V299_K0.6640.17
284_W387_W0.6630.17
227_M231_K0.6630.17
116_L189_N0.6620.17
206_S304_T0.6600.16
45_L118_K0.6590.16
135_V196_I0.6570.16
379_Y389_S0.6560.16
75_G80_Y0.6560.16
220_E232_K0.6550.16
160_L237_A0.6550.16
368_M372_I0.6540.16
304_T348_C0.6520.16
133_G239_L0.6500.16
38_V347_V0.6490.16
195_W404_S0.6460.16
138_L302_L0.6460.16
55_H352_P0.6450.16
237_A241_I0.6440.16
17_Y25_T0.6440.16
263_A400_I0.6430.16
238_Y302_L0.6420.16
204_A269_V0.6420.16
140_L334_A0.6400.16
71_E107_A0.6400.16
220_E229_K0.6380.16
200_V354_A0.6370.16
28_L212_S0.6360.16
150_I241_I0.6360.16
96_A358_I0.6350.16
39_V258_P0.6340.16
209_P358_I0.6340.16
390_I397_I0.6340.16
10_T236_V0.6330.16
47_A270_T0.6300.16
55_H303_G0.6280.16
107_A238_Y0.6270.16
241_I297_M0.6260.16
234_M285_L0.6250.16
285_L369_I0.6240.16
123_D266_E0.6240.16
45_L259_S0.6230.16
196_I203_F0.6230.16
206_S311_G0.6220.15
293_A300_S0.6220.15
59_C238_Y0.6200.15
125_R128_M0.6200.15
127_R205_F0.6190.15
235_K330_A0.6190.15
110_N351_N0.6180.15
330_A333_R0.6170.15
284_W316_V0.6170.15
207_H307_G0.6170.15
20_A93_Y0.6170.15
151_R326_K0.6170.15
288_S306_F0.6160.15
381_I388_R0.6150.15
150_I302_L0.6150.15
236_V357_M0.6140.15
155_F257_P0.6120.15
15_A232_K0.6120.15
89_I138_L0.6110.15
34_S204_A0.6100.15
21_V45_L0.6090.15
246_L311_G0.6080.15
15_A160_L0.6070.15
131_S198_I0.6070.15
25_T153_M0.6050.15
84_K388_R0.6050.15
126_I391_G0.6050.15
48_W153_M0.6040.15
269_V273_S0.6040.15
379_Y392_N0.6020.15
152_V286_S0.6010.15
185_E328_S0.6010.15
372_I380_L0.6000.15
255_S320_L0.6000.15
58_L369_I0.6000.15
146_R365_L0.5980.15
46_V71_E0.5980.15
105_A344_T0.5980.15
53_W107_A0.5960.15
190_T344_T0.5950.15
238_Y299_K0.5940.15
153_M302_L0.5930.15
158_F164_F0.5920.15
153_M358_I0.5920.15
275_L300_S0.5920.15
240_I266_E0.5920.15
17_Y241_I0.5880.15
72_G276_S0.5880.15
56_K164_F0.5850.15
361_I369_I0.5840.15
16_L20_A0.5810.14
297_M362_S0.5810.14
76_A391_G0.5770.14
191_L401_L0.5750.14
204_A396_L0.5740.14
99_V359_Y0.5730.14
142_F241_I0.5720.14
398_V407_F0.5720.14
226_A245_V0.5700.14
14_F48_W0.5690.14
47_A302_L0.5680.14
105_A397_I0.5680.14
32_L73_I0.5660.14
255_S279_P0.5660.14
248_F300_S0.5660.14
66_K197_S0.5640.14
41_F148_A0.5640.14
78_T83_K0.5630.14
209_P311_G0.5630.14
219_R260_Y0.5620.14
73_I153_M0.5620.14
156_L365_L0.5610.14
28_L109_T0.5600.14
328_S335_L0.5600.14
209_P370_L0.5590.14
139_N305_Y0.5570.14
133_G400_I0.5570.14
87_N253_L0.5560.14
166_F284_W0.5550.14
155_F295_V0.5540.14
108_I189_N0.5530.14
11_L21_V0.5520.14
170_Y249_V0.5510.14
81_Y293_A0.5500.14
67_T151_R0.5500.14
47_A398_V0.5500.14
312_A336_S0.5490.14
274_A304_T0.5480.14
164_F277_M0.5470.14
93_Y109_T0.5470.14
332_N339_L0.5460.14
17_Y168_S0.5460.14
76_A345_F0.5460.14
162_A376_L0.5450.14
84_K400_I0.5430.14
156_L185_E0.5420.13
10_T13_S0.5410.13
23_A55_H0.5400.13
37_A140_L0.5390.13
62_I207_H0.5370.13
100_V211_I0.5350.13
62_I149_T0.5350.13
132_L345_F0.5350.13
149_T306_F0.5290.13
12_W24_G0.5280.13
308_V355_I0.5270.13
222_Y229_K0.5270.13
60_Q99_V0.5260.13
99_V306_F0.5260.13
19_T55_H0.5260.13
226_A404_S0.5260.13
127_R290_I0.5240.13
401_L404_S0.5230.13
330_A354_A0.5230.13
45_L280_N0.5220.13
133_G401_L0.5220.13
282_P285_L0.5210.13
149_T299_K0.5200.13
15_A299_K0.5190.13
16_L171_L0.5180.13
13_S292_V0.5170.13
31_Q40_L0.5170.13
184_V292_V0.5170.13
161_I180_L0.5160.13
119_H256_I0.5150.13
131_S402_C0.5120.13
78_T400_I0.5100.13
334_A385_K0.5100.13
311_G358_I0.5090.13
171_L277_M0.5080.13
207_H249_V0.5070.13
44_A161_I0.5060.13
245_V270_T0.5040.13
37_A113_T0.5030.13
320_L328_S0.5030.13
67_T247_F0.5030.13
242_C246_L0.5030.13
135_V276_S0.5030.13
142_F168_S0.5020.13
346_I393_L0.5020.13
32_L242_C0.5020.13
34_S181_T0.5010.13
96_A195_W0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9144 99.8 0.868 Contact Map
3giaA 1 0.934 99.7 0.877 Contact Map
4djkA 2 0.9071 99.2 0.913 Contact Map
4wgvA 2 0.8704 97.8 0.945 Contact Map
4us3A 1 0.9095 92.1 0.964 Contact Map
3dh4A 3 0.8949 91.9 0.964 Contact Map
2xq2A 2 0.8998 88.1 0.967 Contact Map
4xp4A 1 0.9242 86.1 0.968 Contact Map
2a65A 2 0.9364 83.7 0.969 Contact Map
2jlnA 1 0.8924 50.2 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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