GREMLIN Database
CBPM - Chaperone modulatory protein CbpM
UniProt: P63264 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12194
Length: 101 (90)
Sequences: 235 (186)
Seq/√Len: 19.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_A70_I3.6171.00
46_D49_A3.3651.00
13_F53_V2.3460.96
23_E27_I2.3090.95
86_E91_R2.2830.95
14_C24_L2.2170.94
27_I32_V2.2000.94
37_E40_E2.1340.93
32_V67_W2.1060.92
79_D84_K1.9340.89
56_A75_T1.8230.86
13_F50_A1.8100.85
5_T85_Q1.7920.85
67_W87_N1.7850.84
9_T32_V1.7660.84
66_D69_G1.7320.82
66_D87_N1.6650.80
69_G73_A1.5860.76
33_V53_V1.5370.74
80_I84_K1.5100.73
35_P43_W1.4850.71
55_R65_L1.4590.70
31_G69_G1.4360.69
54_Q68_P1.4120.67
4_V66_D1.3830.66
29_G72_V1.3530.64
41_T84_K1.3450.64
7_T68_P1.3140.62
27_I67_W1.3080.61
10_I52_V1.2990.61
77_M90_L1.2910.60
27_I60_R1.2580.58
11_T21_E1.2180.56
37_E44_V1.2110.55
35_P45_F1.1720.53
52_V66_D1.1480.51
70_I75_T1.1330.50
31_G63_L1.1200.49
9_T12_E1.0860.47
62_E75_T1.0840.47
50_A74_L1.0820.47
50_A80_I1.0560.45
4_V67_W1.0480.45
14_C56_A1.0470.45
17_T87_N1.0420.44
8_F38_I1.0250.43
3_N50_A1.0020.42
18_G80_I0.9960.42
27_I52_V0.9880.41
12_E51_I0.9650.40
42_T70_I0.9590.39
33_V50_A0.9500.39
33_V73_A0.9090.36
32_V87_N0.9040.36
28_V43_W0.9000.36
39_Q42_T0.9000.36
3_N20_S0.8910.35
25_N81_A0.8660.34
26_E64_A0.8650.34
73_A84_K0.8540.33
7_T32_V0.8540.33
63_L73_A0.8490.33
60_R92_Q0.8340.32
62_E66_D0.8270.32
48_H78_D0.8060.30
52_V79_D0.8040.30
71_A77_M0.8030.30
28_V39_Q0.8010.30
8_F34_E0.7960.30
17_T27_I0.7950.30
8_F57_V0.7830.29
11_T29_G0.7810.29
19_I83_L0.7770.29
15_L87_N0.7750.29
22_E34_E0.7550.28
64_A87_N0.7540.28
49_A82_H0.7410.27
28_V71_A0.7350.27
56_A77_M0.7260.26
74_L78_D0.7260.26
8_F69_G0.6970.25
61_H77_M0.6970.25
55_R82_H0.6950.25
37_E72_V0.6940.25
50_A57_V0.6930.25
13_F47_D0.6920.25
3_N41_T0.6900.25
31_G59_L0.6840.24
22_E53_V0.6800.24
35_P53_V0.6780.24
49_A62_E0.6780.24
12_E46_D0.6740.24
28_V78_D0.6690.24
30_L34_E0.6650.23
44_V83_L0.6540.23
9_T20_S0.6540.23
23_E70_I0.6410.22
68_P81_A0.6330.22
69_G74_L0.6220.21
8_F54_Q0.6210.21
17_T68_P0.6210.21
28_V47_D0.6190.21
16_H53_V0.6180.21
40_E51_I0.6170.21
37_E43_W0.6040.21
74_L79_D0.6030.21
66_D91_R0.5930.20
62_E65_L0.5910.20
40_E73_A0.5900.20
48_H89_L0.5890.20
60_R78_D0.5870.20
20_S73_A0.5800.20
31_G73_A0.5790.20
17_T65_L0.5740.19
68_P73_A0.5710.19
6_V39_Q0.5670.19
25_N38_I0.5660.19
68_P87_N0.5580.19
18_G53_V0.5560.19
25_N51_I0.5540.19
63_L71_A0.5510.19
13_F35_P0.5430.18
9_T52_V0.5390.18
29_G81_A0.5370.18
19_I37_E0.5350.18
22_E79_D0.5330.18
4_V17_T0.5270.18
11_T51_I0.5260.18
7_T15_L0.5240.17
9_T23_E0.5120.17
32_V53_V0.5070.17
23_E77_M0.5060.17
9_T57_V0.5040.17
48_H82_H0.5000.17
12_E82_H0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ucsA 2 0.9901 99.4 0.635 Contact Map
4r24B 2 0.8317 98.3 0.763 Contact Map
4ua1A 2 0.8812 98 0.781 Contact Map
1r8dA 2 0.9406 97.9 0.783 Contact Map
2vz4A 2 0.8812 97.8 0.788 Contact Map
4r4eB 2 0.7921 97.8 0.788 Contact Map
3gpvA 2 0.9208 97.6 0.798 Contact Map
1q06A 2 0.9208 97.5 0.803 Contact Map
2jmlA 1 0.7822 97.4 0.804 Contact Map
2zhgA 2 0.9208 97.4 0.805 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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