GREMLIN Database
GADC - Probable glutamate/gamma-aminobutyrate antiporter
UniProt: P63235 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12456
Length: 511 (426)
Sequences: 24628 (16173)
Seq/√Len: 783.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_A346_L4.3561.00
328_A340_T4.2881.00
391_V395_K3.4641.00
50_G246_I3.1661.00
331_K340_T3.1451.00
232_R236_L2.9621.00
14_T228_S2.9111.00
76_F322_K2.8671.00
383_F420_L2.7471.00
227_M233_D2.7301.00
92_I319_T2.6811.00
229_N232_R2.6781.00
320_A330_A2.6171.00
333_N339_V2.5391.00
19_F240_L2.4951.00
63_E393_V2.4921.00
175_A255_S2.4861.00
135_L350_S2.4791.00
225_N321_Q2.4761.00
15_L240_L2.4121.00
328_A331_K2.4111.00
288_W292_V2.3581.00
30_Y33_P2.3311.00
15_L233_D2.1951.00
80_S88_G2.1911.00
343_I347_V2.1851.00
317_Y321_Q2.1611.00
226_E314_R2.1611.00
15_L19_F2.1571.00
142_A342_V2.1231.00
143_L147_G2.1161.00
150_K154_R2.0891.00
18_F227_M2.0881.00
173_A177_I2.0771.00
139_W350_S2.0541.00
146_F339_V1.9921.00
83_L391_V1.9821.00
96_Y345_Q1.9621.00
277_V280_S1.9591.00
14_T17_G1.9561.00
323_N327_A1.9501.00
80_S85_P1.9281.00
417_I421_L1.9201.00
135_L353_L1.9191.00
134_A353_L1.9021.00
458_A462_I1.8981.00
60_C386_F1.8941.00
236_L240_L1.8781.00
51_I55_I1.8641.00
161_F165_L1.8501.00
329_F344_S1.8491.00
261_P264_E1.8481.00
333_N337_V1.8411.00
34_T38_S1.8311.00
9_K332_M1.8121.00
239_L243_V1.8101.00
459_L463_L1.8031.00
452_S456_V1.7891.00
83_L387_I1.7681.00
29_V32_Y1.7631.00
17_G157_K1.7591.00
22_T241_L1.7421.00
29_V33_P1.7381.00
79_V91_A1.7361.00
91_A384_M1.7211.00
264_E281_H1.7141.00
412_K416_A1.7021.00
454_L458_A1.6901.00
145_Q306_A1.6891.00
84_G87_W1.6891.00
386_F419_G1.6831.00
413_L417_I1.6811.00
421_L425_M1.6771.00
229_N233_D1.6581.00
139_W346_L1.6491.00
129_T132_I1.6461.00
448_L452_S1.6271.00
19_F244_A1.6261.00
146_F343_I1.6251.00
107_L305_I1.6181.00
138_L349_T1.6081.00
13_L17_G1.6021.00
45_F206_V1.6001.00
452_S455_V1.5921.00
277_V281_H1.5911.00
103_F349_T1.5761.00
193_T196_P1.5741.00
243_V247_C1.5711.00
457_L460_P1.5681.00
335_N339_V1.5581.00
114_L133_A1.5491.00
431_F434_P1.5421.00
34_T42_L1.5391.00
229_N236_L1.5321.00
166_L296_L1.5191.00
391_V394_L1.5071.00
450_V454_L1.4971.00
187_I191_S1.4951.00
453_F457_L1.4561.00
223_H310_V1.4501.00
316_M341_L1.4441.00
165_L170_I1.4421.00
445_Y452_S1.4371.00
49_G210_F1.4241.00
340_T344_S1.4181.00
327_A331_K1.4131.00
147_G335_N1.4081.00
456_V460_P1.4021.00
107_L138_L1.4001.00
138_L346_L1.4001.00
387_I391_V1.3981.00
313_S342_V1.3871.00
17_G153_A1.3871.00
83_L87_W1.3811.00
317_Y332_M1.3691.00
194_F197_D1.3631.00
444_M447_E1.3621.00
291_R295_A1.3591.00
312_P345_Q1.3591.00
72_E225_N1.3501.00
128_I132_I1.3481.00
58_G242_M1.3431.00
142_A343_I1.3421.00
423_S426_A1.3371.00
280_S290_V1.3361.00
414_V418_V1.3311.00
110_V137_I1.3271.00
195_F198_F1.3231.00
10_A336_G1.3181.00
327_A330_A1.3181.00
57_V386_F1.3121.00
187_I190_D1.3111.00
110_V298_L1.3101.00
135_L139_W1.3031.00
79_V384_M1.3031.00
82_T388_G1.3021.00
230_P235_P1.2931.00
316_M325_L1.2771.00
15_L236_L1.2741.00
86_R461_F1.2661.00
13_L153_A1.2651.00
164_I169_F1.2591.00
247_C251_V1.2591.00
331_K339_V1.2591.00
68_D81_N1.2581.00
431_F435_D1.2541.00
460_P464_Y1.2521.00
177_I182_G1.2351.00
43_V254_L1.2311.00
387_I420_L1.2251.00
59_L239_L1.2171.00
106_M304_E1.2171.00
13_L18_F1.2141.00
9_K317_Y1.2131.00
58_G238_M1.2001.00
396_H399_L1.1961.00
71_E77_A1.1961.00
426_A430_S1.1941.00
141_L305_I1.1931.00
41_S195_F1.1891.00
26_V245_A1.1831.00
52_L422_T1.1801.00
77_A81_N1.1781.00
22_T220_S1.1781.00
126_D129_T1.1721.00
414_V417_I1.1681.00
233_D236_L1.1611.00
67_V401_R1.1581.00
425_M429_V1.1531.00
131_T135_L1.1531.00
144_T155_I1.1511.00
194_F198_F1.1501.00
193_T197_D1.1491.00
16_L20_A1.1481.00
286_I289_T1.1471.00
445_Y448_L1.1471.00
457_L461_F1.1431.00
18_F237_A1.1411.00
428_I432_L1.1371.00
419_G423_S1.1351.00
79_V87_W1.1251.00
204_L425_M1.1251.00
71_E81_N1.1211.00
262_G265_I1.1211.00
407_G413_L1.1181.00
170_I174_L1.1171.00
340_T343_I1.1131.00
176_A180_H1.1131.00
61_A75_V1.1101.00
23_A244_A1.1031.00
424_I428_I1.1011.00
156_A306_A1.0921.00
280_S287_E1.0901.00
171_L175_A1.0831.00
12_Q228_S1.0811.00
142_A146_F1.0791.00
65_A78_W1.0781.00
89_F93_S1.0761.00
155_I159_G1.0741.00
455_V459_L1.0741.00
176_A255_S1.0731.00
443_D447_E1.0661.00
169_F173_A1.0621.00
81_N396_H1.0541.00
397_P401_R1.0531.00
456_V462_I1.0531.00
132_I136_I1.0511.00
180_H184_P1.0481.00
179_L258_M1.0471.00
413_L430_S1.0471.00
273_Q277_V1.0461.00
451_V455_V1.0421.00
321_Q330_A1.0371.00
76_F318_V1.0361.00
136_I140_A1.0341.00
96_Y316_M1.0341.00
114_L118_L1.0311.00
67_V399_L1.0311.00
419_G422_T1.0301.00
228_S233_D1.0291.00
456_V463_L1.0291.00
111_L133_A1.0221.00
55_I418_V1.0221.00
416_A420_L1.0191.00
403_F406_P1.0181.00
146_F337_V1.0171.00
458_A461_F1.0151.00
423_S427_F1.0141.00
261_P281_H1.0111.00
446_V450_V1.0081.00
172_I251_V1.0081.00
445_Y456_V1.0031.00
50_G214_Y1.0021.00
332_M336_G0.9971.00
447_E451_V0.9961.00
41_S203_T0.9961.00
398_D401_R0.9961.00
182_G185_V0.9951.00
21_I223_H0.9941.00
427_F430_S0.9941.00
420_L424_I0.9941.00
459_L462_I0.9911.00
347_V351_I0.9891.00
149_T310_V0.9851.00
114_L298_L0.9841.00
215_M378_Y0.9701.00
154_R158_V0.9671.00
181_S184_P0.9671.00
146_F333_N0.9631.00
139_W143_L0.9621.00
416_A430_S0.9561.00
180_H183_A0.9521.00
27_M163_G0.9521.00
159_G303_A0.9501.00
38_S41_S0.9491.00
403_F407_G0.9491.00
427_F431_F0.9431.00
47_L250_S0.9421.00
422_T426_A0.9391.00
426_A429_V0.9341.00
218_E222_T0.9301.00
111_L134_A0.9301.00
397_P400_K0.9291.00
35_F42_L0.9281.00
105_P212_L0.9271.00
164_I248_L0.9261.00
175_A259_V0.9231.00
63_E66_T0.9171.00
461_F465_A0.9111.00
224_V234_Y0.9071.00
12_Q150_K0.9001.00
383_F387_I0.8991.00
47_L51_I0.8981.00
456_V459_L0.8981.00
333_N336_G0.8941.00
163_G300_G0.8921.00
20_A157_K0.8901.00
84_G462_I0.8841.00
51_I414_V0.8821.00
66_T402_T0.8741.00
449_L452_S0.8731.00
43_V257_A0.8721.00
177_I181_S0.8711.00
394_L397_P0.8711.00
339_V343_I0.8681.00
16_L157_K0.8631.00
454_L457_L0.8621.00
179_L183_A0.8611.00
141_L306_A0.8601.00
285_E289_T0.8541.00
399_L402_T0.8541.00
309_I346_L0.8541.00
17_G154_R0.8541.00
274_T279_M0.8541.00
417_I420_L0.8531.00
79_V388_G0.8511.00
416_A423_S0.8491.00
193_T198_F0.8431.00
445_Y454_L0.8411.00
329_F340_T0.8391.00
425_M428_I0.8351.00
358_N367_F0.8341.00
105_P371_L0.8331.00
9_K226_E0.8331.00
111_L130_K0.8281.00
240_L244_A0.8281.00
42_L253_G0.8271.00
23_A245_A0.8261.00
80_S322_K0.8251.00
346_L350_S0.8241.00
9_K314_R0.8241.00
140_A302_L0.8231.00
179_L184_P0.8211.00
420_L423_S0.8211.00
279_M282_V0.8191.00
426_A431_F0.8141.00
60_C416_A0.8121.00
287_E291_R0.8111.00
195_F199_S0.8101.00
325_L329_F0.8061.00
444_M448_L0.8051.00
442_T445_Y0.8051.00
44_F47_L0.8041.00
182_G186_A0.8021.00
449_L453_F0.8021.00
171_L279_M0.8001.00
456_V461_F0.8001.00
415_V419_G0.7981.00
172_I255_S0.7971.00
430_S434_P0.7961.00
73_G76_F0.7951.00
87_W384_M0.7931.00
215_M382_Y0.7931.00
460_P463_L0.7921.00
54_F59_L0.7891.00
430_S433_P0.7881.00
86_R90_A0.7851.00
235_P238_M0.7841.00
93_S325_L0.7821.00
110_V302_L0.7811.00
143_L146_F0.7791.00
428_I431_F0.7771.00
416_A419_G0.7761.00
34_T39_G0.7741.00
413_L416_A0.7731.00
254_L258_M0.7711.00
115_S130_K0.7701.00
133_A136_I0.7691.00
422_T425_M0.7681.00
28_A249_S0.7681.00
55_I415_V0.7671.00
110_V301_V0.7671.00
219_A311_G0.7651.00
448_L451_V0.7641.00
373_L377_I0.7631.00
42_L45_F0.7611.00
246_I250_S0.7591.00
383_F423_S0.7591.00
416_A426_A0.7541.00
195_F203_T0.7531.00
35_F38_S0.7521.00
64_M78_W0.7511.00
268_S277_V0.7481.00
138_L353_L0.7471.00
73_G77_A0.7461.00
396_H401_R0.7441.00
450_V457_L0.7431.00
179_L182_G0.7431.00
172_I176_A0.7431.00
183_A186_A0.7421.00
259_V278_L0.7381.00
131_T353_L0.7381.00
459_L464_Y0.7371.00
146_F335_N0.7371.00
447_E450_V0.7371.00
15_L237_A0.7361.00
95_G99_I0.7351.00
328_A344_S0.7341.00
462_I465_A0.7311.00
54_F239_L0.7301.00
141_L309_I0.7291.00
44_F203_T0.7261.00
347_V350_S0.7251.00
443_D446_V0.7241.00
43_V47_L0.7241.00
154_R157_K0.7231.00
64_M389_Y0.7231.00
19_F237_A0.7221.00
44_F48_L0.7211.00
108_Y370_A0.7201.00
404_N407_G0.7191.00
67_V402_T0.7191.00
114_L137_I0.7171.00
43_V46_L0.7171.00
229_N235_P0.7151.00
147_G151_Y0.7151.00
205_V209_A0.7131.00
76_F80_S0.7111.00
46_L49_G0.7041.00
456_V464_Y0.7031.00
240_L243_V0.7021.00
102_G374_T0.6991.00
316_M344_S0.6961.00
192_K197_D0.6961.00
25_M307_S0.6951.00
338_P341_L0.6931.00
82_T391_V0.6921.00
448_L453_F0.6911.00
186_A193_T0.6891.00
450_V461_F0.6891.00
61_A385_L0.6841.00
448_L454_L0.6831.00
100_A348_I0.6801.00
199_S203_T0.6791.00
451_V454_L0.6781.00
98_Q378_Y0.6771.00
446_V452_S0.6761.00
145_Q310_V0.6761.00
175_A179_L0.6751.00
40_F257_A0.6741.00
177_I180_H0.6741.00
145_Q342_V0.6731.00
275_F279_M0.6731.00
175_A180_H0.6731.00
390_I416_A0.6721.00
423_S430_S0.6711.00
187_I192_K0.6691.00
25_M28_A0.6691.00
309_I313_S0.6671.00
72_E317_Y0.6661.00
181_S185_V0.6661.00
393_V397_P0.6661.00
288_W291_R0.6651.00
442_T448_L0.6641.00
55_I60_C0.6641.00
16_L154_R0.6631.00
386_F420_L0.6611.00
446_V456_V0.6601.00
67_V70_W0.6601.00
390_I417_I0.6591.00
221_A238_M0.6531.00
432_L435_D0.6501.00
390_I394_L0.6501.00
178_Y181_S0.6491.00
12_Q149_T0.6481.00
192_K195_F0.6481.00
453_F456_V0.6471.00
127_P130_K0.6471.00
376_V427_F0.6451.00
101_I373_L0.6441.00
448_L455_V0.6411.00
162_A166_L0.6411.00
416_A427_F0.6401.00
282_V285_E0.6391.00
58_G217_V0.6391.00
137_I305_I0.6381.00
28_A163_G0.6381.00
314_R317_Y0.6381.00
460_P465_A0.6351.00
153_A157_K0.6341.00
422_T428_I0.6341.00
244_A247_C0.6341.00
23_A160_F0.6331.00
135_L354_I0.6331.00
402_T406_P0.6331.00
329_F341_L0.6331.00
12_Q16_L0.6321.00
225_N317_Y0.6311.00
419_G426_A0.6281.00
334_K339_V0.6271.00
83_L388_G0.6261.00
443_D448_L0.6231.00
453_F460_P0.6211.00
388_G392_L0.6191.00
34_T40_F0.6191.00
251_V255_S0.6191.00
234_Y238_M0.6191.00
94_F381_A0.6171.00
84_G88_G0.6161.00
313_S341_L0.6151.00
179_L255_S0.6141.00
76_F88_G0.6141.00
273_Q276_T0.6131.00
266_N269_A0.6121.00
202_G205_V0.6121.00
389_Y393_V0.6111.00
461_F464_Y0.6111.00
131_T134_A0.6101.00
82_T392_L0.6101.00
99_I308_W0.6091.00
27_M248_L0.6091.00
423_S435_D0.6081.00
449_L454_L0.6071.00
24_S160_F0.6061.00
149_T223_H0.6051.00
19_F22_T0.6031.00
16_L19_F0.6031.00
25_M219_A0.6031.00
146_F342_V0.6031.00
102_G105_P0.6031.00
153_A306_A0.6021.00
444_M450_V0.6011.00
227_M234_Y0.6011.00
113_A297_L0.6011.00
65_A221_A0.5991.00
67_V397_P0.5991.00
442_T446_V0.5991.00
448_L459_L0.5961.00
76_F92_I0.5961.00
192_K196_P0.5951.00
116_Y294_S0.5951.00
178_Y184_P0.5941.00
162_A296_L0.5931.00
445_Y458_A0.5921.00
75_V218_E0.5871.00
320_A329_F0.5861.00
141_L302_L0.5861.00
332_M335_N0.5861.00
215_M218_E0.5851.00
46_L213_S0.5841.00
174_L286_I0.5831.00
104_I370_A0.5831.00
276_T280_S0.5831.00
295_A299_L0.5821.00
443_D456_V0.5821.00
244_A248_L0.5811.00
446_V455_V0.5801.00
455_V458_A0.5791.00
65_A234_Y0.5781.00
269_A274_T0.5781.00
43_V250_S0.5761.00
64_M82_T0.5761.00
176_A251_V0.5761.00
383_F424_I0.5741.00
151_Y154_R0.5741.00
184_P257_A0.5731.00
178_Y183_A0.5731.00
100_A345_Q0.5731.00
256_I275_F0.5731.00
139_W142_A0.5681.00
53_W217_V0.5681.00
430_S435_D0.5671.00
35_F39_G0.5661.00
447_E454_L0.5611.00
106_M301_V0.5601.00
117_I294_S0.5601.00
213_S249_S0.5591.00
48_L207_F0.5581.00
172_I252_G0.5581.00
148_G151_Y0.5561.00
138_L350_S0.5561.00
450_V453_F0.5551.00
119_K126_D0.5541.00
215_M374_T0.5541.00
448_L460_P0.5531.00
75_V222_T0.5531.00
252_G256_I0.5521.00
255_S258_M0.5521.00
407_G412_K0.5511.00
252_G275_F0.5481.00
74_G221_A0.5481.00
279_M286_I0.5461.00
151_Y155_I0.5461.00
222_T311_G0.5451.00
344_S348_I0.5441.00
106_M305_I0.5421.00
18_F233_D0.5421.00
36_A39_G0.5421.00
445_Y453_F0.5411.00
174_L178_Y0.5401.00
104_I352_A0.5391.00
137_I302_L0.5391.00
351_I354_I0.5391.00
25_M308_W0.5371.00
23_A27_M0.5361.00
428_I433_P0.5361.00
139_W343_I0.5361.00
292_V296_L0.5351.00
419_G430_S0.5341.00
111_L114_L0.5341.00
40_F43_V0.5321.00
218_E382_Y0.5311.00
312_P316_M0.5311.00
415_V422_T0.5311.00
231_G236_L0.5301.00
445_Y450_V0.5301.00
117_I298_L0.5301.00
160_F163_G0.5301.00
413_L433_P0.5291.00
421_L424_I0.5291.00
142_A309_I0.5281.00
26_V241_L0.5281.00
49_G52_L0.5271.00
415_V423_S0.5261.00
314_R338_P0.5261.00
300_G303_A0.5251.00
407_G415_V0.5251.00
446_V461_F0.5251.00
416_A431_F0.5251.00
104_I349_T0.5251.00
156_A303_A0.5221.00
34_T37_T0.5221.00
24_S27_M0.5221.00
152_T310_V0.5211.00
454_L461_F0.5211.00
24_S28_A0.5201.00
377_I381_A0.5201.00
113_A276_T0.5191.00
57_V218_E0.5191.00
46_L253_G0.5191.00
63_E406_P0.5171.00
368_L371_L0.5171.00
447_E456_V0.5161.00
62_A66_T0.5151.00
49_G211_I0.5141.00
444_M455_V0.5141.00
93_S452_S0.5141.00
157_K161_F0.5141.00
157_K160_F0.5131.00
57_V423_S0.5131.00
426_A434_P0.5111.00
57_V419_G0.5101.00
230_P233_D0.5101.00
394_L413_L0.5101.00
226_E338_P0.5091.00
444_M458_A0.5091.00
58_G62_A0.5071.00
249_S253_G0.5071.00
102_G106_M0.5061.00
19_F241_L0.5041.00
106_M109_F0.5041.00
192_K198_F0.5031.00
42_L46_L0.5021.00
389_Y416_A0.5011.00
416_A433_P0.5011.00
412_K427_F0.5011.00
419_G427_F0.5001.00
22_T26_V0.5001.00
446_V451_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4djkA 2 0.8728 100 0.323 Contact Map
3l1lA 2 0.8219 100 0.383 Contact Map
3giaA 1 0.8376 100 0.425 Contact Map
2jlnA 1 0.82 99.1 0.862 Contact Map
4xp4A 1 0.8885 98.4 0.893 Contact Map
3dh4A 3 0.8474 98.3 0.895 Contact Map
2xq2A 2 0.8474 98.3 0.896 Contact Map
2a65A 2 0.863 98.1 0.9 Contact Map
4us3A 1 0.7613 98.1 0.901 Contact Map
4wgvA 2 0.7143 97.6 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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