GREMLIN Database
GMHBB - D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase
UniProt: P63228 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11736
Length: 191 (166)
Sequences: 2584 (1802)
Seq/√Len: 139.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_H107_C3.4151.00
18_V30_E2.8061.00
90_Y123_Y2.6941.00
59_A95_H2.5131.00
94_H109_C2.5011.00
121_R128_M2.4961.00
8_I42_L2.3991.00
65_E69_E2.1481.00
39_M49_L2.0571.00
144_A151_T2.0521.00
50_V124_L2.0491.00
88_G123_Y2.0431.00
88_G124_L1.9661.00
31_F78_S1.8881.00
90_Y120_A1.8611.00
25_E28_N1.8541.00
78_S81_D1.8201.00
117_L133_M1.7931.00
114_P118_L1.7851.00
58_I68_F1.7831.00
127_D130_A1.7581.00
57_G63_F1.7311.00
174_N178_D1.6681.00
40_R44_K1.6561.00
41_E181_Q1.6461.00
64_T67_Q1.6281.00
43_K84_V1.6201.00
68_F72_T1.6111.00
76_D89_I1.5871.00
117_L143_A1.5781.00
20_H23_V1.5721.00
92_C107_C1.5671.00
74_W78_S1.5531.00
156_R174_N1.5491.00
56_S60_R1.5101.00
106_V113_H1.5081.00
24_H28_N1.5021.00
6_P130_A1.4921.00
5_V48_A1.4701.00
65_E91_Y1.4451.00
43_K49_L1.4391.00
126_I131_S1.4211.00
79_L84_V1.4041.00
20_H30_E1.4031.00
16_I39_M1.3991.00
92_C109_C1.3921.00
113_H146_A1.3741.00
17_N29_F1.3661.00
50_V120_A1.3391.00
48_A87_D1.3291.00
175_S178_D1.3241.00
134_V179_L1.3181.00
51_V89_I1.2751.00
43_K85_D1.2691.00
133_M143_A1.2401.00
39_M43_K1.2391.00
173_L182_A1.2371.00
75_M89_I1.2251.00
31_F36_I1.2211.00
51_V86_L1.2171.00
41_E45_M1.2101.00
114_P146_A1.2081.00
119_S123_Y1.2011.00
90_Y119_S1.2001.00
26_I71_L1.1931.00
138_L142_Q1.1931.00
41_E177_A1.1891.00
9_F50_V1.1881.00
177_A181_Q1.1851.00
173_L179_L1.1841.00
9_F131_S1.1801.00
9_F52_V1.1590.99
38_A180_P1.1580.99
29_F75_M1.1420.99
142_Q146_A1.1340.99
141_M151_T1.1080.99
133_M144_A1.0970.99
43_K87_D1.0930.99
117_L147_A1.0910.99
128_M149_V1.0860.99
143_A147_A1.0740.99
58_I93_P1.0650.99
22_Y56_S1.0630.99
35_V38_A1.0620.99
19_D159_K1.0560.99
52_V133_M1.0530.99
108_D113_H1.0460.99
26_I74_W1.0390.99
43_K79_L1.0290.99
145_V170_D1.0290.99
67_Q70_T1.0190.99
68_F89_I1.0180.99
108_D118_L1.0160.99
157_T160_P1.0120.99
132_Y153_V1.0070.98
133_M149_V1.0040.98
49_L86_L0.9970.98
73_E77_W0.9960.98
39_M79_L0.9940.98
42_L49_L0.9930.98
74_W77_W0.9870.98
17_N23_V0.9860.98
6_P47_F0.9830.98
95_H105_Q0.9810.98
142_Q145_V0.9770.98
7_A48_A0.9760.98
19_D56_S0.9680.98
128_M131_S0.9420.98
50_V88_G0.9350.98
153_V179_L0.9330.98
114_P143_A0.9310.97
15_T139_E0.9140.97
80_A85_D0.9020.97
36_I82_R0.8920.97
36_I79_L0.8910.97
90_Y124_L0.8900.97
114_P147_A0.8890.97
39_M84_V0.8820.97
59_A105_Q0.8740.96
56_S62_K0.8730.96
40_R82_R0.8720.96
34_G37_D0.8620.96
107_C113_H0.8490.96
97_Q105_Q0.8210.95
18_V32_I0.8150.95
41_E44_K0.8140.95
24_H56_S0.8080.94
72_T75_M0.8070.94
52_V120_A0.8060.94
77_W80_A0.8060.94
151_T170_D0.8060.94
6_P48_A0.8030.94
49_L84_V0.7990.94
132_Y150_G0.7940.94
41_E180_P0.7850.93
10_L16_I0.7840.93
36_I84_V0.7760.93
34_G177_A0.7760.93
138_L154_L0.7760.93
69_E73_E0.7670.93
24_H71_L0.7650.93
118_L147_A0.7620.92
22_Y57_G0.7600.92
20_H28_N0.7510.92
156_R160_P0.7510.92
32_I35_V0.7480.92
143_A146_A0.7470.92
16_I51_V0.7440.91
19_D23_V0.7410.91
56_S95_H0.7370.91
22_Y62_K0.7320.91
19_D137_K0.7290.91
52_V117_L0.7270.91
86_L89_I0.7250.90
121_R149_V0.7210.90
29_F71_L0.7160.90
57_G62_K0.7140.90
24_H63_F0.7140.90
156_R172_V0.7070.89
72_T89_I0.7050.89
26_I67_Q0.7030.89
150_G171_W0.7020.89
18_V33_D0.7000.89
50_V90_Y0.6980.89
144_A149_V0.6970.89
12_R72_T0.6960.89
48_A126_I0.6930.88
93_P109_C0.6910.88
31_F75_M0.6890.88
38_A177_A0.6880.88
32_I155_V0.6860.88
66_A69_E0.6820.88
115_G118_L0.6800.87
169_A172_V0.6800.87
7_A126_I0.6770.87
40_R84_V0.6760.87
38_A42_L0.6740.87
17_N71_L0.6730.87
171_W182_A0.6710.87
56_S63_F0.6680.86
58_I63_F0.6680.86
22_Y60_R0.6660.86
118_L121_R0.6660.86
42_L180_P0.6640.86
118_L122_D0.6630.86
78_S82_R0.6610.86
117_L128_M0.6600.86
26_I70_T0.6600.86
71_L75_M0.6580.86
63_F71_L0.6570.86
9_F126_I0.6430.84
71_L74_W0.6420.84
133_M141_M0.6420.84
37_D82_R0.6390.84
136_D140_D0.6360.84
9_F120_A0.6310.83
173_L178_D0.6280.83
138_L169_A0.6250.83
8_I153_V0.6150.82
15_T141_M0.6120.81
17_N21_G0.6110.81
90_Y116_M0.6080.81
109_C119_S0.6020.80
26_I29_F0.6000.80
132_Y151_T0.5970.80
79_L82_R0.5970.80
17_N75_M0.5960.80
16_I31_F0.5930.79
68_F71_L0.5920.79
67_Q71_L0.5910.79
107_C116_M0.5830.78
58_I65_E0.5790.78
117_L149_V0.5750.77
29_F89_I0.5740.77
7_A87_D0.5740.77
116_M119_S0.5730.77
24_H57_G0.5710.77
24_H137_K0.5690.76
36_I78_S0.5660.76
25_E67_Q0.5610.75
53_T89_I0.5590.75
63_F68_F0.5580.75
57_G110_R0.5570.75
35_V42_L0.5550.75
94_H116_M0.5540.74
24_H68_F0.5490.74
79_L86_L0.5460.73
35_V176_L0.5450.73
156_R161_I0.5420.73
158_G172_V0.5410.73
48_A124_L0.5400.73
23_V71_L0.5370.72
153_V173_L0.5370.72
21_G60_R0.5340.72
178_D181_Q0.5300.71
54_N111_K0.5300.71
95_H106_V0.5280.71
133_M139_E0.5270.71
58_I72_T0.5250.70
37_D177_A0.5230.70
134_V153_V0.5210.70
17_N28_N0.5200.70
8_I49_L0.5190.70
69_E91_Y0.5190.70
50_V123_Y0.5130.69
8_I179_L0.5090.68
155_V159_K0.5030.67
10_L176_L0.5020.67
10_L86_L0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l8hA 1 0.9162 100 0.495 Contact Map
2gmwA 1 0.9581 100 0.532 Contact Map
4pnhA 4 0.7958 100 0.563 Contact Map
2fprA 2 0.8272 100 0.563 Contact Map
2o2xA 1 0.9791 100 0.572 Contact Map
3zvlA 1 0.9162 99.9 0.625 Contact Map
2ho4A 1 0.9058 99.9 0.636 Contact Map
3ib6A 4 0.8639 99.9 0.652 Contact Map
2odaA 2 0.8325 99.9 0.664 Contact Map
2ymmA 2 0.8377 99.9 0.679 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0072 seconds.