GREMLIN Database
GMHA - Phosphoheptose isomerase
UniProt: P63224 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13146
Length: 192 (178)
Sequences: 2122 (1612)
Seq/√Len: 120.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_G139_M4.3541.00
50_C115_L4.0071.00
143_T156_A3.5321.00
131_I152_M3.4561.00
13_A17_L2.9591.00
40_S114_V2.8691.00
129_K132_A2.8541.00
131_I141_V2.7491.00
33_A142_I2.4961.00
40_S45_G2.4871.00
62_F179_I2.4461.00
123_N151_K2.3341.00
135_R157_D2.2851.00
45_G112_G2.0121.00
73_N95_F1.9921.00
34_A185_L1.9351.00
117_G131_I1.9221.00
49_S62_F1.8591.00
48_L105_V1.8451.00
67_T87_H1.8071.00
76_G107_A1.7721.00
49_S116_L1.7601.00
33_A158_I1.7311.00
50_C127_V1.6751.00
133_A137_K1.6631.00
146_G171_I1.6461.00
30_I178_V1.6111.00
162_V174_I1.5761.00
133_A136_E1.5711.00
119_S152_M1.5591.00
41_F47_V1.5391.00
87_H91_V1.5271.00
49_S179_I1.5091.00
36_L158_I1.4911.00
115_L139_M1.4861.00
144_L178_V1.4771.00
66_L186_I1.4621.00
98_N125_A1.4361.00
36_L140_K1.4251.00
99_D129_K1.4171.00
45_G110_R1.4051.00
92_G97_F1.3991.00
76_G106_E1.3941.00
18_A22_K1.3691.00
68_G91_V1.3641.00
71_R166_G1.3511.00
15_E18_A1.3311.00
145_T161_R1.3181.00
148_D161_R1.3141.00
118_I144_L1.2931.00
117_G127_V1.2781.00
37_L114_V1.2530.99
132_A155_T1.2510.99
15_E19_N1.2480.99
31_Q35_V1.2450.99
9_E184_Q1.2410.99
176_I179_I1.2400.99
49_S63_A1.2390.99
147_K165_F1.2370.99
153_A161_R1.2370.99
145_T159_E1.2100.99
50_C130_A1.2070.99
170_R173_E1.2050.99
151_K154_G1.1940.99
37_L47_V1.1780.99
52_N126_N1.1660.99
166_G169_D1.1600.99
83_S86_S1.1510.99
14_A18_A1.1500.99
80_I108_V1.1250.99
38_A189_E1.1210.99
102_S133_A1.1210.99
125_A129_K1.1170.99
62_F66_L1.1000.99
120_T168_A1.0880.99
47_V116_L1.0850.98
11_N15_E1.0840.98
110_R137_K1.0840.98
123_N150_G1.0700.98
61_H65_E1.0550.98
68_G90_C1.0540.98
60_M83_S1.0480.98
71_R169_D1.0440.98
49_S59_A1.0400.98
46_K78_P1.0390.98
150_G153_A1.0340.98
39_D43_A1.0330.98
12_E15_E1.0260.98
48_L139_M1.0250.98
20_F174_I1.0240.98
103_R106_E1.0210.98
96_G99_D1.0200.98
20_F26_N1.0160.98
125_A151_K1.0130.98
50_C117_G1.0120.98
109_G115_L1.0110.98
14_A17_L1.0060.98
143_T152_M0.9960.97
60_M85_V0.9900.97
106_E133_A0.9820.97
135_R141_V0.9810.97
117_G141_V0.9780.97
160_I178_V0.9750.97
88_I100_I0.9630.97
144_L175_H0.9610.97
181_I185_L0.9570.97
49_S79_A0.9480.96
177_K181_I0.9470.96
17_L174_I0.9460.96
67_T107_A0.9420.96
28_H32_R0.9350.96
34_A182_L0.9320.96
41_F78_P0.9220.96
99_D106_E0.9130.96
65_E172_Q0.9050.95
147_K161_R0.9050.95
37_L182_L0.8990.95
115_L130_A0.8940.95
97_F100_I0.8760.94
48_L109_G0.8750.94
37_L116_L0.8730.94
77_Y186_I0.8720.94
128_I151_K0.8690.94
11_N18_A0.8660.94
58_D65_E0.8640.94
132_A136_E0.8570.94
48_L80_I0.8540.94
38_A186_I0.8540.94
37_L142_I0.8500.94
34_A186_I0.8490.94
105_V130_A0.8400.93
13_A174_I0.8370.93
36_L114_V0.8310.93
82_I104_Y0.8260.93
184_Q188_K0.8240.92
36_L40_S0.8190.92
111_E138_G0.8070.92
102_S129_K0.8040.92
37_L186_I0.8010.91
29_A32_R0.8000.91
120_T172_Q0.7870.91
17_L20_F0.7840.91
132_A151_K0.7800.90
39_D140_K0.7750.90
164_H171_I0.7690.90
87_H104_Y0.7680.90
78_P110_R0.7580.89
91_V99_D0.7560.89
61_H93_N0.7560.89
169_D183_I0.7540.89
42_K189_E0.7530.89
65_E168_A0.7530.89
156_A159_E0.7520.89
93_N121_S0.7480.88
12_E166_G0.7460.88
68_G103_R0.7450.88
41_F77_Y0.7420.88
105_V115_L0.7400.88
162_V178_V0.7400.88
145_T152_M0.7330.87
170_R177_K0.7320.87
105_V133_A0.7320.87
101_F104_Y0.7310.87
40_S140_K0.7310.87
61_H180_H0.7300.87
64_E68_G0.7200.86
85_V90_C0.7190.86
33_A182_L0.7170.86
26_N160_I0.7070.85
63_A81_A0.7000.85
19_N22_K0.6980.85
92_G100_I0.6910.84
63_A79_A0.6900.84
92_G96_G0.6890.84
26_N29_A0.6850.84
58_D120_T0.6830.83
36_L39_D0.6740.83
121_S124_S0.6730.82
57_C86_S0.6710.82
131_I156_A0.6700.82
153_A159_E0.6700.82
54_G93_N0.6670.82
56_H89_S0.6630.82
60_M64_E0.6610.81
44_G110_R0.6590.81
71_R184_Q0.6590.81
41_F108_V0.6580.81
93_N120_T0.6500.80
35_V38_A0.6480.80
148_D165_F0.6480.80
69_R95_F0.6470.80
102_S106_E0.6420.79
58_D172_Q0.6410.79
65_E120_T0.6390.79
35_V189_E0.6370.79
128_I132_A0.6350.79
32_R36_L0.6260.78
140_K158_I0.6260.78
121_S172_Q0.6240.77
162_V175_H0.6230.77
52_N94_D0.6200.77
30_I182_L0.6190.77
62_F118_I0.6130.76
98_N129_K0.6130.76
64_E90_C0.6090.76
99_D102_S0.6060.75
91_V104_Y0.6050.75
58_D176_I0.6010.75
47_V79_A0.5940.74
84_D104_Y0.5910.74
147_K150_G0.5880.73
66_L70_Y0.5870.73
143_T159_E0.5850.73
13_A16_T0.5850.73
36_L142_I0.5850.73
54_G124_S0.5780.72
56_H104_Y0.5750.72
145_T153_A0.5740.71
78_P108_V0.5730.71
38_A42_K0.5680.71
141_V156_A0.5660.70
52_N93_N0.5640.70
10_L181_I0.5620.70
69_R73_N0.5610.70
64_E183_I0.5600.70
62_F176_I0.5600.70
54_G120_T0.5590.69
9_E13_A0.5550.69
57_C60_M0.5550.69
90_C96_G0.5550.69
105_V109_G0.5530.69
62_F116_L0.5520.69
58_D168_A0.5490.68
183_I187_E0.5450.68
32_R35_V0.5440.67
75_P106_E0.5430.67
70_Y169_D0.5410.67
93_N124_S0.5380.67
52_N119_S0.5350.66
66_L77_Y0.5330.66
134_A139_M0.5330.66
58_D117_G0.5330.66
55_S124_S0.5280.65
61_H94_D0.5280.65
39_D42_K0.5270.65
125_A132_A0.5250.65
29_A158_I0.5230.64
109_G112_G0.5220.64
114_V142_I0.5220.64
52_N121_S0.5210.64
77_Y187_E0.5190.64
48_L108_V0.5180.64
119_S143_T0.5170.64
128_I155_T0.5150.63
60_M84_D0.5120.63
32_R158_I0.5110.63
37_L49_S0.5110.63
57_C64_E0.5100.62
63_A67_T0.5090.62
60_M86_S0.5070.62
150_G161_R0.5040.62
70_Y74_R0.5040.62
115_L131_I0.5030.61
93_N126_N0.5010.61
46_K110_R0.5010.61
55_S121_S0.5010.61
60_M81_A0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i2wA 4 0.9948 100 0.432 Contact Map
2yvaA 4 0.9792 100 0.477 Contact Map
1x92A 4 0.9844 100 0.482 Contact Map
3trjA 4 0.9688 100 0.485 Contact Map
2xblA 4 0.9948 100 0.487 Contact Map
1tk9A 4 0.9688 100 0.491 Contact Map
3w0lB 1 0.9844 99.9 0.636 Contact Map
3cvjA 2 0.9635 99.9 0.642 Contact Map
4s12A 2 0.9896 99.9 0.642 Contact Map
1nriA 2 0.9896 99.9 0.645 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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