GREMLIN Database
GADW - HTH-type transcriptional regulator GadW
UniProt: P63201 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12242
Length: 242 (230)
Sequences: 35667 (31024)
Seq/√Len: 2045.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
193_R226_Y3.3821.00
178_T186_A3.3411.00
146_S187_S3.0771.00
189_M226_Y3.0531.00
201_I209_K3.0371.00
191_M194_R2.8501.00
144_L148_D2.8141.00
156_R166_E2.7431.00
186_A225_Y2.6561.00
148_D151_K2.5101.00
222_F233_F2.3351.00
141_V169_I2.2611.00
173_L183_I2.2251.00
192_A218_F2.2031.00
195_L209_K2.1541.00
149_I187_S2.0341.00
154_Y157_D2.0261.00
142_E176_E2.0171.00
228_V236_H1.9581.00
201_I205_T1.9141.00
195_L210_C1.9071.00
144_L161_R1.8971.00
145_I184_L1.8711.00
189_M225_Y1.8221.00
141_V162_M1.8191.00
181_S185_L1.7961.00
138_S176_E1.7961.00
215_T219_I1.7711.00
15_D22_K1.7701.00
158_I180_F1.7641.00
202_P205_T1.6811.00
143_R147_F1.6801.00
169_I180_F1.6791.00
195_L201_I1.6781.00
194_R198_L1.6741.00
155_L170_K1.6701.00
193_R233_F1.6571.00
217_Y221_T1.6231.00
15_D24_S1.6181.00
168_L172_K1.6141.00
221_T224_Q1.5951.00
112_L115_S1.5881.00
178_T182_K1.5801.00
17_Y22_K1.5781.00
187_S191_M1.5771.00
144_L153_W1.5661.00
180_F184_L1.5561.00
196_L203_L1.5351.00
13_S24_S1.5251.00
168_L171_K1.5221.00
191_M195_L1.4771.00
204_H215_T1.4621.00
228_V232_Q1.4521.00
150_A209_K1.4511.00
231_H235_Q1.4491.00
26_H29_S1.4471.00
142_E146_S1.4451.00
166_E170_K1.4381.00
149_I191_M1.4381.00
170_K180_F1.4311.00
111_M118_S1.4221.00
146_S183_I1.4201.00
204_H208_E1.4161.00
167_S171_K1.4061.00
145_I187_S1.3861.00
199_R234_A1.3801.00
179_C182_K1.3781.00
205_T209_K1.3781.00
205_T208_E1.3771.00
13_S26_H1.3691.00
192_A210_C1.3541.00
156_R160_E1.3471.00
164_T168_L1.3391.00
151_K157_D1.3351.00
216_S219_I1.3241.00
186_A190_S1.3151.00
15_D42_A1.3131.00
185_L221_T1.3121.00
157_D161_R1.3071.00
191_M210_C1.3061.00
212_Y221_T1.3041.00
111_M115_S1.3031.00
141_V158_I1.2871.00
17_Y40_D1.2861.00
19_E37_L1.2691.00
206_I210_C1.2631.00
193_R197_E1.2421.00
219_I229_T1.2341.00
164_T169_I1.2191.00
187_S190_S1.2191.00
10_I49_R1.2051.00
165_S168_L1.1991.00
11_R27_N1.1951.00
220_N224_Q1.1861.00
219_I231_H1.1681.00
34_E37_L1.1631.00
137_V164_T1.1571.00
190_S193_R1.1431.00
155_L180_F1.1401.00
144_L162_M1.1351.00
118_S122_H1.1281.00
153_W158_I1.1281.00
110_N114_L1.1231.00
214_S220_N1.0911.00
108_L112_L1.0901.00
115_S119_M1.0861.00
201_I206_I1.0841.00
136_T140_K1.0821.00
111_M114_L1.0751.00
88_M92_T1.0591.00
172_K175_D1.0331.00
231_H234_A1.0311.00
185_L224_Q1.0301.00
150_A191_M1.0291.00
101_S105_S1.0201.00
89_P92_T1.0101.00
140_K161_R1.0091.00
158_I161_R1.0071.00
195_L206_I1.0041.00
159_A166_E1.0021.00
232_Q235_Q1.0011.00
139_G143_R0.9991.00
92_T96_D0.9911.00
229_T232_Q0.9881.00
137_V162_M0.9881.00
199_R206_I0.9841.00
137_V172_K0.9821.00
157_D160_E0.9761.00
219_I223_R0.9761.00
167_S170_K0.9761.00
142_E183_I0.9721.00
181_S217_Y0.9601.00
93_A97_S0.9551.00
152_R157_D0.9551.00
79_R83_N0.9501.00
152_R213_S0.9491.00
108_L115_S0.9461.00
188_R210_C0.9441.00
221_T225_Y0.9421.00
189_M221_T0.9401.00
138_S172_K0.9401.00
17_Y20_Q0.9381.00
203_L206_I0.9301.00
182_K185_L0.9251.00
185_L225_Y0.9241.00
155_L166_E0.9201.00
11_R47_D0.9191.00
173_L180_F0.9171.00
145_I180_F0.9131.00
182_K186_A0.9081.00
226_Y233_F0.9071.00
9_L14_F0.9041.00
162_M169_I0.9021.00
114_L118_S0.9021.00
149_I153_W0.9001.00
193_R222_F0.8981.00
148_D161_R0.8931.00
89_P93_A0.8921.00
140_K162_M0.8911.00
223_R229_T0.8911.00
144_L158_I0.8801.00
18_H21_Q0.8781.00
173_L176_E0.8751.00
140_K143_R0.8731.00
164_T172_K0.8601.00
138_S141_V0.8511.00
196_L206_I0.8471.00
217_Y220_N0.8451.00
13_S44_C0.8401.00
181_S184_L0.8351.00
149_I184_L0.8321.00
197_E233_F0.8311.00
141_V173_L0.8291.00
139_G142_E0.8291.00
142_E173_L0.8271.00
14_F25_L0.8101.00
196_L234_A0.8091.00
232_Q236_H0.8091.00
189_M218_F0.7981.00
170_K179_C0.7921.00
208_E213_S0.7891.00
132_N135_S0.7881.00
16_I31_L0.7851.00
145_I183_I0.7841.00
207_A215_T0.7831.00
148_D157_D0.7811.00
182_K225_Y0.7801.00
79_R82_I0.7791.00
14_F24_S0.7761.00
170_K174_Q0.7741.00
137_V140_K0.7731.00
149_I210_C0.7711.00
135_S172_K0.7661.00
86_P89_P0.7641.00
15_D44_C0.7631.00
55_E58_V0.7591.00
192_A195_L0.7531.00
149_I188_R0.7521.00
141_V144_L0.7501.00
183_I187_S0.7471.00
228_V233_F0.7451.00
33_L39_D0.7401.00
8_I30_I0.7401.00
214_S217_Y0.7321.00
213_S217_Y0.7311.00
14_F48_T0.7271.00
107_I111_M0.7201.00
108_L118_S0.7191.00
29_S82_I0.7171.00
86_P90_L0.7151.00
222_F228_V0.7111.00
216_S229_T0.7041.00
17_Y42_A0.7031.00
223_R232_Q0.6971.00
106_P110_N0.6961.00
141_V180_F0.6951.00
90_L93_A0.6931.00
146_S191_M0.6921.00
115_S118_S0.6901.00
86_P119_M0.6901.00
200_Q206_I0.6901.00
55_E59_C0.6891.00
170_K181_S0.6881.00
153_W188_R0.6871.00
171_K175_D0.6851.00
107_I110_N0.6741.00
138_S142_E0.6711.00
158_I169_I0.6711.00
108_L111_M0.6671.00
59_C63_Q0.6641.00
178_T183_I0.6641.00
153_W157_D0.6611.00
214_S224_Q0.6581.00
97_S101_S0.6551.00
185_L189_M0.6541.00
86_P93_A0.6531.00
189_M212_Y0.6521.00
176_E183_I0.6511.00
174_Q179_C0.6471.00
108_L122_H0.6471.00
16_I39_D0.6431.00
14_F41_F0.6431.00
218_F222_F0.6431.00
155_L181_S0.6401.00
70_R73_G0.6371.00
206_I234_A0.6331.00
7_V16_I0.6331.00
158_I162_M0.6331.00
141_V161_R0.6301.00
155_L167_S0.6281.00
7_V33_L0.6271.00
80_L83_N0.6261.00
51_L55_E0.6221.00
18_H33_L0.6201.00
25_L31_L0.6191.00
144_L157_D0.6171.00
54_D57_T0.6161.00
49_R52_D0.6131.00
160_E163_Y0.6091.00
57_T60_H0.6091.00
215_T218_F0.6081.00
9_L25_L0.6081.00
95_F99_N0.6061.00
138_S162_M0.6041.00
218_F230_P0.6021.00
50_R55_E0.6021.00
93_A96_D0.6021.00
77_K80_L0.6001.00
90_L98_F0.5981.00
141_V145_I0.5971.00
190_S226_Y0.5971.00
190_S225_Y0.5961.00
119_M123_K0.5951.00
185_L217_Y0.5921.00
60_H64_N0.5861.00
216_S220_N0.5851.00
124_K127_I0.5831.00
96_D100_E0.5821.00
141_V172_K0.5821.00
138_S169_I0.5811.00
56_L59_C0.5801.00
52_D55_E0.5781.00
184_L188_R0.5781.00
95_F98_F0.5731.00
184_L187_S0.5721.00
169_I176_E0.5721.00
56_L60_H0.5721.00
49_R55_E0.5701.00
35_K40_D0.5691.00
87_P98_F0.5691.00
196_L199_R0.5681.00
202_P206_I0.5671.00
196_L233_F0.5661.00
143_R146_S0.5661.00
158_I188_R0.5641.00
105_S109_S0.5621.00
159_A162_M0.5591.00
204_H216_S0.5591.00
194_R197_E0.5571.00
212_Y217_Y0.5571.00
41_F48_T0.5561.00
195_L198_L0.5561.00
148_D153_W0.5531.00
119_M122_H0.5521.00
145_I153_W0.5501.00
9_L27_N0.5501.00
185_L212_Y0.5481.00
107_I114_L0.5471.00
203_L231_H0.5461.00
83_N87_P0.5451.00
93_A112_L0.5441.00
153_W184_L0.5421.00
60_H63_Q0.5421.00
191_M209_K0.5411.00
203_L215_T0.5401.00
93_A115_S0.5391.00
222_F226_Y0.5381.00
7_V50_R0.5371.00
192_A206_I0.5361.00
13_S45_S0.5301.00
8_I91_V0.5291.00
16_I41_F0.5291.00
7_V31_L0.5281.00
182_K224_Q0.5281.00
221_T226_Y0.5241.00
10_I92_T0.5231.00
216_S223_R0.5221.00
16_I33_L0.5211.00
193_R228_V0.5201.00
66_R69_P0.5201.00
89_P96_D0.5161.00
190_S194_R0.5151.00
208_E215_T0.5141.00
64_N68_L0.5141.00
141_V164_T0.5121.00
105_S108_L0.5091.00
87_P95_F0.5061.00
107_I118_S0.5061.00
131_F134_I0.5041.00
200_Q234_A0.5041.00
207_A210_C0.5031.00
131_F135_S0.5021.00
136_T139_G0.5001.00
94_I98_F0.5001.00
30_I33_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gbgA 1 0.9463 100 0.194 Contact Map
3mklA 1 0.4587 100 0.42 Contact Map
1bl0A 1 0.4504 100 0.43 Contact Map
3oouA 1 0.4298 100 0.43 Contact Map
3mn2A 1 0.4339 100 0.437 Contact Map
3w6vA 1 0.4463 100 0.439 Contact Map
3oioA 1 0.4587 100 0.439 Contact Map
2k9sA 1 0.4339 99.9 0.442 Contact Map
3lsgA 2 0.4174 99.9 0.453 Contact Map
1d5yA 1 0.4504 99.9 0.463 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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