GREMLIN Database
RLMB - 23S rRNA (guanosine-2'-O-)-methyltransferase RlmB
UniProt: P63177 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12483
Length: 243 (230)
Sequences: 8406 (5831)
Seq/√Len: 384.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_M227_V4.0851.00
173_G210_C3.5011.00
99_I192_A3.2501.00
204_R208_E2.8811.00
229_V232_G2.8781.00
174_T234_C2.7531.00
23_Q75_K2.7181.00
112_C231_T2.7011.00
195_M231_T2.4711.00
173_G202_M2.4411.00
24_E51_Q2.3541.00
237_E240_R2.3481.00
162_R209_H2.2301.00
175_A207_R2.0971.00
98_L112_C2.0691.00
165_Q211_D2.0471.00
11_V72_A1.9711.00
101_D203_R1.9611.00
172_V214_I1.9511.00
123_A150_P1.9041.00
58_L71_I1.8621.00
113_L124_V1.8521.00
95_P190_R1.8371.00
21_R75_K1.8091.00
119_A236_F1.7811.00
156_N159_R1.7471.00
142_A146_A1.7421.00
117_D220_G1.7161.00
98_L235_L1.7151.00
117_D149_V1.7151.00
96_F121_V1.7051.00
97_L123_A1.7041.00
170_W212_E1.6911.00
231_T235_L1.6821.00
172_V191_L1.6471.00
180_H212_E1.5841.00
145_A222_V1.5531.00
182_L234_C1.5461.00
139_K146_A1.5311.00
121_V235_L1.5081.00
172_V212_E1.4891.00
193_L238_A1.4881.00
169_I192_A1.4861.00
193_L234_C1.4781.00
194_V202_M1.4731.00
30_G55_R1.4651.00
24_E73_R1.4541.00
118_A218_M1.4501.00
169_I190_R1.4481.00
29_K52_L1.4471.00
55_R59_D1.4411.00
116_A121_V1.4361.00
98_L116_A1.4301.00
119_A182_L1.3621.00
117_D145_A1.3601.00
179_D215_S1.3521.00
185_S214_I1.3501.00
111_A228_S1.3411.00
161_M171_I1.3401.00
5_I14_L1.3281.00
181_T184_Q1.3261.00
176_G215_S1.3091.00
53_A57_Y1.3081.00
104_T199_G1.3011.00
197_A200_E1.2901.00
95_P122_H1.2881.00
175_A213_L1.2861.00
98_L121_V1.2841.00
103_V227_V1.2761.00
162_R166_E1.2741.00
93_D122_H1.2731.00
207_R213_L1.2731.00
219_A239_V1.2721.00
97_L169_I1.2681.00
163_M167_E1.2631.00
102_G129_D1.2611.00
119_A233_I1.2601.00
53_A58_L1.2591.00
117_D148_S1.2541.00
115_S232_G1.2431.00
117_D222_V1.2401.00
12_Q16_E1.2381.00
25_V72_A1.2361.00
194_V206_T1.2351.00
170_W211_D1.2271.00
81_Q84_D1.2231.00
99_I161_M1.2061.00
96_F122_H1.1921.00
173_G213_L1.1881.00
12_Q38_P1.1861.00
22_F72_A1.1841.00
158_A209_H1.1741.00
195_M230_A1.1701.00
97_L125_I1.1601.00
171_I192_A1.1561.00
181_T215_S1.1541.00
164_L192_A1.1521.00
96_F238_A1.1461.00
57_Y60_E1.1451.00
29_K54_N1.1401.00
183_Y240_R1.1391.00
98_L195_M1.1391.00
187_M238_A1.1381.00
125_I160_T1.1351.00
119_A239_V1.1321.00
116_A124_V1.1051.00
154_V160_T1.0991.00
180_H184_Q1.0971.00
13_A16_E1.0921.00
113_L151_L1.0911.00
25_V43_L1.0871.00
123_A152_I1.0721.00
99_I157_L1.0701.00
126_V151_L1.0621.00
203_R206_T1.0571.00
11_V70_I1.0461.00
109_L131_S1.0421.00
115_S229_V1.0371.00
109_L126_V1.0311.00
20_E77_G1.0301.00
125_I154_V1.0201.00
161_M206_T1.0181.00
16_E42_A1.0171.00
56_Q59_D1.0061.00
13_A148_S0.9981.00
62_S71_I0.9921.00
28_L55_R0.9911.00
22_F74_V0.9901.00
158_A162_R0.9881.00
115_S235_L0.9871.00
180_H185_S0.9791.00
113_L138_A0.9641.00
194_V210_C0.9571.00
162_R165_Q0.9541.00
187_M191_L0.9481.00
210_C213_L0.9401.00
158_A205_L0.9361.00
96_F235_L0.9331.00
214_I234_C0.9301.00
159_R162_R0.9301.00
27_I52_L0.9281.00
100_L195_M0.9241.00
126_V130_R0.9211.00
148_S221_S0.9211.00
107_H141_V0.9161.00
157_L206_T0.9161.00
100_L112_C0.9131.00
27_I70_I0.9121.00
28_L31_R0.9071.00
117_D221_S0.9051.00
174_T195_M0.9031.00
5_I10_A0.9021.00
191_L238_A0.9001.00
5_I74_V0.8951.00
128_K155_T0.8921.00
182_L187_M0.8911.00
86_P167_E0.8881.00
12_Q42_A0.8821.00
120_G219_A0.8791.00
115_S119_A0.8721.00
54_N57_Y0.8711.00
101_D206_T0.8711.00
170_W189_G0.8701.00
163_M166_E0.8681.00
63_D136_A0.8611.00
94_Q122_H0.8521.00
77_G134_L0.8511.00
118_A222_V0.8451.00
173_G207_R0.8401.00
177_E207_R0.8391.00
97_L164_L0.8381.00
4_M71_I0.8361.00
96_F191_L0.8361.00
177_E213_L0.8351.00
100_L109_L0.8341.00
178_A215_S0.8311.00
27_I50_I0.8311.00
99_I164_L0.8301.00
164_L169_I0.8291.00
101_D202_M0.8251.00
24_E49_V0.8181.00
159_R163_M0.8101.00
99_I194_V0.8071.00
82_E152_I0.8071.00
107_H111_A0.8041.00
102_G200_E0.8001.00
102_G127_P0.7991.00
20_E147_E0.7981.00
95_P169_I0.7941.00
205_L208_E0.7931.00
26_F61_K0.7911.00
83_N163_M0.7871.00
17_R148_S0.7851.00
38_P42_A0.7831.00
172_V185_S0.7801.00
82_E85_L0.7771.00
42_A45_S0.7771.00
131_S135_N0.7761.00
205_L209_H0.7741.00
165_Q209_H0.7711.00
4_M73_R0.7611.00
174_T202_M0.7591.00
119_A183_Y0.7591.00
28_L58_L0.7571.00
14_L74_V0.7561.00
14_L147_E0.7541.00
170_W191_L0.7541.00
161_M192_A0.7541.00
183_Y237_E0.7531.00
161_M209_H0.7521.00
6_Y64_G0.7511.00
139_K147_E0.7481.00
103_V109_L0.7471.00
102_G197_A0.7421.00
102_G203_R0.7421.00
155_T159_R0.7361.00
9_H143_C0.7351.00
26_F53_A0.7311.00
158_A206_T0.7291.00
94_Q189_G0.7281.00
113_L146_A0.7261.00
165_Q171_I0.7251.00
185_S212_E0.7231.00
23_Q73_R0.7181.00
202_M210_C0.7181.00
53_A71_I0.7171.00
177_E215_S0.7141.00
124_V149_V0.7111.00
171_I194_V0.7091.00
204_R207_R0.7081.00
175_A215_S0.7061.00
100_L103_V0.7051.00
112_C227_V0.7031.00
179_D212_E0.7021.00
103_V112_C0.7001.00
175_A178_A0.7001.00
42_A46_Q0.6991.00
160_T164_L0.6960.99
119_A235_L0.6960.99
85_L123_A0.6940.99
183_Y217_P0.6930.99
109_L138_A0.6920.99
178_A213_L0.6830.99
195_M234_C0.6830.99
61_K71_I0.6820.99
183_Y239_V0.6750.99
174_T193_L0.6720.99
43_L48_V0.6680.99
128_K156_N0.6660.99
104_T197_A0.6630.99
82_E86_P0.6570.99
26_F73_R0.6540.99
107_H137_T0.6510.99
176_G223_S0.6500.99
111_A229_V0.6480.99
17_R20_E0.6470.99
23_Q49_V0.6460.99
37_L41_H0.6450.99
99_I125_I0.6420.99
148_S222_V0.6410.99
58_L68_Q0.6400.99
34_K37_L0.6380.99
27_I32_E0.6380.99
58_L62_S0.6370.99
173_G194_V0.6360.99
216_I236_F0.6350.99
31_R36_L0.6290.99
168_N190_R0.6290.99
119_A216_I0.6270.99
35_R38_P0.6250.99
41_H44_E0.6230.99
116_A235_L0.6230.99
115_S231_T0.6220.99
82_E125_I0.6200.99
126_V133_Q0.6190.99
40_I44_E0.6190.99
118_A223_S0.6180.99
176_G179_D0.6120.99
32_E52_L0.6110.99
113_L145_A0.6110.99
183_Y236_F0.6070.99
59_D65_A0.6070.99
145_A148_S0.6070.99
92_L122_H0.6060.99
38_P41_H0.6040.99
125_I164_L0.6000.98
122_H169_I0.5980.98
187_M237_E0.5980.98
5_I22_F0.5980.98
14_L18_A0.5970.98
6_Y140_K0.5940.98
59_D67_H0.5930.98
97_L192_A0.5920.98
80_Y152_I0.5890.98
107_H228_S0.5870.98
132_A135_N0.5870.98
160_T163_M0.5860.98
9_H12_Q0.5780.98
104_T200_E0.5770.98
6_Y136_A0.5740.98
10_A139_K0.5710.98
58_L67_H0.5700.98
228_S231_T0.5690.98
119_A218_M0.5670.98
8_I35_R0.5670.98
99_I127_P0.5670.98
26_F51_Q0.5660.98
8_I12_Q0.5630.98
9_H13_A0.5620.98
85_L97_L0.5620.98
82_E160_T0.5540.97
41_H45_S0.5500.97
129_D203_R0.5490.97
161_M165_Q0.5470.97
16_E221_S0.5420.97
56_Q60_E0.5410.97
53_A61_K0.5400.97
117_D219_A0.5380.97
68_Q105_D0.5370.97
127_P157_L0.5340.97
202_M206_T0.5340.97
5_I139_K0.5300.97
22_F75_K0.5290.97
86_P163_M0.5270.97
85_L152_I0.5270.97
118_A236_F0.5250.97
121_V238_A0.5230.96
127_P206_T0.5220.96
216_I233_I0.5210.96
197_A223_S0.5210.96
80_Y84_D0.5200.96
8_I36_L0.5190.96
18_A21_R0.5180.96
139_K142_A0.5150.96
206_T209_H0.5140.96
175_A202_M0.5110.96
170_W188_T0.5100.96
154_V159_R0.5080.96
28_L52_L0.5070.96
11_V25_V0.5050.96
118_A225_L0.5040.96
28_L32_E0.5040.96
183_Y233_I0.5020.96
94_Q190_R0.5010.95
39_L43_L0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gz0A 2 0.9877 100 0.127 Contact Map
3nk6A 2 0.9424 100 0.158 Contact Map
1ipaA 1 0.9465 100 0.161 Contact Map
1x7oA 2 0.963 100 0.179 Contact Map
2i6dA 2 0.9136 100 0.198 Contact Map
4kgnA 2 0.6214 100 0.371 Contact Map
1v2xA 2 0.6914 100 0.382 Contact Map
1zjrA 2 0.6872 100 0.383 Contact Map
3n4jA 2 0.6173 100 0.385 Contact Map
3l8uA 2 0.5802 100 0.39 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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