GREMLIN Database
NFUA - Fe/S biogenesis protein NfuA
UniProt: P63020 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12935
Length: 191 (189)
Sequences: 414 (220)
Seq/√Len: 16.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_V135_I4.8251.00
110_R173_E4.5081.00
154_M157_V3.6821.00
140_Y176_G3.4260.99
164_E168_L2.7330.97
139_G175_K2.2110.90
155_V163_I2.1940.90
55_A62_T2.1450.89
186_G189_S2.0800.87
11_H41_V2.0670.87
62_T171_F2.0520.86
92_K96_A2.0100.85
57_K62_T1.9630.84
114_M117_S1.9380.83
13_A17_A1.8620.80
26_R53_D1.8400.80
118_Q143_L1.7980.78
177_V187_E1.7310.75
140_Y175_K1.7310.75
112_E116_Q1.7100.74
79_D94_P1.7060.74
3_R6_D1.7030.74
150_N188_H1.6930.73
22_G48_A1.6860.73
55_A64_Y1.6790.73
140_Y178_R1.6760.73
122_Q130_V1.6650.72
19_Q162_G1.6640.72
6_D70_A1.6530.72
96_A161_E1.6310.71
153_S157_V1.5970.69
126_H148_G1.5870.68
17_A20_E1.5780.68
107_L135_I1.5730.68
107_L111_V1.5680.67
155_V159_L1.5360.66
25_I41_V1.5250.65
9_Q161_E1.5220.65
141_A174_L1.5190.65
10_A60_L1.5160.65
184_Q189_S1.5100.64
111_V137_E1.5070.64
179_D183_H1.5040.64
150_N189_S1.4880.63
6_D10_A1.4860.63
49_V65_V1.4530.61
22_G46_P1.4470.61
67_E119_I1.4460.61
14_K17_A1.4230.60
95_N133_M1.4180.59
161_E165_K1.4160.59
110_R124_A1.4090.59
135_I139_G1.4070.59
130_V177_V1.4010.58
9_Q55_A1.3560.56
122_Q154_M1.3480.55
30_I41_V1.3450.55
155_V174_L1.3380.55
119_I159_L1.3260.54
135_I174_L1.3090.53
61_L139_G1.3050.53
120_N126_H1.2880.52
25_I154_M1.2880.52
185_R189_S1.2410.49
73_L93_A1.2350.49
35_P167_L1.2330.49
126_H183_H1.2290.49
6_D67_E1.2120.48
79_D124_A1.1960.47
13_A60_L1.1840.46
28_F38_E1.1740.45
63_A141_A1.1740.45
143_L190_Y1.1660.45
25_I163_I1.1650.45
146_G156_D1.1570.44
139_G174_L1.1530.44
114_M119_I1.1390.43
24_Q61_L1.1380.43
2_I27_V1.1370.43
163_I171_F1.1330.43
10_A17_A1.1320.43
111_V140_Y1.1280.43
123_L153_S1.1260.43
10_A119_I1.1190.42
151_G172_P1.1060.41
118_Q170_E1.1060.41
13_A59_D1.0960.41
19_Q124_A1.0940.41
6_D142_I1.0860.40
148_G179_D1.0800.40
22_G122_Q1.0790.40
86_G132_L1.0700.39
85_L141_A1.0650.39
41_V63_A1.0610.39
17_A137_E1.0540.39
38_E53_D1.0430.38
58_F61_L1.0220.37
25_I31_N1.0160.36
66_D134_E1.0000.36
45_P50_E0.9990.36
101_V106_P0.9960.35
2_I13_A0.9950.35
166_Q170_E0.9950.35
123_L151_G0.9940.35
124_A151_G0.9930.35
4_I63_A0.9920.35
72_Y145_F0.9890.35
107_L123_L0.9810.35
72_Y109_E0.9790.35
13_A80_F0.9770.34
63_A67_E0.9750.34
34_T93_A0.9680.34
3_R7_A0.9640.34
120_N183_H0.9600.34
69_S80_F0.9560.33
31_N36_N0.9520.33
40_G45_P0.9380.32
126_H179_D0.9310.32
65_V177_V0.9270.32
168_L174_L0.9230.32
108_M112_E0.9210.32
6_D187_E0.9130.31
6_D27_V0.8910.30
115_L130_V0.8890.30
89_L93_A0.8860.30
123_L165_K0.8850.30
39_C43_Y0.8840.30
132_L179_D0.8790.29
31_N39_C0.8770.29
48_A64_Y0.8750.29
52_T56_L0.8700.29
6_D13_A0.8690.29
184_Q188_H0.8670.29
41_V46_P0.8600.29
64_Y68_L0.8550.28
176_G180_L0.8550.28
120_N181_T0.8520.28
17_A21_E0.8470.28
16_L19_Q0.8380.28
126_H181_T0.8370.27
70_A190_Y0.8350.27
136_T139_G0.8350.27
29_V190_Y0.8340.27
11_H20_E0.8330.27
111_V118_Q0.8150.26
24_Q62_T0.8040.26
130_V160_K0.8010.26
167_L174_L0.8010.26
148_G183_H0.8000.26
150_N153_S0.7980.26
5_S77_E0.7970.26
170_E178_R0.7910.25
6_D9_Q0.7900.25
119_I186_G0.7890.25
49_V60_L0.7880.25
59_D140_Y0.7870.25
117_S139_G0.7860.25
38_E83_D0.7850.25
4_I136_T0.7800.25
60_L85_L0.7780.25
105_A109_E0.7780.25
33_G145_F0.7730.25
5_S180_L0.7690.24
171_F189_S0.7680.24
11_H186_G0.7640.24
157_V177_V0.7590.24
115_L172_P0.7580.24
165_K169_N0.7550.24
49_V66_D0.7490.24
124_A181_T0.7460.23
26_R177_V0.7420.23
6_D52_T0.7410.23
65_V114_M0.7400.23
10_A59_D0.7360.23
16_L25_I0.7350.23
5_S114_M0.7340.23
11_H14_K0.7310.23
5_S116_Q0.7300.23
79_D92_K0.7290.23
76_A89_L0.7260.23
2_I17_A0.7250.23
24_Q185_R0.7250.23
108_M114_M0.7190.22
110_R151_G0.7160.22
66_D69_S0.7120.22
13_A30_I0.7110.22
40_G186_G0.7070.22
41_V88_Q0.6970.21
30_I186_G0.6970.21
123_L172_P0.6960.21
165_K176_G0.6940.21
38_E69_S0.6930.21
37_A93_A0.6920.21
185_R188_H0.6910.21
129_R170_E0.6880.21
92_K102_A0.6870.21
5_S12_F0.6770.21
87_S91_L0.6770.21
69_S76_A0.6620.20
90_T97_K0.6610.20
52_T68_L0.6590.20
151_G181_T0.6590.20
29_V70_A0.6560.20
10_A20_E0.6560.20
134_E142_I0.6530.20
151_G183_H0.6530.20
37_A89_L0.6420.19
52_T67_E0.6420.19
32_P37_A0.6290.19
5_S55_A0.6260.19
60_L134_E0.6190.19
146_G150_N0.6180.19
57_K163_I0.6180.19
64_Y130_V0.6160.18
41_V58_F0.6140.18
66_D71_P0.6090.18
27_V65_V0.6060.18
6_D60_L0.6060.18
108_M172_P0.6050.18
52_T60_L0.6020.18
55_A187_E0.6010.18
54_T59_D0.6010.18
73_L94_P0.6000.18
54_T67_E0.5990.18
20_E70_A0.5980.18
37_A43_Y0.5980.18
171_F174_L0.5970.18
137_E140_Y0.5970.18
44_C93_A0.5960.18
102_A170_E0.5950.18
42_S48_A0.5940.18
150_N181_T0.5930.18
120_N148_G0.5920.18
4_I21_E0.5910.18
5_S129_R0.5890.18
3_R187_E0.5870.17
37_A44_C0.5850.17
14_K115_L0.5840.17
106_P175_K0.5790.17
3_R13_A0.5780.17
11_H184_Q0.5760.17
16_L28_F0.5710.17
3_R177_V0.5680.17
24_Q189_S0.5670.17
74_E119_I0.5610.17
146_G162_G0.5570.17
77_E135_I0.5550.16
38_E43_Y0.5530.16
15_L42_S0.5520.16
57_K138_D0.5450.16
92_K97_K0.5430.16
46_P57_K0.5410.16
111_V122_Q0.5410.16
7_A184_Q0.5370.16
7_A13_A0.5340.16
34_T145_F0.5320.16
88_Q96_A0.5320.16
129_R169_N0.5290.16
88_Q113_Y0.5250.16
105_A132_L0.5240.15
64_Y70_A0.5230.15
27_V190_Y0.5210.15
53_D95_N0.5210.15
115_L142_I0.5210.15
12_F163_I0.5190.15
14_K29_V0.5180.15
166_Q169_N0.5170.15
12_F20_E0.5170.15
3_R17_A0.5170.15
40_G43_Y0.5160.15
114_M118_Q0.5130.15
128_G152_C0.5100.15
128_G158_T0.5100.15
128_G147_G0.5100.15
149_C158_T0.5100.15
128_G149_C0.5100.15
149_C152_C0.5100.15
147_G152_C0.5100.15
147_G158_T0.5100.15
152_C158_T0.5100.15
108_M174_L0.5060.15
19_Q25_I0.5060.15
146_G179_D0.5020.15
26_R33_G0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vehA 1 0.4817 100 0.572 Contact Map
2m5oA 1 0.5079 100 0.591 Contact Map
1xhjA 1 0.4607 99.9 0.61 Contact Map
2z51A 2 0.4555 99.9 0.61 Contact Map
1th5A 1 0.3822 99.8 0.683 Contact Map
2k4zA 1 0.534 99.6 0.754 Contact Map
2d2aA 2 0.555 99.5 0.764 Contact Map
1x0gA 4 0.5707 99.5 0.77 Contact Map
2apnA 1 0.555 99.4 0.777 Contact Map
1nwbA 1 0.4817 99.4 0.779 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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