GREMLIN Database
YEIH - UPF0324 inner membrane protein YeiH
UniProt: P62723 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12027
Length: 349 (321)
Sequences: 2464 (1768)
Seq/√Len: 98.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_G134_S4.5961.00
194_P219_S4.3061.00
193_S196_T4.2481.00
119_A138_G4.2091.00
119_A329_L4.1501.00
118_L332_W4.0181.00
50_A304_A4.0121.00
216_H223_E3.8081.00
20_L76_A3.6511.00
90_F274_V3.5771.00
192_F338_G3.2811.00
130_D162_K3.1481.00
269_I273_V3.0231.00
270_L273_V3.0071.00
132_H162_K3.0021.00
205_V214_A2.9771.00
215_G226_A2.9591.00
152_T244_L2.7781.00
149_V170_V2.7141.00
83_L86_I2.6981.00
139_A152_T2.6121.00
185_Y197_F2.6021.00
86_I270_L2.5951.00
86_I274_V2.5471.00
335_V339_A2.4661.00
143_I240_F2.3351.00
200_Y334_I2.2871.00
79_Y83_L2.2711.00
114_S332_W2.1581.00
313_S316_K2.1231.00
215_G223_E2.0681.00
26_I304_A1.9561.00
24_A301_M1.9321.00
33_G49_L1.9291.00
107_I203_S1.8931.00
154_P158_A1.8591.00
122_L328_V1.8571.00
28_G32_W1.8461.00
197_F214_A1.8381.00
159_E162_K1.7671.00
46_A300_A1.7621.00
140_G149_V1.7371.00
208_V234_V1.7351.00
76_A80_L1.7291.00
149_V166_A1.7191.00
115_T142_S1.7161.00
201_I205_V1.7161.00
174_G210_Q1.7151.00
274_V277_F1.6961.00
221_D224_N1.6931.00
94_F276_I1.6741.00
153_E163_V1.6511.00
194_P221_D1.6311.00
264_I269_I1.6021.00
197_F218_I1.5811.00
123_G325_M1.5501.00
311_H314_A1.5491.00
278_N288_V1.5211.00
97_I275_A1.5191.00
273_V277_F1.5181.00
116_F139_A1.5061.00
219_S222_A1.5011.00
67_K70_D1.5011.00
196_T341_N1.4961.00
113_S117_L1.4881.00
177_A330_F1.4871.00
177_A205_V1.4651.00
283_L288_V1.4641.00
96_Q228_I1.4481.00
22_L69_C1.4441.00
178_I213_A1.4391.00
119_A142_S1.4351.00
290_M294_L1.4311.00
116_F142_S1.4281.00
33_G53_L1.4191.00
27_T301_M1.4141.00
313_S317_K1.4101.00
173_F327_L1.4041.00
320_A324_L1.4021.00
93_T279_S1.4021.00
127_F324_L1.4001.00
152_T241_L1.3960.99
276_I280_F1.3840.99
205_V210_Q1.3720.99
339_A342_Y1.3720.99
257_G260_S1.3690.99
266_W270_L1.3570.99
174_G207_E1.3520.99
122_L127_F1.3420.99
26_I53_L1.3100.99
139_A240_F1.3060.99
116_F240_F1.3040.99
122_L126_V1.2930.99
117_L121_F1.2890.99
204_T337_G1.2800.99
110_L340_I1.2740.99
30_A49_L1.2690.99
98_A102_I1.2640.99
206_H299_L1.2630.99
114_S118_L1.2630.99
243_L247_R1.2600.99
32_W36_I1.2590.99
147_A171_V1.2540.99
129_L325_M1.2500.99
121_F126_V1.2330.99
194_P222_A1.2260.99
57_L61_I1.2260.99
200_Y338_G1.2080.99
147_A207_E1.1860.98
112_L236_M1.1800.98
203_S341_N1.1690.98
104_G199_I1.1690.98
277_F282_L1.1680.98
198_G222_A1.1670.98
88_Y147_A1.1560.98
141_S329_L1.1520.98
218_I222_A1.1470.98
197_F201_I1.1410.98
155_V241_L1.1370.98
90_F291_L1.1140.97
62_Y73_V1.1120.97
108_D232_L1.1120.97
186_P218_I1.1090.97
79_Y86_I1.1070.97
339_A343_V1.1070.97
146_A209_A1.1050.97
157_K248_V1.1020.97
266_W269_I1.0930.97
90_F281_H1.0900.97
113_S243_L1.0870.97
127_F325_M1.0870.97
220_P224_N1.0830.97
337_G341_N1.0830.97
198_G225_A1.0810.97
275_A279_S1.0780.97
91_R292_V1.0730.97
141_S330_F1.0710.97
181_Y204_T1.0590.97
329_L337_G1.0580.97
94_F279_S1.0550.97
16_F20_L1.0460.96
58_G311_H1.0440.96
219_S223_E1.0430.96
273_V276_I1.0350.96
286_S289_N1.0300.96
95_S98_A1.0240.96
132_H156_V1.0220.96
76_A301_M1.0220.96
213_A227_V1.0190.96
73_V308_L1.0060.95
128_G132_H1.0020.95
147_A151_A0.9980.95
70_D74_L0.9920.95
207_E303_M0.9760.95
142_S244_L0.9750.95
56_V59_N0.9710.94
146_A207_E0.9620.94
118_L122_L0.9610.94
81_L302_A0.9600.94
200_Y204_T0.9590.94
161_S314_A0.9550.94
256_S294_L0.9540.94
142_S152_T0.9540.94
25_V29_V0.9540.94
88_Y223_E0.9530.94
207_E210_Q0.9510.94
93_T96_Q0.9500.94
166_A326_A0.9480.94
281_H288_V0.9480.94
194_P218_I0.9480.94
290_M293_T0.9460.94
287_V290_M0.9410.93
174_G234_V0.9390.93
114_S117_L0.9380.93
93_T275_A0.9350.93
45_S207_E0.9300.93
185_Y204_T0.9300.93
105_I232_L0.9260.93
90_F270_L0.9220.93
242_I246_A0.9220.93
108_D203_S0.9030.92
277_F283_L0.9000.92
171_V210_Q0.9000.92
111_T203_S0.9000.92
158_A163_V0.8970.92
210_Q234_V0.8950.92
107_I340_I0.8890.91
175_T299_L0.8880.91
234_V237_L0.8850.91
149_V163_V0.8830.91
152_T240_F0.8740.91
52_L56_V0.8700.90
146_A299_L0.8640.90
253_G256_S0.8640.90
204_T333_L0.8630.90
68_S71_G0.8630.90
146_A234_V0.8620.90
21_A25_V0.8600.90
32_W35_S0.8550.90
23_S76_A0.8550.90
27_T297_F0.8540.90
283_L287_V0.8540.90
234_V306_L0.8520.90
255_N258_E0.8480.89
82_R207_E0.8450.89
155_V245_A0.8440.89
250_Q253_G0.8410.89
56_V60_T0.8370.89
138_G329_L0.8370.89
24_A28_G0.8350.89
285_Q289_N0.8230.88
286_S290_M0.8210.88
132_H248_V0.8200.88
269_I272_I0.8180.88
270_L274_V0.8150.87
30_A53_L0.8120.87
23_S305_A0.8120.87
27_T300_A0.8100.87
209_A330_F0.8060.87
55_M312_V0.8050.87
314_A317_K0.8030.87
130_D133_T0.8020.87
53_L56_V0.8010.86
146_A171_V0.8000.86
82_R209_A0.7930.86
88_Y268_A0.7930.86
171_V306_L0.7910.86
175_T206_H0.7900.86
277_F285_Q0.7900.86
147_A303_M0.7890.86
235_M268_A0.7860.85
126_V331_A0.7840.85
146_A206_H0.7840.85
114_S336_G0.7840.85
232_L240_F0.7810.85
100_V228_I0.7790.85
84_G237_L0.7770.85
49_L53_L0.7710.84
90_F277_F0.7700.84
251_L328_V0.7690.84
85_I274_V0.7680.84
164_T310_T0.7670.84
172_I323_L0.7660.84
176_V180_L0.7640.84
143_I156_V0.7580.83
78_Q164_T0.7570.83
88_Y213_A0.7570.83
110_L336_G0.7540.83
112_L143_I0.7530.83
173_F182_P0.7530.83
55_M293_T0.7520.83
24_A27_T0.7480.82
94_F97_I0.7460.82
220_P223_E0.7460.82
138_G142_S0.7450.82
206_H234_V0.7450.82
278_N310_T0.7430.82
26_I308_L0.7420.82
201_I218_I0.7420.82
178_I214_A0.7410.82
225_A229_S0.7410.82
32_W256_S0.7370.82
167_V305_A0.7280.81
212_V227_V0.7230.80
93_T241_L0.7210.80
30_A304_A0.7200.80
146_A237_L0.7170.80
109_V113_S0.7130.79
208_V237_L0.7120.79
127_F321_K0.7090.79
23_S73_V0.7090.79
147_A306_L0.7090.79
87_L295_D0.7040.79
141_S169_T0.7030.78
82_R146_A0.6950.78
237_L241_L0.6940.78
192_F196_T0.6930.77
209_A303_M0.6910.77
319_G322_P0.6870.77
138_G216_H0.6870.77
171_V177_A0.6860.77
296_T300_A0.6860.77
31_L35_S0.6850.77
71_G74_L0.6850.77
171_V303_M0.6850.77
261_K266_W0.6850.77
209_A234_V0.6850.77
76_A176_V0.6820.76
185_Y218_I0.6800.76
183_A187_L0.6720.75
181_Y205_V0.6720.75
16_F75_F0.6710.75
115_T332_W0.6710.75
23_S304_A0.6710.75
184_I187_L0.6700.75
177_A334_I0.6690.75
135_W244_L0.6680.75
206_H233_R0.6680.75
19_G72_G0.6670.75
210_Q237_L0.6650.75
134_S325_M0.6620.74
72_G75_F0.6610.74
179_F183_A0.6600.74
48_T175_T0.6590.74
180_L183_A0.6590.74
336_G340_I0.6580.74
178_I182_P0.6580.74
75_F79_Y0.6560.74
91_R295_D0.6560.74
184_I188_M0.6560.74
135_W156_V0.6510.73
132_H157_K0.6480.73
101_G279_S0.6470.72
305_A310_T0.6460.72
160_A326_A0.6440.72
146_A239_P0.6430.72
169_T318_A0.6430.72
53_L340_I0.6420.72
258_E343_V0.6390.72
183_A186_P0.6350.71
297_F301_M0.6330.71
118_L121_F0.6330.71
96_Q99_D0.6330.71
253_G294_L0.6330.71
47_L306_L0.6310.71
196_T228_I0.6300.70
102_I311_H0.6300.70
143_I189_S0.6300.70
175_T203_S0.6280.70
98_A105_I0.6280.70
284_P287_V0.6250.70
291_L294_L0.6240.70
338_G342_Y0.6240.70
238_A275_A0.6230.70
169_T326_A0.6190.69
136_L149_V0.6170.69
152_T156_V0.6160.69
141_S206_H0.6150.69
115_T333_L0.6140.69
245_A248_V0.6140.69
23_S27_T0.6120.68
251_L259_K0.6110.68
309_T314_A0.6110.68
117_L243_L0.6100.68
150_L164_T0.6090.68
174_G208_V0.6090.68
80_L297_F0.6070.68
85_I302_A0.6060.68
51_I75_F0.6050.67
111_T333_L0.6030.67
139_A310_T0.5990.67
269_I282_L0.5980.67
160_A309_T0.5970.66
85_I233_R0.5960.66
181_Y209_A0.5960.66
15_H71_G0.5940.66
204_T207_E0.5920.66
58_G62_Y0.5900.65
323_L327_L0.5890.65
185_Y338_G0.5860.65
150_L181_Y0.5850.65
253_G258_E0.5830.65
15_H36_I0.5810.64
147_A333_L0.5780.64
154_P168_A0.5780.64
130_D134_S0.5780.64
47_L82_R0.5760.64
86_I257_G0.5750.64
174_G303_M0.5750.64
254_A258_E0.5740.63
197_F330_F0.5730.63
107_I199_I0.5710.63
200_Y222_A0.5700.63
285_Q293_T0.5700.63
56_V126_V0.5690.63
174_G209_A0.5680.63
228_I264_I0.5670.62
48_T213_A0.5660.62
110_L114_S0.5650.62
171_V234_V0.5650.62
29_V35_S0.5640.62
216_H219_S0.5630.62
206_H330_F0.5630.62
75_F80_L0.5630.62
153_E158_A0.5620.62
110_L335_V0.5610.62
84_G147_A0.5600.61
151_A239_P0.5600.61
142_S169_T0.5590.61
33_G179_F0.5590.61
104_G218_I0.5590.61
96_Q279_S0.5590.61
200_Y337_G0.5560.61
147_A216_H0.5550.61
169_T322_P0.5540.61
82_R206_H0.5540.61
117_L276_I0.5530.61
277_F281_H0.5520.60
252_S256_S0.5520.60
171_V209_A0.5490.60
88_Y296_T0.5490.60
85_I216_H0.5490.60
165_V322_P0.5480.60
271_F279_S0.5470.60
171_V174_G0.5470.60
72_G76_A0.5470.60
198_G227_V0.5470.60
201_I222_A0.5470.60
19_G23_S0.5460.60
18_P26_I0.5460.60
208_V218_I0.5450.59
118_L253_G0.5440.59
105_I236_M0.5440.59
257_G276_I0.5440.59
141_S171_V0.5430.59
133_T162_K0.5430.59
199_I261_K0.5430.59
21_A32_W0.5430.59
90_F288_V0.5420.59
228_I232_L0.5410.59
147_A208_V0.5410.59
48_T138_G0.5400.59
197_F213_A0.5390.59
66_W69_C0.5380.58
147_A227_V0.5370.58
47_L146_A0.5370.58
238_A272_I0.5360.58
80_L155_V0.5360.58
207_E330_F0.5350.58
163_V196_T0.5350.58
51_I303_M0.5350.58
199_I225_A0.5340.58
140_G174_G0.5340.58
76_A305_A0.5320.58
212_V222_A0.5310.57
131_K134_S0.5310.57
140_G233_R0.5310.57
150_L268_A0.5300.57
238_A299_L0.5290.57
21_A35_S0.5290.57
29_V71_G0.5270.57
85_I140_G0.5240.56
171_V206_H0.5240.56
24_A297_F0.5230.56
73_V76_A0.5230.56
312_V339_A0.5230.56
84_G111_T0.5220.56
121_F125_K0.5210.56
177_A181_Y0.5210.56
84_G244_L0.5210.56
182_P205_V0.5190.56
111_T164_T0.5190.56
171_V207_E0.5180.56
111_T340_I0.5180.56
116_F120_C0.5180.56
58_G308_L0.5180.56
106_I215_G0.5180.56
82_R175_T0.5170.55
21_A28_G0.5150.55
114_S139_A0.5150.55
207_E299_L0.5150.55
224_N227_V0.5150.55
65_I256_S0.5150.55
163_V166_A0.5140.55
201_I215_G0.5110.55
189_S192_F0.5110.55
173_F325_M0.5090.54
17_I21_A0.5090.54
197_F217_A0.5080.54
59_N312_V0.5080.54
45_S48_T0.5080.54
51_I162_K0.5070.54
82_R299_L0.5070.54
299_L322_P0.5060.54
205_V310_T0.5060.54
140_G166_A0.5060.54
107_I341_N0.5050.54
249_K254_A0.5030.53
227_V300_A0.5020.53
119_A134_S0.5020.53
53_L192_F0.5020.53
193_S259_K0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bwzA 2 0.8052 96.6 0.926 Contact Map
4czbA 2 0.8395 96.5 0.926 Contact Map
4cz8A 2 0.8997 96.3 0.928 Contact Map
3zuxA 1 0.788 96.1 0.929 Contact Map
4n7wA 2 0.7736 93.5 0.939 Contact Map
1zcdA 1 0.5014 23.7 0.967 Contact Map
1pw4A 1 0.5989 23.1 0.967 Contact Map
4tphA 2 0.7335 21.3 0.968 Contact Map
3v5uA 1 0.6275 12 0.971 Contact Map
2mgyA 1 0.4527 7.2 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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