YEIH - ECOLI - GREMLIN Contacts

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YEIH - UPF0324 inner membrane protein YeiH

UniProt:	P62723	Sequences: MTNITLQKQHRTLWHFIPGLALSAVITGVALWGGSIPAVAGAGFSALTLAILLGMVLGNTIYPHIWKSCDGGVLFAKQYLLRLGIILYGFRLTFSQIADVGISGIIIDVLTLSSTFLLACFLGQKVFGLDKHTSWLIGAGSSICGAAAVLATEPVVKAEASKVTVAVATVVIFGTVAIFLYPAIYPLMSQWFSPETFGIYIGSTVHEVAQVVAAGHAISPDAENAAVISKMLRVMMLAPFLILLAARVKQLSGANSGEKSKITIPWFAILFIVVAIFNSFHLLPQSVVNMLVTLDTFLLAMAMAALGLTTHVSALKKAGAKPLLMALVLFAWLIVGGGAINYVIQSVIA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12027
Length:	349 (321)
Sequences:	2464 (1768)
Seq/√Len:	98.7

ECOLI - YEIH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
123_G	134_S	4.596	1.00
194_P	219_S	4.306	1.00
193_S	196_T	4.248	1.00
119_A	138_G	4.209	1.00
119_A	329_L	4.150	1.00
118_L	332_W	4.018	1.00
50_A	304_A	4.012	1.00
216_H	223_E	3.808	1.00
20_L	76_A	3.651	1.00
90_F	274_V	3.577	1.00
192_F	338_G	3.281	1.00
130_D	162_K	3.148	1.00
269_I	273_V	3.023	1.00
270_L	273_V	3.007	1.00
132_H	162_K	3.002	1.00
205_V	214_A	2.977	1.00
215_G	226_A	2.959	1.00
152_T	244_L	2.778	1.00
149_V	170_V	2.714	1.00
83_L	86_I	2.698	1.00
139_A	152_T	2.612	1.00
185_Y	197_F	2.602	1.00
86_I	270_L	2.595	1.00
86_I	274_V	2.547	1.00
335_V	339_A	2.466	1.00
143_I	240_F	2.335	1.00
200_Y	334_I	2.287	1.00
79_Y	83_L	2.271	1.00
114_S	332_W	2.158	1.00
313_S	316_K	2.123	1.00
215_G	223_E	2.068	1.00
26_I	304_A	1.956	1.00
24_A	301_M	1.932	1.00
33_G	49_L	1.929	1.00
107_I	203_S	1.893	1.00
154_P	158_A	1.859	1.00
122_L	328_V	1.857	1.00
28_G	32_W	1.846	1.00
197_F	214_A	1.838	1.00
159_E	162_K	1.767	1.00
46_A	300_A	1.762	1.00
140_G	149_V	1.737	1.00
208_V	234_V	1.735	1.00
76_A	80_L	1.729	1.00
149_V	166_A	1.719	1.00
115_T	142_S	1.716	1.00
201_I	205_V	1.716	1.00
174_G	210_Q	1.715	1.00
274_V	277_F	1.696	1.00
221_D	224_N	1.693	1.00
94_F	276_I	1.674	1.00
153_E	163_V	1.651	1.00
194_P	221_D	1.631	1.00
264_I	269_I	1.602	1.00
197_F	218_I	1.581	1.00
123_G	325_M	1.550	1.00
311_H	314_A	1.549	1.00
278_N	288_V	1.521	1.00
97_I	275_A	1.519	1.00
273_V	277_F	1.518	1.00
116_F	139_A	1.506	1.00
219_S	222_A	1.501	1.00
67_K	70_D	1.501	1.00
196_T	341_N	1.496	1.00
113_S	117_L	1.488	1.00
177_A	330_F	1.487	1.00
177_A	205_V	1.465	1.00
283_L	288_V	1.464	1.00
96_Q	228_I	1.448	1.00
22_L	69_C	1.444	1.00
178_I	213_A	1.439	1.00
119_A	142_S	1.435	1.00
290_M	294_L	1.431	1.00
116_F	142_S	1.428	1.00
33_G	53_L	1.419	1.00
27_T	301_M	1.414	1.00
313_S	317_K	1.410	1.00
173_F	327_L	1.404	1.00
320_A	324_L	1.402	1.00
93_T	279_S	1.402	1.00
127_F	324_L	1.400	1.00
152_T	241_L	1.396	0.99
276_I	280_F	1.384	0.99
205_V	210_Q	1.372	0.99
339_A	342_Y	1.372	0.99
257_G	260_S	1.369	0.99
266_W	270_L	1.357	0.99
174_G	207_E	1.352	0.99
122_L	127_F	1.342	0.99
26_I	53_L	1.310	0.99
139_A	240_F	1.306	0.99
116_F	240_F	1.304	0.99
122_L	126_V	1.293	0.99
117_L	121_F	1.289	0.99
204_T	337_G	1.280	0.99
110_L	340_I	1.274	0.99
30_A	49_L	1.269	0.99
98_A	102_I	1.264	0.99
206_H	299_L	1.263	0.99
114_S	118_L	1.263	0.99
243_L	247_R	1.260	0.99
32_W	36_I	1.259	0.99
147_A	171_V	1.254	0.99
129_L	325_M	1.250	0.99
121_F	126_V	1.233	0.99
194_P	222_A	1.226	0.99
57_L	61_I	1.226	0.99
200_Y	338_G	1.208	0.99
147_A	207_E	1.186	0.98
112_L	236_M	1.180	0.98
203_S	341_N	1.169	0.98
104_G	199_I	1.169	0.98
277_F	282_L	1.168	0.98
198_G	222_A	1.167	0.98
88_Y	147_A	1.156	0.98
141_S	329_L	1.152	0.98
218_I	222_A	1.147	0.98
197_F	201_I	1.141	0.98
155_V	241_L	1.137	0.98
90_F	291_L	1.114	0.97
62_Y	73_V	1.112	0.97
108_D	232_L	1.112	0.97
186_P	218_I	1.109	0.97
79_Y	86_I	1.107	0.97
339_A	343_V	1.107	0.97
146_A	209_A	1.105	0.97
157_K	248_V	1.102	0.97
266_W	269_I	1.093	0.97
90_F	281_H	1.090	0.97
113_S	243_L	1.087	0.97
127_F	325_M	1.087	0.97
220_P	224_N	1.083	0.97
337_G	341_N	1.083	0.97
198_G	225_A	1.081	0.97
275_A	279_S	1.078	0.97
91_R	292_V	1.073	0.97
141_S	330_F	1.071	0.97
181_Y	204_T	1.059	0.97
329_L	337_G	1.058	0.97
94_F	279_S	1.055	0.97
16_F	20_L	1.046	0.96
58_G	311_H	1.044	0.96
219_S	223_E	1.043	0.96
273_V	276_I	1.035	0.96
286_S	289_N	1.030	0.96
95_S	98_A	1.024	0.96
132_H	156_V	1.022	0.96
76_A	301_M	1.022	0.96
213_A	227_V	1.019	0.96
73_V	308_L	1.006	0.95
128_G	132_H	1.002	0.95
147_A	151_A	0.998	0.95
70_D	74_L	0.992	0.95
207_E	303_M	0.976	0.95
142_S	244_L	0.975	0.95
56_V	59_N	0.971	0.94
146_A	207_E	0.962	0.94
118_L	122_L	0.961	0.94
81_L	302_A	0.960	0.94
200_Y	204_T	0.959	0.94
161_S	314_A	0.955	0.94
256_S	294_L	0.954	0.94
142_S	152_T	0.954	0.94
25_V	29_V	0.954	0.94
88_Y	223_E	0.953	0.94
207_E	210_Q	0.951	0.94
93_T	96_Q	0.950	0.94
166_A	326_A	0.948	0.94
281_H	288_V	0.948	0.94
194_P	218_I	0.948	0.94
290_M	293_T	0.946	0.94
287_V	290_M	0.941	0.93
174_G	234_V	0.939	0.93
114_S	117_L	0.938	0.93
93_T	275_A	0.935	0.93
45_S	207_E	0.930	0.93
185_Y	204_T	0.930	0.93
105_I	232_L	0.926	0.93
90_F	270_L	0.922	0.93
242_I	246_A	0.922	0.93
108_D	203_S	0.903	0.92
277_F	283_L	0.900	0.92
171_V	210_Q	0.900	0.92
111_T	203_S	0.900	0.92
158_A	163_V	0.897	0.92
210_Q	234_V	0.895	0.92
107_I	340_I	0.889	0.91
175_T	299_L	0.888	0.91
234_V	237_L	0.885	0.91
149_V	163_V	0.883	0.91
152_T	240_F	0.874	0.91
52_L	56_V	0.870	0.90
146_A	299_L	0.864	0.90
253_G	256_S	0.864	0.90
204_T	333_L	0.863	0.90
68_S	71_G	0.863	0.90
146_A	234_V	0.862	0.90
21_A	25_V	0.860	0.90
32_W	35_S	0.855	0.90
23_S	76_A	0.855	0.90
27_T	297_F	0.854	0.90
283_L	287_V	0.854	0.90
234_V	306_L	0.852	0.90
255_N	258_E	0.848	0.89
82_R	207_E	0.845	0.89
155_V	245_A	0.844	0.89
250_Q	253_G	0.841	0.89
56_V	60_T	0.837	0.89
138_G	329_L	0.837	0.89
24_A	28_G	0.835	0.89
285_Q	289_N	0.823	0.88
286_S	290_M	0.821	0.88
132_H	248_V	0.820	0.88
269_I	272_I	0.818	0.88
270_L	274_V	0.815	0.87
30_A	53_L	0.812	0.87
23_S	305_A	0.812	0.87
27_T	300_A	0.810	0.87
209_A	330_F	0.806	0.87
55_M	312_V	0.805	0.87
314_A	317_K	0.803	0.87
130_D	133_T	0.802	0.87
53_L	56_V	0.801	0.86
146_A	171_V	0.800	0.86
82_R	209_A	0.793	0.86
88_Y	268_A	0.793	0.86
171_V	306_L	0.791	0.86
175_T	206_H	0.790	0.86
277_F	285_Q	0.790	0.86
147_A	303_M	0.789	0.86
235_M	268_A	0.786	0.85
126_V	331_A	0.784	0.85
146_A	206_H	0.784	0.85
114_S	336_G	0.784	0.85
232_L	240_F	0.781	0.85
100_V	228_I	0.779	0.85
84_G	237_L	0.777	0.85
49_L	53_L	0.771	0.84
90_F	277_F	0.770	0.84
251_L	328_V	0.769	0.84
85_I	274_V	0.768	0.84
164_T	310_T	0.767	0.84
172_I	323_L	0.766	0.84
176_V	180_L	0.764	0.84
143_I	156_V	0.758	0.83
78_Q	164_T	0.757	0.83
88_Y	213_A	0.757	0.83
110_L	336_G	0.754	0.83
112_L	143_I	0.753	0.83
173_F	182_P	0.753	0.83
55_M	293_T	0.752	0.83
24_A	27_T	0.748	0.82
94_F	97_I	0.746	0.82
220_P	223_E	0.746	0.82
138_G	142_S	0.745	0.82
206_H	234_V	0.745	0.82
278_N	310_T	0.743	0.82
26_I	308_L	0.742	0.82
201_I	218_I	0.742	0.82
178_I	214_A	0.741	0.82
225_A	229_S	0.741	0.82
32_W	256_S	0.737	0.82
167_V	305_A	0.728	0.81
212_V	227_V	0.723	0.80
93_T	241_L	0.721	0.80
30_A	304_A	0.720	0.80
146_A	237_L	0.717	0.80
109_V	113_S	0.713	0.79
208_V	237_L	0.712	0.79
127_F	321_K	0.709	0.79
23_S	73_V	0.709	0.79
147_A	306_L	0.709	0.79
87_L	295_D	0.704	0.79
141_S	169_T	0.703	0.78
82_R	146_A	0.695	0.78
237_L	241_L	0.694	0.78
192_F	196_T	0.693	0.77
209_A	303_M	0.691	0.77
319_G	322_P	0.687	0.77
138_G	216_H	0.687	0.77
171_V	177_A	0.686	0.77
296_T	300_A	0.686	0.77
31_L	35_S	0.685	0.77
71_G	74_L	0.685	0.77
171_V	303_M	0.685	0.77
261_K	266_W	0.685	0.77
209_A	234_V	0.685	0.77
76_A	176_V	0.682	0.76
185_Y	218_I	0.680	0.76
183_A	187_L	0.672	0.75
181_Y	205_V	0.672	0.75
16_F	75_F	0.671	0.75
115_T	332_W	0.671	0.75
23_S	304_A	0.671	0.75
184_I	187_L	0.670	0.75
177_A	334_I	0.669	0.75
135_W	244_L	0.668	0.75
206_H	233_R	0.668	0.75
19_G	72_G	0.667	0.75
210_Q	237_L	0.665	0.75
134_S	325_M	0.662	0.74
72_G	75_F	0.661	0.74
179_F	183_A	0.660	0.74
48_T	175_T	0.659	0.74
180_L	183_A	0.659	0.74
336_G	340_I	0.658	0.74
178_I	182_P	0.658	0.74
75_F	79_Y	0.656	0.74
91_R	295_D	0.656	0.74
184_I	188_M	0.656	0.74
135_W	156_V	0.651	0.73
132_H	157_K	0.648	0.73
101_G	279_S	0.647	0.72
305_A	310_T	0.646	0.72
160_A	326_A	0.644	0.72
146_A	239_P	0.643	0.72
169_T	318_A	0.643	0.72
53_L	340_I	0.642	0.72
258_E	343_V	0.639	0.72
183_A	186_P	0.635	0.71
297_F	301_M	0.633	0.71
118_L	121_F	0.633	0.71
96_Q	99_D	0.633	0.71
253_G	294_L	0.633	0.71
47_L	306_L	0.631	0.71
196_T	228_I	0.630	0.70
102_I	311_H	0.630	0.70
143_I	189_S	0.630	0.70
175_T	203_S	0.628	0.70
98_A	105_I	0.628	0.70
284_P	287_V	0.625	0.70
291_L	294_L	0.624	0.70
338_G	342_Y	0.624	0.70
238_A	275_A	0.623	0.70
169_T	326_A	0.619	0.69
136_L	149_V	0.617	0.69
152_T	156_V	0.616	0.69
141_S	206_H	0.615	0.69
115_T	333_L	0.614	0.69
245_A	248_V	0.614	0.69
23_S	27_T	0.612	0.68
251_L	259_K	0.611	0.68
309_T	314_A	0.611	0.68
117_L	243_L	0.610	0.68
150_L	164_T	0.609	0.68
174_G	208_V	0.609	0.68
80_L	297_F	0.607	0.68
85_I	302_A	0.606	0.68
51_I	75_F	0.605	0.67
111_T	333_L	0.603	0.67
139_A	310_T	0.599	0.67
269_I	282_L	0.598	0.67
160_A	309_T	0.597	0.66
85_I	233_R	0.596	0.66
181_Y	209_A	0.596	0.66
15_H	71_G	0.594	0.66
204_T	207_E	0.592	0.66
58_G	62_Y	0.590	0.65
323_L	327_L	0.589	0.65
185_Y	338_G	0.586	0.65
150_L	181_Y	0.585	0.65
253_G	258_E	0.583	0.65
15_H	36_I	0.581	0.64
147_A	333_L	0.578	0.64
154_P	168_A	0.578	0.64
130_D	134_S	0.578	0.64
47_L	82_R	0.576	0.64
86_I	257_G	0.575	0.64
174_G	303_M	0.575	0.64
254_A	258_E	0.574	0.63
197_F	330_F	0.573	0.63
107_I	199_I	0.571	0.63
200_Y	222_A	0.570	0.63
285_Q	293_T	0.570	0.63
56_V	126_V	0.569	0.63
174_G	209_A	0.568	0.63
228_I	264_I	0.567	0.62
48_T	213_A	0.566	0.62
110_L	114_S	0.565	0.62
171_V	234_V	0.565	0.62
29_V	35_S	0.564	0.62
216_H	219_S	0.563	0.62
206_H	330_F	0.563	0.62
75_F	80_L	0.563	0.62
153_E	158_A	0.562	0.62
110_L	335_V	0.561	0.62
84_G	147_A	0.560	0.61
151_A	239_P	0.560	0.61
142_S	169_T	0.559	0.61
33_G	179_F	0.559	0.61
104_G	218_I	0.559	0.61
96_Q	279_S	0.559	0.61
200_Y	337_G	0.556	0.61
147_A	216_H	0.555	0.61
169_T	322_P	0.554	0.61
82_R	206_H	0.554	0.61
117_L	276_I	0.553	0.61
277_F	281_H	0.552	0.60
252_S	256_S	0.552	0.60
171_V	209_A	0.549	0.60
88_Y	296_T	0.549	0.60
85_I	216_H	0.549	0.60
165_V	322_P	0.548	0.60
271_F	279_S	0.547	0.60
171_V	174_G	0.547	0.60
72_G	76_A	0.547	0.60
198_G	227_V	0.547	0.60
201_I	222_A	0.547	0.60
19_G	23_S	0.546	0.60
18_P	26_I	0.546	0.60
208_V	218_I	0.545	0.59
118_L	253_G	0.544	0.59
105_I	236_M	0.544	0.59
257_G	276_I	0.544	0.59
141_S	171_V	0.543	0.59
133_T	162_K	0.543	0.59
199_I	261_K	0.543	0.59
21_A	32_W	0.543	0.59
90_F	288_V	0.542	0.59
228_I	232_L	0.541	0.59
147_A	208_V	0.541	0.59
48_T	138_G	0.540	0.59
197_F	213_A	0.539	0.59
66_W	69_C	0.538	0.58
147_A	227_V	0.537	0.58
47_L	146_A	0.537	0.58
238_A	272_I	0.536	0.58
80_L	155_V	0.536	0.58
207_E	330_F	0.535	0.58
163_V	196_T	0.535	0.58
51_I	303_M	0.535	0.58
199_I	225_A	0.534	0.58
140_G	174_G	0.534	0.58
76_A	305_A	0.532	0.58
212_V	222_A	0.531	0.57
131_K	134_S	0.531	0.57
140_G	233_R	0.531	0.57
150_L	268_A	0.530	0.57
238_A	299_L	0.529	0.57
21_A	35_S	0.529	0.57
29_V	71_G	0.527	0.57
85_I	140_G	0.524	0.56
171_V	206_H	0.524	0.56
24_A	297_F	0.523	0.56
73_V	76_A	0.523	0.56
312_V	339_A	0.523	0.56
84_G	111_T	0.522	0.56
121_F	125_K	0.521	0.56
177_A	181_Y	0.521	0.56
84_G	244_L	0.521	0.56
182_P	205_V	0.519	0.56
111_T	164_T	0.519	0.56
171_V	207_E	0.518	0.56
111_T	340_I	0.518	0.56
116_F	120_C	0.518	0.56
58_G	308_L	0.518	0.56
106_I	215_G	0.518	0.56
82_R	175_T	0.517	0.55
21_A	28_G	0.515	0.55
114_S	139_A	0.515	0.55
207_E	299_L	0.515	0.55
224_N	227_V	0.515	0.55
65_I	256_S	0.515	0.55
163_V	166_A	0.514	0.55
201_I	215_G	0.511	0.55
189_S	192_F	0.511	0.55
173_F	325_M	0.509	0.54
17_I	21_A	0.509	0.54
197_F	217_A	0.508	0.54
59_N	312_V	0.508	0.54
45_S	48_T	0.508	0.54
51_I	162_K	0.507	0.54
82_R	299_L	0.507	0.54
299_L	322_P	0.506	0.54
205_V	310_T	0.506	0.54
140_G	166_A	0.506	0.54
107_I	341_N	0.505	0.54
249_K	254_A	0.503	0.53
227_V	300_A	0.502	0.53
119_A	134_S	0.502	0.53
53_L	192_F	0.502	0.53
193_S	259_K	0.500	0.53

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4bwzA	2	0.8052	96.6	0.926	Contact Map
4czbA	2	0.8395	96.5	0.926	Contact Map
4cz8A	2	0.8997	96.3	0.928	Contact Map
3zuxA	1	0.788	96.1	0.929	Contact Map
4n7wA	2	0.7736	93.5	0.939	Contact Map
1zcdA	1	0.5014	23.7	0.967	Contact Map
1pw4A	1	0.5989	23.1	0.967	Contact Map
4tphA	2	0.7335	21.3	0.968	Contact Map
3v5uA	1	0.6275	12	0.971	Contact Map
2mgyA	1	0.4527	7.2	0.974	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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